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Volumn 10, Issue 5, 2014, Pages S290-S298

Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels

Author keywords

Alzheimer's disease; Biomarker; Cerebrospinal fluid; Dementia; Dementia with; Lewy bodies tau; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; ALPHA SYNUCLEIN 140; AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; HEMOGLOBIN; LEVODOPA; TAU PROTEIN; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); MAPT PROTEIN, HUMAN; PEPTIDE FRAGMENT; SNCA PROTEIN, HUMAN;

EID: 84908245806     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2013.10.004     Document Type: Article
Times cited : (74)

References (46)
  • 1
    • 0038526366 scopus 로고    scopus 로고
    • Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
    • A.R. Merdes, L.A. Hansen, D.V. Jeste, D. Galasko, C.R. Hofstetter, and G.J. Ho Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies Neurology 60 2003 1586 1590
    • (2003) Neurology , vol.60 , pp. 1586-1590
    • Merdes, A.R.1    Hansen, L.A.2    Jeste, D.V.3    Galasko, D.4    Hofstetter, C.R.5    Ho, G.J.6
  • 3
    • 84876355554 scopus 로고    scopus 로고
    • Amyloid pathology influences abeta1-42 cerebrospinal fluid levels in dementia with Lewy bodies
    • S. Slaets, Bastard N. Le, J. Theuns, K. Sleegers, A. Verstraeten, and Leenheir E. De Amyloid pathology influences abeta1-42 cerebrospinal fluid levels in dementia with Lewy bodies J Alzheimers Dis 35 2013 137 146
    • (2013) J Alzheimers Dis , vol.35 , pp. 137-146
    • Slaets, S.1    Le, B.N.2    Theuns, J.3    Sleegers, K.4    Verstraeten, A.5    De, L.E.6
  • 5
    • 33748325848 scopus 로고    scopus 로고
    • Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease
    • T. Tokuda, S.A. Salem, D. Allsop, T. Mizuno, M. Nakagawa, and M.M. Qureshi Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease Biochem Biophys Res Commun 349 2006 162 166
    • (2006) Biochem Biophys Res Commun , vol.349 , pp. 162-166
    • Tokuda, T.1    Salem, S.A.2    Allsop, D.3    Mizuno, T.4    Nakagawa, M.5    Qureshi, M.M.6
  • 6
    • 49449105990 scopus 로고    scopus 로고
    • Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
    • B. Mollenhauer, V. Cullen, I. Kahn, B. Krastins, T.F. Outeiro, and I. Pepivani Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration Exp Neurol 213 2008 315 325
    • (2008) Exp Neurol , vol.213 , pp. 315-325
    • Mollenhauer, B.1    Cullen, V.2    Kahn, I.3    Krastins, B.4    Outeiro, T.F.5    Pepivani, I.6
  • 7
    • 77953716788 scopus 로고    scopus 로고
    • Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
    • K. Kasuga, T. Tokutake, A. Ishikawa, T. Uchiyama, T. Tokuda, and O. Onodera Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease J Neurol Neurosurg Psychiatry 81 2010 608 610
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 608-610
    • Kasuga, K.1    Tokutake, T.2    Ishikawa, A.3    Uchiyama, T.4    Tokuda, T.5    Onodera, O.6
  • 8
    • 78649990079 scopus 로고    scopus 로고
    • Detection of elevated levels of alpha-synuclein oligomers in CSF from patients with Parkinson disease
    • T. Tokuda, M.M. Qureshi, M.T. Ardah, S. Varghese, S.A. Shehab, and T. Kasai Detection of elevated levels of alpha-synuclein oligomers in CSF from patients with Parkinson disease Neurology 75 2010 1766 1772
    • (2010) Neurology , vol.75 , pp. 1766-1772
    • Tokuda, T.1    Qureshi, M.M.2    Ardah, M.T.3    Varghese, S.4    Shehab, S.A.5    Kasai, T.6
  • 10
    • 77950223687 scopus 로고    scopus 로고
    • DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    • Z. Hong, M. Shi, K.A. Chung, J.F. Quinn, E.R. Peskind, and D. Galasko DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease Brain 133 2010 713 726
    • (2010) Brain , vol.133 , pp. 713-726
    • Hong, Z.1    Shi, M.2    Chung, K.A.3    Quinn, J.F.4    Peskind, E.R.5    Galasko, D.6
  • 11
    • 79960613150 scopus 로고    scopus 로고
    • Cerebrospinal fluid Tau/alpha-synuclein ratio in Parkinson's disease and degenerative dementias
    • L. Parnetti, D. Chiasserini, G. Bellomo, D. Giannandrea, C.C. De, and M.M. Qureshi Cerebrospinal fluid Tau/alpha-synuclein ratio in Parkinson's disease and degenerative dementias Mov Disord 26 2011 1428 1435
    • (2011) Mov Disord , vol.26 , pp. 1428-1435
    • Parnetti, L.1    Chiasserini, D.2    Bellomo, G.3    Giannandrea, D.4    De, C.C.5    Qureshi, M.M.6
  • 12
    • 84865756966 scopus 로고    scopus 로고
    • Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease
    • F. Tateno, R. Sakakibara, T. Kawai, M. Kishi, and T. Murano Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease Alzheimer Dis Assoc Disord 26 2012 213 216
    • (2012) Alzheimer Dis Assoc Disord , vol.26 , pp. 213-216
    • Tateno, F.1    Sakakibara, R.2    Kawai, T.3    Kishi, M.4    Murano, T.5
  • 14
    • 60349122813 scopus 로고    scopus 로고
    • Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders
    • P.E. Spies, R.J. Melis, M.J. Sjogren, M.G. Rikkert, and M.M. Verbeek Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders J Alzheimers Dis 16 2009 363 369
    • (2009) J Alzheimers Dis , vol.16 , pp. 363-369
    • Spies, P.E.1    Melis, R.J.2    Sjogren, M.J.3    Rikkert, M.G.4    Verbeek, M.M.5
  • 16
  • 17
    • 33144489150 scopus 로고    scopus 로고
    • Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
    • I.G. McKeith, D.W. Dickson, J. Lowe, M. Emre, J.T. O'Brien, and H. Feldman Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium Neurology 65 2005 1863 1872
    • (2005) Neurology , vol.65 , pp. 1863-1872
    • McKeith, I.G.1    Dickson, D.W.2    Lowe, J.3    Emre, M.4    O'Brien, J.T.5    Feldman, H.6
  • 18
    • 0014082977 scopus 로고
    • Parkinsonism: Onset, progression and mortality
    • M.M. Hoehn, and M.D. Yahr Parkinsonism: onset, progression and mortality Neurology 17 1967 427 442
    • (1967) Neurology , vol.17 , pp. 427-442
    • Hoehn, M.M.1    Yahr, M.D.2
  • 19
    • 0003652388 scopus 로고    scopus 로고
    • American Psychiatric Association 4th ed. American Psychiatric Association Washington, DC
    • American Psychiatric Association DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders 4th ed. 2000 American Psychiatric Association Washington, DC
    • (2000) DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders
  • 21
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 34 1984 939 944
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 22
    • 34548292987 scopus 로고    scopus 로고
    • No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease
    • S. Engelborghs, K. Sleegers, P. Cras, N. Brouwers, S. Serneels, and E. De Leenheir No association of CSF biomarkers with APOEepsilon4, plaque and tangle burden in definite Alzheimer's disease Brain 130 2007 2320 2326
    • (2007) Brain , vol.130 , pp. 2320-2326
    • Engelborghs, S.1    Sleegers, K.2    Cras, P.3    Brouwers, N.4    Serneels, S.5    De Leenheir, E.6
  • 23
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • H. Braak, and E. Braak Neuropathological staging of Alzheimer-related changes Acta Neuropathol 82 1991 239 259
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 24
    • 33749150163 scopus 로고    scopus 로고
    • Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
    • H. Braak, I. Alafuzoff, T. Arzberger, H. Kretzschmar, and T.K. Del Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry Acta Neuropathol 112 2006 389 404
    • (2006) Acta Neuropathol , vol.112 , pp. 389-404
    • Braak, H.1    Alafuzoff, I.2    Arzberger, T.3    Kretzschmar, H.4    Del, T.K.5
  • 26
    • 84868585835 scopus 로고    scopus 로고
    • Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or Parkinsonian disorders
    • S. Hall, A. Ohrfelt, R. Constantinescu, U. Andreasson, Y. Surova, and F. Bostrom Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or Parkinsonian disorders Arch Neurol 69 2012 1445 1452
    • (2012) Arch Neurol , vol.69 , pp. 1445-1452
    • Hall, S.1    Ohrfelt, A.2    Constantinescu, R.3    Andreasson, U.4    Surova, Y.5    Bostrom, F.6
  • 27
    • 58149469520 scopus 로고    scopus 로고
    • Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?
    • A. Ohrfelt, P. Grognet, N. Andreasen, A. Wallin, E. Vanmechelen, and K. Blennow Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss? Neurosci Lett 450 2009 332 335
    • (2009) Neurosci Lett , vol.450 , pp. 332-335
    • Ohrfelt, A.1    Grognet, P.2    Andreasen, N.3    Wallin, A.4    Vanmechelen, E.5    Blennow, K.6
  • 28
    • 84855176252 scopus 로고    scopus 로고
    • Analytical error and interference in immunoassay: Minimizing risk
    • C.M. Sturgeon, and A. Viljoen Analytical error and interference in immunoassay: minimizing risk Ann Clin Biochem 48 2011 418 432
    • (2011) Ann Clin Biochem , vol.48 , pp. 418-432
    • Sturgeon, C.M.1    Viljoen, A.2
  • 30
    • 74149089257 scopus 로고    scopus 로고
    • Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment
    • O. Hansson, H. Zetterberg, E. Vanmechelen, H. Vanderstichele, U. Andreasson, and E. Londos Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment Neurobiol Aging 31 2010 357 367
    • (2010) Neurobiol Aging , vol.31 , pp. 357-367
    • Hansson, O.1    Zetterberg, H.2    Vanmechelen, E.3    Vanderstichele, H.4    Andreasson, U.5    Londos, E.6
  • 31
    • 79951936156 scopus 로고    scopus 로고
    • The decrease of beta-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies
    • K. Beyer, M. Domingo-Sabat, C. Santos, E. Tolosa, I. Ferrer, and A. Ariza The decrease of beta-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies Brain 133 2010 3724 3733
    • (2010) Brain , vol.133 , pp. 3724-3733
    • Beyer, K.1    Domingo-Sabat, M.2    Santos, C.3    Tolosa, E.4    Ferrer, I.5    Ariza, A.6
  • 32
    • 84867021118 scopus 로고    scopus 로고
    • Alternative alpha-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology
    • H. Rhinn, L. Qiang, T. Yamashita, D. Rhee, A. Zolin, and W. Vanti Alternative alpha-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology Nat Commun 3 2012 1084
    • (2012) Nat Commun , vol.3 , pp. 1084
    • Rhinn, H.1    Qiang, L.2    Yamashita, T.3    Rhee, D.4    Zolin, A.5    Vanti, W.6
  • 33
    • 0034651575 scopus 로고    scopus 로고
    • A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
    • B.I. Giasson, R. Jakes, M. Goedert, J.E. Duda, S. Leight, and J.Q. Trojanowski A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease J Neurosci Res 59 2000 528 533
    • (2000) J Neurosci Res , vol.59 , pp. 528-533
    • Giasson, B.I.1    Jakes, R.2    Goedert, M.3    Duda, J.E.4    Leight, S.5    Trojanowski, J.Q.6
  • 35
    • 84888202286 scopus 로고    scopus 로고
    • CSF alpha-synuclein improves diagnostic and prognostic performance of CSF tau and Abeta in Alzheimer's disease
    • J.B. Toledo, A. Korff, L.M. Shaw, J.Q. Trojanowski, and J. Zhang CSF alpha-synuclein improves diagnostic and prognostic performance of CSF tau and Abeta in Alzheimer's disease Acta Neuropathol 126 2013 683 697
    • (2013) Acta Neuropathol , vol.126 , pp. 683-697
    • Toledo, J.B.1    Korff, A.2    Shaw, L.M.3    Trojanowski, J.Q.4    Zhang, J.5
  • 36
    • 84881424881 scopus 로고    scopus 로고
    • Alpha-synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment
    • A. Korff, C. Liu, C. Ginghina, M. Shi, and J. Zhang Alpha-synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment J Alzheimers Dis 36 2013 679 688
    • (2013) J Alzheimers Dis , vol.36 , pp. 679-688
    • Korff, A.1    Liu, C.2    Ginghina, C.3    Shi, M.4    Zhang, J.5
  • 37
    • 84858136734 scopus 로고    scopus 로고
    • Altered CSF orexin and alpha-synuclein levels in dementia patients
    • M. Wennstrom, E. Londos, L. Minthon, and H.M. Nielsen Altered CSF orexin and alpha-synuclein levels in dementia patients J Alzheimers Dis 29 2012 125 132
    • (2012) J Alzheimers Dis , vol.29 , pp. 125-132
    • Wennstrom, M.1    Londos, E.2    Minthon, L.3    Nielsen, H.M.4
  • 38
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer's disease facts and figures
    • W. Thies, and L. Bleiler 2013 Alzheimer's disease facts and figures Alzheimers Dement 9 2013 208 245
    • (2013) Alzheimers Dement , vol.9 , pp. 208-245
    • Thies, W.1    Bleiler, L.2
  • 39
    • 84872189834 scopus 로고    scopus 로고
    • Low CSF levels of both alpha-synuclein and the alpha-synuclein cleaving enzyme neurosin in patients with synucleinopathy
    • M. Wennstrom, Y. Surova, S. Hall, C. Nilsson, L. Minthon, and F. Bostrom Low CSF levels of both alpha-synuclein and the alpha-synuclein cleaving enzyme neurosin in patients with synucleinopathy PLoS One 8 2013 e53250
    • (2013) PLoS One , vol.8 , pp. 53250
    • Wennstrom, M.1    Surova, Y.2    Hall, S.3    Nilsson, C.4    Minthon, L.5    Bostrom, F.6
  • 40
    • 77949423619 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    • K. Blennow, H. Hampel, M. Weiner, and H. Zetterberg Cerebrospinal fluid and plasma biomarkers in Alzheimer disease Nat Rev Neurol 6 2010 131 144
    • (2010) Nat Rev Neurol , vol.6 , pp. 131-144
    • Blennow, K.1    Hampel, H.2    Weiner, M.3    Zetterberg, H.4
  • 41
    • 79951811787 scopus 로고    scopus 로고
    • Alpha-synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: The effect of therapeutic hypothermia
    • E. Su, M.J. Bell, S.R. Wisniewski, P.D. Adelson, K.L. Janesko-Feldman, and R. Salonia Alpha-synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia Dev Neurosci 32 2010 385 395
    • (2010) Dev Neurosci , vol.32 , pp. 385-395
    • Su, E.1    Bell, M.J.2    Wisniewski, S.R.3    Adelson, P.D.4    Janesko-Feldman, K.L.5    Salonia, R.6
  • 42
    • 84862222003 scopus 로고    scopus 로고
    • Cerebrospinal fluid alpha-synuclein levels are elevated in multiple sclerosis and neuromyelitis optica patients during replase
    • H. Wang, K. Wang, W. Xu, C. Wang, W. Qiu, and X. Zhong Cerebrospinal fluid alpha-synuclein levels are elevated in multiple sclerosis and neuromyelitis optica patients during replase J Neurochem 122 2012 19 23
    • (2012) J Neurochem , vol.122 , pp. 19-23
    • Wang, H.1    Wang, K.2    Xu, W.3    Wang, C.4    Qiu, W.5    Zhong, X.6
  • 45
    • 0032033832 scopus 로고    scopus 로고
    • Consensus report of the Working Group on: "molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group
    • The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and National Institute on Aging Working Group
    • The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and National Institute on Aging Working Group Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group Neurobiol Aging 19 1998 109 116
    • (1998) Neurobiol Aging , vol.19 , pp. 109-116
  • 46
    • 79953283868 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    • M. Shi, J. Bradner, A.M. Hancock, K.A. Chung, J.F. Quinn, and E.R. Peskind Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression Ann Neurol 69 2011 570 580
    • (2011) Ann Neurol , vol.69 , pp. 570-580
    • Shi, M.1    Bradner, J.2    Hancock, A.M.3    Chung, K.A.4    Quinn, J.F.5    Peskind, E.R.6


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