Pentoxifylline attenuates methionine- and choline-deficient-diet-induced steatohepatitis by suppressing TNF-α expression and endoplasmic reticulum stress

Experimental Diabetes Research

Volumn 2012, Issue , 2012, Pages

  Chae, Min Kyung ^a   Park, Sang Gyu ^b,c   Song, Sun Ok ^a   Kang, Eun Seok ^a   Cha, Bong Soo ^a   Lee, Hyun Chul ^a   Lee, Byung Wan ^a  

^a Yonsei University College of Medicine   (South Korea)

^b CHA University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALANINE AMINOTRANSFERASE; CHOLINE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; JANUS KINASE; MESSENGER RNA; METHIONINE; PENTOXIFYLLINE; PROTEIN; PROTEIN IRE1; TRANSCRIPTION FACTOR ELF 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PHOSPHODIESTERASE INHIBITOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL VIABILITY; CONTROLLED STUDY; DIET; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER WEIGHT; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BLOOD; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; FATTY LIVER; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; VITAMIN DEFICIENCY;

ALANINE TRANSAMINASE; ANIMALS; CELL LINE; CHOLINE DEFICIENCY; DIET; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; MALE; METHIONINE; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UNFOLDED PROTEIN RESPONSE;

EID: 84858319282     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/762565     Document Type: Article

References (12)

1. Angulo P., Medical progress: nonalcoholic fatty liver disease New England Journal of Medicine 2002 346 16 1221 1231 (Pubitemid 34984585)
2. Barter P. J., The causes and consequences of low levels of high density lipoproteins in patients with diabetes Diabetes Metabolism Journal 2011 35 2 101 106
3. Shoelson S. E., Lee J., Goldfine A. B., Inflammation and insulin resistance Journal of Clinical Investigation 2006 116 7 1793 1801 (Pubitemid 44033299)
4. Lee Y. M., Sutedja D. S., Wai C. T., Dan Y. Y., Aung M. O., Zhou L., Cheng C. L., Wee A., Lim S. G., A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH) Hepatology International 2008 2 2 196 201 (Pubitemid 351650148)
5. Georgescu E. F., Georgescu M., Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all agents alike? Results of a preliminary study Journal of Gastrointestinal and Liver Diseases 2007 16 1 39 46 (Pubitemid 46548588)
6. Kugelmas M., Hill D. B., Vivian B., Marsano L., McClain C. J., Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E Hepatology 2003 38 2 413 419 (Pubitemid 36919862)
7. Li W., Zheng L., Sheng C., Cheng X., Qing L., Qu S., Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease Lipids in Health and Disease 2011 10, article 49
8. Bahra P. S., Rainger G. E., Wautier J. L., Nash G. B., Effects of pentoxifylline on the different steps during adhesion and transendothelial migration of flowing neutrophils Cell Biochemistry and Function 2001 19 4 249 257 (Pubitemid 33097880)
9. Zhang K., Wang S., Malhotra J., Hassler J. R., Back S. H., Wang G., Chang L., Xu W., Miao H., Leonardi R., Chen Y. E., Jackowski S., Kaufman R. J., The unfolded protein response transducer IRE1 prevents ER stress-induced hepatic steatosis EMBO Journal 2011 30 7 1357 1375
10. Satapathy S. K., Sakhuja P., Malhotra V., Sharma B. C., Sarin S. K., Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis Journal of Gastroenterology and Hepatology 2007 22 5 634 638 (Pubitemid 46608380)
11. Malhi H., Gores G. J., Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease Seminars in Liver Disease 2008 28 4 360 369
12. Puri P., Mirshahi F., Cheung O., Natarajan R., Maher J. W., Kellum J. M., Sanyal A. J., Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease Gastroenterology 2008 134 2 568 576 (Pubitemid 351173040)