Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 3 39-3, 1996, Pages

  Ma, Jianya ^a   Ayata, Cenk ^a   Huang, Paul L ^a   Fishman, Mark C ^a   Moskowitz, Michael A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Stroke and Neurovascular Regulation Laboratory   (United States)

Author keywords

nitric oxide; N nitro L arginine; transgenic mice; type I nitric oxide synthase; whisker stimulation

Indexed keywords

ACETYLCHOLINE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; LASER DOPPLER FLOWMETRY; MALE; METABOLISM; MOUSE; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; STIMULATION; TRANSGENIC MOUSE; VASODILATATION; VIBRISSA;

EID: 33745351949     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.3.h1085     Document Type: Article

References (33)

1. Adachi, K., S. Takahashi, P. Melzer, K. L. Campos, T. Nelson, C. Kennedy, and L. Sokoloff. Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H2155-H2162, 1994.
2. Akgören, N., M. Fabricius, and M. Lauritzen. Importance of nitric oxide for local increases of blood flow in rat cerebellar cortex during electrical stimulation. Proc. Natl. Acad. Sci. USA 91: 5903-5907, 1994.
3. Cox, S. B., T. A. Woolsey, and C. M. Rovainen. Localized dynamic changes in cortical blood flow with whisker stimulation corresponds to matched vascular and neuronal architecture of rat barrels. J. Cereb. Blood Flow Metab. 13: 899-913, 1993.
4. Dalkara, T., K. Irikura, Z. Huang, N. Panahian, and M. A. Moskowitz. Cerebrovascular responses under controlled physiological conditions in the anesthetized mouse. J. Cereb. Blood Flow Metab. 15: 631-638, 1995.
5. Dinerman, J. T. L., T. M. Dawson, M. J. Schell, A. Snowman, and S. H. Snyder. Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. Proc. Natl. Acad. Sci. USA 91: 4214-4218, 1994.
6. Dirnagl, U., K. Niwa, U. Lindauer, and A. Villringer. Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H296-H301, 1994.
7. Dirnagl, U., U. Lindauer, and A. Villringer. Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats. Neurosci. Lett 149: 43-46, 1993.
8. Dirnagl, U., U. Lindauer, and A. Villringer. Nitric oxide synthase blockade enhances vasomotion in the cerebral microcirculation of the anesthetized rats. Microvasc. Res. 45: 318-323, 1993.
9. Gustaffson, H., M. J. Mulvany, and H. Nilsson. Rhythmic contractions of isolated small arteries from rat: influence of the endothelium. Acta Physiol. Scand. 148: 153-163, 1993.
10. Huang, P. L., T. M. Dawson, T. S. Bredt, S. H. Snyder, and M. C. Fishman. Targeted disruption of neuronal nitric oxide synthase gene. Cell 75: 1273-1286, 1993.
11. Huang, Z., P. L. Huang, N. Panahian, T. Dalkara, M. C. Fishman, and M. A. Moskowitz. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science Wash. DC 265: 1883-1885, 1994.
12. Hudetz, A. G., R. J. Roman, and D. R. Harder. Spontaneous flow oscillations in the cerebral cortex during acute changes in mean arterial pressure. J. Cereb. Blood Flow Metab. 12: 491-499, 1992.
13. Iadecola, C. Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link? Trends Neurosci. 16: 206-215, 1993.
14. Iadecola, C., D. A. Pelligrino, M. A. Moskowitz, and N. A. Lassen. State of the art review, nitric oxide synthase inhibition and cerebrovascular regulation. J. Cereb. Blood Flow Metab. 14: 175-192, 1994.
15. Ibayashi, S., A. C. Ngai, M. A. Howard, J. R. Meno, M. R. Mayberg, and H. R. Winn. Lack of sympathetic and cholinergie influences on cerebral vasodilation caused by sciatic nerve stimulation in the rat. J. Cereb. Blood Flow Metab. 11: 678-83, 1991.
16. Irikura, K., P. L. Huang, J. Ma, W. S. Lee, T. Dalkara, M. C. Fishman, T. M. Dawson, S. H. Snyder, and M. A. Moskowitz. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc. Natl. Acad. Sci. USA 92: 6823-6827, 1995.
17. Irikura, K., K. I. Maynard, and M. A. Moskowitz. Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissal stimulation. J. Cereb. Blood Flow Metab. 14: 45-48, 1994.
18. Kastrup, J., J. Bulow, and N. A. Lassen. Vasomotion in human skin before and after local heating recorded by laser-Doppler flowmetry. Int. J. Microcirc. Clin. Exp. 8: 205-215, 1989.
19. G-nitro-L-arginine on regional cerebral blood flow in the cat. J. Physiol. Lond. 449 183-196, 1992.
20. Lindauer, U., A. Villringer, and U. Dirnagl. Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1223-H1228, 1993.
21. Lou, H. C., L. Edvinsson, and E. T. MacKenzie. The concept of coupling blood flow to brain function: revision required? Ann. Neurol. 22: 289-297, 1987.
22. Maines, M. D., J. A. Mark, and J. F. Ewing. Heme oxygenase, a likely regulator of cGMP production in brain-induction in vivo of HO1 compensates for depression in NO synthase activity. Mol. Cell. Neurosci. 4: 398-405, 1993.
23. Moncada, S., R. M. J. Palmer, and E. A. Higgs. Nitric oxide-physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142, 1992.
24. Morita-Tsuzuki, Y., E. Bouskela, and J. E. Hardebo. Vasomotion in rat cerebral microcirculation recorded by laser-Doppler flowmetry. Acta Physiol. Scand. 146: 431-439, 1992.
25. Northington, F. J., G. P. Matherne, and R. M. Berne. Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation Proc. Natl. Acad. Sci. USA 89: 6649-6652, 1992.
26. Nozaki, K., M. A. Moskowitz, K. I. Maynard, N. Koketsu, T. M. Dawson, D. S. Bredt, and S. H. Snyder. Possible origin and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. J. Cereb. Blood Flow Metab. 13: 70-79, 1993.
27. Prado, R., B. D. Watson, J. Kuluz, and W. D. Dietrich. Endothelium-derived nitric oxide synthase inhibition: effects on cerebral blood flow, pial artery diameter, and vascular morphology in rats. Stroke 23: 1118-1124, 1992.
28. Roy, C. W., and C. S. Sherrington. On the regulation of the blood supply of the brain. J. Physiol. Lond. 11: 85-108, 1890.
29. Schmidt, H. H. H. W., T. D. Warner, K. Ishii, H. Sheng, and F. Murad. Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science Wash. DC 255: 721, 1992.
30. Tanaka, K., F. Gotoh, G. Sintaro, S. Takashima, B. Mihara, T. Shirai, S. Nogawa, and E. Nagata. Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat. Neurosci. Lett. 127: 129-132, 1991.
31. Welker, C. Microelectrode delineation of fine grain somatotopic organization of SmI cerebral neocortex in albino rat. Brain Res. 26: 259-275, 1971.
32. Woolsey, T. A., and H. Van Der Loos. The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex: the description of a cortical field composed of discrete cytoarchitectonic units. Brain Res. 17: 205-242, 1970.
33. Zagvazdin, Y., G. Sancesario, M. E. C. Fitzgerald, and A. Reiner. The effect of 7-nitroindazole, an inhibitor of brain nitric oxide synthase (NOS), on basal cortical blood flow and on vasodilation induced by whisker stimulation. Sac. Neurosci. Abstr. 410.9, 1994.