Transferrin-modified liposome promotes α-mangostin to penetrate the blood-brain barrier

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 12, Issue 2, 2016, Pages 421-430

  Chen, Zhi Lan ^a   Huang, Man ^b   Wang, Xia Rong ^a   Fu, Jun ^c   Han, Min ^a   Shen, You Qing ^d   Xia, Zheng ^e   Gao, Jian Qing ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d ZHEJIANG UNIVERSITY   (China)

^e ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Brain targeting; Liposome; Transferrin; Mangostin

Indexed keywords

BLOOD; LIPOSOMES;

ALZHEIMER'S DISEASE; BLOOD-BRAIN BARRIER; BRAIN DELIVERY; BRAIN TARGETING; CORTICAL NEURONS; IN-VITRO; INTRACELLULAR DISTRIBUTION; TRANSFERRIN;

NEURODEGENERATIVE DISEASES;

ALPHA MANGOSTIN; CLATHRIN; DRUG CARRIER; LIPOSOME; POLYPHENOL DERIVATIVE; TRANSFERRIN; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; MANGOSTIN; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG RELEASE; DRUG UPTAKE; ENCAPSULATION; ENDOCYTOSIS; ENDOTHELIUM CELL; HALF LIFE TIME; IN VITRO STUDY; IN VIVO STUDY; LIPOSOMAL DELIVERY; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PARTICLE SIZE; RAT; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; ALZHEIMER DISEASE; ANIMAL; BRAIN; CELL LINE; CHEMISTRY; GARCINIA MANGOSTANA; METABOLISM; SPRAGUE DAWLEY RAT;

ALZHEIMER DISEASE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE; DRUG DELIVERY SYSTEMS; GARCINIA MANGOSTANA; LIPOSOMES; MICE; NEUROPROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; TRANSFERRIN; XANTHONES;

EID: 84954290380     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2015.10.021     Document Type: Article

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