Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin

Neurological Research

Volumn 25, Issue 3, 2003, Pages 275-279

  Omori, Nobuhiko ^a   Maruyama, K ^b   Jin, G ^a   Li, F ^a   Wang, S J ^a   Hamakawa, Y ^a   Sato, K ^a   Nagano, I ^a   Shoji, M ^a   Abe, K ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

CM Dil; Drug delivery system; Liposome; MCAO; Transferrin receptor

Indexed keywords

LIPOSOME; MACROGOL; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CONJUGATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLUORESCENCE; GENE EXPRESSION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; RAT; STROKE; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; ENDOTHELIUM, VASCULAR; INFARCTION, MIDDLE CEREBRAL ARTERY; LIPOSOMES; MALE; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; RECEPTORS, TRANSFERRIN; TELENCEPHALON; TRANSFERRIN;

EID: 0242500277     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164103101201508     Document Type: Article

References (29)

1. Huwyler J, Wu D, Pardridge WM. Brain drug delivery of small molecules using immunoliposomes. Proc Nat Acad Sci USA 1996; 93: 14164-14169
2. Pardridge WM. Drug delivery to the brain. J Cereb Blood Flow Metab 1997; 17: 713-731
3. Moos T. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol 1996; 375: 675-692
4. Jeong Lee H, Pardridge WM. Drug targeting to the brain using avidin-biotin technology in the mouse: Blood-brain barrier, monoclonal antibody, transferrin receptor, Alzheimer's disease. J Drug Target 2000; 8: 413-424
5. Pardridge WM, Boado RJ, Kang YS. Vector-mediated delivery of a polyamide (′peptide′) nucleic acid analogue through the blood-brain barrier in vivo. Proc Nat Acad Sci USA 1995; 92: 5592-5596
6. Wu D, Pardridge WM. Neuroprotection with non-invasive neurotrophin delivery to brain. Proc Nat Acad Sci USA 1999; 96: 254-259
7. Zhang Y, Pardridge WM. Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin. Brain Res 2001; 889: 49-56
8. Zhang Y, Pardridge WM. Neuroprotection in transient focal brain ischemia after intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system. Stroke 2001; 32: 1378-1383
9. Maruyama K. In vivo targeting by liposomes. Biol Pharm Bull 2000; 23: 791-799
10. Maruyama K, Takizawa T, Yuda T, Kennel SJ, Huang L, Iwatsuru M. Targetability of novel immunoliposomes modified with amphipathic poly (ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies. Biochim Biophys Acta 1995; 1234: 74-80
11. Ishida O, Maruyama K, Tanahashi H, Iwatsuru M, Sasaki K, Eriguchi M, Yanagie H. Liposomes bearing polyethyleneglycol-coupled transferrin with intracellular targeting property to the solid tumors in vivo. Pharm Res 2001; 18: 1042-1048
12. Yuda T, Maruyama K, Iwatsuru M. Prolongation of liposome circulation time by various derivatives of polyethyleneglycols. Biol Pharm Bull 1996; 19: 1347-1351
13. Abe K, Hayashi T. Expression of the GDNF gene in rat brain after transient MCA occlusion. Brain Res 1997; 776: 230-234
14. Abe K, Setoguchi Y, Hayashi T, Itoyama Y. In vivo adenovirus-mediated gene transfer and the expression in ischemic and reperfused rat brain. Brain Res 1997; 763: 191-202
15. Kitagawa H, Sasaki C, Sakai K, Mori A, Mitsumoto Y, Mori T, Fukuchi Y, Setoguchi Y, Abe K. Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents ischemic brain injury after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 1999; 19: 1336-1334
16. Kitagawa H, Warita H, Sasaki C, Zhang WR., Sakai K, Shiro Y, Mitsumoto Y, Mori T, Abe K. Immunoreactive Akt, Pl3-K and ERK protein kinase expression in ischemic rat brain. Neurosci Lett 1999; 274: 45-48
17. Iwai M, Sato K, Omori N, Nagano I, Manabe Y, Shoji M, Abe K. Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia. J Cereb Blood Flow Metab 2002; 22: 411-419
18. Bickel U, Yoshikawa T, Pardridge WM. Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Deliv Rev 2001; 46: 247-279
19. Li H, Sun H, Qiam ZM. The role of transferrin-transferrin-receptor system in drug delivery and targeting. Trends Pharmacol Sci 2002; 23: 206-209.
20. Granholm AC, Albeck D, Backman C, Curtis M, Ebendal T, Friden P, Henry M, Hoffer B, Kordower J, Rose GM, Soderstrom S, Bartus RT. A non-invasive system for delivering neural growth factor across the blood-brain barrier: A review. Rev Neurosci 1998; 9: 31-55
21. Pardridge WM, Buciak JL, Friden PM. Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier. J Pharmacol Exp Ther 1991; 259: 66-70
22. Laskey J, Webb J, Shulman HM, Ponka P. Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis. Exp Cell Res 1988; 176: 87-95
23. Abe K, Aoki M, Kawagoe T, Yoshida T, Hattori A, Kogure K, Itoyama Y. Ischemic delayed neuronal death: A mitochondrial hypothesis. Stroke 1995; 26: 1478-1489
24. Kaur C, Ling EA. Increased expression of transferrin receptors and iron in amoeboid microglial cells postnatal rats following an exposure to hypoxia. Neurosci Lett 1999; 262: 183-186
25. 125I] transferrin through the rat blood-brain barrier. Brain Res 1995; 683: 164-171
26. Broadwell RD, Baker-Cairns BJ, Friden PM, Oliver C, Villegas JC. Transcytosis of protein through the mammalian cerebral epithelium and endothelium. Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferin and antibody against the transferrin receptor. Exp Neurol 1996; 142: 47-65
27. Yuda T, Pongpaibul K, Maruyama K, Iwatsuru M. Activity of amphipathic polyethyleneglycols to prolong the circulation time of liposomes. J Pharm Sci Technol Jpn 1999; 59: 32-42
28. Kono K, Zenitani K, Takagishi T. Novel pH-sensitive liposomes: Liposomes bearing a polyethylene glycol derivative with carboxyl groups. Biochim Biophys Acta 1994; 1193: 1-9
29. Abe K. Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury. J Cereb Blood Flow Metab 2000; 20: 1393-1408