Amyloid assemblies of influenza a virus PB1-F2 protein damage membrane and induce cytotoxicity

Journal of Biological Chemistry

Volumn 291, Issue 2, 2016, Pages 739-751

  Vidic, Jasmina ^a   Richard, Charles Adrien ^a   Péchoux, Christine ^b   Da Costa, Bruno ^a   Bertho, Nicolas ^a   Mazerat, Sandra ^c   Delmas, Bernard ^a   Chevalier, Christophe ^a  

^a INRA Institut National de la Recherche Agronomique   (France)

^b UMR1313 GÉNÉTIQUE ANIMALE ET BIOLOGIE INTÉGRATIVE   (France)

^c UNIVERSITÉ PARIS SUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; AMINO ACIDS; ANIMAL CELL CULTURE; CELL DEATH; CELLS; CYTOLOGY; CYTOTOXICITY; GLYCOPROTEINS; LIPOSOMES; MAMMALS; MEMBRANES; OLIGOMERS; VIRUSES;

AMORPHOUS STRUCTURES; AMYLOID STRUCTURES; ANTI-MICROBIAL ACTIVITY; BACTERIAL INFECTIONS; C-TERMINAL FRAGMENTS; MEMBRANE DISRUPTION; NANOMOLAR CONCENTRATION; SUPRAMOLECULAR ORGANIZATIONS;

PROTEINS;

AMINO ACID DERIVATIVE; AMYLOID PROTEIN; OLIGOMER; PB1 F2 PROTEIN; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS PROTEIN; AMYLOID; ANTIINFECTIVE AGENT; LIPOSOME; PB1-F2 PROTEIN, INFLUENZA A VIRUS; PROTEIN AGGREGATE; VIRAL PROTEIN;

A549 CELL LINE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; HUMAN; HUMAN CELL; INFLUENZA A (H1N1); INFLUENZA A VIRUS (H1N1); MEMBRANE DAMAGE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; U937 CELL LINE; VIRUS CELL INTERACTION; BACILLUS SUBTILIS; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; INFLUENZA A VIRUS; METABOLISM; MICROBIAL SENSITIVITY TEST; PATHOGENICITY; PERMEABILITY; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; ULTRASTRUCTURE;

AMYLOID; ANTI-INFECTIVE AGENTS; BACILLUS SUBTILIS; CELL DEATH; CELL LINE, TUMOR; ESCHERICHIA COLI; HUMANS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS; LIPOSOMES; MICROBIAL SENSITIVITY TESTS; PERMEABILITY; PROTEIN AGGREGATES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS;

EID: 84954152698     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.652917     Document Type: Article

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