A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo

Journal of Virology

Volumn 85, Issue 2, 2011, Pages 652-662

  Conenello, Gina M ^a   Tisoncik, Jennifer R ^b   Rosenzweig, Elizabeth ^b   Varga, Zsuzsanna T ^a   Palese, Peter ^a   Katze, Michael G ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BETA INTERFERON; INTERFERON; PROTEIN PB1 F2; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; FEMALE; GENE MUTATION; IMMUNE RESPONSE; IN VIVO STUDY; INFLUENZA A; INFLUENZA VIRUS A; INNATE IMMUNITY; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RIG I GENE; VIRUS GENE; VIRUS VIRULENCE;

AMINO ACID SUBSTITUTION; ANIMALS; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INTERFERONS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; MUTATION, MISSENSE; NEUTROPHILS; REASSORTANT VIRUSES; TIME FACTORS; UP-REGULATION; VIRAL PROTEINS; VIRULENCE; VIRULENCE FACTORS;

INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 78650648417     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01987-10     Document Type: Article

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