Methylation of serotonin receptor 3A in ADHD, Borderline personality, and bipolar disorders: Link with severity of the disorders and childhood maltreatment

Depression and Anxiety

Volumn 33, Issue 1, 2016, Pages 45-55

  Perroud, Nader ^a,b   Zewdie, Seblewongel ^b   Stenz, Ludwig ^b   Adouan, Wafae ^b   Bavamian, Sabine ^b   Prada, Paco ^a   Nicastro, Rosetta ^a   Hasler, Roland ^b   Nallet, Audrey ^a   Piguet, Camille ^a   Paoloni Giacobino, Ariane ^c   Aubry, Jean Michel ^a,b   Dayer, Alexandre ^a,b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

depression; epigenetics; methylation; mood episodes; rs1062613; serotonin receptor

Indexed keywords

SEROTONIN 3A RECEPTOR; SEROTONIN 3 RECEPTOR;

5 HT3AR GENE; ALCOHOLISM; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; BIPOLAR DISORDER; BORDERLINE STATE; CHILD; CHILD ABUSE; CHILD NEGLECT; CONTROLLED STUDY; CPG ISLAND; DISEASE SEVERITY; DNA METHYLATION; EMOTIONAL ABUSE; FEMALE; GENETIC VARIABILITY; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PHYSICAL ABUSE; PRIORITY JOURNAL; SEXUAL ABUSE; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTANCE ABUSE; SUICIDE ATTEMPT; ADULT; GENETIC POLYMORPHISM; GENETICS; PSYCHOLOGY; SEVERITY OF ILLNESS INDEX;

ADULT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIPOLAR DISORDER; BORDERLINE PERSONALITY DISORDER; CHILD; CHILD ABUSE; DNA METHYLATION; FEMALE; HUMANS; MALE; POLYMORPHISM, GENETIC; RECEPTORS, SEROTONIN, 5-HT3; SEVERITY OF ILLNESS INDEX;

EID: 84954076400     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22406     Document Type: Article

References (74)

1. Perroud N, Paoloni-Giacobino A, Prada P, et al., Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry 2011; 1: e59.
2. Martin-Blanco A, Ferrer M, Soler J, et al., Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder. J Psychiatr Res; 57: 34-40.
3. Mehta D, Klengel T, Conneely KN, et al., Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci U S A 2013; 110 (2): 8302-8307.
4. Thaler L, Gauvin L, Joober R, et al., Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry 2014; 54: 43-49.
5. Oh G, Wang SC, Pal M, et al., DNA modification study of major depressive disorder: beyond locus-by-locus comparisons. Biol Psychiatry 2014; 77 (3): 246-255.
6. Chameau P, Inta D, Vitalis T, et al., The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons. Proc Natl Acad Sci USA 2009; 106 (17): 7227-7232.
7. Murthy S, Niquille M, Hurni N, et al., Serotonin receptor 3A controls interneuron migration into the neocortex. Nat Commun 2014; 5: 5524.
8. Kondo M, Nakamura Y, Ishida Y, Shimada S,. The 5-HT receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. Mol Psychiatry 2014, doi: 10.1038/mp.2014.153.
9. Kondo M, Nakamura Y, Ishida Y, et al., The 5-HT3A receptor is essential for fear extinction. Learn Mem 2014; 21 (1): 1-4.
10. Smit-Rigter LA, Wadman WJ, van Hooft JA,. Impaired social behavior in 5-HT(3A) receptor knockout mice. Front Behav Neurosci 2010; 4: 169.
11. Bhatnagar S, Sun LM, Raber J, et al., Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor. Physiol Behav 2004; 81 (4): 545-555.
12. Barker JM, Zhang Y, Wang F, et al., Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain. Alcohol Clin Exp Res 2013; 37 (Suppl. 1): E101-E107.
13. Zhang H, Herman AI, Kranzler HR, et al., Array-based profiling of DNA methylation changes associated with alcohol dependence. Alcohol Clin Exp Res 2013; 37 (Suppl. 1): E108-E1015.
14. Johnson BA, Seneviratne C, Wang XQ, et al., Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron. Am J Psychiatry 2013; 170 (9): 1020-1031.
15. Seneviratne C, Franklin J, Beckett K, et al., Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. Hum Genet 2013; 132 (10): 1165-1176.
16. Yang J, Li MD,. Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data. Hum Genet 2014; 133 (7): 905-918.
17. Hammer C, Cichon S, Muhleisen TW, et al., Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study. Transl Psychiatry 2012; 2: e103.
18. Niesler B, Flohr T, Nothen MM, et al., Association between the 5′ UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder. Pharmacogenetics 2001; 11 (6): 471-475.
19. Gatt JM, Williams LM, Schofield PR, et al., Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood. Depress Anxiety 2010; 27 (8): 752-759.
20. Kessler RC, Adler L, Barkley R, et al., The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 2006; 163 (4): 716-723.
21. Bernardi S, Faraone SV, Cortese S, et al., The lifetime impact of attention deficit hyperactivity disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Psychol Med 2012; 42 (4): 875-887.
22. Philipsen A, Limberger MF, Lieb K, et al., Attention-deficit hyperactivity disorder as a potentially aggravating factor in borderline personality disorder. Br J Psychiatry 2008; 192 (2): 118-123.
23. Nierenberg AA, Miyahara S, Spencer T, et al., Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants. Biol Psychiatry 2005; 57 (11): 1467-1473.
24. Wingo AP, Ghaemi SN,. A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder. J Clin Psychiatry 2007; 68 (11): 1776-1784.
25. Perugi G, Ceraudo G, Vannucchi G, et al., Attention deficit/hyperactivity disorder symptoms in Italian bipolar adult patients: a preliminary report. J Affect Disord 2013; 149 (1-3): 430-434.
26. McIntyre RS, Kennedy SH, Soczynska JK, et al., Attention-deficit/hyperactivity disorder in adults with bipolar disorder or major depressive disorder: results from the international mood disorders collaborative project. Prim Care Companion J Clin Psychiatry 2010; 12 (3): e1-e7.
27. Halmoy A, Halleland H, Dramsdahl M, et al., Bipolar symptoms in adult attention-deficit/hyperactivity disorder: a cross-sectional study of 510 clinically diagnosed patients and 417 population-based controls. J Clin Psychiatry 2010; 71 (1): 48-57.
28. McGough JJ, Smalley SL, McCracken JT, et al., Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex families. Am J Psychiatry 2005; 162 (9): 1621-1627.
29. Fan AH, Hassell J,. Bipolar disorder and comorbid personality psychopathology: a review of the literature. J Clin Psychiatry 2008; 69 (11): 1794-1803.
30. Paris J, Gunderson J, Weinberg I,. The interface between borderline personality disorder and bipolar spectrum disorders. Compr Psychiatry 2007; 48 (2): 145-154.
31. Merikangas KR, Akiskal HS, Angst J, et al., Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007; 64 (5): 543-552.
32. Bohus M, Schmahl C, Lieb K,. New developments in the neurobiology of borderline personality disorder. Curr Psychiatry Rep 2004; 6 (1): 43-50.
33. Davids E, Gastpar M,. Attention deficit hyperactivity disorder and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29 (6): 865-877.
34. Philipsen A., Differential diagnosis and comorbidity of attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) in adults. Eur Arch Psychiatry Clin Neurosci 2006; 256 (Suppl. 1): i42-i46.
35. Matthies S, van Elst LT, Feige B, et al., Severity of childhood attention-deficit hyperactivity disorder-a risk factor for personality disorders in adult life? J Pers Disord 2011; 25 (1): 101-114.
36. Speranza M, Revah-Levy A, Cortese S, et al., ADHD in adolescents with borderline personality disorder. BMC Psychiatry 2011; 11: 158.
37. Youngstrom EA, Arnold LE, Frazier TW,. Bipolar and ADHD comorbidity: both artifact and outgrowth of shared mechanisms. Clin Psychol 2010; 17 (4): 350-359.
38. Zanarini MC, Yong L, Frankenburg FR, et al., Severity of reported childhood sexual abuse and its relationship to severity of borderline psychopathology and psychosocial impairment among borderline inpatients. J Nerv Ment Dis 2002; 190 (6): 381-387.
39. Fossati A, Madeddu F, Maffei C,. Borderline personality disorder and childhood sexual abuse: a meta-analytic study. J Pers Disord 1999; 13 (3): 268-280.
40. Garno JL, Goldberg JF, Ramirez PM, Ritzler BA,. Impact of childhood abuse on the clinical course of bipolar disorder. Br J Psychiatry 2005; 186: 121-125.
41. Watson S, Gallagher P, Dougall D, et al., Childhood trauma in bipolar disorder. Aust N Z J Psychiatry 2013; 48 (6): 564-570.
42. Etain B, Aas M, Andreassen OA, et al., Childhood trauma is associated with severe clinical characteristics of bipolar disorders. J Clin Psychiatry 2013; 74 (10): 991-998.
43. Leichsenring F, Leibing E, Kruse J, et al., Borderline personality disorder. Lancet 2011; 377 (9759): 74-84.
44. Fuller-Thomson E, Lewis DA,. The relationship between early adversities and attention-deficit/hyperactivity disorder. Child Abuse Negl 2015, doi: 10.1016/j.chiabu.2015.03.005.
45. De Sanctis VA, Nomura Y, Newcorn JH, Halperin JM,. Childhood maltreatment and conduct disorder: independent predictors of criminal outcomes in ADHD youth. Child Abuse Negl 2012; 36 (11-12): 782-789.
46. Lotan A, Fenckova M, Bralten J, et al., Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders. Front Neurosci 2014; 8: 331.
47. Cross-Disorder Group of the Psychiatric Genomics C, Lee SH, Ripke S, et al., Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45 (9): 984-994.
48. Song J, Bergen SE, Kuja-Halkola R, et al., Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish population. Bipolar Disord 2015; 17 (2): 184-193.
49. Arloth J, Bogdan R, Weber P, et al., Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron 2015; 86 (5): 1189-1202.
50. Albert PR., Transcriptional regulation of the 5-HT1A receptor: implications for mental illness. Philos Trans R Soc Lond B Biol Sci 2012; 367 (1601): 2402-2415.
51. Huang YY, Battistuzzi C, Oquendo MA, et al., Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology. Int J Neuropsychopharmacol 2004; 7 (4): 441-451.
52. Kishi T, Yoshimura R, Fukuo Y, et al., The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. Eur Arch Psychiatry Clin Neurosci 2013; 263 (2): 105-118.
53. Perroud N, Salzmann A, Prada P, et al., Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene. Transl Psychiatry 2013; 3: e207.
54. Prada P, Hasler R, Baud P, et al., Distinguishing borderline personality disorder from adult attention deficit/hyperactivity disorder: a clinical and dimensional perspective. Psychiatry Res 2014; 217 (1-2): 107-114.
55. Preisig M, Fenton BT, Matthey ML, et al., Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci 1999; 249 (4): 174-179.
56. First M, Gibbon M, Spitzer R, et al., Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II). Washington, DC: American Psychiatric Association; 1994.
57. Ward MF, Wender PH, Reimherr FW,. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 1993; 150 (6): 885-890.
58. Fossati A, Novella L, Donati D, et al., History of childhood attention deficit/hyperactivity disorder symptoms and borderline personality disorder: a controlled study. Compr Psychiatry 2002; 43 (5): 369-377.
59. Romo L, Legauffre C, Mille S, et al., Psychometric properties of the French version of the Wender Utah Rating Scale and Brown's Attention Deficit Disorders Scale for adults. Encephale 2010; 36 (5): 380-389.
60. Kooij JJS, Francken MH,. Entretien diagnostique pour le TDAH chez l'adulte (DIVA). In:, Foundation D, editor. Pays Bas: DIVA Foundation; 2010. http://www.divacenter.eu/Content/Downloads/DIVA-2-FRANCAIS.pdf.
61. First MB, Spitzer RL, Gibbon M, Williams JBW,. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington, DC: American Psychiatric Press, Inc; 1996.
62. Bernstein DP, Fink L,. Childhood Trauma Questionnaire. A Retrospective Self-Report. San Antonio, TX: The Psychological Corporation; 1998.
63. Schaffer A, Isometsa ET, Tondo L, et al., International Society for Bipolar Disorders Task Force on Suicide: meta-analyses and meta-regression of correlates of suicide attempts and suicide deaths in bipolar disorder. Bipolar Disord 2014; 17 (1): 1-16.
64. Schraut KG, Jakob SB, Weidner MT, et al., Prenatal stress-induced programming of genome-wide promoter DNA methylation in 5-HTT-deficient mice. Transl Psychiatry 2014; 4: e473.
65. Schurhoff F, Bellivier F, Jouvent R, et al., Early and late onset bipolar disorders: two different forms of manic-depressive illness? J Affect Disord 2000; 58 (3): 215-221.
66. Post RM, Altshuler L, Leverich GS, et al., Relationship of clinical course of illness variables to medical comorbidities in 900 adult outpatients with bipolar disorder. Compr Psychiatry 2014; 56: 21-28.
67. Falkenberg VR, Rajeevan MS,. Identification of a potential molecular link between the glucocorticoid and serotonergic signaling systems. J Mol Neurosci 2010; 41 (2): 322-327.
68. Hicks R, Tingley D,. Causal Mediation Analysis. Stata J 2011; 11 (4): 609-615.
69. Gatt JM, Nemeroff CB, Schofield PR, et al., Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression. Biol Psychiatry 2010; 68 (9): 818-824.
70. McGowan PO, Suderman M, Sasaki A, et al., Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One 2011; 6 (2): e14739.
71. Klengel T, Mehta D, Anacker C, et al., Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 2013; 16 (1): 33-41.
72. Carlberg L, Scheibelreiter J, Hassler MR, et al., Brain-derived neurotrophic factor (BDNF)-epigenetic regulation in unipolar and bipolar affective disorder. J Affect Disord 2014; 168: 399-406.
73. Jaenisch R, Bird A,. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33 (Suppl.): 245-254.
74. Perroud N, Rutembesa E, Paoloni-Giacobino A, et al., The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis. World J Biol Psychiatry 2014; 15 (4): 334-345.