Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability

Nature Communications

Volumn 7, Issue , 2016, Pages

  Leiva, Magdalena ^a   Quintana, Juan A ^a   Ligos, José M ^a   Hidalgo, Andrés ^a,b  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; CD150 ANTIGEN; CD48 ANTIGEN; E SELECTIN LIGAND 1; FLUOROURACIL; GLYCOPROTEIN; PROTEIN PRECURSOR; STROMAL CELL DERIVED FACTOR 1; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CHEMOKINE; CYSTEINE-RICH FIBROBLAST GROWTH FACTOR RECEPTOR; CYTOKINE; FIBROBLAST GROWTH FACTOR RECEPTOR; SIALOGLYCOPROTEIN; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA1;

BIOLOGICAL ANALYSIS; BONE; CELL ORGANELLE;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL EXPANSION; CELL FUNCTION; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; STEM CELL NICHE; WILD TYPE; ANIMAL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HOMEOSTASIS; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ANIMALS; BLOTTING, WESTERN; BONE MARROW; CELL PROLIFERATION; CHEMOKINES; CYTOKINES; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; IN VITRO TECHNIQUES; MICE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, FIBROBLAST GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIALOGLYCOPROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84953932008     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10222     Document Type: Article

References (36)

1. Pietras, E. M.,Warr, M. R. & Passegue, E. Cell cycle regulation in hematopoietic stem cells. J. Cell Biol. 195, 709-720 (2011).
2. Kunisaki, Y. et al. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature 502, 637-643 (2013).
3. Yamazaki, S. et al. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell 147, 1146-1158 (2011).
4. Winkler, I. G. et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat. Med. 18, 1651-1657 (2012).
5. Zhao, J. L. et al. Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis. Cell Stem Cell 14, 445-459 (2014).
6. Yamazaki, S. et al. TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood 113, 1250-1256 (2009).
7. Sreeramkumar, V. et al. Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in mice. Blood 122, 3993-4001 (2013).
8. Yang, T. et al. E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J. Clin. Invest. 120, 2474-2485 (2010).
9. Fan, X. et al. Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells. J. Immunol. 168, 755-762 (2002).
10. Scandura, J. M., Boccuni, P., Massague, J. & Nimer, S. D. Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. Proc. Natl Acad. Sci. USA 101, 15231-15236 (2004).
11. Brenet, F., Kermani, P., Spektor, R., Rafii, S. & Scandura, J. M. TGFbeta restores hematopoietic homeostasis after myelosuppressive chemotherapy. J. Exp. Med. 210, 623-639 (2013).
12. Yang, T. et al. E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-beta in the bone microenvironment. Proc. Natl Acad. Sci. USA 110, 7336-7341 (2013).
13. Fadok, V. A. et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101, 890-898 (1998).
14. Casanova-Acebes, M. et al. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell 153, 1025-1035 (2013).
15. Omatsu, Y. et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity 33, 387-399 (2010).
16. Wright, N. et al. Transforming growth factor-beta1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion. Blood 102, 1978-1984 (2003).
17. Morrison, S. J. & Scadden, D. T. The bone marrow niche for haematopoietic stem cells. Nature 505, 327-334 (2014).
18. Mendez-Ferrer, S. et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466, 829-834 (2010).
19. Hanoun, M. et al. Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche. Cell Stem Cell 15, 365-375 (2014).
20. Schepers, K. et al. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell 13, 285-299 (2013).
21. Chow, A. et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med. 208, 261-271 (2011).
22. Winkler, I. G. et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood 116, 4815-4828 (2010).
23. Bruns, I. et al. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nature Med. 20, 1315-1320 (2014).
24. Zhao, M. et al. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nature Med. 20, 1321-1326 (2014).
25. Hatzfeld, J. et al. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides. J. Exp. Med. 174, 925-929 (1991).
26. Beerman, I., Maloney, W. J., Weissmann, I. L. & Rossi, D. J. Stem cells and the aging hematopoietic system. Curr. Opin. Immunol. 22, 500-506 (2010)
27. Challen, G. A., Boles, N. C., Chambers, S. M. & Goodell, M. A. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell 6, 265-278 (2010).
28. Quere, R. et al. Tif1gamma regulates the TGF-beta1 receptor and promotes physiological aging of hematopoietic stem cells. Proc. Natl Acad. Sci. USA 111, 10592-10597 (2014).
29. Wang, L. et al. Identification of a clonally expanding haematopoietic compartment in bone marrow. EMBO J. 32, 219-230 (2013).
30. Ding, L. & Morrison, S. J. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495, 231-235 (2013):
31. Hidalgo, A., Peired, A. J., Wild, M. K., Vestweber, D. & Frenette, P. S. Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44. Immunity 26, 477-489 (2007).
32. Yago, T. et al. Core 1-derived O-glycans are essential E-selectin ligands on neutrophils. Proc. Natl Acad. Sci. USA 107, 9204-9209 (2010).
33. Katayama, Y. et al. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood 102, 2060-2067 (2003).
34. Sugiyama, T., Kohara, H., Noda, M. & Nagasawa, T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25, 977-988 (2006).
35. Hu, Y. & Smyth, G. K. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods 347, 70-78 (2009).
36. Purton, L. E. & Scadden, D. T. Limiting factors in murine hematopoietic stem cell assays. Cell Stem Cell 1, 263-270 (2007).