Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

Arthritis Research and Therapy

Volumn 18, Issue 1, 2016, Pages

  Fernandes, Elizabeth S ^a,c   Russell, Fiona A ^a   Alawi, Khadija M ^a   Sand, Claire ^a   Liang, Lihuan ^a   Salamon, Robin ^a   Bodkin, Jennifer V ^a   Aubdool, Aisah A ^a   Arno, Matthew ^a   Gentry, Clive ^a   Smillie, Sarah Jane ^a   Bevan, Stuart ^a   Keeble, Julie E ^b   Malcangio, Marzia ^a   Brain, Susan D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CEUMA UNIVERSITY   (Brazil)

Author keywords

Blood flow; Cold; Pain; Rheumatoid arthritis; TRPA1

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CATION CHANNEL; CGRP 8-37; FREUND ADJUVANT; MESSENGER RNA; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; NEUROKININ 1 RECEPTOR ANTAGONIST; NOLPITANTIUM; SUBSTANCE P; TECHNETIUM 99M; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CD-1 MOUSE; COLD; COLD EXPOSURE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FREUND ADJUVANT-INDUCED ARTHRITIS; HARGREAVES TEST; KNEE; LOW TEMPERATURE; MALE; MECHANICAL HYPERALGESIA; MONARTHRITIS; MOUSE; NOCICEPTION; NONHUMAN; PATELLA; ROOM TEMPERATURE; SENSORY NERVE; SPINAL GANGLION; SYMPTOM; SYNOVIUM; VON FREY TEST; WEIGHT BEARING; 129 MOUSE; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; BLOOD FLOW VELOCITY; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; HINDLIMB; INTRAARTICULAR DRUG ADMINISTRATION; JOINT; KNOCKOUT MOUSE; METABOLISM; PAIN MEASUREMENT; PAIN THRESHOLD; PATHOLOGY; PHYSIOLOGY; PROCEDURES;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOOD FLOW VELOCITY; COLD TEMPERATURE; FREUND'S ADJUVANT; HINDLIMB; INJECTIONS, INTRA-ARTICULAR; JOINTS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PAIN MEASUREMENT; PAIN THRESHOLD; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84953852027     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-015-0905-x     Document Type: Article

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