TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 1, 2016, Pages 212-217

  Papageorgiou, Ismini E ^a,b   Lewen, Andrea ^a   Galow, Lukas V ^a   Cesetti, Tiziana ^a   Scheffel, Jörg ^b,d   Regen, Tommy ^b,e   Hanisch, Uwe Karsten ^b,c   Kann, Oliver ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Hippocampus; Microglia; Neuronal activity; Slice culture; Toll like receptor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD11B ANTIGEN; CD68 ANTIGEN; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE; PARVALBUMIN; POTASSIUM; TOLL LIKE RECEPTOR 4; 4 AMINOBUTYRIC ACID RECEPTOR; CD68 PROTEIN, RAT; DIFFERENTIATION ANTIGEN; INTERFERON RECEPTOR; LEUKOCYTE ANTIGEN; LIPOPOLYSACCHARIDE; NOS2 PROTEIN, RAT; TLR4 PROTEIN, RAT; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; ELECTROPHYSIOLOGICAL PROCEDURES; GABAERGIC TRANSMISSION; GLUTAMATERGIC SYNAPSE; HIPPOCAMPAL SLICE; IMMUNOHISTOCHEMISTRY; MICROGLIA; MORPHOMETRICS; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE CELL STIMULATION; NERVE DEGENERATION; NERVE EXCITABILITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OSCILLATION; PHENOTYPE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; STEREOLOGY; TH1 CELL; UPREGULATION; AGONISTS; ANIMAL; CELL CULTURE; CELL DEATH; DEGENERATIVE DISEASE; HIPPOCAMPUS; IMMUNOLOGY; INFLAMMATION; INTERNEURON; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD11B; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ASTROCYTES; CELL DEATH; CELLS, CULTURED; GABAERGIC NEURONS; HIPPOCAMPUS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERNEURONS; LIPOPOLYSACCHARIDES; MICROGLIA; NEURODEGENERATIVE DISEASES; NEURONAL PLASTICITY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; RECEPTORS, INTERFERON; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84953252996     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1513853113     Document Type: Article

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