메뉴 건너뛰기




Volumn 220, Issue 4, 2015, Pages 2423-2439

Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration

Author keywords

CD11b; Iba 1; Microglia; Neurolucida; Pilocarpine; Stereology

Indexed keywords

CD11B ANTIGEN; IONIZED CALCIUM BINDING ADAPTER MOLECULE 1; PILOCARPINE; PROTEIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; AIF1 PROTEIN, RAT; CALCIUM BINDING PROTEIN; MUSCARINIC AGENT;

EID: 84933181602     PISSN: 18632653     EISSN: 18632661     Source Type: Journal    
DOI: 10.1007/s00429-014-0802-0     Document Type: Article
Times cited : (33)

References (82)
  • 1
    • 0024842108 scopus 로고
    • The three-dimensional organization of the hippocampal formation: a review of anatomical data
    • COI: 1:STN:280:DyaK3c%2Fot1WjtA%3D%3D, PID: 2687721
    • Amaral DG, Witter MP (1989) The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31:571–591. doi:10.1016/0306-4522(89)90424-7
    • (1989) Neuroscience , vol.31 , pp. 571-591
    • Amaral, D.G.1    Witter, M.P.2
  • 3
    • 0029031842 scopus 로고
    • Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy
    • COI: 1:CAS:528:DyaK2MXlvFKksLg%3D, PID: 7659283
    • Beach TG, Woodhurst WB, MacDonald DB, Jones MW (1995) Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci Lett 191:27–30. doi:10.1016/0304-3940(94)11548-1
    • (1995) Neurosci Lett , vol.191 , pp. 27-30
    • Beach, T.G.1    Woodhurst, W.B.2    MacDonald, D.B.3    Jones, M.W.4
  • 4
    • 0346751061 scopus 로고    scopus 로고
    • Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy
    • PID: 14656328
    • Becker AJ, Chen J, Zien A, Sochivko D, Normann S, Schramm J, Elger CE, Wiestler OD, Blümcke I (2003) Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy. Eur J Neurosci 18:2792–2802. doi:10.1111/j.1460-9568.2003.02993.x
    • (2003) Eur J Neurosci , vol.18 , pp. 2792-2802
    • Becker, A.J.1    Chen, J.2    Zien, A.3    Sochivko, D.4    Normann, S.5    Schramm, J.6    Elger, C.E.7    Wiestler, O.D.8    Blümcke, I.9
  • 5
    • 84859803413 scopus 로고    scopus 로고
    • Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis
    • PID: 22497612
    • Blümcke I, Coras R, Miyata H, Özkara C (2012) Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis. Brain Pathol 22:402–411. doi:10.1111/j.1750-3639.2012.00583.x
    • (2012) Brain Pathol , vol.22 , pp. 402-411
    • Blümcke, I.1    Coras, R.2    Miyata, H.3    Özkara, C.4
  • 6
    • 0038434119 scopus 로고    scopus 로고
    • Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model
    • COI: 1:CAS:528:DC%2BD3sXkvVCgu7w%3D, PID: 12821374
    • Borges K, Gearing M, McDermott DL, Smith AB, Almonte AG, Wainer BH, Dingledine R (2003) Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Exp Neurol 182:21–34. doi:10.1016/S0014-4886(03)00086-4
    • (2003) Exp Neurol , vol.182 , pp. 21-34
    • Borges, K.1    Gearing, M.2    McDermott, D.L.3    Smith, A.B.4    Almonte, A.G.5    Wainer, B.H.6    Dingledine, R.7
  • 7
    • 0036703768 scopus 로고    scopus 로고
    • Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit
    • COI: 1:CAS:528:DC%2BD38XlvFKntrg%3D, PID: 12151544
    • Buckmaster PS, Zhang GF, Yamawaki R (2002) Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit. J Neurosci 22:6650–6658
    • (2002) J Neurosci , vol.22 , pp. 6650-6658
    • Buckmaster, P.S.1    Zhang, G.F.2    Yamawaki, R.3
  • 8
    • 0026340904 scopus 로고
    • Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures
    • COI: 1:CAS:528:DyaK38XhtVeks7k%3D, PID: 1743148
    • Cavalheiro EA, Leite JP, Bortolotto ZA, Turski WA, Ikonomidou C, Turski L (1991) Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia 32:778–782. doi:10.1111/j.1528-1157.1991.tb05533.x
    • (1991) Epilepsia , vol.32 , pp. 778-782
    • Cavalheiro, E.A.1    Leite, J.P.2    Bortolotto, Z.A.3    Turski, W.A.4    Ikonomidou, C.5    Turski, L.6
  • 10
    • 84875235637 scopus 로고    scopus 로고
    • Glia and epilepsy: excitability and inflammation
    • COI: 1:CAS:528:DC%2BC3sXkt1aisw%3D%3D, PID: 23298414
    • Devinsky O, Vezzani A, Najjar S, de Lanerolle NC, Rogawski MA (2013) Glia and epilepsy: excitability and inflammation. Trends Neurosci 36:174–184. doi:10.1016/j.tins.2012.11.008
    • (2013) Trends Neurosci , vol.36 , pp. 174-184
    • Devinsky, O.1    Vezzani, A.2    Najjar, S.3    de Lanerolle, N.C.4    Rogawski, M.A.5
  • 11
    • 0027530684 scopus 로고
    • The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands
    • COI: 1:CAS:528:DyaK3sXpvF2ltw%3D%3D, PID: 7679388
    • Diamond MS, Garcia-Aguilar J, Bickford JK, Corbi AL, Springer TA (1993) The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J Cell Biol 120:1031–1043. doi:10.1083/jcb.120.4.1031
    • (1993) J Cell Biol , vol.120 , pp. 1031-1043
    • Diamond, M.S.1    Garcia-Aguilar, J.2    Bickford, J.K.3    Corbi, A.L.4    Springer, T.A.5
  • 12
    • 0033460317 scopus 로고    scopus 로고
    • Morphological, immunophenotypical and electrophysiological properties of resting microglia in vitro
    • COI: 1:STN:280:DC%2BD3c%2Fmt1CqsA%3D%3D, PID: 10594651
    • Eder C, Schilling T, Heinemann U, Haas D, Hailer N, Nitsch R (1999) Morphological, immunophenotypical and electrophysiological properties of resting microglia in vitro. Eur J Neurosci 11:4251–4261. doi:10.1046/j.1460-9568.1999.00852.x
    • (1999) Eur J Neurosci , vol.11 , pp. 4251-4261
    • Eder, C.1    Schilling, T.2    Heinemann, U.3    Haas, D.4    Hailer, N.5    Nitsch, R.6
  • 13
    • 33750585514 scopus 로고    scopus 로고
    • ILAE classification of epilepsy syndromes
    • PID: 16822650
    • Engel J Jr (2006) ILAE classification of epilepsy syndromes. Epilepsy Res 70(Suppl 1):S5–S10. doi:10.1016/j.eplepsyres.2005.11.014
    • (2006) Epilepsy Res , vol.70 , pp. 5-10
    • Engel, J.1
  • 14
    • 84862778651 scopus 로고    scopus 로고
    • Glial activation in a pilocarpine rat model for epileptogenesis: a morphometric and quantitative analysis
    • COI: 1:CAS:528:DC%2BC38XjsleltrY%3D, PID: 22395088
    • Estrada FS, Hernández VS, López-Hernández E, Corona-Morales AA, Solís H, Escobar A, Zhang L (2012) Glial activation in a pilocarpine rat model for epileptogenesis: a morphometric and quantitative analysis. Neurosci Lett 514:51–56. doi:10.1016/j.neulet.2012.02.055
    • (2012) Neurosci Lett , vol.514 , pp. 51-56
    • Estrada, F.S.1    Hernández, V.S.2    López-Hernández, E.3    Corona-Morales, A.A.4    Solís, H.5    Escobar, A.6    Zhang, L.7
  • 15
    • 74549199252 scopus 로고    scopus 로고
    • Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus
    • PID: 20034406
    • Foresti ML, Arisi GM, Katki K, Montañez A, Sanchez RM, Shapiro LA (2009) Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus following pilocarpine-induced status epilepticus. J Neuroinflammation 6:40. doi:10.1186/1742-2094-6-40
    • (2009) J Neuroinflammation , vol.6 , pp. 40
    • Foresti, M.L.1    Arisi, G.M.2    Katki, K.3    Montañez, A.4    Sanchez, R.M.5    Shapiro, L.A.6
  • 16
    • 0142089193 scopus 로고    scopus 로고
    • Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation
    • PID: 14588110
    • Grady MS, Charleston JS, Maris D, Witgen BM, Lifshitz J (2003) Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation. J Neurotrauma 20:929–941. doi:10.1089/089771503770195786
    • (2003) J Neurotrauma , vol.20 , pp. 929-941
    • Grady, M.S.1    Charleston, J.S.2    Maris, D.3    Witgen, B.M.4    Lifshitz, J.5
  • 17
    • 84886752759 scopus 로고    scopus 로고
    • Functional diversity of microglia—how heterogeneous are they to begin with?
    • PID: 23717262
    • Hanisch U-K (2013) Functional diversity of microglia—how heterogeneous are they to begin with? Front Cell Neurosci 7:65. doi:10.3389/fncel.2013.00065
    • (2013) Front Cell Neurosci , vol.7 , pp. 65
    • Hanisch, U.-K.1
  • 18
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • COI: 1:CAS:528:DC%2BD2sXht1ajsbbE, PID: 17965659
    • Hanisch U-K, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10:1387–1394. doi:10.1038/nn1997
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.-K.1    Kettenmann, H.2
  • 20
    • 0027033707 scopus 로고
    • Morphological changes in the dentate gyrus in human temporal lobe epilepsy
    • COI: 1:STN:280:DyaK3s7gtlGitg%3D%3D, PID: 1466768
    • Houser CR (1992) Morphological changes in the dentate gyrus in human temporal lobe epilepsy. Epilepsy Res Suppl 7:223–234
    • (1992) Epilepsy Res Suppl , vol.7 , pp. 223-234
    • Houser, C.R.1
  • 22
    • 71749083143 scopus 로고    scopus 로고
    • Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology
    • COI: 1:CAS:528:DC%2BD1MXhsVyntrbP, PID: 19559784
    • Hung J, Chansard M, Ousman SS, Nguyen MD, Colicos MA (2010) Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology. Brain Behav Immun 24:31–40. doi:10.1016/j.bbi.2009.06.150
    • (2010) Brain Behav Immun , vol.24 , pp. 31-40
    • Hung, J.1    Chansard, M.2    Ousman, S.S.3    Nguyen, M.D.4    Colicos, M.A.5
  • 23
    • 0035572897 scopus 로고    scopus 로고
    • CD11b/CD18 mediates production of reactive oxygen species by mouse and human macrophages adherent to matrixes containing oxidized LDL
    • COI: 1:CAS:528:DC%2BD3MXmtVarsbc%3D, PID: 11498457
    • Husemann J, Obstfeld A, Febbraio M, Kodama T, Silverstein SC (2001) CD11b/CD18 mediates production of reactive oxygen species by mouse and human macrophages adherent to matrixes containing oxidized LDL. Arterioscler Thromb Vasc Biol 21:1301–1305. doi:10.1161/hq0801.095150
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1301-1305
    • Husemann, J.1    Obstfeld, A.2    Febbraio, M.3    Kodama, T.4    Silverstein, S.C.5
  • 24
    • 33846261108 scopus 로고    scopus 로고
    • Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4
    • COI: 1:CAS:528:DC%2BD2sXivVyrsb4%3D, PID: 16985175
    • Ihanus E, Uotila LM, Toivanen A, Varis M, Gahmberg CG (2007) Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4. Blood 109:802–810. doi:10.1182/blood-2006-04-014878
    • (2007) Blood , vol.109 , pp. 802-810
    • Ihanus, E.1    Uotila, L.M.2    Toivanen, A.3    Varis, M.4    Gahmberg, C.G.5
  • 25
    • 0032102358 scopus 로고    scopus 로고
    • Microglia-specific localisation of a novel calcium binding protein, Iba1
    • COI: 1:CAS:528:DyaK1cXjs1alsrs%3D, PID: 9630473
    • Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S (1998) Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res Mol Brain Res 57:1–9. doi:10.1016/S0169-328X(98)00040-0
    • (1998) Brain Res Mol Brain Res , vol.57
    • Ito, D.1    Imai, Y.2    Ohsawa, K.3    Nakajima, K.4    Fukuuchi, Y.5    Kohsaka, S.6
  • 27
    • 84861374626 scopus 로고    scopus 로고
    • Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier
    • COI: 1:CAS:528:DC%2BC38XhtFWhurfO, PID: 22612806
    • Janigro D (2012) Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier. Epilepsia 53(Suppl 1):26–34. doi:10.1111/j.1528-1167.2012.03472.x
    • (2012) Epilepsia , vol.53 , pp. 26-34
    • Janigro, D.1
  • 28
    • 47349101536 scopus 로고    scopus 로고
    • Reduction of Iba1-expressing microglial process density in the hippocampus following electroconvulsive shock
    • COI: 1:CAS:528:DC%2BD1cXptVCjt7g%3D, PID: 18538764
    • Jinno S, Kosaka T (2008) Reduction of Iba1-expressing microglial process density in the hippocampus following electroconvulsive shock. Exp Neurol 212:440–447. doi:10.1016/j.expneurol.2008.04.028
    • (2008) Exp Neurol , vol.212 , pp. 440-447
    • Jinno, S.1    Kosaka, T.2
  • 29
    • 34548201694 scopus 로고    scopus 로고
    • Spatial arrangement of microglia in the mouse hippocampus: a stereological study in comparison with astrocytes
    • PID: 17647290
    • Jinno S, Fleischer F, Eckel S, Schmidt V, Kosaka T (2007) Spatial arrangement of microglia in the mouse hippocampus: a stereological study in comparison with astrocytes. Glia 55:1334–1347. doi:10.1002/glia.20552
    • (2007) Glia , vol.55 , pp. 1334-1347
    • Jinno, S.1    Fleischer, F.2    Eckel, S.3    Schmidt, V.4    Kosaka, T.5
  • 30
    • 79952574257 scopus 로고    scopus 로고
    • Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin
    • COI: 1:CAS:528:DC%2BC3MXnvVaqtbY%3D, PID: 21269282
    • Jung K-H, Chu K, Lee S-T, Park K-I, Kim J-H, Kang K-M, Kim S, Jeon D, Kim M, Lee SK, Roh J-K (2011) Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin. Epilepsia 52:541–550. doi:10.1111/j.1528-1167.2010.02916.x
    • (2011) Epilepsia , vol.52 , pp. 541-550
    • Jung, K.-H.1    Chu, K.2    Lee, S.-T.3    Park, K.-I.4    Kim, J.-H.5    Kang, K.-M.6    Kim, S.7    Jeon, D.8    Kim, M.9    Lee, S.K.10    Roh, J.-K.11
  • 31
    • 3342889370 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level
    • COI: 1:CAS:528:DC%2BD2cXmsFersb4%3D, PID: 15255929
    • Kann O, Hoffmann A, Schumann RR, Weber JR, Kettenmann H, Hanisch U-K (2004) The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level. J Neurochem 90:513–525. doi:10.1111/j.1471-4159.2004.02534.x
    • (2004) J Neurochem , vol.90 , pp. 513-525
    • Kann, O.1    Hoffmann, A.2    Schumann, R.R.3    Weber, J.R.4    Kettenmann, H.5    Hanisch, U.-K.6
  • 32
    • 26044454554 scopus 로고    scopus 로고
    • Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans
    • PID: 15958506
    • Kann O, Kovács R, Njunting M, Behrens CJ, Otáhal J, Lehmann T-N, Gabriel S, Heinemann U (2005) Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans. Brain 128:2396–2407. doi:10.1093/brain/awh568
    • (2005) Brain , vol.128 , pp. 2396-2407
    • Kann, O.1    Kovács, R.2    Njunting, M.3    Behrens, C.J.4    Otáhal, J.5    Lehmann, T.-N.6    Gabriel, S.7    Heinemann, U.8
  • 33
    • 79955605102 scopus 로고    scopus 로고
    • Physiology of microglia
    • COI: 1:CAS:528:DC%2BC3MXns1Cms78%3D, PID: 21527731
    • Kettenmann H, Hanisch U-K, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91:461–553. doi:10.1152/physrev.00011.2010
    • (2011) Physiol Rev , vol.91 , pp. 461-553
    • Kettenmann, H.1    Hanisch, U.-K.2    Noda, M.3    Verkhratsky, A.4
  • 34
    • 84896044684 scopus 로고    scopus 로고
    • MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy
    • PID: 23474541
    • Kharatishvili I, Shan ZY, She DT, Foong S, Kurniawan ND, Reutens DC (2013) MRI changes and complement activation correlate with epileptogenicity in a mouse model of temporal lobe epilepsy. Brain Struct Funct. doi:10.1007/s00429-013-0528-4
    • (2013) Brain Struct Funct
    • Kharatishvili, I.1    Shan, Z.Y.2    She, D.T.3    Foong, S.4    Kurniawan, N.D.5    Reutens, D.C.6
  • 35
    • 77957921360 scopus 로고    scopus 로고
    • Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus
    • PID: 20886625
    • Kim J-E, Yeo S-I, Ryu HJ, Kim M-J, Kim D-S, Jo S-M, Kang T-C (2010) Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. J Comp Neurol 518:4612–4628. doi:10.1002/cne.22482
    • (2010) J Comp Neurol , vol.518 , pp. 4612-4628
    • Kim, J.-E.1    Yeo, S.-I.2    Ryu, H.J.3    Kim, M.-J.4    Kim, D.-S.5    Jo, S.-M.6    Kang, T.-C.7
  • 36
    • 0033815978 scopus 로고    scopus 로고
    • Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats
    • Lehmann T-N, Gabriel S, Kovacs R, Eilers A, Kivi A, Schulze K, Lanksch WR, Meencke HJ, Heinemann U (2000) Alterations of neuronal connectivity in area CA1 of hippocampal slices from temporal lobe epilepsy patients and from pilocarpine-treated epileptic rats. Epilepsia 41(Suppl 6):190–194. doi:10.1111/j.1528-1157.2000.tb01580.x
    • (2000) Epilepsia , vol.41 , pp. 190-194
    • Lehmann, T.-N.1    Gabriel, S.2    Kovacs, R.3    Eilers, A.4    Kivi, A.5    Schulze, K.6    Lanksch, W.R.7    Meencke, H.J.8    Heinemann, U.9
  • 37
    • 0034903354 scopus 로고    scopus 로고
    • Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity
    • COI: 1:STN:280:DC%2BD3MvktlGisA%3D%3D, PID: 11488952
    • Lehmann T-N, Gabriel S, Eilers A, Njunting M, Kovacs R, Schulze K, Lanksch WR, Heinemann U (2001) Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity. Eur J Neurosci 14:83–95. doi:10.1046/j.0953-816x.2001.01632.x
    • (2001) Eur J Neurosci , vol.14 , pp. 83-95
    • Lehmann, T.-N.1    Gabriel, S.2    Eilers, A.3    Njunting, M.4    Kovacs, R.5    Schulze, K.6    Lanksch, W.R.7    Heinemann, U.8
  • 39
    • 77953308841 scopus 로고    scopus 로고
    • Role for complement in the development of seizures following acute viral infection
    • COI: 1:CAS:528:DC%2BC3cXptVehtbk%3D, PID: 20427530
    • Libbey JE, Kirkman NJ, Wilcox KS, White HS, Fujinami RS (2010) Role for complement in the development of seizures following acute viral infection. J Virol 84:6452–6460. doi:10.1128/JVI.00422-10
    • (2010) J Virol , vol.84 , pp. 6452-6460
    • Libbey, J.E.1    Kirkman, N.J.2    Wilcox, K.S.3    White, H.S.4    Fujinami, R.S.5
  • 40
    • 77955333957 scopus 로고    scopus 로고
    • Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice
    • PID: 20384764
    • Longo B, Romariz S, Blanco MM, Vasconcelos JF, Bahia L, Soares MBP, Mello LE, Ribeiro-dos-Santos R (2010) Distribution and proliferation of bone marrow cells in the brain after pilocarpine-induced status epilepticus in mice. Epilepsia 51:1628–1632. doi:10.1111/j.1528-1167.2010.02570.x
    • (2010) Epilepsia , vol.51 , pp. 1628-1632
    • Longo, B.1    Romariz, S.2    Blanco, M.M.3    Vasconcelos, J.F.4    Bahia, L.5    Soares, M.B.P.6    Mello, L.E.7    Ribeiro-dos-Santos, R.8
  • 41
    • 34249802037 scopus 로고    scopus 로고
    • Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue
    • COI: 1:CAS:528:DC%2BD2sXlsVWgtrk%3D, PID: 17571348
    • Majores M, Schoch S, Lie A, Becker AJ (2007) Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue. Epilepsia 48(Suppl 2):4–12. doi:10.1111/j.1528-1167.2007.01062.x
    • (2007) Epilepsia , vol.48 , pp. 4-12
    • Majores, M.1    Schoch, S.2    Lie, A.3    Becker, A.J.4
  • 42
    • 80053028698 scopus 로고    scopus 로고
    • Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1
    • COI: 1:CAS:528:DC%2BC3MXhtlClt73P, PID: 21793950
    • Maroso M, Balosso S, Ravizza T, Liu J, Bianchi ME, Vezzani A (2011) Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1. J Intern Med 270:319–326. doi:10.1111/j.1365-2796.2011.02431.x
    • (2011) J Intern Med , vol.270 , pp. 319-326
    • Maroso, M.1    Balosso, S.2    Ravizza, T.3    Liu, J.4    Bianchi, M.E.5    Vezzani, A.6
  • 43
    • 0027143716 scopus 로고
    • Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting
    • COI: 1:STN:280:DyaK2c%2Fmt1Ohuw%3D%3D, PID: 7694849
    • Mello LEAM, Cavalheiro EA, Tan AM, Kupfer WR, Pretorius JK, Babb TL, Finch DM (1993) Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 34:985–995. doi:10.1111/j.1528-1157.1993.tb02123.x
    • (1993) Epilepsia , vol.34 , pp. 985-995
    • Mello, L.E.A.M.1    Cavalheiro, E.A.2    Tan, A.M.3    Kupfer, W.R.4    Pretorius, J.K.5    Babb, T.L.6    Finch, D.M.7
  • 44
    • 84865575381 scopus 로고    scopus 로고
    • Hippocampal sclerosis
    • PID: 22939057
    • Özkara C, Aronica E (2012) Hippocampal sclerosis. Handb Clin Neurol 108:621–639. doi:10.1016/B978-0-444-52899-5.00019-8
    • (2012) Handb Clin Neurol , vol.108 , pp. 621-639
    • Özkara, C.1    Aronica, E.2
  • 45
    • 80052814456 scopus 로고    scopus 로고
    • Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats
    • PID: 21780187
    • Papageorgiou IE, Gabriel S, Fetani AF, Kann O, Heinemann U (2011) Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats. Glia 59:1706–1718. doi:10.1002/glia.21217
    • (2011) Glia , vol.59 , pp. 1706-1718
    • Papageorgiou, I.E.1    Gabriel, S.2    Fetani, A.F.3    Kann, O.4    Heinemann, U.5
  • 46
    • 84856384517 scopus 로고    scopus 로고
    • Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission
    • COI: 1:CAS:528:DC%2BC38Xis1yrtLw%3D, PID: 22167804
    • Pascual O, Ben Achour S, Rostaing P, Triller A, Bessis A (2012) Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci USA 109:e197–e205. doi:10.1073/pnas.1111098109
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 197-205
    • Pascual, O.1    Ben Achour, S.2    Rostaing, P.3    Triller, A.4    Bessis, A.5
  • 50
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • COI: 1:CAS:528:DC%2BD2sXhtFehsrrI, PID: 17904651
    • Pocock JM, Kettenmann H (2007) Neurotransmitter receptors on microglia. Trends Neurosci 30:527–535. doi:10.1016/j.tins.2007.07.007
    • (2007) Trends Neurosci , vol.30 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 52
    • 78149435065 scopus 로고    scopus 로고
    • The myeloid cells of the central nervous system parenchyma
    • COI: 1:CAS:528:DC%2BC3cXhsVWjsLfP, PID: 21068834
    • Ransohoff RM, Cardona AE (2010) The myeloid cells of the central nervous system parenchyma. Nature 468:253–262. doi:10.1038/nature09615
    • (2010) Nature , vol.468 , pp. 253-262
    • Ransohoff, R.M.1    Cardona, A.E.2
  • 53
    • 21844464283 scopus 로고    scopus 로고
    • Inflammatory response and glia activation in developing rat hippocampus after status epilepticus
    • COI: 1:CAS:528:DC%2BD2sXjvF2gsg%3D%3D, PID: 15987264
    • Ravizza T, Rizzi M, Perego C, Richichi C, Velískôvá J, Moshé SL, De Simoni MG, Vezzani A (2005) Inflammatory response and glia activation in developing rat hippocampus after status epilepticus. Epilepsia 46(Suppl 5):113–117. doi:10.1111/j.1528-1167.2005.01006.x
    • (2005) Epilepsia , vol.46 , pp. 113-117
    • Ravizza, T.1    Rizzi, M.2    Perego, C.3    Richichi, C.4    Velískôvá, J.5    Moshé, S.L.6    De Simoni, M.G.7    Vezzani, A.8
  • 54
    • 36549071601 scopus 로고    scopus 로고
    • Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BD2sXhsVSnsL7I, PID: 17931873
    • Ravizza T, Gagliardi B, Noé F, Boer K, Aronica E, Vezzani A (2008) Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis 29:142–160. doi:10.1016/j.nbd.2007.08.012
    • (2008) Neurobiol Dis , vol.29 , pp. 142-160
    • Ravizza, T.1    Gagliardi, B.2    Noé, F.3    Boer, K.4    Aronica, E.5    Vezzani, A.6
  • 55
    • 55949107105 scopus 로고    scopus 로고
    • Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation
    • COI: 1:CAS:528:DC%2BD1cXhtlKlt7zK, PID: 18955701
    • Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ (2008) Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation. Proc Natl Acad Sci USA 105:17151–17156. doi:10.1073/pnas.0806682105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17151-17156
    • Riazi, K.1    Galic, M.A.2    Kuzmiski, J.B.3    Ho, W.4    Sharkey, K.A.5    Pittman, Q.J.6
  • 56
    • 0036556325 scopus 로고    scopus 로고
    • Microglia and astrocytes may participate in the shaping of visual callosal projections during postnatal development
    • COI: 1:STN:280:DC%2BD38novVKitQ%3D%3D, PID: 12445895
    • Rochefort N, Quenech’du N, Watroba L, Mallat M, Giaume C, Milleret C (2002) Microglia and astrocytes may participate in the shaping of visual callosal projections during postnatal development. J Physiol Paris 96:183–192. doi:10.1016/S0928-4257(02)00005-0
    • (2002) J Physiol Paris , vol.96 , pp. 183-192
    • Rochefort, N.1    Quenech’du, N.2    Watroba, L.3    Mallat, M.4    Giaume, C.5    Milleret, C.6
  • 58
    • 0142059006 scopus 로고    scopus 로고
    • Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting
    • PID: 14534276
    • Scharfman HE, Sollas AL, Berger RE, Goodman JH (2003) Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting. J Neurophysiol 90:2536–2547. doi:10.1152/jn.00251.2003
    • (2003) J Neurophysiol , vol.90 , pp. 2536-2547
    • Scharfman, H.E.1    Sollas, A.L.2    Berger, R.E.3    Goodman, J.H.4
  • 59
    • 0035725230 scopus 로고    scopus 로고
    • + channel expression in microglia via distinct signalling pathways
    • COI: 1:STN:280:DC%2BD3MrgtlyjtA%3D%3D, PID: 11553296
    • + channel expression in microglia via distinct signalling pathways. Eur J Neurosci 14:463–473. doi:10.1046/j.0953-816x.2001.01661.x
    • (2001) Eur J Neurosci , vol.14 , pp. 463-473
    • Schilling, T.1    Nitsch, R.2    Heinemann, U.3    Haas, D.4    Eder, C.5
  • 60
    • 84863205849 scopus 로고    scopus 로고
    • NIH Image to ImageJ: 25 years of image analysis
    • COI: 1:CAS:528:DC%2BC38XhtVKntb7P, PID: 22930834
    • Schneider CA, Rasband WS, Eliceiri KW (2012) NIH Image to ImageJ: 25 years of image analysis. Nat Methods 9:671–675. doi:10.1038/nmeth.2089
    • (2012) Nat Methods , vol.9 , pp. 671-675
    • Schneider, C.A.1    Rasband, W.S.2    Eliceiri, K.W.3
  • 61
    • 33644870168 scopus 로고    scopus 로고
    • Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant path
    • COI: 1:CAS:528:DC%2BD28XhtlKnur0%3D, PID: 16282203
    • Scimemi A, Schorge S, Kullmann DM, Walker MC (2006) Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant path. J Neurophysiol 95:1213–1220. doi:10.1152/jn.00680.2005
    • (2006) J Neurophysiol , vol.95 , pp. 1213-1220
    • Scimemi, A.1    Schorge, S.2    Kullmann, D.M.3    Walker, M.C.4
  • 62
    • 84862835235 scopus 로고    scopus 로고
    • Cellular markers of neuroinflammation and neurogenesis after ischemic brain injury in the long-term survival rat model
    • COI: 1:CAS:528:DC%2BC38XlsVWnsLs%3D, PID: 21706330
    • Sekeljic V, Bataveljic D, Stamenkovic S, Ułamek M, Jabłoński M, Radenovic L, Pluta R, Andjus PR (2012) Cellular markers of neuroinflammation and neurogenesis after ischemic brain injury in the long-term survival rat model. Brain Struct Funct 217:411–420. doi:10.1007/s00429-011-0336-7
    • (2012) Brain Struct Funct , vol.217 , pp. 411-420
    • Sekeljic, V.1    Bataveljic, D.2    Stamenkovic, S.3    Ułamek, M.4    Jabłoński, M.5    Radenovic, L.6    Pluta, R.7    Andjus, P.R.8
  • 63
    • 38449102377 scopus 로고    scopus 로고
    • Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats
    • COI: 1:CAS:528:DC%2BD1cXisl2ktb8%3D, PID: 18226170
    • Shapiro LA, Wang L, Ribak CE (2008) Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats. Epilepsia 49(Suppl 2):33–41. doi:10.1111/j.1528-1167.2008.01491.x
    • (2008) Epilepsia , vol.49 , pp. 33-41
    • Shapiro, L.A.1    Wang, L.2    Ribak, C.E.3
  • 64
    • 63249124696 scopus 로고    scopus 로고
    • Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus
    • COI: 1:CAS:528:DC%2BD1MXktFalsLY%3D, PID: 19249294
    • Shapiro LA, Perez ZD, Foresti ML, Arisi GM, Ribak CE (2009) Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus. Brain Res 1266:29–36. doi:10.1016/j.brainres.2009.02.031
    • (2009) Brain Res , vol.1266 , pp. 29-36
    • Shapiro, L.A.1    Perez, Z.D.2    Foresti, M.L.3    Arisi, G.M.4    Ribak, C.E.5
  • 65
    • 0025667136 scopus 로고
    • Tetanus toxin-induced seizures cause microglial activation in rat hippocampus
    • COI: 1:CAS:528:DyaK3MXhtFKlt7w%3D, PID: 2293095
    • Shaw JAG, Perry VH, Mellanby J (1990) Tetanus toxin-induced seizures cause microglial activation in rat hippocampus. Neurosci Lett 120:66–69. doi:10.1016/0304-3940(90)90169-A
    • (1990) Neurosci Lett , vol.120 , pp. 66-69
    • Shaw, J.A.G.1    Perry, V.H.2    Mellanby, J.3
  • 66
    • 3543144446 scopus 로고
    • Dendritic organization in the neurons of the visual and motor cortices of the cat
    • COI: 1:STN:280:DyaG2c%2FjvVOiuw%3D%3D, PID: 13117757
    • Sholl DA (1953) Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 87:387–406
    • (1953) J Anat , vol.87 , pp. 387-406
    • Sholl, D.A.1
  • 67
    • 57249094423 scopus 로고    scopus 로고
    • Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the “latent period” and other concepts
    • PID: 19087122
    • Sloviter RS (2008) Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the “latent period” and other concepts. Epilepsia 49(Suppl 9):85–92. doi:10.1111/j.1528-1167.2008.01931.x
    • (2008) Epilepsia , vol.49 , pp. 85-92
    • Sloviter, R.S.1
  • 69
    • 0037025262 scopus 로고    scopus 로고
    • Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activity
    • PID: 12151014
    • Steinhäuser C, Seifert G (2002) Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activity. Eur J Pharmacol 447:227–237. doi:10.1016/S0014-2999(02)01846-0
    • (2002) Eur J Pharmacol , vol.447 , pp. 227-237
    • Steinhäuser, C.1    Seifert, G.2
  • 70
    • 0035101188 scopus 로고    scopus 로고
    • Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices
    • COI: 1:STN:280:DC%2BD3M3lvFOgsQ%3D%3D, PID: 11241743
    • Stence N, Waite M, Dailey ME (2001) Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33:256–266. doi:10.1002/1098-1136(200103)33:3<256:AID-GLIA1024>3.0.CO;2-J
    • (2001) Glia , vol.33 , pp. 256-266
    • Stence, N.1    Waite, M.2    Dailey, M.E.3
  • 72
    • 0030188493 scopus 로고    scopus 로고
    • The continuing saga of complement receptor type 3 (CR3)
    • COI: 1:CAS:528:DyaK28XktFWgs7Y%3D, PID: 8690779
    • Todd RF III (1996) The continuing saga of complement receptor type 3 (CR3). J Clin Invest 98:1–2. doi:10.1172/JCI118752
    • (1996) J Clin Invest , vol.98
    • Todd, R.F.1
  • 73
    • 18744393378 scopus 로고    scopus 로고
    • Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy
    • PID: 12383279
    • Tooyama I, Bellier J-P, Park M, Minnasch P, Uemura S, Hisano T, Iwami M, Aimi Y, Yasuhara O, Kimura H (2002) Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy. Epilepsia 43(Suppl 9):39–43. doi:10.1046/j.1528-1157.43.s.9.10.x
    • (2002) Epilepsia , vol.43 , pp. 39-43
    • Tooyama, I.1    Bellier, J.-P.2    Park, M.3    Minnasch, P.4    Uemura, S.5    Hisano, T.6    Iwami, M.7    Aimi, Y.8    Yasuhara, O.9    Kimura, H.10
  • 74
    • 84880699376 scopus 로고    scopus 로고
    • Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus
    • PID: 23828736
    • Ulmann L, Levavasseur F, Avignone E, Peyroutou R, Hirbec H, Audinat E, Rassendren F (2013) Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus. Glia 61:1306–1319. doi:10.1002/glia.22516
    • (2013) Glia , vol.61 , pp. 1306-1319
    • Ulmann, L.1    Levavasseur, F.2    Avignone, E.3    Peyroutou, R.4    Hirbec, H.5    Audinat, E.6    Rassendren, F.7
  • 75
    • 62849101387 scopus 로고    scopus 로고
    • The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network
    • PID: 19300446
    • van Strien NM, Cappaert NLM, Witter MP (2009) The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network. Nat Rev Neurosci 10:272–282. doi:10.1038/nrn2614
    • (2009) Nat Rev Neurosci , vol.10 , pp. 272-282
    • van Strien, N.M.1    Cappaert, N.L.M.2    Witter, M.P.3
  • 76
    • 78651369895 scopus 로고    scopus 로고
    • The role of inflammation in epilepsy
    • COI: 1:CAS:528:DC%2BC3MXjs1OmtA%3D%3D, PID: 21135885
    • Vezzani A, French J, Bartfai T, Baram TZ (2011) The role of inflammation in epilepsy. Nat Rev Neurol 7:31–40. doi:10.1038/nrneurol.2010.178
    • (2011) Nat Rev Neurol , vol.7 , pp. 31-40
    • Vezzani, A.1    French, J.2    Bartfai, T.3    Baram, T.Z.4
  • 77
    • 30944468498 scopus 로고    scopus 로고
    • Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures
    • PID: 16431219
    • Wennström M, Hellsten J, Ekstrand J, Lindgren H, Tingström A (2006) Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures. Biol Psychiatry 59:178–186. doi:10.1016/j.biopsych.2005.08.032
    • (2006) Biol Psychiatry , vol.59 , pp. 178-186
    • Wennström, M.1    Hellsten, J.2    Ekstrand, J.3    Lindgren, H.4    Tingström, A.5
  • 78
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • COI: 1:STN:280:DyaK387ntFWrtw%3D%3D, PID: 1793176
    • West MJ, Slomianka L, Gundersen HJG (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482–497. doi:10.1002/ar.1092310411
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.G.3
  • 80
    • 84879794919 scopus 로고    scopus 로고
    • Differential distribution and activation of microglia in the brain of male C57BL/6J mice
    • COI: 1:CAS:528:DC%2BC3sXhtVGks7bJ, PID: 22886465
    • Yang T-T, Lin C, Hsu C-T, Wang T-F, Ke F-Y, Kuo Y-M (2013) Differential distribution and activation of microglia in the brain of male C57BL/6J mice. Brain Struct Funct 218:1051–1060. doi:10.1007/s00429-012-0446-x
    • (2013) Brain Struct Funct , vol.218 , pp. 1051-1060
    • Yang, T.-T.1    Lin, C.2    Hsu, C.-T.3    Wang, T.-F.4    Ke, F.-Y.5    Kuo, Y.-M.6
  • 81
    • 79952769307 scopus 로고    scopus 로고
    • Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BC3MXjvFWmt7c%3D, PID: 21411646
    • Zattoni M, Mura ML, Deprez F, Schwendener RA, Engelhardt B, Frei K, Fritschy J-M (2011) Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J Neurosci 31:4037–4050. doi:10.1523/JNEUROSCI.6210-10.2011
    • (2011) J Neurosci , vol.31 , pp. 4037-4050
    • Zattoni, M.1    Mura, M.L.2    Deprez, F.3    Schwendener, R.A.4    Engelhardt, B.5    Frei, K.6    Fritschy, J.-M.7
  • 82
    • 84863012627 scopus 로고    scopus 로고
    • Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BC38Xjt1CmsLs%3D, PID: 22279204
    • Zhang W, Huguenard JR, Buckmaster PS (2012) Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy. J Neurosci 32:1183–1196. doi:10.1523/JNEUROSCI.5342-11.2012
    • (2012) J Neurosci , vol.32 , pp. 1183-1196
    • Zhang, W.1    Huguenard, J.R.2    Buckmaster, P.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.