Antioxidant, anti-inflammatory, and antiulcer potential of manuka honey against gastric ulcer in rats

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Almasaudi, Saad B ^a   El Shitany, Nagla A ^a,b   Abbas, Aymn T ^a,c   Abdel Dayem, Umama A ^a   Ali, Soad S ^d   Al Jaouni, Soad K ^d   Harakeh, Steve ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Tanta University   (Egypt)

^c MANSOURA UNIVERSITY   (Egypt)

^d King Abdulaziz University   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; DISEASES; ENZYMES; ETHANOL; GLYCOPROTEINS; IMMUNOLOGY; NITRIC OXIDE; OXIDATION; OXYGEN; PEPTIDES; RATS;

ANTI-INFLAMMATORIES; GLUTATHIONE PEROXIDASE; HEMORRHAGIC LESIONS; INFLAMMATORY CYTOKINES; LIPID PEROXIDATION; NECROSIS FACTORS; REDUCED GLUTATHIONE; SUPEROXIDE DISMUTASES;

FOOD PRODUCTS;

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ANTIULCER AGENT; CATALASE; CHOLESTEROL; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; NATURAL PRODUCT; NITRIC OXIDE; OMEPRAZOLE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ALCOHOL; GLUCOSE BLOOD LEVEL; GLYCOPROTEIN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; ETHANOL-INDUCED GASTRIC ULCER; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HONEY; LEPTOSPERMUM; LEPTOSPERMUM SCOPARIUM; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ULCERATION INDEX; ANIMAL; BLOOD; DISEASE MODEL; DRINKING BEHAVIOR; DRUG EFFECTS; FEEDING BEHAVIOR; METABOLISM; PATHOLOGY; STAINING; STOMACH ULCER; WEIGHT GAIN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BLOOD GLUCOSE; CATALASE; CHOLESTEROL; DISEASE MODELS, ANIMAL; DRINKING BEHAVIOR; ETHANOL; FEEDING BEHAVIOR; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLYCOPROTEINS; HONEY; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MALONDIALDEHYDE; NITRIC OXIDE; RATS; STAINING AND LABELING; STOMACH ULCER; SUPEROXIDE DISMUTASE; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT GAIN;

EID: 84953225202     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/3643824     Document Type: Article

References (51)

1. M. C. Brucker and M. A. Faucher, Pharmacologic management of common gastrointestinal health problems inwomen, Journal of Nurse-Midwifery, vol. 42, no. 3, pp. 145-162, 1997.
2. H. P. Rang, Pharmacology, Churchill Livingstone, Edinburgh, UK, 2003.
3. K. R. DeVault and N. J. Talley, Insights into the future of gastric acid suppression, Nature Reviews Gastroenterology and Hepatology, vol. 6, no. 9, pp. 524-532, 2009.
4. S.-H. Chen, Y.-C. Liang, J. C. J. Chao et al., Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats,World Journal of Gastroenterology, vol. 11, no. 24, pp. 3746-3750, 2005.
5. S. I. Abdelwahab, M. M. E. Taha, M. A. Abdulla et al., Gastroprotective mechanism of Bauhinia thonningii Schum, Journal of Ethnopharmacology, vol. 148, no. 1, pp. 277-286, 2013.
6. P. Arda-Pirincci, S. Bolkent, and R. Yanardag, The role of zinc sulfate and metallothionein in protection against ethanolinduced gastric damage in rats, Digestive Diseases and Sciences, vol. 51, no. 12, pp. 2353-2360, 2006.
7. S. W. Park, T. Y. Oh, Y. S. Kim et al., Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats, Journal of Gastroenterology and Hepatology, vol. 23, no. 6, pp. 976-984, 2008.
8. Y. Du, W. Zhao, L. Lu et al., Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-α (TNF-κ) and endothelin-1 (ET-1), Asian Pacific Journal of Tropical Biomedicine, vol. 3, no. 12, pp. 925-930, 2013.
9. K. S. Mota, G. E. N. Dias, M. E. F. Pinto et al., Flavonoids with gastroprotective activity,Molecules, vol. 14, no. 3, pp. 979-1012, 2009.
10. Y. Kato, N. Umeda, A. Maeda, D. Matsumoto, N. Kitamoto, and H. Kikuzaki, Identification of a novel glycoside, leptosin, as a chemical marker of manuka honey, Journal of Agricultural and Food Chemistry, vol. 60, no. 13, pp. 3418-3423, 2012.
11. S. Patel and S. Cichello, Manuka honey: an emerging natural food with medicinal use, Natural Products and Bioprospecting, vol. 3, pp. 121-128, 2013.
12. P. C. Molan, The role of honey in themanagement of wounds, Journal ofWound Care, vol. 8, no. 8, pp. 415-418, 1999.
13. H. A. Alzahrani, R. Alsabehi, L. Boukraa, F. Abdellah, Y. Bellik, and B. A. Bakhotmah, Antibacterial andantioxidant potencyof floral honeys fromdifferent botanical and geographical origins, Molecules, vol. 17, no. 9, pp. 10540-10549, 2012.
14. C. W. Chan, B. J. Deadman, M. Manley-Harris, A. L. Wilkins, D. G. Alber, and E. Harry, Analysis of the flavonoid component of bioactive New Zealand manuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole, Food Chemistry, vol. 141, no. 3, pp. 1772-1781, 2013.
15. Z. Jubri, N. B. Abdul Rahim, and G. J. Aan, Manuka honey protects middle-aged rats from oxidative damage, Clinics, vol. 68, no. 11, pp. 1446-1454, 2013.
16. N. Al-Jaber, The relationship between antioxidant and antiulcer activities in saudi honey samples harvested from various regions in different seasons, Food and Nutrition Sciences, vol. 04, no. 08, pp. 131-138, 2013.
17. D. Hollander, A. Tarnawski, W. J. Krause, and H. Gergely, Protective effect of sucralfate against alcohol-induced gastric mucosal injury in the rat. Macroscopic, histologic, ultrastructural, and functional time sequence analysis, Gastroenterology, vol. 88, no. 1, pp. 366-374, 1985.
18. S. Kwiecien, T. Brzozowski, and S. J. Konturek, Effect of reactive oxygen species action on gastric mucosa in various models of mucosal injury, Journal of Physiology and Pharmacology, vol. 53, no. 1, pp. 39-50, 2002.
19. N. A. El-Shitany, Mechanism of omeprazole induced-gastric protection against ethanol-induced gastric injury in rats: role of mucosal nitric oxide and apoptotic cell death, in Proceedings of the 1st International Egyptian-Jordanian Conference on Biotechnology and Sustainable Development: Current Status and Future Scenarios, pp. 183-194, Cairo, Egypt, 2006.
20. T. K. Motawi, M. A. Hamed, R. M. Hashem, M. H. Shabana, and O. R. Ahmed, Protective and therapeutic effects of Argyreia speciosa against ethanol-induced gastric ulcer in rats, Zeitschrift fur Naturforschung C, vol. 67, no. 1-2, pp. 47-57, 2012.
21. K. Gharzouli, A. Gharzouli, S. Amira, and S. Khennouf, Prevention of ethanol-induced gastric lesions in rats by natural honey and glucose-fructose-sucrose-maltose mixture, Pharmacological Research, vol. 39, no. 2, pp. 151-156, 1999.
22. A. Bozkurt, M. Yuksel, G. Haklar, H. Kurtel, B. C. Yegen, and I. Alican, Adenosine protects against indomethacin-induced gastric damage in rats, Digestive Diseases and Sciences, vol. 43, no. 6, pp. 1258-1263, 1998.
23. D. Das and R. K. Banerjee, Effect of stress on the antioxidant enzymes and gastric ulceration, Molecular and Cellular Biochemistry, vol. 125, no. 2, pp. 115-125, 1993.
24. M. M. Tarpey, D. A. Wink, and M. B. Grisham, Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations, The American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 286, no. 3, pp. R431-R444, 2004.
25. G. L. Ellman, Tissue sulfhydryl groups, Archives of Biochemistry and Biophysics, vol. 74, pp. 214-226, 1959.
26. M. Uchiyama and M. Mihara, Determination of malondialdehyde precursor in tissues by thiobarbituric acid test, Analytical Biochemistry, vol. 86, pp. 271-278, 1979.
27. D. E. Paglia and W. N. Valentine, Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase, The Journal of Laboratory and Clinical Medicine, vol. 70, no. 1, pp. 158-169, 1967.
28. M. Nishikimi, N. Appaji Rao, and K. Yagi, The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen, Biochemical and Biophysical Research Communications, vol. 46, no. 2, pp. 849-854, 1972.
29. H. Aebi, Catalase in vitro,Methods in Enzymology, vol. 105, pp. 121-126, 1984.
30. L. Chepulis and N. Starkey, The long-term effects of feeding honey compared with sucrose and a sugar-free diet on weight gain, lipid profiles, and DEXA measurements in rats, Journal of Food Science, vol. 73, no. 1, pp. H1-H7, 2008.
31. N. S. Al-Waili, Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bonemarrow function, lipid profile and carbon tetrachloride-induced liver injury, Journal of Medicinal Food, vol. 6, no. 3, pp. 231-247, 2003.
32. L. M. Chepulis, The effect of honey compared to sucrose, mixed sugars, and a sugar-free diet on weight gain in young rats, Journal of Food Science, vol. 72, no. 3, pp. S224-S229, 2007.
33. O. O. Erejuwa, S. A. Sulaiman, M. S. A. Wahab, K. N. S. Sirajudeen, M. S. M. Salleh, and S. Gurtu, Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats, International Journal of Biological Sciences, vol. 7, no. 2, pp. 244-252, 2011.
34. E. A. Alagwu, R. O. Nneli, J. N. Egwurugwu, and E. E. Osim, Gastric cytoprotection and honey intake in albino rats, Nigerian Journal of Physiological Sciences, vol. 26, no. 1, pp. 39-42, 2011.
35. K. Gharzouli, S. Amira, A. Gharzouli, and S. Khennouf, Gastroprotective effects of honey and glucose-fructose-sucrosemaltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat, Experimental and Toxicologic Pathology, vol. 54, no. 3, pp. 217-221, 2002.
36. S. Szabo, J. S. Trier, and P. W. Frankel, Sulfhydryl compounds may mediate gastric cytoprotection, Science, vol. 214, no. 4517, pp. 200-202, 1981.
37. B. J. R. Whittle and J. Lopez-Belmonte, Gastric mucosal damage and protection: involvement of novel endotheliumderived mediators, in The Stomach, W. Domschke and S. J. Konturek, Eds., pp. 68-82, Springer, Berlin, Germany, 1993.
38. M. Hajrezaie, S. Golbabapour, P. Hassandarvish et al., Acute toxicity and gastroprotection studies of a new schiff base derived copper (II) complex against ethanol-induced acute gastric lesions in rats, PLoSONE, vol. 7, no. 12, Article IDe51537, 2012.
39. K. A. Ketuly, A. H. A. Hadi, S. Golbabapour et al., Acute toxicity and gastroprotection studies with a newly synthesized steroid, PLoS ONE, vol. 8, no. 3, Article ID e59296, 9 pages, 2013.
40. H. M. A. Sidahmed, S. I. Abdelwahab, S. Mohan et al., α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property: a mechanistic study, Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 450840, 10 pages, 2013.
41. N. H. P. Cnubben, I. M. C. M. Rietjens, H. Wortelboer, J. P. J. Van Zanden, and P. J. Van Bladeren, The interplay of glutathionerelated processes in antioxidant defense, Environmental Toxicology and Pharmacology, vol. 10, no. 4, pp. 141-152, 2001.
42. F. G. Gonzalez and L. C. Di Stasi, Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice, Phytomedicine, vol. 9, no. 2, pp. 125-134, 2002.
43. O. Coskun, M. Kanter, F. Armutcu, K. Cetin, B. Kaybolmaz, and O. Yazgan, Protective effects of quercetin, a flavonoid antioxidant, in absolute ethanol-induced acute gastric ulcer, European Journal of General Medicine, vol. 1, no. 3, pp. 37-42, 2004.
44. P. Molan and T. Rhodes, Honey: a biologic wound dressing, Wounds, vol. 27, no. 6, pp. 141-151, 2015.
45. W. A. Gunzler and L. Flohe, Glutathione peroxidase, in CRC Handbook of Methods for Oxygen Radical Research, R. A. Greenwal, Ed., pp. 285-290, CRC Press, Boca Raton, Fla, USA, 1985.
46. T. Mizui, H. Sato, F. Hirose, and M. Doteuchi, Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats, Life Sciences, vol. 41, no. 6, pp. 755-763, 1987.
47. J. S. Stamler, D. J. Singel, and J. Loscalzo, Biochemistry of nitric oxide and its redox-activated forms, Science, vol. 258, no. 5090, pp. 1898-1902, 1992.
48. J. M. Griscavage, J. M. Fukuto, Y. Komori, and L. J. Ignarro, Nitricoxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterinin modulating the inhibitory action of nitric oxide, The Journal of Biological Chemistry, vol. 269, pp. 21644-21649, 1994.
49. J. F. Brown, A. C. Keates, P. J. Hanson, and B. J. R. Whittle, Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells, The American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 265, no. 3, pp. G418-G422, 1993.
50. J. L. Wallace, B. Reuter, C. Cicala, W. McKnight, M. B. Grisham, and G. Cirino, Novel nonsteroidal anti-inflammatory drug derivativeswithmarkedly reduced ulcerogenic properties in the rat, Gastroenterology, vol. 107, no. 1, pp. 173-179, 1994.
51. R. I. Bersimbaev, Y. E. Yugai, P. J. Hanson, and I. G. Tzoy, Effect of nitric oxide on apoptotic activity in the rat gastrointestinal tract, European Journal of Pharmacology, vol. 423, no. 1, pp. 9-16, 2001.