Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 6, 2008, Pages 976-984

  Park, Sang Woon ^b   Oh, Tae Young ^c   Kim, Yong Seok ^d   Sim, Hyejin ^b   Park, Sang Jong ^b   Jang, Eun Jung ^b   Park, Joo Sang ^b   Baik, Hyun Wook ^b   Hahm, Ki Baik ^a,b  

^a Bundang Jesaeng Hospital   (South Korea)

^b DMC Jesaeng Hospital   (South Korea)

^c Dong A Pharmaceutical Company   (South Korea)

^d Hanyang University   (South Korea)

Author keywords

Artemisia asiatica; DA 9601; Ethanol; Gastric injury; Glutathione; Lipid peroxide

Indexed keywords

ARTEMISIA ASIATICA EXTRACT; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; PLANT EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA LESION; WESTERN BLOTTING;

EID: 44949133340     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05333.x     Document Type: Article

References (40)

1. Franke A, Teyssen S, Singer MV. Alcohol-related disease of the esophagus and stomach. Dig. Dis. 2005 23: 204 13.
2. Taylor B, Rehm J. Moderate alcohol consumption and diseases of the gastrointestinal system: a review of pathophysiological processes. Dig. Dis. 2005 23: 177 80.
3. Laine L, Weinstein WM. Histology of alcoholic hemorrhagic 'gastritis', a prospective evaluation. Gastroenterology 1988 94: 1254 62.
4. Tarnawski A, Stachura J, Hollander D, Sarfeh IJ, Bogdal J. Cellular aspects of alcohol-induced injury and prostaglandin protection of the human gastric mucosa. J. Clin. Gastroenterol. 1988 10: S35 45.
5. Hernandez-Munoz R, Montiel-Ruiz C, Vazquez-Martinez O. Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Laboratory Invest 2000 80: 1161 9.
6. Kwiecien S, Brzozowski T, Konturek SJ. Effect of reactive oxygen species action on gastric mucosa in a various models of mucosal injury. J. Physiol. Pharmacol. 2002 53 (1 39 50.
7. Gonzalez-Quintela A, Dominguez-Santalla MJ, Perez LF, Vidal C, Lojo S, Barrio E. Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12. Cytokine 2000 12: 1437 40.
8. Mandrekar P, Catalano D, Girouard L, Szabo G. Human monocyte IL-10 production is increased by acute ethanol treatment. Cytokine 1996 8: 567 77.
9. Szabo G, Mandrekar P, Dolganiuc A, Catalano D, Kodys K. Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNγ Levels. Alcohol. Clin. Exp. Res. 2001 25: 1766 72.
10. Szabo G. Consequences of alcohol consumption on host defence. Alcohol Alcoholism 1999 34: 830 41.
11. Sacanella E, Estruch R, Badia E, Fernandez-Sola J, Nicolas JM, Urbano-Marquez A. Chronic alcohol consumption increases serum levels of circulating endothelial cell/leucocyte adhesion molecules E-selectin and ICAM-1. Alcohol Alcoholism 1999 34: 678 84.
12. Horie Y, Yamagishi Y, Kato S et al. Role of ICAM-1 in chronic ethanol consumption-enhanced liver injury after gut ischemia-reperfusion in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2002 283: G537 43.
13. Yoshikawa T, Minamiyama Y, Ichikawa H, Takahashi S, Naito N, Kondo M. Role of lipid peroxidation and antioxidants in gastric mucosal injury by the hypoxanthine-xanthine oxidase system in rats. Free Radic. Biol. Med. 1997 23: 243 50.
14. Szabo S, Nagy L, Plebani M. Glutathione, protein sulfhydryls and cysteine proteases in gastric mucosal injury and protection. Clin. Chim. Acta 1992 206: 95 105.
15. Mutoh H, Hiraishi H, Ota S et al. Protective role of intracellular glutathione against ethanol-induced damage in cultured rat gastric mucosal cells. Gastroenterology 1990 98: 1452 9.
16. Kim D, Na HK, Oh TY, Kim WB, Surh YJ. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. Biochem. Pharmacol. 2004 68: 1081 7.
17. Cheong JY, Oh TY, Lee KM et al. Suppressive Effects of Antioxidant DA-9601 on Hepatic Fibrosis in Rats. Korean J. Hepatol. 2002 8: 436 47.
18. Oh TY, Ryu BK, Ko JI. Protective effect of DA-9601, an extract of Artemisia herba, against naproxen-induced gastric damage in arthritic rats. Arch. Pharm. Res. 1997 20: 414 9.
19. Huh K, Kwon TH, Shin US et al. Inhibitory effects of DA-9601 on ethanol-induced gastrohemorrhagic lesions and gastric xanthine oxidase activity in rats. J. Ethnopharmacol. 2003 88: 269 73.
20. Oh TY, Ahn GJ, Choi SM, Ahn BO, Kim WB. Increased susceptibility of ethanol-treated gastric mucosa to naproxen and its inhibition by DA-9601, an Artemisia asiatica extract. World J. Gastroenterol. 2005 11: 7450 6.
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979 95: 351 8.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951 15: 265 70.
23. Koshihara Y, Neichi T, Murota S, Lao A, Fujimoto Y, Tatsuno T. Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants, Artemisia rubripes Nakai. Federation European Biochem. Societies 1983 158: 41 4.
24. Hahm KB, Kim JH, You BM et al. Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats. Pancreas 1998 17: 153 7.
25. Lee H, Kim YO, Kim H et al. Flavonoid eupatilin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J 2003 17: 1943 4.
26. Jimenez-Lopez JM, Cederbaum AI. Green tea polyphenol epigallocatechin-3- gallate protects HepG2 cells against CYP2E1-dependent toxicity. Free Radic. Biol. Med. 2004 36: 359 70.
27. Luczaj W, Waszkiewicz E, Skrzydlewska E, Roszkowska-Jakimiec W. Green tea protection against age-dependent ethanol-induced oxidative stress. J. Toxicol. Environ. Health 2004 67: 595 606.
28. Sprag SG, Light ME, Van Stadn J. Biological activities and distribution of plant saponins. J. Ethnophamacol. 2004 94: 219 43.
29. Park JS, Choi MA, Kim BS, Han IS, Kurata T, Yu R. Capsaicin protects against ethanol-induced oxidative injury in the gastric mucosa of rats. Life Sci. 2000 67: 3087 93.
30. Dokmeci D, Akpolat M, Aydogdu N, Doganay L, Turan FN. L-carnitine inhibits ethanol-induced gastric mucosal injury in rats. Pharmacol. Rep. 2005 57: 481 8.
31. Park S, Hahm KB, Ih TY, Jin JH, Choue R. Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 2004 49: 384 94.
32. Lee WR, Shen SC, Lin HY, Hou WC, Yang LL, Chen YC. Eupatilin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca2+ - dependent endonuclease. Biochem. Pharmacol. 2002 63: 225 36.
33. Moss M, Guidot DM, Wong-Lambertina M, Ten Hoor T, Perez RL, Brown LAS. The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am. J. Respir. Crit. Care Med. 2000 161: 414 9.
34. Loquercio C, Taranto D, Beneduce F et al. Glutathione prevents ethanol induced gastric mucosal damage and depletion of sulfhydryl compounds in humans. Gut 1993 34: 161 5.
35. Brown LAS, Harris FL, Ping XD, Gauthier TW. Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability? Alcohol 2004 33: 191 7.
36. Szabo G, Mandrekar P, Girouard L, Catalano D. Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol. Clin. Exp. Res. 1996 20: 900 7.
37. Davis RL, Syapin PJ. Acute ethanol exposure modulates expression of inducible nitric-oxide synthase in human astroglia: evidence for a transcriptional mechanism. Alcohol 2004 32: 195 202.
38. Saika M, Ueyama T, Senba E. Expression of immediate early genes, HSP70, and COX2mRNA in rat stomach following ethanol ingestion. Dig. Dis. Sci. 2000 45: 2455 62.
39. Hahm KB, Park IS, Kim YS et al. Role of rebamipide on induction of heat-shock proteins and protection against reactive oxygen metabolite-mediated cell damage in cultured gastric mucosal cells. Free Radic. Biol. Med. 1997 22: 711 6.
40. Lappas GD, Karl IE, Hotchkiss RS. Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model. Shock 1994 2: 34 9.