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Volumn 36, Issue 2, 2011, Pages 101-113

Vorapaxar. PAR1 receptor antagonist, antiplatelet therapy

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; PLACEBO; PROTEINASE ACTIVATED RECEPTOR 1; VORAPAXAR;

EID: 84952982547     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2011.036.02.1514948     Document Type: Review
Times cited : (6)

References (53)
  • 1
    • 44949114152 scopus 로고    scopus 로고
    • Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
    • Chackalamannil, S., Wang, Y., Greenlee, W.J. et al. Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J Med Chem 2008, 51(11): 3061-4.
    • (2008) J Med Chem , vol.51 , Issue.11 , pp. 3061-3064
    • Chackalamannil, S.1    Wang, Y.2    Greenlee, W.J.3
  • 2
    • 84952986621 scopus 로고    scopus 로고
    • Tricyclic thrombin receptor antagonists
    • (Schering Corp.). EP 1495018, EP 1860106, EP 1982984, EP 2062890, EP 2065384, JP 2005528406, JP 2010132710, US 2003216437, US 7304078, WO 200308928
    • Chackalamannil, S., Greenlee, W.J., Xia, Y., Chelliah, M., Clasby, M.C., Wang, Y., Veltri, E.P. (Schering Corp.). Tricyclic thrombin receptor antagonists. EP 1495018, EP 1860106, EP 1982984, EP 2062890, EP 2065384, JP 2005528406, JP 2010132710, US 2003216437, US 7304078, WO 200308928.
    • Chackalamannil, S.1    Greenlee, W.J.2    Xia, Y.3    Chelliah, M.4    Clasby, M.C.5    Wang, Y.6    Veltri, E.P.7
  • 3
    • 84952981743 scopus 로고    scopus 로고
    • An exo-selective synthesis of himbacine analogs
    • (Schering Corp.). EP 1846385, JP 2008526974, US 2006217422, US 7772276, WO 2006076452
    • Sudhakar, A., Kwok, D.-I., Wu, G.G., Green, M.D., Thiruvengadam, T.K., Lim, N.K., Wang, T., Huang, M. (Schering Corp.). An exo-selective synthesis of himbacine analogs. EP 1846385, JP 2008526974, US 2006217422, US 7772276, WO 2006076452.
    • Sudhakar, A.1    Kwok, D.-I.2    Wu, G.G.3    Green, M.D.4    Thiruvengadam, T.K.5    Lim, N.K.6    Wang, T.7    Huang, M.8
  • 4
    • 84952985993 scopus 로고    scopus 로고
    • Exo- and diastereo- selective synthesis of himbacine analogs
    • (Schering Corp.). CA 2594871, EP 1848705, EP 2196454, EP 2196468, EP 2206697, JP 2008526972, US 2006247450, WO 2006076415
    • Wu, G., Sudhakar, A.R., Wang, T. et al. (Schering Corp.). Exo- and diastereo- selective synthesis of himbacine analogs. CA 2594871, EP 1848705, EP 2196454, EP 2196468, EP 2206697, JP 2008526972, US 2006247450, WO 2006076415.
    • Wu, G.1    Sudhakar, A.R.2    Wang, T.3
  • 5
    • 33846260165 scopus 로고    scopus 로고
    • Metabolism-based identification of a potent thrombin receptor antagonist
    • Clasby, M.C., Chackalamannil, S., Czarniecki, M. et al. Metabolism-based identification of a potent thrombin receptor antagonist. J Med Chem 2007, 50(1): 129-38.
    • (2007) J Med Chem , vol.50 , Issue.1 , pp. 129-138
    • Clasby, M.C.1    Chackalamannil, S.2    Czarniecki, M.3
  • 7
    • 84952981775 scopus 로고    scopus 로고
    • Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs
    • (Schering Corp.). CA 2594742, EP 1848683, JP 2008526254, US 2006172397, WO 2006076565
    • Li, T., Tamarez, M.M., Zaks, A. (Schering Corp.). Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs. CA 2594742, EP 1848683, JP 2008526254, US 2006172397, WO 2006076565.
    • Li, T.1    Tamarez, M.M.2    Zaks, A.3
  • 8
    • 84952988321 scopus 로고    scopus 로고
    • Synthesis of 3-(5-nitrocyclohex-1-enyl)acrylic acid and esters thereof
    • (Schering Corp.). EP 2035364, JP 2009542675, US 2008009651, WO 2008005344
    • Thiruvengadam, T.K., Wang, T., Chiu, J.S., Liao, J. (Schering Corp.). Synthesis of 3-(5-nitrocyclohex-1-enyl)acrylic acid and esters thereof. EP 2035364, JP 2009542675, US 2008009651, WO 2008005344.
    • Thiruvengadam, T.K.1    Wang, T.2    Chiu, J.S.3    Liao, J.4
  • 9
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002, 324(7329): 71-86.
    • (2002) BMJ , vol.324 , Issue.7329 , pp. 71-86
  • 10
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration
    • Collaborative overview of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ 1994, 308(6921): 81-106.
    • (1994) BMJ , vol.308 , Issue.6921 , pp. 81-106
  • 11
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996, 348(9038): 1329-39.
    • (1996) Lancet , vol.348 , Issue.9038 , pp. 1329-1339
  • 12
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials
    • Baigent, C., Blackwell, L., Collins, R. et al. Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009, 373(9678):1849-60.
    • (2009) Lancet , vol.373 , Issue.9678 , pp. 1849-1860
    • Baigent, C.1    Blackwell, L.2    Collins, R.3
  • 13
    • 46249090130 scopus 로고    scopus 로고
    • Dual antithrombotic therapy increases severe bleeding events in patients with stroke and cardiovascular disease: A prospective, multicenter, observational study
    • Toyoda, K., Yasaka, M., Iwade, K. et al. Dual antithrombotic therapy increases severe bleeding events in patients with stroke and cardiovascular disease: A prospective, multicenter, observational study. Stroke 2008, 39(6): 1740-5.
    • (2008) Stroke , vol.39 , Issue.6 , pp. 1740-1745
    • Toyoda, K.1    Yasaka, M.2    Iwade, K.3
  • 14
    • 33144482404 scopus 로고    scopus 로고
    • Cilostazol: Potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding
    • Goto, S. Cilostazol: Potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding. Atheroscler Suppl 2005, 6(4): 3-11.
    • (2005) Atheroscler Suppl , vol.6 , Issue.4 , pp. 3-11
    • Goto, S.1
  • 15
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf, S., Zhao, F., Mehta, S.R., Chrolavicius, S., Tognoni, G., Fox, K.K. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001, 345(7):494-502.
    • (2001) N Engl J Med , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 16
    • 77953806506 scopus 로고    scopus 로고
    • Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: Results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial
    • Berger, P.B., Bhatt, D.L., Fuster, V. et al. Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: Results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial. Circulation 2010, 121(23): 2575-83.
    • (2010) Circulation , vol.121 , Issue.23 , pp. 2575-2583
    • Berger, P.B.1    Bhatt, D.L.2    Fuster, V.3
  • 17
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott, S.D., Braunwald, E., McCabe, C.H. et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007, 357(20): 2001-15.
    • (2007) N Engl J Med , vol.357 , Issue.20 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 18
    • 57449102051 scopus 로고    scopus 로고
    • Antiplatelet therapy use after discharge among acute myocardial infarction patients with in-hospital bleeding
    • Wang, T.Y., Xiao, L., Alexander, K.P. et al. Antiplatelet therapy use after discharge among acute myocardial infarction patients with in-hospital bleeding. Circulation 2008, 118(21): 2139-45.
    • (2008) Circulation , vol.118 , Issue.21 , pp. 2139-2145
    • Wang, T.Y.1    Xiao, L.2    Alexander, K.P.3
  • 19
    • 33947533514 scopus 로고    scopus 로고
    • One-year cardiovascular event rates in outpatients with atherothrombosis
    • Steg, P.G., Bhatt, D.L., Wilson, P.W. et al. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA 2007, 297(11): 1197-206.
    • (2007) JAMA , vol.297 , Issue.11 , pp. 1197-1206
    • Steg, P.G.1    Bhatt, D.L.2    Wilson, P.W.3
  • 20
    • 77956922384 scopus 로고    scopus 로고
    • Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis
    • Bhatt, D.L., Eagle, K.A., Ohman, E.M. et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA 2010, 304(12): 1350-7.
    • (2010) JAMA , vol.304 , Issue.12 , pp. 1350-1357
    • Bhatt, D.L.1    Eagle, K.A.2    Ohman, E.M.3
  • 21
    • 70349680747 scopus 로고    scopus 로고
    • Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry
    • Alberts, M.J., Bhatt, D.L., Mas, J.L. et al. Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry. Eur Heart J 2009, 30(19): 2318-26.
    • (2009) Eur Heart J , vol.30 , Issue.19 , pp. 2318-2326
    • Alberts, M.J.1    Bhatt, D.L.2    Mas, J.L.3
  • 22
    • 30444453441 scopus 로고    scopus 로고
    • International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis
    • Bhatt, D.L., Steg, P.G., Ohman, E.M. et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006, 295(2): 180-9.
    • (2006) JAMA , vol.295 , Issue.2 , pp. 180-189
    • Bhatt, D.L.1    Steg, P.G.2    Ohman, E.M.3
  • 23
    • 72949116778 scopus 로고    scopus 로고
    • Glanzmann's thrombasthenia (defective platelet integrin alphaIIb-beta3): Proposals for management between evidence and open issues
    • Di Minno, G., Coppola, A., Di Minno, M.N., Poon, M.C. Glanzmann's thrombasthenia (defective platelet integrin alphaIIb-beta3): Proposals for management between evidence and open issues. Thromb Haemost 2009, 102(6): 1157-64.
    • (2009) Thromb Haemost , vol.102 , Issue.6 , pp. 1157-1164
    • Di Minno, G.1    Coppola, A.2    Di Minno, M.N.3    Poon, M.C.4
  • 24
    • 33847254554 scopus 로고    scopus 로고
    • Delayed thrombin-induced platelet-fibrin clot generation by clopidogrel: A new dose-related effect demonstrated by thrombelastography in patients undergoing coronary artery stenting
    • Gurbel, P.A., Bliden, K.P., Guyer, K., Aggarwal, N., Tantry, U.S. Delayed thrombin-induced platelet-fibrin clot generation by clopidogrel: A new dose-related effect demonstrated by thrombelastography in patients undergoing coronary artery stenting. Thromb Res 2007, 119(5): 563-70.
    • (2007) Thromb Res , vol.119 , Issue.5 , pp. 563-570
    • Gurbel, P.A.1    Bliden, K.P.2    Guyer, K.3    Aggarwal, N.4    Tantry, U.S.5
  • 25
    • 9144228045 scopus 로고    scopus 로고
    • A clinical trial of abciximab in elective percutaneous coronary intervention after pretreatment with clopidogrel
    • Kastrati, A., Mehilli, J., Schuhlen, H. et al. A clinical trial of abciximab in elective percutaneous coronary intervention after pretreatment with clopidogrel. N Engl J Med 2004, 350(3): 232-8.
    • (2004) N Engl J Med , vol.350 , Issue.3 , pp. 232-238
    • Kastrati, A.1    Mehilli, J.2    Schuhlen, H.3
  • 26
    • 58549104723 scopus 로고    scopus 로고
    • Efficacy of abciximab for patients undergoing balloon angioplasty: Data from Japanese evaluation of c7E3 Fab for elective and primary PCI organization in randomized trial (JEPPORT)
    • Nakagawa, Y., Nobuyoshi, M., Yamaguchi, T. et al. Efficacy of abciximab for patients undergoing balloon angioplasty: Data from Japanese evaluation of c7E3 Fab for elective and primary PCI organization in randomized trial (JEPPORT). Circ J 2009, 73(1): 145-51.
    • (2009) Circ J , vol.73 , Issue.1 , pp. 145-151
    • Nakagawa, Y.1    Nobuyoshi, M.2    Yamaguchi, T.3
  • 27
    • 0242300217 scopus 로고    scopus 로고
    • Antiplatelet therapy: In search of the 'magic bullet'
    • Jackson, S.P., Schoenwaelder, S.M. Antiplatelet therapy: In search of the 'magic bullet'. Nat Rev Drug Discov 2003, 2(10): 775-89.
    • (2003) Nat Rev Drug Discov , vol.2 , Issue.10 , pp. 775-789
    • Jackson, S.P.1    Schoenwaelder, S.M.2
  • 28
    • 57349184561 scopus 로고    scopus 로고
    • The challenge of monitoring platelet response after clopidogrel
    • Serebruany, V.L., Goto, S. The challenge of monitoring platelet response after clopidogrel. Eur Heart J 2008, 29(23): 2833-4.
    • (2008) Eur Heart J , vol.29 , Issue.23 , pp. 2833-2834
    • Serebruany, V.L.1    Goto, S.2
  • 29
    • 70350223578 scopus 로고    scopus 로고
    • Circadian variations of gastrointestinal mucosal damage detected with transnasal endoscopy in apparently healthy subjects treated with low-dose aspirin (ASA) for a short period
    • Kawai, T., Yamagishi, T., Goto, S. Circadian variations of gastrointestinal mucosal damage detected with transnasal endoscopy in apparently healthy subjects treated with low-dose aspirin (ASA) for a short period. J Atheroscler Thromb 2009, 16(3): 155-63.
    • (2009) J Atheroscler Thromb , vol.16 , Issue.3 , pp. 155-163
    • Kawai, T.1    Yamagishi, T.2    Goto, S.3
  • 30
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter, G., Jantzen, H.M., Vincent, D. et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 2001, 409(6817): 202-7.
    • (2001) Nature , vol.409 , Issue.6817 , pp. 202-207
    • Hollopeter, G.1    Jantzen, H.M.2    Vincent, D.3
  • 31
    • 70350332201 scopus 로고    scopus 로고
    • A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel
    • Hagihara, K., Kazui, M., Kurihara, A. et al. A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel. Drug Metab Dispos 2009, 37(11): 2145-52.
    • (2009) Drug Metab Dispos , vol.37 , Issue.11 , pp. 2145-2152
    • Hagihara, K.1    Kazui, M.2    Kurihara, A.3
  • 32
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin, L., Becker, R.C., Budaj, A. et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009, 361(11):1045-57.
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 33
    • 0020614164 scopus 로고
    • A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions
    • Sano, K., Takai, Y., Yamanishi, J., Nishizuka, Y. A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions. J Biol Chem 1983, 258(3):2010-3.
    • (1983) J Biol Chem , vol.258 , Issue.3 , pp. 2010-2013
    • Sano, K.1    Takai, Y.2    Yamanishi, J.3    Nishizuka, Y.4
  • 34
    • 0032514474 scopus 로고    scopus 로고
    • A dual thrombin receptor system for platelet activation
    • Kahn, M.L., Zheng, Y.W., Huang, W. et al. A dual thrombin receptor system for platelet activation. Nature 1998, 394(6694): 690-4.
    • (1998) Nature , vol.394 , Issue.6694 , pp. 690-694
    • Kahn, M.L.1    Zheng, Y.W.2    Huang, W.3
  • 35
    • 0028181751 scopus 로고
    • Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha
    • De Marco, L., Mazzucato, M., Masotti, A., Ruggeri, Z.M. Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. J Biol Chem 1994, 269(9): 6478-84.
    • (1994) J Biol Chem , vol.269 , Issue.9 , pp. 6478-6484
    • De Marco, L.1    Mazzucato, M.2    Masotti, A.3    Ruggeri, Z.M.4
  • 36
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin, S.R. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 2005, 3(8): 1800-14.
    • (2005) J Thromb Haemost , vol.3 , Issue.8 , pp. 1800-1814
    • Coughlin, S.R.1
  • 37
    • 0035817822 scopus 로고    scopus 로고
    • Role of thrombin signalling in platelets in haemostasis and thrombosis
    • Sambrano, G.R., Weiss, E.J., Zheng, Y.W., Huang, W., Coughlin, S.R. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 2001, 413(6851): 74-8.
    • (2001) Nature , vol.413 , Issue.6851 , pp. 74-78
    • Sambrano, G.R.1    Weiss, E.J.2    Zheng, Y.W.3    Huang, W.4    Coughlin, S.R.5
  • 38
    • 62649125696 scopus 로고    scopus 로고
    • Important regulatory role of activated platelet-derived procoagulant activity in the propagation of thrombi formed under arterial blood flow conditions
    • Tamura, N., Kitajima, I., Kawamura, Y., Toda, E., Eguchi, Y., Ishida, H., Goto, S. Important regulatory role of activated platelet-derived procoagulant activity in the propagation of thrombi formed under arterial blood flow conditions. Circ J 2009, 73(3): 540-8.
    • (2009) Circ J , vol.73 , Issue.3 , pp. 540-548
    • Tamura, N.1    Kitajima, I.2    Kawamura, Y.3    Toda, E.4    Eguchi, Y.5    Ishida, H.6    Goto, S.7
  • 39
    • 0031772197 scopus 로고    scopus 로고
    • Coronary thrombosis. Effects of blood flow on the mechanism of thrombus formation
    • Goto, S., Handa, S. Coronary thrombosis. Effects of blood flow on the mechanism of thrombus formation. Jpn Heart J 1998, 39(5): 579-96.
    • (1998) Jpn Heart J , vol.39 , Issue.5 , pp. 579-596
    • Goto, S.1    Handa, S.2
  • 40
    • 0030008312 scopus 로고    scopus 로고
    • Role of the thrombin receptor in development and evidence for a second receptor
    • Connolly, A.J., Ishihara, H., Kahn, M.L., Farese, R.V. Jr., Coughlin, S.R. Role of the thrombin receptor in development and evidence for a second receptor. Nature 1996, 381(6582): 516-9.
    • (1996) Nature , vol.381 , Issue.6582 , pp. 516-519
    • Connolly, A.J.1    Ishihara, H.2    Kahn, M.L.3    Farese Jr., R.V.4    Coughlin, S.R.5
  • 41
    • 0033613269 scopus 로고    scopus 로고
    • Protease-activated receptor 1 is the primary mediator of thrombinstimulated platelet procoagulant activity
    • Andersen, H., Greenberg, D.L., Fujikawa, K., Xu, W., Chung, D.W., Davie, E.W. Protease-activated receptor 1 is the primary mediator of thrombinstimulated platelet procoagulant activity. Proc Natl Acad Sci U S A 1999, 96(20): 11189-93.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.20 , pp. 11189-11193
    • Andersen, H.1    Greenberg, D.L.2    Fujikawa, K.3    Xu, W.4    Chung, D.W.5    Davie, E.W.6
  • 42
    • 0033559805 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
    • Kahn, M.L., Nakanishi-Matsui, M., Shapiro, M.J., Ishihara, H., Coughlin, S.R. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest 1999, 103(6): 879-87.
    • (1999) J Clin Invest , vol.103 , Issue.6 , pp. 879-887
    • Kahn, M.L.1    Nakanishi-Matsui, M.2    Shapiro, M.J.3    Ishihara, H.4    Coughlin, S.R.5
  • 43
    • 33748495552 scopus 로고    scopus 로고
    • Protease-activated receptors in cardiovascular diseases
    • Leger, A.J., Covic, L., Kuliopulos, A. Protease-activated receptors in cardiovascular diseases. Circulation 2006, 114(10): 1070-7.
    • (2006) Circulation , vol.114 , Issue.10 , pp. 1070-1077
    • Leger, A.J.1    Covic, L.2    Kuliopulos, A.3
  • 44
    • 77949876317 scopus 로고    scopus 로고
    • Thrombin receptor antagonism - The potential of antiplatelet medication SCH 530348
    • Macaulay, T.E., Allen, C., Ziada, K.M. Thrombin receptor antagonism - The potential of antiplatelet medication SCH 530348. Expert Opin Pharmacother 2010, 11(6): 1015-22.
    • (2010) Expert Opin Pharmacother , vol.11 , Issue.6 , pp. 1015-1022
    • Macaulay, T.E.1    Allen, C.2    Ziada, K.M.3
  • 45
    • 73949157474 scopus 로고    scopus 로고
    • Platelet thrombin receptor antagonism and atherothrombosis
    • Angiolillo, D.J., Capodanno, D., Goto, S. Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J 2010, 31(1): 17-28.
    • (2010) Eur Heart J , vol.31 , Issue.1 , pp. 17-28
    • Angiolillo, D.J.1    Capodanno, D.2    Goto, S.3
  • 46
    • 0033594156 scopus 로고    scopus 로고
    • Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists
    • Doller, D., Chackalamannil, S., Czarniecki, M., McQuade, R., Ruperto, V. Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists. Bioorg Med Chem Lett 1999, 9(6): 901-6.
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.6 , pp. 901-906
    • Doller, D.1    Chackalamannil, S.2    Czarniecki, M.3    McQuade, R.4    Ruperto, V.5
  • 47
    • 0033583274 scopus 로고    scopus 로고
    • Total synthesis of (+)-himbacine and (+)-himbeline
    • Chackalamannil, S., Davies, R.J., Wang, Y. et al. Total synthesis of (+)-himbacine and (+)-himbeline. J Org Chem 1999, 64(6): 1932-40.
    • (1999) J Org Chem , vol.64 , Issue.6 , pp. 1932-1940
    • Chackalamannil, S.1    Davies, R.J.2    Wang, Y.3
  • 48
    • 78649524025 scopus 로고    scopus 로고
    • Inhibiting PAR-1 in the prevention and treatment of atherothrombotic events
    • Tomasello, S.D., Angiolillo, D.J., Goto, S. Inhibiting PAR-1 in the prevention and treatment of atherothrombotic events. Expert Opin Investig Drugs 2010, 19(12): 1557-67.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.12 , pp. 1557-1567
    • Tomasello, S.D.1    Angiolillo, D.J.2    Goto, S.3
  • 49
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study
    • Becker, R.C., Moliterno, D.J., Jennings, L.K. et al. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study. Lancet 2009, 373(9667): 919-28.
    • (2009) Lancet , vol.373 , Issue.9667 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 50
    • 77649207578 scopus 로고    scopus 로고
    • Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome
    • Goto, S., Yamaguchi, T., Ikeda, Y., Kato, K., Yamaguchi, H., Jensen, P. Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome. J Atheroscler Thromb 2010, 17(2): 156-64.
    • (2010) J Atheroscler Thromb , vol.17 , Issue.2 , pp. 156-164
    • Goto, S.1    Yamaguchi, T.2    Ikeda, Y.3    Kato, K.4    Yamaguchi, H.5    Jensen, P.6
  • 51
    • 80052779693 scopus 로고    scopus 로고
    • Safety of the novel protease-activated receptor-1 antagonist vorapaxar in Japanese patients with a history of ischemic stroke
    • Epub ahead of print
    • Shinohara, Y., Goto, S., Doi, M., Jensen, P. Safety of the novel protease-activated receptor-1 antagonist vorapaxar in Japanese patients with a history of ischemic stroke. J Stroke Cerebrovasc Dis 2010, Epub ahead of print.
    • (2010) J Stroke Cerebrovasc Dis
    • Shinohara, Y.1    Goto, S.2    Doi, M.3    Jensen, P.4
  • 52
    • 68949156886 scopus 로고    scopus 로고
    • Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial
    • Morrow, D.A., Scirica, B.M., Fox, K.A. et al. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial. Am Heart J 2009, 158(3): 335-41.
    • (2009) Am Heart J , vol.158 , Issue.3 , pp. 335-341
    • Morrow, D.A.1    Scirica, B.M.2    Fox, K.A.3
  • 53
    • 68949131480 scopus 로고    scopus 로고
    • The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: Study design and rationale
    • The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: Study design and rationale. Am Heart J 2009, 158(3): 327-34.
    • (2009) Am Heart J , vol.158 , Issue.3 , pp. 327-334


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