Important regulatory role of activated platelet-derived procoagulant activity in the propagation of thrombi formed under arterial blood flow conditions

Circulation Journal

Volumn 73, Issue 3, 2009, Pages 540-548

  Tamura, Noriko ^a   Kitajima, Isao ^b   Kawamura, Yota ^a   Toda, Eri ^a   Eguchi, Yu ^a   Ishida, Hideyuki ^a   Goto, Shinya ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Blood flow; Calcium; Fibrin monomer complex; Platelet; Thrombin

Indexed keywords

ARGATROBAN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CD40 LIGAND; COLLAGEN FIBRIL; FIBRIN MONOMER; LANTHANUM CHLORIDE; PROCOAGULANT; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; SCRAMBLASE; THROMBIN; THROMBIN INHIBITOR;

ARTERY BLOOD FLOW; ARTICLE; BLOOD CLOTTING; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM LESION; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; INFLAMMATION; QUANTITATIVE ANALYSIS; SHEAR RATE; STATISTICAL ANALYSIS; THROMBOCYTE ACTIVATION; THROMBOGENESIS;

ADULT; ARTERIES; BLOOD COAGULATION; BLOOD FLOW VELOCITY; BLOOD PLATELETS; CALCIUM; FEMALE; FIBRIN; HUMANS; MALE; MICROSCOPY, CONFOCAL; PLATELET ACTIVATION; PLATELET ADHESIVENESS; THROMBOSIS;

EID: 62649125696     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-08-0465     Document Type: Article

References (49)

1. Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8: 1227-1234.
2. Hoshiba Y, Hatakeyama K, Tanabe T, Asada Y, Goto S. Co-localization of von Willebrand factor with platelet thrombi, tissue factor and platelets with fbrin, and consistent presence of infammatory cells in coronary thrombi obtained by an aspiration device from patients with acute myocardial infarction. J Thromb Haemost 2006; 4: 114-120.
3. Yamashita A, Sumi T, Goto S, Hoshiba Y, Nishihira K, Kawamoto R, et al. Detection of von Willebrand factor and tissue factor in plateletsfbrin rich coronary thrombi in acute myocardial infarction. Am J Cardiol 2006; 97: 26-28.
4. Goto S. Understanding the mechanism and prevention of arterial occlusive thrombus formation by anti-platelet agents. Curr Med Chem Cardiovasc Hematol Agents 2004; 2: 149-156.
5. Ma YQ, Qin J, Plow EF. Platelet integrin α(IIb)β: Activation mechanisms. J Thromb Haemost 2007; 5: 1345-1352.
6. Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol 2007; 27: 1687-1693.
7. Gailani D, Renne T. Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vasc Biol 2007; 27: 2507-2513.
8. Libby P, Aikawa M. Stabilization of atherosclerotic plaques: New mechanisms and clinical targets. Nat Med 2002; 8: 1257-1262.
9. Goto S. Propagation of arterial thrombi: Local and remote contributory factors. Arterioscler Thromb Vasc Biol 2004; 24: 2207-2208.
10. Gawaz M, Langer H, May AE. Platelets in infammation and atherogenesis. J Clin Invest 2005; 115: 3378-3384.
11. Wagner DD, Burger PC. Platelets in infammation and thrombosis. Arterioscler Thromb Vasc Biol 2003; 23: 2131-2137.
12. Strukova SM. Role of platelets and serine proteinases in coupling of blood coagulation and infammation. Biochemistry (Mosc) 2004; 69: 1067-1081.
13. Gear AR, Camerini D. Platelet chemokines and chemokine receptors: Linking hemostasis, infammation, and host defense. Microcirculation 2003; 10: 335-350.
14. Goto S, Tamura N, Eto K, Ikeda Y, Handa S. Functional signifcance of adenosine 5′-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Iba induced by conditions of high shear rate. Circulation 2002; 105: 2531-2536.
15. 2+-ATPase inhibitors. Biochemistry 1995; 34: 11625-11634.
16. Tamura N, Yoshida M, Ichikawa N, Handa M, Ikeda Y, Tanabe T, et al. Shear-induced von Willebrand factor-mediated platelet surface translocation of the CD40 ligand. Thromb Res 2002; 108: 311-315.
17. Youssef AA, Chang LT, Sheu JJ, Lee FY, Chua S, Yeh KH, et al. Association between circulating level of CD40 ligand and angiographic morphologic features indicating high-burden thrombus formation in patients with acute myocardial infarction undergoing primary coronary intervention. Circ J 2007; 71: 1857-1861.
18. Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G, et al. CD40 ligand on activated platelets triggers an infammatory reaction of endothelial cells. Nature 1998; 391: 591-594.
19. Hagihara M, Higuchi A, Tamura N, Ueda Y, Hirabayashi K, Ikeda Y, et al. Platelets, after exposure to a high shear stress, induce IL-10-producing, mature dendritic cells in vitro. J Immunol 2004; 172: 5297-5303.
20. Miyazaki Y, Nomura S, Miyake T, Kagawa H, Kitada C, Taniguchi H, et al. High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles. Blood 1996; 88: 3456-3464.
21. Reininger AJ, Heijnen HF, Schumann H, Specht HM, Schramm W, Ruggeri ZM. Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress. Blood 2006; 107: 3537-3545.
22. Dorsam RT, Tuluc M, Kunapuli SP. Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets. J Thromb Haemost 2004; 2: 804-812.
23. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000; 407: 258-264.
24. Andre P, Prasad KS, Denis CV, He M, Papalia JM, Hynes RO, et al. CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med 2002; 8: 247-252.
25. Goto S, Tamura N, Handa S, Arai M, Kodama K, Takayama H. Involvement of glycoprotein VI in platelet thrombus formation on both collagen and von Willebrand factor surfaces under fow conditions. Circulation 2002; 106: 266-272.
26. Goto S, Tamura N, Ishida H, Ruggeri ZM. Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5′-diphosphate receptor stimulation and cyclic calcium signaling. J Am Coll Cardiol 2006; 47: 155-162.
27. Sakakibara M, Goto S, Eto K, Tamura N, Isshiki T, Handa S. Application of ex vivo fow chamber system for assessment of stent thrombosis. Arterioscler Thromb Vasc Biol 2002; 22: 1360-1364.
28. Savage B, Saldivar E, Ruggeri ZM. Initiation of platelet adhesion by arrest onto fbrinogen or translocation on von Willebrand factor. Cell 1996; 84: 289-297.
29. Nesbitt WS, Giuliano S, Kulkarni S, Dopheide SM, Harper IS, Jackson SP. Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol 2003; 160: 1151-1161.
30. Goto S, Tamura N, Ishida H. Ability of anti-glycoprotein IIb/IIIa agents to dissolve platelet thrombi formed on a collagen surface under blood fow conditions. J Am Coll Cardiol 2004; 44: 316-323.
31. 2+ diffusion from cytosol to nucleus in contracting adult rat cardiac myocytes with an ultra-fast confocal imaging system. Cell Calcium 1999; 25: 199-208.
32. Hamano A, Tanaka S, Takeda Y, Umeda M, Sakata Y. A novel monoclonal antibody to fbrin monomer and soluble fbrin for the detection of soluble fbrin in plasma. Clin Chim Acta 2002; 318: 25-32.
33. Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B. Real-time in vivo imaging of platelets, tissue factor and fbrin during arterial thrombus formation in the mouse. Nat Med 2002; 8: 1175-1181.
34. 2+. Biochem J 1990; 269: 513-519.
35. Friedman H, Meir S, Rosenberger I, Halevy AH, Kaufman PB, Philosoph-Hadas S. Inhibition of the gravitropic response of snapdragon spikes by the calcium-channel blocker lanthanum chloride. Plant Physiol 1998; 118: 483-492.
36. Zhou Q, Zhao J, Wiedmer T, Sims PJ. Normal hemostasis but defective hematopoietic response to growth factors in mice defcient in phospholipid scramblase 1. Blood 2002; 99: 4030-4038.
37. Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ. Molecular cloning of human plasma membrane phospholipid scramblase A protein mediating transbilayer movement of plasma membrane phospholipids. J Biol Chem 1997; 272: 18240-18244.
38. Goto S. Understanding the mechanism of platelet thrombus formation under blood fow conditions and the effect of new antiplatelet agents. Curr Vasc Pharmacol 2004; 2: 23-32.
39. Goto S, Salomon DR, Ikeda Y, Ruggeri ZM. Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets. J Biol Chem 1995; 270: 23352-23361.
40. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068.
41. Goto S, Tamura N, Li M, Handa M, Ikeda Y, Handa S, et al. Different effects of various anti-GPIIb-IIIa agents on shear-induced platelet activation and expression of procoagulant activity. J Thromb Haemost 2003; 1: 2022-2030.
42. Andersen H, Greenberg DL, Fujikawa K, Xu W, Chung DW, Davie EW. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci USA 1999; 96: 11189-11193.
43. Bahou WF, Scudder L, Rubenstein D, Jesty J. A shear-restricted pathway of platelet procoagulant activity is regulated by IQGAP1. J Biol Chem 2004; 279: 22571-22577.
44. Goto S. Factor XIa as a possible new target of antithrombotic therapy. J Thromb Haemost 2006; 4: 1494-1495.
45. Sims PJ, Wiedmer T. Unraveling the mysteries of phospholipid scrambling. Thromb Haemost 2001; 86: 266-275.
46. Keuren JF, Wielders SJ, Ulrichts H, Hackeng T, Heemskerk JW, Deckmyn H, et al. Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1. Arterioscler Thromb Vasc Biol 2005; 25: 1499-1505.
47. London FS, Marcinkiewicz M, Walsh PN. PAR-1-stimulated factor IXa binding to a small platelet subpopulation requires a pronounced and sustained increase of cytoplasmic calcium. Biochemistry 2006; 45: 7289-7298.
48. Falati S, Liu Q, Gross P, Merrill-Skoloff G, Chou J, Vandendries E, et al. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med 2003; 197: 1585-1598.
49. Iwata H, Kaibara M. Activation of factor IX by erythrocyte membranes causes intrinsic coagulation. Blood Coagul Fibrinolysis 2002; 13: 489-496.