Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 6, 1999, Pages 901-906

  Doller, Darío ^a   Chackalamannil, Samuel ^a   Czarniecki, Michael ^a   McQuade, Robert ^a   Ruperto, Vilma ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROHIMBACINE; HIMBACINE DERIVATIVE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ALKYLATION; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CHO CELL; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; FURANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUSCARINIC ANTAGONISTS; NAPHTHALENES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0033594156     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00101-8     Document Type: Article

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