Developmental Activation of the AHR Increases Effector CD4+ T Cells and Exacerbates Symptoms in Autoimmune Disease-Prone Gnaq+/- Mice

Toxicological Sciences

Volumn 148, Issue 2, 2015, Pages 555-566

  Boule, Lisbeth A ^a   Burke, Catherine G ^a   Fenton, Bruce M ^a   Thevenet Morrison, Kelly ^a   Jusko, Todd A ^a   Lawrence, B Paige ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Aryl hydrocarbon receptor; Autoimmune disease; CD4 T cell; Developmental exposure; Gene environment interactions; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; DOUBLE STRANDED DNA ANTIBODY; AHR PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; POLLUTANT; POLYCHLORINATED DIBENZODIOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; JOINT SWELLING; LACTATION; MALE; MOUSE; NONHUMAN; SEX DIFFERENCE; SYMPTOM; T LYMPHOCYTE; AGE; AGONISTS; ANIMAL; AUTOIMMUNITY; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; GESTATIONAL AGE; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHENOTYPE; POLLUTANT; PREGNANCY; PRENATAL EXPOSURE; RISK FACTOR; SEVERITY OF ILLNESS INDEX; TOXICITY;

AGE FACTORS; ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CD4-POSITIVE T-LYMPHOCYTES; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GESTATIONAL AGE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; POLYCHLORINATED DIBENZODIOXINS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RECEPTORS, ARYL HYDROCARBON; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 84952904517     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv203     Document Type: Article

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