Pre- and postnatal polychlorinated biphenyl concentrations and longitudinal measures of thymus volume in infants

Environmental Health Perspectives

Volumn 120, Issue 4, 2012, Pages 595-600

  Jusko, Todd A ^a   Sonneborn, Dean ^b   Palkovicova, Lubica ^c   Kocan, Anton ^c,d   Drobna, Beata ^c   Trnovec, Tomas ^c   Hertz Picciotto, Irva ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^d MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Atrophy; Cohort; Epidemiology; Immune; Roma; T cell

Indexed keywords

POLYCHLORINATED BIPHENYL;

ARTICLE; CHILD; DRUG BLOOD LEVEL; DRUG CONCENTRATION; ECHOGRAPHY; FEMALE; HOSPITALIZATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MOTHER; ORGAN SIZE; PERINATAL DRUG EXPOSURE; PRENATAL DRUG EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; THYMUS;

ADULT; CHROMATOGRAPHY, GAS; COHORT STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; INFANT; LONGITUDINAL STUDIES; MALE; MATERNAL EXPOSURE; MULTIVARIATE ANALYSIS; ORGAN SIZE; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SLOVAKIA; THYMUS GLAND; YOUNG ADULT;

EID: 84859311915     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104229     Document Type: Article

References (38)

1. Agency for Toxic Substances and Disease Registry. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA:Agency for Toxic Substances and Disease Registry.
2. Akins JR, Waldrep K, Bernert JT, Jr. 1989. The estimation of total serum lipids by a completely enzymatic "summation" method. Clin Chim Acta 184(3):219-226.
3. Benn CS, Jeppesen DL, Hasselbalch H, Olesen AB, Nielsen J, Bjorksten B, et al. 2001. Thymus size and head circumference at birth and the development of allergic diseases. Clin Exp Allergy 31(12):1862-1866.
4. Conka K, Drobna B, Kocan A, Petrik J. 2005. Simple solid-phase extraction method for determination of polychlorinated biphenyls and selected organochlorine pesticides in human serum. J Chromatogr A 1084(1-2):33-38.
5. Dallaire F, Dewailly É, Muckle G, Vezina C, Jacobson SW, Jacobson JL, et al. 2004. Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik. Environ Health Perspect 112:1359-1365.
6. Faith RE, Luster MI. 1979. Investigations on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on parameters of various immune functions. Ann NY Acad Sci 320:564-571.
7. Fangstrom B, Strid A, Grandjean P, Weihe P, Bergman A. 2005. A retrospective study of PBDEs and PCBs in human milk from the Faroe Islands. Environ Health 4:12; doi:10.1186/1476-069X-4-12 [Online 14 July 2005].
8. Fernandez-Salguero PM, Hilbert DM, Rudikoff S, Ward JM, Gonzalez FJ. 1996. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol Appl Pharmacol 140(1):173-179.
9. Fine JS, Gasiewicz TA, Silverstone AE. 1989. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol 35(1):18-25.
10. George AJ, Ritter MA. 1996. Thymic involution with ageing: obsolescence or good housekeeping? Immunol Today 17(6):267-272.
11. Greenland S, Pearl J, Robins JM. 1999. Causal diagrams for epidemiologic research. Epidemiology 10(1):37-48.
12. Hansen L, DeCaprio A, Nisbet I. 2003. PCB congener comparisons reveal exposure histories for residents of Anniston, Alabama, USA. Fresenius Environ Bull 12:181-190.
13. Hasselbalch H, Jeppesen DL, Ersboll AK, Engelmann MD, Nielsen MB. 1997. Thymus size evaluated by sonography. A longitudinal study on infants during the first year of life. Acta Radiol 38(2):222-227.
14. Hasselbalch H, Nielsen MB, Jeppesen D, Pedersen JF, Karkov J. 1996. Sonographic measurement of the thymus in infants. Eur Radiol 6(5):700-703.
15. Hertz-Picciotto I, Trnovec T, Kocan A, Charles MJ, Ciznar P, Langer P, et al. 2003. PCBs and early childhood development in Slovakia: study design and background. Fresenius Environ Bull 12(2):208-214.
16. Holladay SD, Lindstrom P, Blaylock BL, Comment CE, Germolec DR, Heindel JJ, et al. 1991. Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 44(4):385-393.
17. Iscan A, Tarhan S, Guven H, Bilgi Y, Yuncu M. 2000. Sonographic measurement of the thymus in newborns: close association between thymus size and birth weight. Eur J Pediatr 159(3):223-224.
18. Jusko TA, De Roos AJ, Schwartz SM, Lawrence BP, Palkovicova L, Nemessanyi T, et al. 2010. A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age. Environ Res 110(4):388-395.
19. Kocan A, Petrik J, Jursa S, Chovancova J, Drobna B. 2001. Environmental contamination with polychlorinated biphenyls in the area of their former manufacture in Slovakia. Chemosphere 43(4-7):595-600.
20. Lawrence BP, Kerkvliet NI. 2006. Immune modulation by TCDD and related polyhalogenated aromatic hydrocarbons. In: Immunotoxicology and Immunopharmacology, Part III (Luebke RW, House RV, Kimber I, eds). Boca Raton, FL:CRC Press, 239-258.
21. Longnecker MP, Wolff MS, Gladen BC, Brock JW, Grandjean P, Jacobson JL, et al. 2003. Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environ Health Perspect 111:65-70.
22. Lubin JH, Colt JS, Camann D, Davis S, Cerhan JR, Severson RK, et al. 2004. Epidemiologic evaluation of measurement data in the presence of detection limits. Environ Health Perspect 112:1691-1696.
23. McConkey DJ, Hartzell P, Duddy SK, Hakansson H, Orrenius S. 1988. 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation. Science 242(4876):256-259.
24. Moore MA, Owen JJ. 1967. Experimental studies on the development of the thymus. J Exp Med 126(4):715-726.
25. Norén K. 1988. Changes in the levels of organochlorine pesticides, polychlorinated-biphenyls, dibenzo-para-dioxins and dibenzofurans in human-milk from Stockholm, 1972-1985. Chemosphere 17(1):39-49.
26. Park HY, Hertz-Picciotto I, Petrik J, Palkovicova L, Kocan A, Trnovec T. 2008. Prenatal PCB exposure and thymus size at birth in neonates in eastern Slovakia. Environ Health Perspect 116:104-109.
27. Park JS, Linderholm L, Charles MJ, Athanasiadou M, Petrik J, Kocan A, et al. 2007. Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBS) in pregnant women from eastern Slovakia. Environ Health Perspect 115:20-27.
28. Pauwels A, Cenijn PH, Schepens PJ, Brouwer A. 2000. Comparison of chemical-activated luciferase gene expression bioassay and gas chromatography for PCB determination in human serum and follicular fluid. Environ Health Perspect 108:553-557.
29. Petrik J, Drobna B, Pavuk M, Jursa S, Wimmerova S, Chovancova J. 2006. Serum PCBs and organochlorine pesticides in Slovakia: age, gender, and residence as determinants of organochlorine concentrations. Chemosphere 65(3):410-418.
30. Safe SH. 1994. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24(2):87-149.
31. Schecter A, Papke O, Tung KC, Joseph J, Harris TR, Dahlgren J. 2005. Polybrominated diphenyl ether flame retardants in the U.S. population: current levels, temporal trends, and comparison with dioxins, dibenzofurans, and polychlorinated biphenyls. J Occup Environ Med 47(3):199-211.
32. Silkworth JB, Antrim L, Kaminsky LS. 1984. Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice. Toxicol Appl Pharmacol 75(1):156-165.
33. Silverstone AE, Frazier DE Jr, Fiore NC, Soults JA, Gasiewicz TA. 1994. Dexamethasone, beta-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets. Toxicol Appl Pharmacol 126(2):248-259.
34. Steinmann GG, Klaus B, Muller-Hermelink HK. 1985. The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 22(5):563-575.
35. Tryphonas H, Feeley M. 2001. Polychlorinated biphenyl-induced immunomodulation and human health effects. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects (Robertson LW, Hansen LG, eds). Lexington:University Press of Kentucky, 193-209.
36. Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, et al. 2006. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93(2):223-241.
37. Vorderstrasse BA, Steppan LB, Silverstone AE, Kerkvliet NI. 2001. Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression. Toxicol Appl Pharmacol 171(3):157-164.
38. Yekeler E, Tambag A, Tunaci A, Genchellac H, Dursun M, Gokcay G, et al. 2004. Analysis of the thymus in 151 healthy infants from 0 to 2 years of age. J Ultrasound Med 23(10):1321-1326.