SIGIRR, a negative regulator of colon tumorigenesis

Drug Discovery Today: Disease Mechanisms

Volumn 8, Issue 3-4, 2011, Pages

  Zhao, Junjie ^a,b   Zepp, Jarod ^a,b   Bulek, Katarzyna ^a   Li, Xiaoxia ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; JANUS KINASE; SINGLE IMMUNOGLOBULIN INTERLEUKIN 1 RECEPTOR RELATED MOLECULE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELL; COLON CARCINOGENESIS; ENZYME ACTIVATION; INTESTINE EPITHELIUM; INTESTINE FLORA; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TUMOR MICROENVIRONMENT;

EID: 84862790361     PISSN: None     EISSN: 17406765     Source Type: Journal    
DOI: 10.1016/j.ddmec.2012.02.003     Document Type: Review

References (46)

1. Hooper, L.V. and Gordon, J.I. (2001) Commensal host-bacterial relationships in the gut. Science 292, 1115-1118 (Pubitemid 32440925)
2. Clevers, H. (2004) At the crossroads of inflammation and cancer. Cell 118, 671-674 (Pubitemid 39221727)
3. Balkwill, F. et al. (2005) Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7, 211-217 (Pubitemid 40568680)
4. Rakoff-Nahoum, S. and Medzhitov, R. (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317, 124-127 (Pubitemid 47056471)
5. Takeda, K. et al. (2003) Toll-like receptors. Annu. Rev. Immunol. 21, 335-376 (Pubitemid 37174535)
6. Kropf, P. et al. (2003) Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection. Infect. Immun. 71, 1961-1971 (Pubitemid 36368729)
7. Bulek, K. et al. (2009) The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. J. Immunol. 182, 2601-2609
8. Chung, Y. et al. (2009) Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30, 576-587
9. Yao, J. et al. (2007) Interleukin-1 (IL-1)-induced TAK1-dependent versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification. J. Biol. Chem. 282, 6075-6089 (Pubitemid 47100872)
10. Fraczek, J. et al. (2008) The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation. J. Biol. Chem. 283, 31697-31705
11. Kim, T.W. et al. (2007) A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J. Exp. Med. 204, 1025-1036
12. Wan, Y. et al. (2009) Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control. J. Biol. Chem. 284, 10367-10375
13. Garlanda, C. et al. (2004) Intestinal inflammation in mice deficient in Tir8: an inhibitory member of the IL-1 receptor family. Proc. Natl. Acad. Sci. U. S. A. 101, 3522-3526 (Pubitemid 38338228)
14. Wald, D. et al. (2003) SIGIRR: a negative regulator of Toll-like receptorinterleukin 1 receptor signaling. Nat. Immunol. 4, 920-927 (Pubitemid 37098664)
15. Garlanda, C. et al. (2007) Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/ single Ig IL-1-related receptor: a negative regulator of IL-1/TLR signaling. J. Immunol. 179, 3119-3125
16. Thomassen, E. et al. (1999) Identification and characterization of SIGIRR: a molecule representing a novel subtype of the IL-1R superfamily. Cytokine 11, 389-399 (Pubitemid 29259633)
17. Qin, J. et al. (2005) SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. J. Biol. Chem. 280, 25233-25241 (Pubitemid 40934617)
18. Lech, M. et al. (2010) Lack of SIGIRR/TIR8 aggravates hydrocarbon oilinduced lupus nephritis. J. Pathol. 220, 596-607
19. Zhang, C. et al. (2011) SIGIRR inhibits toll-like receptor 4: 5,9-mediated immune responses in human airway epithelial cells. Mol. Biol. Rep. 38, 601-609
20. Rakoff-Nahoum, S. et al. (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (Pubitemid 38962578)
21. Fukata, M. et al. (2007) Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133, 1869-1881
22. Salcedo, R. et al. (2010) MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625-1636
23. Dupaul-Chicoine, J. et al. (2010) Control of intestinal homeostasis: colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367-378
24. Hu, B. et al. (2010) Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc. Natl. Acad. Sci. U. S. A. 107, 21635-21640
25. Xiao, H. et al. (2007) The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis: inflammation, and tumorigenesis. Immunity 26, 461-475 (Pubitemid 46602997)
26. Garlanda, C. et al. (2007) Increased susceptibility to colitis-associated cancer of mice lacking TIR8: an inhibitory member of the interleukin-1 receptor family. Cancer Res. 67, 6017-6021 (Pubitemid 47037479)
27. Xiao, H. et al. (2010) Loss of single immunoglobulin interlukin-1 receptorrelated molecule leads to enhanced colonic polyposis in Apc(min) mice. Gastroenterology 139, 574-585
28. Fukata, M. et al. (2009) Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm. Bowel Dis. 15, 997-1006
29. Greten, F.R. et al. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296 (Pubitemid 39061110)
30. Grivennikov, S. et al. (2009) IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103-113
31. Ma, X.T. et al. (2004) Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J. Gastroenterol. 10, 1569-1573
32. Corvinus, F.M. et al. (2005) Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia 7, 545-555 (Pubitemid 40967755)
33. Sancho, R. et al. (2009) JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J. 28, 1843-1854
34. Aoki, K. et al. (2003) Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat. Genet. 35, 323-330 (Pubitemid 37486915)
35. Lee, S.H. et al. (2010) ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat. Med. 16, 665-670
36. Dohi, T. and Fujihashi, K. (2006) Type 1 and 2 T helper cell-mediated colitis. Curr. Opin. Gastroenterol. 22, 651-657 (Pubitemid 44624533)
37. Leppkes, M. et al. (2009) RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136, 257-267
38. Mantovani, A. et al. (2008) Cancer-related inflammation. Nature 454, 436-444
39. Gulen, M.F. et al. (2010) The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32, 54-66
40. Bozza, S. et al. (2008) Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. J. Immunol. 180, 4022-4031
41. Lech, M. et al. (2008) Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J. Exp. Med. 205, 1879-1888
42. Wu, S. et al. (2009) A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17T cell responses. Nat. Med. 15, 1016-1022
43. Noris, M. et al. (2009) The Toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts. J. Immunol. 183, 4249-4260
44. Riva, F. et al. (2009) The expression pattern of TIR8 is conserved among vertebrates. Vet. Immunol. Immunopathol. 131, 44-49
45. Khan, M.A. et al. (2010) The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. J. Immunol. 184, 2305-2313
46. Kadota, C. et al. (2010) Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 162, 348-361