Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage

Osteoarthritis and Cartilage

Volumn 24, Issue 1, 2016, Pages 146-157

  Madej, W ^a   van Caam, A ^a   Blaney Davidson, E N ^a   Hannink, G ^a   Buma, P ^a   van der Kraan, P M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Ageing; Cartilage; Mechanosensitivity; Signal transduction; Smad2 3P signaling; TGF beta

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 2; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; AGGRECAN; PERLECAN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN SERINE THREONINE KINASE; PROTEOHEPARAN SULFATE; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADOLESCENT; AGING; ARTICLE; ARTICULAR CARTILAGE; BMP2 GENE; BONE REMODELING; CARTILAGE EXPLANT; CHILD; COL2A1 GENE; COMPRESSION; CONTROLLED STUDY; CTGF GENE; EXTRACELLULAR MATRIX; FN1 GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MECHANICAL STIMULATION; MOLECULAR PATHOLOGY; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SMAD2 GENE; SMAD3 GENE; TGFB1 GENE; UPREGULATION; ANIMAL; BOVINE; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; PHYSIOLOGY; PRESSURE; SIGNAL TRANSDUCTION;

AGGRECANS; AGING; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CARTILAGE, ARTICULAR; CATTLE; COLLAGEN TYPE II; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX; FIBRONECTINS; GENE EXPRESSION PROFILING; HEPARAN SULFATE PROTEOGLYCANS; OSTEOARTHRITIS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PRESSURE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84952877238     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2015.07.018     Document Type: Article

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