Tensile strain increases expression of CCN2 and COL2A1 by activating TGF-β-Smad2/3 pathway in chondrocytic cells

Journal of Biomechanics

Volumn 46, Issue 9, 2013, Pages 1508-1515

  Furumatsu, Takayuki ^a   Matsumoto, Emi ^a   Kanazawa, Tomoko ^a   Fujii, Masataka ^a   Lu, Zhichao ^a   Kajiki, Ryotaro ^a   Ozaki, Toshifumi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

CCN2; Cyclic tensile strain; SOX9; TGF receptor regulated Smad2 3; Type II collagen

Indexed keywords

CCN2; CHROMATIN IMMUNOPRECIPITATION; CYCLIC TENSILE STRAIN; LUCIFERASE REPORTER ASSAYS; SOX9; TRANSCRIPTIONAL REGULATION; TRANSFORMING GROWTH FACTORS; TYPE II COLLAGENS;

COLLAGEN; PHYSIOLOGY; STRESSES; TENSILE STRAIN; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CHEMICAL ACTIVATION;

CONNECTIVE TISSUE GROWTH FACTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CARTILAGE CELL; CCN2 GENE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; COL2A1 GENE; COMPLEX FORMATION; CONTROLLED STUDY; CYCLIC TENSILE STRAIN; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MECHANICAL STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

CELL LINE; CHONDROCYTES; COLLAGEN TYPE II; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX PROTEINS; HUMANS; SMAD2 PROTEIN; SMAD3 PROTEIN; SOX9 TRANSCRIPTION FACTOR; STRESS, MECHANICAL; TRANSFORMING GROWTH FACTOR BETA;

EID: 84878015779     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2013.03.028     Document Type: Article

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