메뉴 건너뛰기




Volumn 48, Issue 3, 2003, Pages 689-699

Microenvironment regulation of extracellular signal-regulated kinase activity in chondrocytes: Effects of culture configuration, interleukin-1, and compressive stress

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 0037334522     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10849     Document Type: Article
Times cited : (49)

References (54)
  • 2
    • 0034792290 scopus 로고    scopus 로고
    • Cytokines in cartilage injury and repair
    • Lotz M. Cytokines in cartilage injury and repair. Clin Orthop 2001;391 Suppl:S108-15.
    • (2001) Clin Orthop , vol.391 , Issue.SUPPL.
    • Lotz, M.1
  • 3
    • 0028954513 scopus 로고
    • Growth factor actions on articular cartilage
    • Trippel SB. Growth factor actions on articular cartilage. J Rheumatol Suppl 1995;43:129-32.
    • (1995) J Rheumatol Suppl , vol.43 , pp. 129-132
    • Trippel, S.B.1
  • 4
    • 0034786674 scopus 로고    scopus 로고
    • The role of the extracellular matrix in articular chondrocyte regulation
    • Scully SP, Lee JW, Ghert PMA, Qi W. The role of the extracellular matrix in articular chondrocyte regulation. Clin Orthop 2001;391 Suppl:S72-89.
    • (2001) Clin Orthop , vol.391 , Issue.SUPPL.
    • Scully, S.P.1    Lee, J.W.2    Ghert, P.M.A.3    Qi, W.4
  • 5
    • 0034094471 scopus 로고    scopus 로고
    • Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis
    • Knudson W, Casey B, Nishida Y, Eger W, Kuettner KE, Knudson CB. Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. Arthritis Rheum 2000;43:1165-74.
    • (2000) Arthritis Rheum , vol.43 , pp. 1165-1174
    • Knudson, W.1    Casey, B.2    Nishida, Y.3    Eger, W.4    Kuettner, K.E.5    Knudson, C.B.6
  • 6
  • 7
    • 0002777334 scopus 로고    scopus 로고
    • Physical regulation of cartilage metabolism
    • Mow VC, Hayes WC, editors. New York: Raven Press
    • Guilak F, Sah RL, Setton LA. Physical regulation of cartilage metabolism. In: Mow VC, Hayes WC, editors. Basic orthopaedic biomechanics. New York: Raven Press; 1997. p. 179-207.
    • (1997) Basic Orthopaedic Biomechanics , pp. 179-207
    • Guilak, F.1    Sah, R.L.2    Setton, L.A.3
  • 8
    • 0025676464 scopus 로고
    • Indentation stiffness of young canine knee articular cartilage: Influence of strenuous joint loading
    • Jurvelin J, Kiviranta I, Saamanen AM, Tammi M, Helminen HJ. Indentation stiffness of young canine knee articular cartilage: influence of strenuous joint loading. J Biomech 1990;23:1239-46.
    • (1990) J Biomech , vol.23 , pp. 1239-1246
    • Jurvelin, J.1    Kiviranta, I.2    Saamanen, A.M.3    Tammi, M.4    Helminen, H.J.5
  • 9
    • 0030763495 scopus 로고    scopus 로고
    • Detection of interleukin-1 in the cartilage of patients with osteoarthritis: A possible autocrine/paracrine role in pathogenesis
    • Towle CA, Hung HH, Bonassar LJ, Treadwell BV, Mangham DC. Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis. Osteoarthritis Cartilage 1997;5:293-300.
    • (1997) Osteoarthritis Cartilage , vol.5 , pp. 293-300
    • Towle, C.A.1    Hung, H.H.2    Bonassar, L.J.3    Treadwell, B.V.4    Mangham, D.C.5
  • 10
    • 0028210290 scopus 로고
    • Effect of interleukin-1 on articular cartilage from young and aged horses and comparison with metabolism of osteoarthritic cartilage
    • Morris EA, Treadwell BV. Effect of interleukin-1 on articular cartilage from young and aged horses and comparison with metabolism of osteoarthritic cartilage. Am J Vet Res 1994;55:138-46.
    • (1994) Am J Vet Res , vol.55 , pp. 138-146
    • Morris, E.A.1    Treadwell, B.V.2
  • 11
    • 0029043151 scopus 로고
    • IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2
    • Blanco FJ, Lotz M. IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2. Exp Cell Res 1995;218:319-25.
    • (1995) Exp Cell Res , vol.218 , pp. 319-325
    • Blanco, F.J.1    Lotz, M.2
  • 12
    • 0032766969 scopus 로고    scopus 로고
    • Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
    • Flannery CR, Little CB, Caterson B, Hughes CE. Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes. Matrix Biol 1999;18:225-37.
    • (1999) Matrix Biol , vol.18 , pp. 225-237
    • Flannery, C.R.1    Little, C.B.2    Caterson, B.3    Hughes, C.E.4
  • 13
    • 0029829536 scopus 로고    scopus 로고
    • 2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes
    • 2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest 1996;98:2425-30.
    • (1996) J Clin Invest , vol.98 , pp. 2425-2430
    • Geng, Y.1    Valbracht, J.2    Lotz, M.3
  • 15
    • 0035284754 scopus 로고    scopus 로고
    • Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway
    • Li WQ, Dehnade F, Zafarullah M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol 2001;166:3491-8.
    • (2001) J Immunol , vol.166 , pp. 3491-3498
    • Li, W.Q.1    Dehnade, F.2    Zafarullah, M.3
  • 16
    • 0033854959 scopus 로고    scopus 로고
    • Activation of specific MEK-ERK cascade is necessary for TGFβ signaling and crosstalk with PKA and PKC pathways in cultured rat articular chondrocytes
    • Hirota Y, Tsukazaki T, Yonekura A, Miyazaki Y, Osaki M, Shindo H, et al. Activation of specific MEK-ERK cascade is necessary for TGFβ signaling and crosstalk with PKA and PKC pathways in cultured rat articular chondrocytes. Osteoarthritis Cartilage 2000;8:241-7.
    • (2000) Osteoarthritis Cartilage , vol.8 , pp. 241-247
    • Hirota, Y.1    Tsukazaki, T.2    Yonekura, A.3    Miyazaki, Y.4    Osaki, M.5    Shindo, H.6
  • 18
    • 0030885574 scopus 로고    scopus 로고
    • Outside-in signaling in the chondrocyte: Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex
    • Clancy RM, Rediske J, Tang X, Nijher N, Frenkel S, Philips M, et al. Outside-in signaling in the chondrocyte: nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. J Clin Invest 1997;100:1789-96.
    • (1997) J Clin Invest , vol.100 , pp. 1789-1796
    • Clancy, R.M.1    Rediske, J.2    Tang, X.3    Nijher, N.4    Frenkel, S.5    Philips, M.6
  • 19
    • 0344374450 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization
    • Hung CT, Henshaw DR, Wang CC, Mauck RL, Raia F, Palmer G, et al. Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization. J Biomech 2000;33:73-80.
    • (2000) J Biomech , vol.33 , pp. 73-80
    • Hung, C.T.1    Henshaw, D.R.2    Wang, C.C.3    Mauck, R.L.4    Raia, F.5    Palmer, G.6
  • 20
    • 0034319216 scopus 로고    scopus 로고
    • Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes
    • Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res 2000;18:899-908.
    • (2000) J Orthop Res , vol.18 , pp. 899-908
    • Jin, G.1    Sah, R.L.2    Li, Y.S.3    Lotz, M.4    Shyy, J.Y.5    Chien, S.6
  • 21
    • 0000955368 scopus 로고    scopus 로고
    • Response of cartilage to mechanical loading is correlated with sustained ERK1/2 activation
    • Fanning P, Emkey G, Smith R, Grodzinsky A, Trippel S. Response of cartilage to mechanical loading is correlated with sustained ERK1/2 activation. Trans Orthop Res Soc 2001;26:172.
    • (2001) Trans Orthop Res Soc , vol.26 , pp. 172
    • Fanning, P.1    Emkey, G.2    Smith, R.3    Grodzinsky, A.4    Trippel, S.5
  • 22
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001;22:153-83.
    • (2001) Endocr Rev , vol.22 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Beers Gibson, T.3    Xu, B.E.4    Karandikar, M.5    Berman, K.6
  • 23
    • 0037040939 scopus 로고    scopus 로고
    • Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase
    • Yoon YM, Kim SJ, Oh CD, Ju JW, Song WK, Yoo YJ, et al. Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase. J Biol Chem 2002;277:8412-20.
    • (2002) J Biol Chem , vol.277 , pp. 8412-8420
    • Yoon, Y.M.1    Kim, S.J.2    Oh, C.D.3    Ju, J.W.4    Song, W.K.5    Yoo, Y.J.6
  • 24
    • 0035957924 scopus 로고    scopus 로고
    • Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-β-induced aggrecan gene expression in chondrogenic ATDC5 cells
    • Watanabe H, de Caestecker MP, Yamada Y. Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-β-induced aggrecan gene expression in chondrogenic ATDC5 cells. J Biol Chem 2001;276:14466-73.
    • (2001) J Biol Chem , vol.276 , pp. 14466-14473
    • Watanabe, H.1    De Caestecker, M.P.2    Yamada, Y.3
  • 25
    • 0028075476 scopus 로고
    • Modulation of extracellular matrix gene expression in bovine high-density chondrocyte cultures by ascorbic acid and enzymatic resuspension
    • Hering TM, Kollar J, Huynh TD, Varelas JB, Sandell LJ. Modulation of extracellular matrix gene expression in bovine high-density chondrocyte cultures by ascorbic acid and enzymatic resuspension. Arch Biochem Biophys 1994;314:90-8.
    • (1994) Arch Biochem Biophys , vol.314 , pp. 90-98
    • Hering, T.M.1    Kollar, J.2    Huynh, T.D.3    Varelas, J.B.4    Sandell, L.J.5
  • 27
    • 0020369710 scopus 로고
    • Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
    • Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982;30:215-24.
    • (1982) Cell , vol.30 , pp. 215-224
    • Benya, P.D.1    Shaffer, J.D.2
  • 31
    • 0037255442 scopus 로고    scopus 로고
    • A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: The alginate-recovered-chondrocyte (ARC) method
    • Masuda K, Sah RL, Hejna MJ, Thonar EJ. A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method. J Orthop Res 2003;21:139-48.
    • (2003) J Orthop Res , vol.21 , pp. 139-148
    • Masuda, K.1    Sah, R.L.2    Hejna, M.J.3    Thonar, E.J.4
  • 33
    • 0034797460 scopus 로고    scopus 로고
    • Growth responses of cartilage to static and dynamic compression
    • Li KW, Williamson AK, Wang AS, Sah RL. Growth responses of cartilage to static and dynamic compression. Clin Orthop 2001;391 Suppl:S34-48.
    • (2001) Clin Orthop , vol.391 , Issue.SUPPL.
    • Li, K.W.1    Williamson, A.K.2    Wang, A.S.3    Sah, R.L.4
  • 34
    • 0344142513 scopus 로고    scopus 로고
    • A rapid and sensitive quantitative kinase activity assay using a convenient 96-well format
    • Asthagiri AR, Horwitz AF, Lauffenburger DA. A rapid and sensitive quantitative kinase activity assay using a convenient 96-well format. Anal Biochem 1999;269:342-7.
    • (1999) Anal Biochem , vol.269 , pp. 342-347
    • Asthagiri, A.R.1    Horwitz, A.F.2    Lauffenburger, D.A.3
  • 35
    • 0034041424 scopus 로고    scopus 로고
    • Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase
    • Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, et al. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis Rheum 2000;43:664-72.
    • (2000) Arthritis Rheum , vol.43 , pp. 664-672
    • Billinghurst, R.C.1    Wu, W.2    Ionescu, M.3    Reiner, A.4    Dahlberg, L.5    Chen, J.6
  • 36
    • 0026438456 scopus 로고
    • Influence of interleukin-1 on the morphology and proteoglycan metabolism of cultured bovine articular chondrocytes
    • Aydelotte MB, Raiss RX, Caterson B, Kuettner KE. Influence of interleukin-1 on the morphology and proteoglycan metabolism of cultured bovine articular chondrocytes. Connect Tissue Res 1992;28:143-59.
    • (1992) Connect Tissue Res , vol.28 , pp. 143-159
    • Aydelotte, M.B.1    Raiss, R.X.2    Caterson, B.3    Kuettner, K.E.4
  • 39
    • 0031571627 scopus 로고    scopus 로고
    • Inhibition of cartilage degradation and changes in physical properties induced by IL-1β and retinoic acid using matrix metalloproteinase inhibitors
    • Bonassar LJ, Sandy JD, Lark MW, Plaas AH, Frank EH, Grodzinsky AJ. Inhibition of cartilage degradation and changes in physical properties induced by IL-1β and retinoic acid using matrix metalloproteinase inhibitors. Arch Biochem Biophys 1997;344:404-12.
    • (1997) Arch Biochem Biophys , vol.344 , pp. 404-412
    • Bonassar, L.J.1    Sandy, J.D.2    Lark, M.W.3    Plaas, A.H.4    Frank, E.H.5    Grodzinsky, A.J.6
  • 40
    • 0030025492 scopus 로고    scopus 로고
    • The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures
    • Stefanovic-Racic M, Morales TI, Taskiran D, McIntyre LA, Evans CH. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J Immunol 1996;156:1213-20.
    • (1996) J Immunol , vol.156 , pp. 1213-1220
    • Stefanovic-Racic, M.1    Morales, T.I.2    Taskiran, D.3    McIntyre, L.A.4    Evans, C.H.5
  • 41
    • 0023091526 scopus 로고
    • Transient solute diffusion in articular cartilage
    • Torzilli PA, Adams TC, Mis RJ. Transient solute diffusion in articular cartilage. J Biomech 1987;20:203-14.
    • (1987) J Biomech , vol.20 , pp. 203-214
    • Torzilli, P.A.1    Adams, T.C.2    Mis, R.J.3
  • 42
    • 0016770989 scopus 로고
    • Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport
    • Maroudas A. Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport. Biorheology 1975;12:233-48.
    • (1975) Biorheology , vol.12 , pp. 233-248
    • Maroudas, A.1
  • 43
    • 0027064521 scopus 로고
    • Regulation of matrix metabolism in equine cartilage explant cultures by interleukin-1
    • MacDonald MH, Stover SM, Willits NH, Benton HP. Regulation of matrix metabolism in equine cartilage explant cultures by interleukin-1. Am J Vet Res 1992;53:2278-85.
    • (1992) Am J Vet Res , vol.53 , pp. 2278-2285
    • MacDonald, M.H.1    Stover, S.M.2    Willits, N.H.3    Benton, H.P.4
  • 45
    • 0027169460 scopus 로고
    • Integrin-mediated attachment of articular chondrocytes to extracellular matrix proteins
    • Loeser RF. Integrin-mediated attachment of articular chondrocytes to extracellular matrix proteins. Arthritis Rheum 1993;36:1103-10.
    • (1993) Arthritis Rheum , vol.36 , pp. 1103-1110
    • Loeser, R.F.1
  • 46
    • 0027939187 scopus 로고
    • Integrin-mediated cell adhesion activates mitogen-activated protein kinases
    • Chen Q, Kinch MS, Lin TH, Burridge K, Juliano RL. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J Biol Chem 1994;269:26602-5.
    • (1994) J Biol Chem , vol.269 , pp. 26602-26605
    • Chen, Q.1    Kinch, M.S.2    Lin, T.H.3    Burridge, K.4    Juliano, R.L.5
  • 47
    • 0032589393 scopus 로고    scopus 로고
    • α5β1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells
    • Roovers K, Davey G, Zhu X, Bottazzi ME, Assoian RK. α5β1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol Biol Cell 1999;10:3197-204.
    • (1999) Mol Biol Cell , vol.10 , pp. 3197-3204
    • Roovers, K.1    Davey, G.2    Zhu, X.3    Bottazzi, M.E.4    Assoian, R.K.5
  • 48
    • 0030453194 scopus 로고    scopus 로고
    • Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
    • Miyamoto S, Teramoto H, Gutkind JS, Yamada KM. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol 1996;135:1633-42.
    • (1996) J Cell Biol , vol.135 , pp. 1633-1642
    • Miyamoto, S.1    Teramoto, H.2    Gutkind, J.S.3    Yamada, K.M.4
  • 49
    • 0035970008 scopus 로고    scopus 로고
    • Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
    • Jalali S, del Pozo MA, Chen K, Miao H, Li Y, Schwartz MA, et al. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proc Natl Acad Sci U S A 2001;98:1042-6.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1042-1046
    • Jalali, S.1    Del Pozo, M.A.2    Chen, K.3    Miao, H.4    Li, Y.5    Schwartz, M.A.6
  • 50
    • 0032518286 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts
    • MacKenna DA, Dolfi F, Vuori K, Ruoslahti E. Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. J Clin Invest 1998;101:301-10.
    • (1998) J Clin Invest , vol.101 , pp. 301-310
    • MacKenna, D.A.1    Dolfi, F.2    Vuori, K.3    Ruoslahti, E.4
  • 51
    • 0030032790 scopus 로고    scopus 로고
    • Effects of intermittent pressure-induced strain on the electrophysiology of cultured human chondrocytes: Evidence for the presence of stretch-activated membrane ion channels
    • Wright M, Jobanputra P, Bavington C, Salter DM, Nuki G. Effects of intermittent pressure-induced strain on the electrophysiology of cultured human chondrocytes: evidence for the presence of stretch-activated membrane ion channels. Clin Sci (Colch) 1996;90:61-71.
    • (1996) Clin Sci (Colch) , vol.90 , pp. 61-71
    • Wright, M.1    Jobanputra, P.2    Bavington, C.3    Salter, D.M.4    Nuki, G.5
  • 52
    • 0029100088 scopus 로고
    • Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1
    • Arner EC, Tortorella MD. Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1. Arthritis Rheum 1995;38:1304-14.
    • (1995) Arthritis Rheum , vol.38 , pp. 1304-1314
    • Arner, E.C.1    Tortorella, M.D.2
  • 53
    • 0012171485 scopus 로고    scopus 로고
    • Transient activation of P42/P44MAPK by IL-1α is enhanced by a low oxygen tension in human articular cartilage
    • Dudhia J, Wheeler-Jones C, Bayliss MT. Transient activation of P42/P44MAPK by IL-1α is enhanced by a low oxygen tension in human articular cartilage [abstract]. Trans Orthop Res Soc 2000;25:943.
    • (2000) Trans Orthop Res Soc , vol.25 , pp. 943
    • Dudhia, J.1    Wheeler-Jones, C.2    Bayliss, M.T.3
  • 54
    • 0026720523 scopus 로고
    • Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity
    • Meloche S, Seuwen K, Pages G, Pouyssegur J. Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol Endocrinol 1992;6:845-54.
    • (1992) Mol Endocrinol , vol.6 , pp. 845-854
    • Meloche, S.1    Seuwen, K.2    Pages, G.3    Pouyssegur, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.