Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling

Osteoarthritis and Cartilage

Volumn 22, Issue 7, 2014, Pages 1018-1025

  Madej, W ^a   van Caam, A ^a   Blaney Davidson, E N ^a   van der Kraan, P M ^a   Buma, P ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cartilage; Dynamic mechanical compression; Osteoarthritis; Transforming growth factor beta

Indexed keywords

RESERPINE; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3P PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; SMAD3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL DIFFERENTIATION; COMPRESSION; CONTROLLED STUDY; DOWN REGULATION; EXPLANT; MECHANICAL COMPRESSION; METACARPOPHALANGEAL JOINT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANIMAL MODEL; BIOMECHANICS; BOVINAE; CELL CULTURE; COMPRESSIVE STRENGTH; CYTOLOGY; FEMALE; PHYSIOLOGY;

ANIMALS; BIOMECHANICAL PHENOMENA; CARTILAGE, ARTICULAR; CATTLE; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; COMPRESSIVE STRENGTH; FEMALE; MODELS, ANIMAL; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903766269     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.04.024     Document Type: Article

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