Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 16, 2015, Pages 3157-3163

  Rudolph, Dale A ^a   Alcazar, Jesus ^b   Ameriks, Michael K ^a   Anton, Ana Belen ^b   Ao, Hong ^a   Bonaventure, Pascal ^a   Carruthers, Nicholas I ^a   Chrovian, Christa C ^a   De Angelis, Meri ^b   Lord, Brian ^a   Rech, Jason C ^a   Wang, Qi ^a   Bhattacharya, Anindya ^a   Andres, Jose Ignacio ^b   Letavic, Michael A ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

5,6 Dihydro 1,2,4 triazolo 4,3 a pyrazin 7(8H) yl)methanones; CNS; Depression; P2X7

Indexed keywords

PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; PROTEIN BINDING; PYRAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ARTICLE; DEPRESSION; DRUG ANTAGONISM; DRUG EFFICACY; EPILEPSY; IC50; NONHUMAN; PROCESS OPTIMIZATION; RAT; SUBSTITUTION REACTION; ANIMAL; CHEMISTRY; HALF LIFE TIME; HUMAN; METABOLISM; MICROSOME; STRUCTURE ACTIVITY RELATION;

RATTUS;

ANIMALS; HALF-LIFE; HUMANS; MICROSOMES; PROTEIN BINDING; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRAZINES; RATS; RECEPTORS, PURINERGIC P2X7; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84934809021     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.06.004     Document Type: Article

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