The first cns-active carborane: A novel p2x7 receptor antagonist with antidepressant activity

ACS Chemical Neuroscience

Volumn 5, Issue 5, 2014, Pages 335-339

  Wilkinson, Shane M ^a   Gunosewoyo, Hendra ^a   Barron, Melissa L ^a,b   Boucher, Aurelie ^a,b   McDonnell, Michelle ^a,c   Turner, Peter ^a   Morrison, Daniel E ^a   Bennett, Maxwell R ^a   McGregor, Iain S ^a   Rendina, Louis M ^a   Kassiou, Michael ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b Faculty of Veterinary Science   (Australia)

^c Discipline of Pharmacology   (Australia)

Author keywords

antidepressant; blood brain barrier; Carborane; polycycle

Indexed keywords

ANTIDEPRESSANT AGENT; PURINERGIC P2X RECEPTOR ANTAGONIST; POLYCYCLIC HYDROCARBON; PURINERGIC P2X7 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOADDITION; DECARBOXYLATION; DEPRESSION; DRUG STRUCTURE; DRUG TOLERABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; LIPOPHILICITY; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ANIMAL; CENTRAL NERVOUS SYSTEM; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM;

ANIMALS; ANTIDEPRESSIVE AGENTS; CENTRAL NERVOUS SYSTEM; DEPRESSION; HUMANS; POLYCYCLIC COMPOUNDS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7;

EID: 84901254777     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500054n     Document Type: Article

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