A Timeless Link Between Circadian Patterns and Disease

Trends in Molecular Medicine

Volumn 22, Issue 1, 2016, Pages 68-81

  Mazzoccoli, Gianluigi ^a   Laukkanen, Mikko O ^b   Vinciguerra, Manlio ^a,c,d,e   Colangelo, Tommaso ^f   Colantuoni, Vittorio ^f  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b IRCCS SDN   (Italy)

^c Euro Mediterranean Institute of Science and Technology (IEMEST)   (Italy)

^d NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF SANNIO   (Italy)

Author keywords

Circadian; Clock; Gene; Timeless

Indexed keywords

PROTEIN TIMELESS; DROSOPHILA PROTEIN; TIMELESS PROTEIN, DROSOPHILA;

BEHAVIOR DISORDER; CANCER GENETICS; CELL CYCLE PROGRESSION; CIRCADIAN RHYTHM; DNA DAMAGE; DNA REPLICATION; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; GENE; HOMEOSTASIS; HUMAN; MAMMAL; MOLECULAR CLOCK; NEUROLOGIC DISEASE; NONHUMAN; REVIEW; TIMELESS GENE; ANIMAL; DISEASES; DNA REPAIR; PHYSIOLOGY;

ANIMALS; CIRCADIAN RHYTHM; DISEASE; DNA REPAIR; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS;

EID: 84952861457     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.11.007     Document Type: Review

References (84)

1. Reppert S.M., Weaver D.R. Coordination of circadian timing in mammals. Nature 2002, 418:935-941.
2. Mazzoccoli G., et al. Clock genes and clock controlled genes in the regulation of metabolic rhythms. Chronobiol. Int. 2012, 29:227-251.
3. Peschel N., Helfrich-Förster C. Setting the clock - by nature: circadian rhythm in the fruitfly Drosophila melanogaster. FEBS Lett. 2011, 585:1435-1442.
4. Benna C., et al. Drosophila timeless2 is required for chromosome stability and circadian photoreception. Curr. Biol. 2010, 20:346-352.
5. Jang A.R., et al. Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. PLoS Genet. 2015, 11:e1004974.
6. Garbe D.S., et al. Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila. PLoS Genet. 2013, 9:e1003749.
7. Martinek S., et al. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 2001, 105:769-779.
8. Meuti M.E., Denlinger D.L. Evolutionary links between circadian clocks and photoperiodic diapause in insects. Integr. Comp. Biol. 2013, 53:131-143.
9. Gotter A.L. A Timeless debate: resolving TIM's noncircadian roles with possible clock function. Neuroreport. 2006, 17:1229-1233.
10. Sangoram A.M., et al. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron 1998, 21:1101-1113.
11. Barnes J.W., et al. Requirement of mammalian Timeless for circadian rhythmicity. Science 2003, 302:439-442.
12. Gotter A.L., et al. A time-less function for mouse timeless. Nat. Neurosci. 2000, 3:755-756.
13. Gotter A.L. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J. Mol. Biol. 2003, 331:167-176.
14. Xiao J., et al. Timeless in lung morphogenesis. Dev. Dyn. 2003, 228:82-94.
15. Inaguma Y., et al. Morphological characterization of mammalian timeless in the mouse brain development. Neurosci. Res. 2015, 92:21-28.
16. O'Reilly L.P., et al. An unexpected role for the clock protein timeless in developmental apoptosis. PLoS ONE 2011, 6:e17157.
17. O'Reilly L.P., et al. Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation. Cell Signal. 2013, 25:860-866.
18. Gotter A.L., et al. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J. Mol. Biol. 2007, 366:36-52.
19. Murakami H., Keeney S. Temporospatial coordination of meiotic DNA replication and recombination via DDK recruitment to replisomes. Cell 2014, 158:861-873.
20. Schalbetter S.A., et al. Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proc. Natl. Acad. Sci. U.S.A. 2015, 112:E4565-E4570.
21. Dheekollu J., et al. Timeless links replication termination to mitotic kinase activation. PLoS ONE 2011, 6:e19596.
22. Akamatsu Y., Kobayashi T. The human RNA polymerase I transcription terminator complex acts as a replication fork barrier that coordinates the progress of replication with rRNA transcription activity. Mol. Cell. Biol. 2015, 35:1871-1881.
23. Leman A.R., et al. Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion. J. Cell Sci. 2010, 123:660-670.
24. Leman A.R., et al. Timeless preserves telomere length by promoting efficient DNA replication through human telomeres. Cell Cycle 2012, 11:2337-4237.
25. Dheekollu J., Lieberman P.M. The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus. J. Virol. 2011, 85:5853-5863.
26. Dheekollu J., et al. Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. J. Virol. 2013, 87:3699-3709.
27. Sancar A., et al. Circadian clock control of the cellular response to DNA damage. FEBS Lett. 2010, 584:2618-2625.
28. Bee L., et al. Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock. Nucleic Acids Res. 2015, 43:2126-2137.
29. Gaillard H., et al. Replication stress and cancer. Nat. Rev. Cancer 2015, 15:276-289.
30. Unsal-Kaçmaz K., et al. Coupling of human circadian and cell cycles by the timeless protein. Mol. Cell. Biol. 2005, 25:3109-3116.
31. Engelen E., et al. Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS ONE 2013, 8:e56623.
32. Unsal-Kaçmaz K., et al. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol. Cell. Biol. 2007, 27:3131-3142.
33. Kemp M.G., et al. Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. J. Biol. Chem. 2010, 285:16562-16571.
34. Smith-Roe S.L., et al. Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts. Cell Cycle 2011, 10:1618-1624.
35. Smith-Roe S.L., et al. Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts. Cell Cycle 2013, 12:332-345.
36. Yang X.H., et al. Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev. 2008, 22:1147-1152.
37. Xie S., et al. Timeless interacts with PARP-1 to promote homologous recombination repair. Mol. Cell 2015, 60:163-176.
38. Fu L., Lee C.C. The circadian clock: pacemaker and tumour suppressor. Nat. Rev. Cancer. 2003, 3:350-361.
39. Gerber J.M., et al. Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations. Oncotarget 2013, 4:715-728.
40. Mazzoccoli G., et al. Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol. Int. 2011, 28:841-851.
41. Mazzoccoli G., et al. Circadian clock circuitry in colorectal cancer. World J. Gastroenterol. 2014, 20:4197-4207.
42. Yang X., et al. Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. J. Biol. Chem. 2010, 285:3030-3034.
43. Yoshida K., et al. TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival. Cancer Sci. 2013, 104:171-177.
44. Fu A., et al. Genetic and epigenetic associations of circadian gene TIMELESS and breast cancer risk. Mol. Carcinog. 2012, 51:923-929.
45. Mao Y., et al. Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses. BMC Cancer 2013, 13:498.
46. Tozlu-Kara S., et al. Oligonucleotide microarray analysis of estrogen receptor alpha-positive postmenopausal breast carcinomas: identification of HRPAP20 and TIMELESS as outstanding candidate markers to predict the response to tamoxifen. J. Mol. Endocrinol. 2007, 39:305-318.
47. Schepeler T., et al. A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response. Oncogene 2013, 32:3577-3586.
48. Relles D., et al. Circadian gene expression and clinicopathologic correlates in pancreatic cancer. J. Gastrointest. Surg. 2013, 17:443-450.
49. Mazzoccoli G., et al. Altered expression of the clock gene machinery in kidney cancer patients. Biomed. Pharmacother. 2012, 66:175-179.
50. Fallone F., et al. ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression. Oncogene 2013, 32:4387-4396.
51. Bonny O., et al. Molecular bases of circadian rhythmicity in renal physiology and pathology. Nephrol. Dial. Transplant. 2013, 28:2421-2431.
52. Mazzoccoli G., et al. The circadian clock and the hypoxic response pathway in kidney cancer. Tumour. Biol. 2014, 35:1-7.
53. Lin Y.M., et al. Disturbance of circadian gene expression in hepatocellular carcinoma. Mol. Carcinog. 2008, 47:925-933.
54. Elgohary N., et al. Protumorigenic role of Timeless in hepatocellular carcinoma. Int. J Oncol. 2015, 46:597-606.
55. Mansour H.A., et al. Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav. 2006, 5:150-157.
56. Lamont E.W., et al. Circadian rhythms and clock genes in psychotic disorders. Isr. J. Psychiatry Relat. Sci. 2010, 47:27-35.
57. Schnell A., et al. Rhythm and mood: relationships between the circadian clock and mood-related behavior. Behav. Neurosci. 2014, 128:326-343.
58. Etain B., et al. Association between circadian genes, bipolar disorders and chronotypes. Chronobiol. Int. 2014, 31:807-814.
59. Rybakowski J.K., et al. Polymorphism of circadian clock genes and prophylactic lithium response. Bipolar. Disord. 2014, 16:151-158.
60. Rybakowski J.K., et al. Polymorphism of circadian clock genes and temperamental dimensions of the TEMPS-A in bipolar disorder. J. Affect. Disord. 2014, 159:80-84.
61. Bianco G., et al. Epidemiology and chronorhythmicity of recurrences of attempted suicide. Rec. Prog. Med. 1998, 89:114-117.
62. Pawlak J., et al. Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder - data from an association study of suicide attempts with clock genes. Psychiatry Res. 2015, 226:517-520.
63. Utge S.J., et al. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS ONE 2010, 5:e9259.
64. Pedrazzoli M., et al. A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults. Sleep Res. Online 2000, 3:73-76.
65. Yang Z., et al. Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients. Brain Dev. 2015, Published online May 6, 2015. 10.1016/j.braindev.2015.04.006.
66. Helfrich-Förster C., et al. The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron 2001, 30:249-261.
67. Hunter-Ensor M., et al. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 1996, 84:677-685.
68. Myers M.P., et al. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 1996, 271:1736-1740.
69. Zeng H., et al. A light-entrainment mechanism for the Drosophila circadian clock. Nature 1996, 380:129-135.
70. Peschel N., et al. Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless. Curr. Biol. 2009, 19:241-247.
71. Albrecht U. Timing to perfection: the biology of central and peripheral circadian clocks. Neuron 2012, 74:246-260.
72. Bass J., Takahashi J.S. Circadian integration of metabolism and energetic. Science 2010, 330:1349-1354.
73. Bass J. Circadian topology of metabolism. Nature 2012, 491:348-356.
74. Lowrey P.L., Takahashi J.S. Genetics of circadian rhythms in mammalian model organisms. Adv. Genet. 2011, 74:175-230.
75. Nagoshi E., et al. Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 2004, 119:693-705.
76. Lamia K.A., et al. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 2009, 326:437-440.
77. Sahar S., et al. Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS ONE 2010, 5:e8561.
78. Chou D.M., Elledge S.J. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:18143-18147.
79. Yoshizawa-Sugata N., Masai H. Human Tim/Timeless-interacting protein Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J. Biol. Chem. 2007, 282:2729-2740.
80. Cho W.H., et al. Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:2523-2527.
81. Moyer S.E., et al. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:10236-10241.
82. Smith K.D., et al. Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J. Cell. Biol. 2009, 187:15-23.
83. Aria V., et al. The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity. J. Biol. Chem. 2013, 288:12742-12752.
84. Witosch J., et al. Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex. Nucleic Acids Res. 2014, 42:12912-12927.