Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 6, 2015, Pages 1591-1600

  Gao, Li ^a   Bin, Lianghua ⁱ   Rafaels, Nicholas M ^a   Huang, Lili ^a   Potee, Joseph ^a   Ruczinski, Ingo ^b   Beaty, Terri H ^b   Paller, Amy S ^c   Schneider, Lynda C ^d   Gallo, Rich ^e   Hanifin, Jon M ^f   Beck, Lisa A ^g   Geha, Raif S ^h   Mathias, Rasika A ^a   Barnes, Kathleen C ^a   Leung, Donald Y M ⁱ  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ DEPARTMENT OF MEDICINE   (United States)

Author keywords

atopic dermatitis; eczema herpeticum; genetic variants; IFNGR1

Indexed keywords

CYSTEINE; GAMMA INTERFERON RECEPTOR 1; ISOLEUCINE; METHIONINE; TYROSINE; VALINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERFERON RECEPTOR; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AFRICAN AMERICAN; AGED; ARTICLE; ATOPIC DERMATITIS; CHILD; DISEASE SEVERITY; EUROPEAN AMERICAN; FEMALE; GENE SEQUENCE; GENE TARGETING; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; KAPOSI VARICELLIFORM ERUPTION; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; CELL LINE; GENETIC PREDISPOSITION; GENETICS; HIGH THROUGHPUT SEQUENCING; INFANT; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; REPORTER GENE; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CELL LINE; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; FEMALE; GENES, REPORTER; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INFANT; INTERFERON-GAMMA; KAPOSI VARICELLIFORM ERUPTION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERFERON; RISK; STAT1 TRANSCRIPTION FACTOR; YOUNG ADULT;

EID: 84952639528     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.06.047     Document Type: Article

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