Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum

Journal of Investigative Dermatology

Volumn 132, Issue 3 PART 1, 2012, Pages 650-657

  Gao, Pei Song ^a   Leung, Donald Y M ^b   Rafaels, Nicholas M ^a   Boguniewicz, Mark ^b   Hand, Tracey ^a   Gao, Li ^a   Hata, Tissa R ^c   Schneider, Lynda C ^d   Hanifin, Jon M ^e   Beaty, Terri H ^f   Beck, Lisa A ^g   Weinberg, Adriana ^h   Barnes, Kathleen C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^g UNIVERSITY OF ROCHESTER   (United States)

^h Children's Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 2;

ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ETHNICITY; GENE EXPRESSION; GENETIC VARIABILITY; HAPLOTYPE; HERPES SIMPLEX VIRUS; HUMAN; IMMUNE RESPONSE; KAPOSI VARICELLIFORM ERUPTION; MAJOR CLINICAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84857052949     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.374     Document Type: Article

References (33)

1. Barnes KC (2009) An update on the genetics of atopic dermatitis: Scratching the surface in 2009. J Allergy Clin Immunol 125:16-29 e11-11; quiz 30-11
2. Beck LA, Boguniewicz M, Hata T et al. (2009) Phenotype of atopic dermatitis subjects with a history of eczema herpeticum. J Allergy Clin Immunol 124:260-9, 269 e261-267
3. Boguniewicz M, Leung DY (2010) Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol 125:4-13; quiz 14-15
4. Eichenfield LF, Hanifin JM, Luger TA et al. (2003) Consensus conference on pediatric atopic dermatitis. J Am Acad Dermatol 49:1088-95 (Pubitemid 37475483)
5. Foerster J, Nolte I, Schweiger S et al. (2004a) Evaluation of the IRF-2 gene as a candidate for PSORS3. J Invest Dermatol 122:61-4 (Pubitemid 38114639)
6. Foerster J, Nolte I, Schweiger S et al. (2004b) Evaluation of the IRF-2 gene as a candidate for PSORS3. J Invest Dermatol 122:61-4 (Pubitemid 38114639)
7. Gabriel SB, Schaffner SF, Nguyen H et al. (2002) The structure of haplotype blocks in the human genome. Science 296:2225-9 (Pubitemid 34680308)
8. Gao PS, Rafaels NM, Hand T et al. (2009) Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol 124:507-13, 513 e1-7
9. Gariboldi S, Palazzo M, Zanobbio L et al. (2009) Low dose oral administration of cytokines for treatment of allergic asthma. Pulm Pharmacol Ther 22:497-510
10. Grigoryev DN, Howell MD, Watkins TN et al. (2010) Vaccinia virus-specific molecular signature in atopic dermatitis skin. J Allergy Clin Immunol 125:153-9 e128
11. Hanifin JM, Thurston M, Omoto M et al. (2001) The eczema area and severity index (EASI): Assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp Dermatol 10:11-8 (Pubitemid 32098039)
12. Harada H, Fujita T, Miyamoto M et al. (1989) Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 58:729-39 (Pubitemid 19210966)
13. Herberth G, Heinrich J, Roder S et al. (2010) Reduced IFN-gamma-and enhanced IL-4-producing CD4 cord blood T cells are associated with a higher risk for atopic dermatitis during the first 2 yr of life. Pediatr Allergy Immunol 21:5-13
14. Hida S, Ogasawara K, Sato K et al. (2000) CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/ beta signaling. Immunity 13:643-55
15. Hida S, Tadachi M, Saito T et al. (2005) Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106:2011-7 (Pubitemid 41291714)
16. Homey B, Steinhoff M, Ruzicka T et al. (2006) Cytokines and chemokines orchestrate atopic skin inflammation. J Allergy Clin Immunol 118:178-89 (Pubitemid 43946487)
17. Howell MD, Gallo RL, Boguniewicz M et al. (2006) Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24:341-8
18. Janetzki S, Cox JH, Oden N et al. (2005) Standardization and validation issues of the ELISPOT assay. Methods Mol Biol 302:51-86
19. Kroger A, Koster M, Schroeder K et al. (2002) Activities of IRF-1. J Interferon Cytokine Res 22:5-14 (Pubitemid 34161278)
20. Lace MJ, Anson JR, Haugen TH et al. (2010) Interferon regulatory factor (IRF)-2 activates the HPV-16 E6-E7 promoter in keratinocytes. Virology 399: 270-9
21. Lemaire R, Prasad J, Kashima T et al. (2002) Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: A novel function for SR proteins. Genes Dev 16:594-607 (Pubitemid 34212492)
22. Leung DYM, Gao PS, Grigoryev DN et al. (2011) Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in gamma interferon response. J Allergy Clin Immunol 127:965-73
23. Li X, Manley JL (2005) Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 122:365-78 (Pubitemid 41127139)
24. Mathias RA, Grant AV, Rafaels N et al. (2008) A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol 125:336-46 e334
25. Matsuyama T, Kimura T, Kitagawa M et al. (1993) Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 75:83-97 (Pubitemid 23306023)
26. Neale BM, Sham PC (2004) The future of association studies: Gene-based analysis and replication. Am J Hum Genet 75:353-62 (Pubitemid 39095812)
27. Nemoto-Hasebe I, Akiyama M, Nomura T et al. (2009) Clinical severity correlates with impaired barrier in flaggrin-related eczema. J Invest Dermatol 129:682-9
28. Nishio Y, Noguchi E, Ito S et al. (2001) Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. J Hum Genet 46:664-7 (Pubitemid 33134744)
29. Purcell S, Neale B, Todd-Brown K et al. (2007) PLINK: A tool set for wholegenome association and population-based linkage analyses. Am J Hum Genet 81:559-75 (Pubitemid 47330214)
30. Sierakowska H, Sambade MJ, Agrawal S et al. (1996) Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides. Proc Natl Acad Sci USA 93:12840-4 (Pubitemid 26382730)
31. Tay YK, Khoo BP, Goh CL (1999) The epidemiology of atopic dermatitis at a tertiary referral skin center in Singapore. Asian Pac J Allergy Immunol 17:137-41
32. Wild JS, Sigounas A, Sur N et al. (2000) IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. J Immunol 164: 2701-10 (Pubitemid 30115503)
33. Xu F, Sternberg MR, Kottiri BJ et al. (2006) Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA 296:964-73 (Pubitemid 44285373)