메뉴 건너뛰기




Volumn 14, Issue 12, 2015, Pages 1879-1904

SGLT2 inhibition: Efficacy and safety in type 2 diabetes treatment

Author keywords

canagliflozin; dapagliflozin; empagliflozin; oral antidiabetic drug; SGLT2 inhibitor; type 2 diabetes mellitus

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LIPID; METFORMIN; PLACEBO; POTASSIUM; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2; SULFONYLUREA; URIC ACID; 2-(3-(4-ETHOXYBENZYL)-4-CHLOROPHENYL)-6-HYDROXYMETHYLTETRAHYDRO-2H-PYRAN-3,4,5-TRIOL; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; GLUCOSE BLOOD LEVEL; GLUCOSIDE; SLC5A2 PROTEIN, HUMAN;

EID: 84951905769     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2015.1100167     Document Type: Review
Times cited : (72)

References (131)
  • 3
    • 79651473537 scopus 로고    scopus 로고
    • Renal glucose reabsorption inhibitors to treat diabetes
    • Bailey CJ. Renal glucose reabsorption inhibitors to treat diabetes. Trends Pharmacol Sci. 2011;32:63-71
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 63-71
    • Bailey, C.J.1
  • 4
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • Abdul-Ghani MA, Norton L, Defronzo RA. Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev. 2011;32:515-531
    • (2011) Endocr Rev , vol.32 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 5
    • 84898898964 scopus 로고    scopus 로고
    • Drug-drug interactions with SGLT-2 inhibitors, new oral glucose-lowering agents for the management of type 2 diabetes
    • Scheen AJ. Drug-drug interactions with SGLT-2 inhibitors, new oral glucose-lowering agents for the management of type 2 diabetes. Clin Pharmacokinet. 2014;53:295-304
    • (2014) Clin Pharmacokinet , vol.53 , pp. 295-304
    • Scheen, A.J.1
  • 6
    • 84933676007 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and clinical use of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease
    • Scheen AJ. Pharmacokinetics, pharmacodynamics and clinical use of SGLT2 inhibitors in patients with type 2 diabetes and chronic kidney disease. Clin Pharmacokinet. 2015;54:691-708
    • (2015) Clin Pharmacokinet , vol.54 , pp. 691-708
    • Scheen, A.J.1
  • 7
    • 84882251091 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: A systematic review and meta-Analysis
    • Vasilakou D, Karagiannis T, Athanasiadou E, et al. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: A systematic review and meta-Analysis. Ann Intern Med. 2013;159:262-274
    • (2013) Ann Intern Med , vol.159 , pp. 262-274
    • Vasilakou, D.1    Karagiannis, T.2    Athanasiadou, E.3
  • 8
    • 84890285675 scopus 로고    scopus 로고
    • Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: A meta-Analysis of randomized double-blind controlled trials
    • Berhan A, Barker A. Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: A meta-Analysis of randomized double-blind controlled trials. BMC Endocr Disord. 2013;13:58
    • (2013) BMC Endocr Disord , vol.13 , pp. 58
    • Berhan, A.1    Barker, A.2
  • 9
    • 84923791994 scopus 로고    scopus 로고
    • Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus
    • Scheen AJ. Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs. 2015;75:33-59
    • (2015) Drugs , vol.75 , pp. 33-59
    • Scheen, A.J.1
  • 10
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes 2015: A patient-centered approach: Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140-149
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 11
    • 84901830673 scopus 로고    scopus 로고
    • Canagliflozin: A review of its use in patients with type 2 diabetes mellitus
    • Plosker GL. Canagliflozin: A review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74:807-824
    • (2014) Drugs , vol.74 , pp. 807-824
    • Plosker, G.L.1
  • 12
    • 62949147825 scopus 로고    scopus 로고
    • Assessment report. Canagliflozin. [cited 2015 Oct 15]
    • European Medicines Agency [Internet]. Assessment report. Canagliflozin. 2013. [cited 2015 Oct 15]. Available from: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Public-Assessment-report/human/002649/WC500156457.pdf
    • (2013) European Medicines Agency [Internet]
  • 13
    • 84869998632 scopus 로고    scopus 로고
    • Dapagliflozin: A review of its use in type 2 diabetes mellitus
    • Plosker GL. Dapagliflozin: A review of its use in type 2 diabetes mellitus. Drugs. 2012;72:2289-2312
    • (2012) Drugs , vol.72 , pp. 2289-2312
    • Plosker, G.L.1
  • 14
    • 84915747765 scopus 로고    scopus 로고
    • Dapagliflozin: A review of its use in patients with type 2 diabetes
    • Plosker GL. Dapagliflozin: A review of its use in patients with type 2 diabetes. Drugs. 2014;74:2191-2209
    • (2014) Drugs , vol.74 , pp. 2191-2209
    • Plosker, G.L.1
  • 15
    • 62949147825 scopus 로고    scopus 로고
    • Assessment report. Forxiga (dapagliflozin. [cited 2015 Oct 15]
    • European Medicines Agency [Internet]. Assessment report. Forxiga (dapagliflozin). 2012. [cited 2015 Oct 15]. Available from: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Public-Assessment-report/human/002322/WC500136024.pdf
    • (2012) European Medicines Agency [Internet]
  • 16
    • 84921937734 scopus 로고    scopus 로고
    • Empagliflozin: A review of its use in patients with type 2 diabetes mellitus
    • Scott LJ. Empagliflozin: A review of its use in patients with type 2 diabetes mellitus. Drugs. 2014;74:1769-1784
    • (2014) Drugs , vol.74 , pp. 1769-1784
    • Scott, L.J.1
  • 17
    • 84951909080 scopus 로고    scopus 로고
    • International non-proprietary name: empagliflozin. [cited 2015 Oct 15]
    • European Medicines Agency. Assessment report: Jardiance [Internet]. International non-proprietary name: empagliflozin. 2014. [cited 2015 Oct 15]. Available from: http://www.ema.europa.eu/docs/en-GB/docu ment-library/EPAR-Public-Assessment-report/human/002677/WC500168594.pdf.
    • (2014) European Medicines Agency. Assessment Report: Jardiance [Internet]
  • 18
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Epub 2015 Sep 17
    • Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015. Epub 2015 Sep 17. DOI:10.1056/NEJMoa1504720
    • (2015) N Engl J Med
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 19
    • 84908066747 scopus 로고    scopus 로고
    • Update on developments with SGLT2 inhibitors in the management of type 2 diabetes
    • Nauck MA. Update on developments with SGLT2 inhibitors in the management of type 2 diabetes. Drug Des Devel Ther. 2014;8:1335-1380
    • (2014) Drug des Devel Ther , vol.8 , pp. 1335-1380
    • Nauck, M.A.1
  • 20
    • 84892576563 scopus 로고    scopus 로고
    • Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia
    • Rieg T, Masuda T, Gerasimova M, et al. Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia. Am J Physiol Renal Physiol. 2014;306:F188-93
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. F188-F193
    • Rieg, T.1    Masuda, T.2    Gerasimova, M.3
  • 21
    • 84877865378 scopus 로고    scopus 로고
    • Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: Results of a randomized, placebo-controlled study
    • Polidori D, Sha S, Mudaliar S, et al. Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care. 2013;36:2154-2161
    • (2013) Diabetes Care , vol.36 , pp. 2154-2161
    • Polidori, D.1    Sha, S.2    Mudaliar, S.3
  • 22
    • 84921433098 scopus 로고    scopus 로고
    • Pharmacodynamic differences between canagliflozin and dapagliflozin: Results of a randomized, double-blind, crossover study
    • Sha S, Polidori D, Farrell K, et al. Pharmacodynamic differences between canagliflozin and dapagliflozin: results of a randomized, double-blind, crossover study. Diabetes Obes Metab. 2015;17:188-197
    • (2015) Diabetes Obes Metab , vol.17 , pp. 188-197
    • Sha, S.1    Polidori, D.2    Farrell, K.3
  • 23
    • 84898600889 scopus 로고    scopus 로고
    • Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
    • Polidori D, Mari A, Ferrannini E. Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes. Diabetologia. 2014;57:891-901
    • (2014) Diabetologia , vol.57 , pp. 891-901
    • Polidori, D.1    Mari, A.2    Ferrannini, E.3
  • 24
    • 84879496400 scopus 로고    scopus 로고
    • Canagliflozin: First global approval
    • Elkinson S, Scott LJ. Canagliflozin: first global approval. Drugs. 2013;73:979-988
    • (2013) Drugs , vol.73 , pp. 979-988
    • Elkinson, S.1    Scott, L.J.2
  • 25
    • 84877871970 scopus 로고    scopus 로고
    • Canagliflozin, an inhibitor of sodium-glucose cotransporter 2, for the treatment of type 2 diabetes mellitus
    • Lamos EM, Younk LM, Davis SN. Canagliflozin, an inhibitor of sodium-glucose cotransporter 2, for the treatment of type 2 diabetes mellitus. Expert Opin Drug Metab Toxicol. 2013;9:763-775
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , pp. 763-775
    • Lamos, E.M.1    Younk, L.M.2    Davis, S.N.3
  • 26
    • 84929676338 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes: Systematic review and meta-Analysis
    • Yang XP, Lai D, Zhong XY, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes: systematic review and meta-Analysis. Eur J Clin Pharmacol. 2014;70:1149-1158
    • (2014) Eur J Clin Pharmacol , vol.70 , pp. 1149-1158
    • Yang, X.P.1    Lai, D.2    Zhong, X.Y.3
  • 27
    • 84964240560 scopus 로고    scopus 로고
    • Longterm efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes
    • Bode B, Stenlof K, Harris S, et al. Longterm efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetes. Diabetes Obes Metab. 2015;17:294-303
    • (2015) Diabetes Obes Metab , vol.17 , pp. 294-303
    • Bode, B.1    Stenlof, K.2    Harris, S.3
  • 29
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • Cefalu WT, Leiter LA, Yoon KH, et al. Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet. 2013;382:941-950
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3
  • 30
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: A randomised trial
    • Lavalle-Gonzalez FJ, Januszewicz A, Davidson J, et al. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: A randomised trial. Diabetologia. 2013;56:2582-2592
    • (2013) Diabetologia , vol.56 , pp. 2582-2592
    • Lavalle-Gonzalez, F.J.1    Januszewicz, A.2    Davidson, J.3
  • 31
    • 84891784200 scopus 로고    scopus 로고
    • Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week randomized trial
    • Schernthaner G, Gross JL, Rosenstock J, et al. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week randomized trial. Diabetes Care. 2013;36:2508-2515
    • (2013) Diabetes Care , vol.36 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 32
    • 84940110139 scopus 로고    scopus 로고
    • Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: A randomized, double-blind, phase 3 study
    • Leiter LA, Yoon KH, Arias P, et al. Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: A randomized, double-blind, phase 3 study. Diabetes Care. 2015;38:355-364
    • (2015) Diabetes Care , vol.38 , pp. 355-364
    • Leiter, L.A.1    Yoon, K.H.2    Arias, P.3
  • 33
    • 84905664996 scopus 로고    scopus 로고
    • Attainment of diabetes-related quality measures with canagliflozin versus sitagliptin
    • Bailey RA, Damaraju CV, Martin SC, et al. Attainment of diabetes-related quality measures with canagliflozin versus sitagliptin. Am J Manag Care. 2014;20: S16-24
    • (2014) Am J Manag Care , vol.20 , pp. S16-24
    • Bailey, R.A.1    Damaraju, C.V.2    Martin, S.C.3
  • 34
    • 84929377076 scopus 로고    scopus 로고
    • Dapagliflozin lowers plasma glucose concentration and improves beta-cell function
    • Merovci A, Mari A, Solis C, et al. Dapagliflozin lowers plasma glucose concentration and improves beta-cell function. J Clin Endocrinol Metab. 2015;100:1927-1932
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 1927-1932
    • Merovci, A.1    Mari, A.2    Solis, C.3
  • 35
    • 84918546698 scopus 로고    scopus 로고
    • Metabolic effects SGLT2 inhibitors beyond increased glucosuria: A review of clinical evidence
    • Scheen AJ, Paquot N. Metabolic effects SGLT2 inhibitors beyond increased glucosuria: A review of clinical evidence. Diabetes Metab. 2014;40:S4-S11
    • (2014) Diabetes Metab , vol.40 , pp. S4-S11
    • Scheen, A.J.1    Paquot, N.2
  • 36
    • 84891878819 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2
    • Kasichayanula S, Liu X, Lacreta F, et al. Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014;53:17-27
    • (2014) Clin Pharmacokinet , vol.53 , pp. 17-27
    • Kasichayanula, S.1    Liu, X.2    Lacreta, F.3
  • 37
    • 84873960885 scopus 로고    scopus 로고
    • Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled 102-week trial
    • Bailey CJ, Gross JL, Hennicken D, et al. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43
    • (2013) BMC Med , vol.11 , pp. 43
    • Bailey, C.J.1    Gross, J.L.2    Hennicken, D.3
  • 38
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • Bolinder J, Ljunggren O, Johansson L, et al. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab. 2014;16:159-169
    • (2014) Diabetes Obes Metab , vol.16 , pp. 159-169
    • Bolinder, J.1    Ljunggren, O.2    Johansson, L.3
  • 39
    • 84892488179 scopus 로고    scopus 로고
    • Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: Efficacy and safety over 2 years
    • Wilding JP, Woo V, Rohwedder K, et al. Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years. Diabetes Obes Metab. 2014;16:124-136
    • (2014) Diabetes Obes Metab , vol.16 , pp. 124-136
    • Wilding, J.P.1    Woo, V.2    Rohwedder, K.3
  • 40
    • 84860183617 scopus 로고    scopus 로고
    • A novel approach to control hyperglycemia in type 2 diabetes: Sodium glucose cotransport (SGLT) inhibitors: Systematic review and meta-Analysis of randomized trials
    • Musso G, Gambino R, Cassader M, et al. A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose cotransport (SGLT) inhibitors: systematic review and meta-Analysis of randomized trials. Ann Med. 2012;44:375-393
    • (2012) Ann Med , vol.44 , pp. 375-393
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 41
    • 84899535874 scopus 로고    scopus 로고
    • The efficacy of dapagliflozin combined with hypoglycaemic drugs in treating type 2 diabetes mellitus: Meta-Analysis of randomised controlled trials
    • Sun YN, Zhou Y, Chen X, et al. The efficacy of dapagliflozin combined with hypoglycaemic drugs in treating type 2 diabetes mellitus: meta-Analysis of randomised controlled trials. BMJ Open. 2014 4:e004619. doi:10.1136/bmjopen-2013-004619
    • (2014) BMJ Open , vol.4 , pp. e004619
    • Sun, Y.N.1    Zhou, Y.2    Chen, X.3
  • 42
    • 84895484977 scopus 로고    scopus 로고
    • Dapagliflozin treatment for type 2 diabetes: A systematic review and meta-Analysis of randomized controlled trials
    • Zhang M, Zhang L, Wu B, et al. Dapagliflozin treatment for type 2 diabetes: A systematic review and meta-Analysis of randomized controlled trials. Diabetes Metab Res Rev. 2014;30:204-221
    • (2014) Diabetes Metab Res Rev , vol.30 , pp. 204-221
    • Zhang, M.1    Zhang, L.2    Wu, B.3
  • 43
    • 65349196064 scopus 로고    scopus 로고
    • Sodiumglucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List JF, Woo V, Morales E, et al. Sodiumglucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care. 2009;32:650-657
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3
  • 44
    • 84860218907 scopus 로고    scopus 로고
    • Dapagliflozin, metformin XR, or both: Initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
    • Henry RR, Murray AV, Marmolejo MH, et al. Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract. 2012;66:446-456
    • (2012) Int J Clin Pract , vol.66 , pp. 446-456
    • Henry, R.R.1    Murray, A.V.2    Marmolejo, M.H.3
  • 45
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del Prato S, Meier JJ, et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34:2015-2022
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.A.1    Del Prato, S.2    Meier, J.J.3
  • 46
    • 84914144323 scopus 로고    scopus 로고
    • Durability of glycaemic efficacy over 2 years with dapagliflozin versus glipizide as add-on therapies in patients whose type 2 diabetes mellitus is inadequately controlled with metformin
    • Nauck MA, Del Prato S, Duran-Garcia S, et al. Durability of glycaemic efficacy over 2 years with dapagliflozin versus glipizide as add-on therapies in patients whose type 2 diabetes mellitus is inadequately controlled with metformin. Diabetes Obes Metab. 2014;16:1111-1120
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1111-1120
    • Nauck, M.A.1    Del Prato, S.2    Duran-Garcia, S.3
  • 47
    • 84928426587 scopus 로고    scopus 로고
    • Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data
    • Del Prato S, Nauck M, Duran-Garcia S, et al. Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data. Diabetes Obes Metab. 2015;17:581-590
    • (2015) Diabetes Obes Metab , vol.17 , pp. 581-590
    • Del Prato, S.1    Nauck, M.2    Duran-Garcia, S.3
  • 48
    • 84928201032 scopus 로고    scopus 로고
    • Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: A randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin
    • Rosenstock J, Hansen L, Zee P, et al. Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: A randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metformin. Diabetes Care. 2015;38:376-383
    • (2015) Diabetes Care , vol.38 , pp. 376-383
    • Rosenstock, J.1    Hansen, L.2    Zee, P.3
  • 49
    • 84898789114 scopus 로고    scopus 로고
    • Dapagliflozin compared with other oral anti-diabetes treatments when added to metformin monotherapy: A systematic review and network meta-Analysis
    • Goring S, Hawkins N, Wygant G, et al. Dapagliflozin compared with other oral anti-diabetes treatments when added to metformin monotherapy: A systematic review and network meta-Analysis. Diabetes Obes Metab. 2014;16:433-442
    • (2014) Diabetes Obes Metab , vol.16 , pp. 433-442
    • Goring, S.1    Hawkins, N.2    Wygant, G.3
  • 50
    • 84896826460 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor
    • Scheen AJ. Pharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor. Clin Pharmacokinet. 2014;53:213-225
    • (2014) Clin Pharmacokinet , vol.53 , pp. 213-225
    • Scheen, A.J.1
  • 51
    • 84877652575 scopus 로고    scopus 로고
    • Empagliflozin (BI 10773), a potent and selective SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    • Seman L, Macha S, Nehmiz G, et al. Empagliflozin (BI 10773), a potent and selective SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharmacol Drug Dev. 2013;2:152-161
    • (2013) Clin Pharmacol Drug Dev , vol.2 , pp. 152-161
    • Seman, L.1    Macha, S.2    Nehmiz, G.3
  • 52
    • 84983201802 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin in people with Type 2 diabetes
    • Merker L, Haring HU, Christiansen AV, et al. Empagliflozin as add-on to metformin in people with Type 2 diabetes. Diabet Med. 2015. doi:10.1111/dme.12814
    • (2015) Diabet Med
    • Merker, L.1    Haring, H.U.2    Christiansen, A.V.3
  • 53
    • 84940575211 scopus 로고    scopus 로고
    • Empagliflozin as add-on therapy to pioglitazone with or without metformin in patients with type 2 diabetes mellitus
    • Kovacs CS, Seshiah V, Merker L, et al. Empagliflozin as add-on therapy to pioglitazone with or without metformin in patients with type 2 diabetes mellitus. Clin Ther. 2015;37:1773-1788
    • (2015) Clin Ther , vol.37 , pp. 1773-1788
    • Kovacs, C.S.1    Seshiah, V.2    Merker, L.3
  • 54
    • 84942294658 scopus 로고    scopus 로고
    • Impact of empagliflozin added on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: A 78-week randomized, double-blind, placebocontrolled trial
    • Rosenstock J, Jelaska A, Zeller C, et al. Impact of empagliflozin added on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: A 78-week randomized, double-blind, placebocontrolled trial. Diabetes Obes Metab. 2015;17:936-948
    • (2015) Diabetes Obes Metab , vol.17 , pp. 936-948
    • Rosenstock, J.1    Jelaska, A.2    Zeller, C.3
  • 55
    • 84912533839 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin for type 2 diabetes: A systematic review and meta-Analysis
    • Liakos A, Karagiannis T, Athanasiadou E, et al. Efficacy and safety of empagliflozin for type 2 diabetes: A systematic review and meta-Analysis. Diabetes Obes Metab. 2014;16:984-993
    • (2014) Diabetes Obes Metab , vol.16 , pp. 984-993
    • Liakos, A.1    Karagiannis, T.2    Athanasiadou, E.3
  • 56
    • 84879795546 scopus 로고    scopus 로고
    • A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
    • Ferrannini E, Seman L, Seewaldt-Becker E, et al. A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes. Diabetes Obes Metab. 2013;15:721-728
    • (2013) Diabetes Obes Metab , vol.15 , pp. 721-728
    • Ferrannini, E.1    Seman, L.2    Seewaldt-Becker, E.3
  • 57
    • 84891851923 scopus 로고    scopus 로고
    • Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: An active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    • Ferrannini E, Berk A, Hantel S, et al. Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: An active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care. 2013;36:4015-4021
    • (2013) Diabetes Care , vol.36 , pp. 4015-4021
    • Ferrannini, E.1    Berk, A.2    Hantel, S.3
  • 58
    • 84908332537 scopus 로고    scopus 로고
    • Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: A 104-week randomised, active-controlled, doubleblind, phase 3 trial
    • Ridderstrale M, Andersen KR, Zeller C, et al. Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: A 104-week randomised, active-controlled, doubleblind, phase 3 trial. Lancet Diabetes Endocrinol. 2014;2:691-700
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 691-700
    • Ridderstrale, M.1    Andersen, K.R.2    Zeller, C.3
  • 59
    • 84887191925 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
    • Rosenstock J, Seman LJ, Jelaska A, et al. Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab. 2013;15:1154-1160
    • (2013) Diabetes Obes Metab , vol.15 , pp. 1154-1160
    • Rosenstock, J.1    Seman, L.J.2    Jelaska, A.3
  • 60
    • 84885954870 scopus 로고    scopus 로고
    • Empagliflozin monotherapy in drug-nave patients with type 2 diabetes: A randomised, 24-week, double-blind, placebocontrolled, parallel group, trial with sitagliptin as active comparator
    • Roden M, Weng J, Eilbracht J, et al. Empagliflozin monotherapy in drug-nave patients with type 2 diabetes: A randomised, 24-week, double-blind, placebocontrolled, parallel group, trial with sitagliptin as active comparator. Lancet Diabetes Endocrinol. 2013;1:208-219
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 208-219
    • Roden, M.1    Weng, J.2    Eilbracht, J.3
  • 61
    • 84928199102 scopus 로고    scopus 로고
    • Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes
    • Lewin A, DeFronzo RA, Patel S, et al. Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes. Diabetes Care. 2015;38:394-402
    • (2015) Diabetes Care , vol.38 , pp. 394-402
    • Lewin, A.1    DeFronzo, R.A.2    Patel, S.3
  • 62
    • 84928176749 scopus 로고    scopus 로고
    • Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin
    • DeFronzo RA, Lewin A, Patel S, et al. Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin. Diabetes Care. 2015;38:384-393
    • (2015) Diabetes Care , vol.38 , pp. 384-393
    • DeFronzo, R.A.1    Lewin, A.2    Patel, S.3
  • 63
    • 84891526739 scopus 로고    scopus 로고
    • Impact of sodium glucose cotransporter 2 inhibitors on weight in patients with type 2 diabetes mellitus
    • Barnett AH. Impact of sodium glucose cotransporter 2 inhibitors on weight in patients with type 2 diabetes mellitus. Postgrad Med. 2013;125:92-100
    • (2013) Postgrad Med , vol.125 , pp. 92-100
    • Barnett, A.H.1
  • 64
    • 84901849274 scopus 로고    scopus 로고
    • Combating the dual burden: Therapeutic targeting of common pathways in obesity and type 2 diabetes
    • Scheen AJ, Van Gaal LF. Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes. Lancet Diabetes Endocrinol. 2014;2:911-922
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 911-922
    • Scheen, A.J.1    Van Gaal, L.F.2
  • 65
    • 84940559645 scopus 로고    scopus 로고
    • Weight management in type 2 diabetes: Current and emerging approaches to treatment
    • Van Gaal L, Scheen A. Weight management in type 2 diabetes: current and emerging approaches to treatment. Diabetes Care. 2015;38:1161-1172
    • (2015) Diabetes Care , vol.38 , pp. 1161-1172
    • Van Gaal, L.1    Scheen, A.2
  • 66
    • 84939943275 scopus 로고    scopus 로고
    • Effects of canagliflozin on body weight and relationship to HbA1c and blood pressure changes in patients with type 2 diabetes
    • Cefalu WT, Stenlof K, Leiter LA, et al. Effects of canagliflozin on body weight and relationship to HbA1c and blood pressure changes in patients with type 2 diabetes. Diabetologia. 2015;58:1183-1187
    • (2015) Diabetologia , vol.58 , pp. 1183-1187
    • Cefalu, W.T.1    Stenlof, K.2    Leiter, L.A.3
  • 67
    • 84906926382 scopus 로고    scopus 로고
    • The impact of weight loss on weight-related quality of life and health satisfaction: Results from a trial comparing canagliflozin with sitagliptin in triple therapy among people with type 2 diabetes
    • Traina S, Guthrie R, Slee A. The impact of weight loss on weight-related quality of life and health satisfaction: results from a trial comparing canagliflozin with sitagliptin in triple therapy among people with type 2 diabetes. Postgrad Med. 2014;126:7-15
    • (2014) Postgrad Med , vol.126 , pp. 7-15
    • Traina, S.1    Guthrie, R.2    Slee, A.3
  • 68
    • 84880850027 scopus 로고    scopus 로고
    • Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • Lambers Heerspink HJ, De Zeeuw D, Wie L, et al. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab. 2013;15:853-862
    • (2013) Diabetes Obes Metab , vol.15 , pp. 853-862
    • Lambers Heerspink, H.J.1    De Zeeuw, D.2    Wie, L.3
  • 69
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • Bolinder J, Ljunggren O, Kullberg J, et al. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab. 2012;97:1020-1031
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, O.2    Kullberg, J.3
  • 70
    • 84937817781 scopus 로고    scopus 로고
    • Dapagliflozin-induced weight loss affects 24-week glycated haemoglobin and blood pressure levels
    • Sjostrom CD, Hashemi M, Sugg J, et al. Dapagliflozin-induced weight loss affects 24-week glycated haemoglobin and blood pressure levels. Diabetes Obes Metab. 2015;17:809-812
    • (2015) Diabetes Obes Metab , vol.17 , pp. 809-812
    • Sjostrom, C.D.1    Hashemi, M.2    Sugg, J.3
  • 71
    • 84903179652 scopus 로고    scopus 로고
    • Changes in weight loss-related quality of life among type 2 diabetes mellitus patients treated with dapagliflozin
    • Grandy S, Hashemi M, Langkilde AM, et al. Changes in weight loss-related quality of life among type 2 diabetes mellitus patients treated with dapagliflozin. Diabetes Obes Metab. 2014;16:645-650
    • (2014) Diabetes Obes Metab , vol.16 , pp. 645-650
    • Grandy, S.1    Hashemi, M.2    Langkilde, A.M.3
  • 72
    • 84951905448 scopus 로고    scopus 로고
    • The sodium glucose co-transporter 2 inhibitor (SGLT2i) empagliflozin reduces weight and markers of visceral adiposity (VA) in type 2 diabetes (T2D) in short-And intermediate term [abstract]
    • Neeland I, McGuire DK, Chilton RJ, et al. The sodium glucose co-transporter 2 inhibitor (SGLT2i) empagliflozin reduces weight and markers of visceral adiposity (VA) in type 2 diabetes (T2D) in short-And intermediate term [abstract]. Circulation. 2014;130: 16518
    • (2014) Circulation , vol.130 , pp. 16518
    • Neeland, I.1    McGuire, D.K.2    Chilton, R.J.3
  • 73
    • 84951906012 scopus 로고    scopus 로고
    • Energy balance after sodium glucose cotransporter 2 (SGLT2) inhibition
    • Ferrannini G, Hach T, Crowe S, et al. Energy balance after sodium glucose cotransporter 2 (SGLT2) inhibition. Diabetes Care. 2015;38:1730-1735
    • (2015) Diabetes Care , vol.38 , pp. 1730-1735
    • Ferrannini, G.1    Hach, T.2    Crowe, S.3
  • 74
    • 84899105421 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: Results of an 8-week open-label proof-of-concept trial
    • Perkins BA, Cherney DZ, Partridge H, et al. Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial. Diabetes Care. 2014;37:1480-1483
    • (2014) Diabetes Care , vol.37 , pp. 1480-1483
    • Perkins, B.A.1    Cherney, D.Z.2    Partridge, H.3
  • 75
    • 84901198078 scopus 로고    scopus 로고
    • Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors
    • Oliva RV, Bakris GL. Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors. J Am Soc Hypertens. 2014;8:330-339
    • (2014) J Am Soc Hypertens , vol.8 , pp. 330-339
    • Oliva, R.V.1    Bakris, G.L.2
  • 76
    • 84923108094 scopus 로고    scopus 로고
    • SGLT2 inhibitors: Their potential reduction in blood pressure
    • Maliha G, Townsend RR. SGLT2 inhibitors: their potential reduction in blood pressure. J Am Soc Hypertens. 2015;9:48-53
    • (2015) J Am Soc Hypertens , vol.9 , pp. 48-53
    • Maliha, G.1    Townsend, R.R.2
  • 77
    • 84898854471 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: A systematic review and meta-Analysis
    • Baker WL, Smyth LR, Riche DM, et al. Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: A systematic review and meta-Analysis. J Am Soc Hypertens. 2014;8:262-75 e9
    • (2014) J Am Soc Hypertens , vol.8 , pp. 262-75e9
    • Baker, W.L.1    Smyth, L.R.2    Riche, D.M.3
  • 78
    • 84914154997 scopus 로고    scopus 로고
    • Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus
    • Sha S, Polidori D, Heise T, et al. Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2014;16:1087-1095
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1087-1095
    • Sha, S.1    Polidori, D.2    Heise, T.3
  • 79
    • 84938687573 scopus 로고    scopus 로고
    • Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes
    • Sjostrom CD, Johansson P, Ptaszynska A, et al. Dapagliflozin lowers blood pressure in hypertensive and non-hypertensive patients with type 2 diabetes. Diab Vasc Dis Res. 2015;12:352-358
    • (2015) Diab Vasc Dis Res , vol.12 , pp. 352-358
    • Sjostrom, C.D.1    Johansson, P.2    Ptaszynska, A.3
  • 80
    • 84893666439 scopus 로고    scopus 로고
    • Novel metabolic drugs and blood pressure: Implications for the treatment of obese hypertensive patients?
    • Engeli S, Jordan J. Novel metabolic drugs and blood pressure: implications for the treatment of obese hypertensive patients? Curr Hypertens Rep. 2013;15:470-474
    • (2013) Curr Hypertens Rep , vol.15 , pp. 470-474
    • Engeli, S.1    Jordan, J.2
  • 81
    • 84928196614 scopus 로고    scopus 로고
    • Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension
    • Tikkanen I, Narko K, Zeller C, et al. Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension. Diabetes Care. 2015;38:420-428
    • (2015) Diabetes Care , vol.38 , pp. 420-428
    • Tikkanen, I.1    Narko, K.2    Zeller, C.3
  • 82
    • 84898917720 scopus 로고    scopus 로고
    • Genital and urinary tract infections in diabetes: Impact of pharmacologicallyinduced glucosuria
    • Geerlings S, Fonseca V, Castro-Diaz D, et al. Genital and urinary tract infections in diabetes: impact of pharmacologicallyinduced glucosuria. Diabetes Res Clin Pract. 2014;103:373-381
    • (2014) Diabetes Res Clin Pract , vol.103 , pp. 373-381
    • Geerlings, S.1    Fonseca, V.2    Castro-Diaz, D.3
  • 83
    • 84863610946 scopus 로고    scopus 로고
    • Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study
    • Nicolle LE, Capuano G, Ways K, et al. Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study. Curr Med Res Opin. 2012;28:1167-1171
    • (2012) Curr Med Res Opin , vol.28 , pp. 1167-1171
    • Nicolle, L.E.1    Capuano, G.2    Ways, K.3
  • 84
    • 84904723621 scopus 로고    scopus 로고
    • Safety of canagliflozin in patients with type 2 diabetes
    • Mikhail N. Safety of canagliflozin in patients with type 2 diabetes. Curr Drug Saf. 2014;9:127-132
    • (2014) Curr Drug Saf , vol.9 , pp. 127-132
    • Mikhail, N.1
  • 85
    • 84883810898 scopus 로고    scopus 로고
    • Urinary tract infections in patients with diabetes treated with dapagliflozin
    • Johnsson KM, Ptaszynska A, Schmitz B, et al. Urinary tract infections in patients with diabetes treated with dapagliflozin. J Diabetes Complications. 2013;27:473-478
    • (2013) J Diabetes Complications , vol.27 , pp. 473-478
    • Johnsson, K.M.1    Ptaszynska, A.2    Schmitz, B.3
  • 86
    • 84934288630 scopus 로고    scopus 로고
    • Safety profile of dapagliflozin for type 2 diabetes: Pooled analysis of clinical studies for overall safety and rare events
    • Ptaszynska A, Johnsson KM, Parikh SJ, et al. Safety profile of dapagliflozin for type 2 diabetes: pooled analysis of clinical studies for overall safety and rare events. Drug Saf. 2014;37:815-829
    • (2014) Drug Saf , vol.37 , pp. 815-829
    • Ptaszynska, A.1    Johnsson, K.M.2    Parikh, S.J.3
  • 87
    • 84863617006 scopus 로고    scopus 로고
    • Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor
    • Nyirjesy P, Zhao Y, Ways K, et al. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012;28:1173-1178
    • (2012) Curr Med Res Opin , vol.28 , pp. 1173-1178
    • Nyirjesy, P.1    Zhao, Y.2    Ways, K.3
  • 88
    • 84900823374 scopus 로고    scopus 로고
    • Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • Nyirjesy P, Sobel JD, Fung A, et al. Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: A pooled analysis of clinical studies. Curr Med Res Opin. 2014;30:1109-1119
    • (2014) Curr Med Res Opin , vol.30 , pp. 1109-1119
    • Nyirjesy, P.1    Sobel, J.D.2    Fung, A.3
  • 89
    • 84883799810 scopus 로고    scopus 로고
    • Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin
    • Johnsson KM, Ptaszynska A, Schmitz B, et al. Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin. J Diabetes Complications. 2013;27:479-484
    • (2013) J Diabetes Complications , vol.27 , pp. 479-484
    • Johnsson, K.M.1    Ptaszynska, A.2    Schmitz, B.3
  • 90
    • 84906837116 scopus 로고    scopus 로고
    • Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (EGFR
    • Weir MR, Kline I, Xie J, et al. Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (eGFR). Curr Med Res Opin. 2014;30:1759-1768
    • (2014) Curr Med Res Opin , vol.30 , pp. 1759-1768
    • Weir, M.R.1    Kline, I.2    Xie, J.3
  • 91
    • 84857248030 scopus 로고    scopus 로고
    • Renal function in diabetic disease models: The tubular system in the pathophysiology of the diabetic kidney
    • Vallon V, Thomson SC. Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney. Annu Rev Physiol. 2012;74:351-375
    • (2012) Annu Rev Physiol , vol.74 , pp. 351-375
    • Vallon, V.1    Thomson, S.C.2
  • 92
    • 84903266061 scopus 로고    scopus 로고
    • Sodium/Glucose cotransporter 2 inhibitors and prevention of diabetic nephropathy: Targeting the renal tubule in diabetes
    • De Nicola L, Gabbai FB, Liberti ME, et al. Sodium/Glucose cotransporter 2 inhibitors and prevention of diabetic nephropathy: targeting the renal tubule in diabetes. Am J Kidney Dis. 2014;64:16-24
    • (2014) Am J Kidney Dis , vol.64 , pp. 16-24
    • De Nicola, L.1    Gabbai, F.B.2    Liberti, M.E.3
  • 94
    • 84962339296 scopus 로고    scopus 로고
    • Euglycemic diabetic ketoacidosis: A potential complication of treatment with sodium-glucose cotransporter 2 inhibition
    • Peters AL, Buschur EO, Buse JB, et al. Euglycemic diabetic ketoacidosis: A potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015;38:1687-1693
    • (2015) Diabetes Care , vol.38 , pp. 1687-1693
    • Peters, A.L.1    Buschur, E.O.2    Buse, J.B.3
  • 95
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • Merovci A, Solis-Herrera C, Daniele G, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014;124:509-514
    • (2014) J Clin Invest , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 96
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • Ferrannini E, Muscelli E, Frascerra S, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest. 2014;124:499-508
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 97
    • 84937763347 scopus 로고    scopus 로고
    • Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
    • Bonner C, Kerr-Conte J, Gmyr V, et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med. 2015;21:512-517
    • (2015) Nat Med , vol.21 , pp. 512-517
    • Bonner, C.1    Kerr-Conte, J.2    Gmyr, V.3
  • 98
    • 84939142605 scopus 로고    scopus 로고
    • Perspective: SGLT2 inhibitors may predispose to ketoacidosis
    • Taylor SI, Blau JE, Rother KI. Perspective: SGLT2 inhibitors may predispose to ketoacidosis. J Clin Endocrinol Metab. 2015;100:2849-2852
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 2849-2852
    • Taylor, S.I.1    Blau, J.E.2    Rother, K.I.3
  • 99
    • 84962381148 scopus 로고    scopus 로고
    • Diabetic ketoacidosis and related events in the canagliflozin type 2 diabetes clinical program
    • Erondu N, Desai M, Ways K, et al. Diabetic ketoacidosis and related events in the canagliflozin type 2 diabetes clinical program. Diabetes Care. 2015;38: 1680-1686
    • (2015) Diabetes Care , vol.38 , pp. 1680-1686
    • Erondu, N.1    Desai, M.2    Ways, K.3
  • 100
    • 84882245160 scopus 로고    scopus 로고
    • Effects of dapagliflozin on cardiovascular risk factors
    • Ptaszynska A, Hardy E, Johnsson E, et al. Effects of dapagliflozin on cardiovascular risk factors. Postgrad Med. 2013;125:181-189
    • (2013) Postgrad Med , vol.125 , pp. 181-189
    • Ptaszynska, A.1    Hardy, E.2    Johnsson, E.3
  • 101
    • 84908555003 scopus 로고    scopus 로고
    • SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria
    • Chino Y, Samukawa Y, Sakai S, et al. SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria. Biopharm Drug Dispos. 2014;35:391-404
    • (2014) Biopharm Drug Dispos , vol.35 , pp. 391-404
    • Chino, Y.1    Samukawa, Y.2    Sakai, S.3
  • 102
    • 84924677348 scopus 로고    scopus 로고
    • Effect of canagliflozin on serum uric acid in patients with type 2 diabetes mellitus
    • Davies MJ, Trujillo A, Vijapurkar U, et al. Effect of canagliflozin on serum uric acid in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2015;17:426-429
    • (2015) Diabetes Obes Metab , vol.17 , pp. 426-429
    • Davies, M.J.1    Trujillo, A.2    Vijapurkar, U.3
  • 104
    • 84867142771 scopus 로고    scopus 로고
    • Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin
    • Ljunggren O, Bolinder J, Johansson L, et al. Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin. Diabetes Obes Metab. 2012;14:990-999
    • (2012) Diabetes Obes Metab , vol.14 , pp. 990-999
    • Ljunggren, O.1    Bolinder, J.2    Johansson, L.3
  • 105
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan DE, Fioretto P, Tang W, et al. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int. 2014;85:962-971
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3
  • 106
    • 84921480876 scopus 로고    scopus 로고
    • A review on the relationship between SGLT2 inhibitors and cancer
    • Lin HW, Tseng CH. A review on the relationship between SGLT2 inhibitors and cancer. Int J Endocrinol. 2014;2014:719578
    • (2014) Int J Endocrinol , vol.2014 , pp. 719578
    • Lin, H.W.1    Tseng, C.H.2
  • 107
    • 84880543926 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: A randomized trial
    • Bode B, Stenlof K, Sullivan D, et al. Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: A randomized trial. Hosp Pract (1995).2013;41:72-84
    • (2013) Hosp Pract 1995 , vol.41 , pp. 72-84
    • Bode, B.1    Stenlof, K.2    Sullivan, D.3
  • 108
    • 84899960517 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • Sinclair A, Bode B, Harris S, et al. Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: A pooled analysis of clinical studies. BMC Endocr Disord. 2014;14:37
    • (2014) BMC Endocr Disord , vol.14 , pp. 37
    • Sinclair, A.1    Bode, B.2    Harris, S.3
  • 109
    • 84904466033 scopus 로고    scopus 로고
    • Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: A 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension
    • Leiter LA, Cefalu WT, De Bruin TW, et al. Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: A 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension. J Am Geriatr Soc. 2014;62:1252-1262
    • (2014) J Am Geriatr Soc , vol.62 , pp. 1252-1262
    • Leiter, L.A.1    Cefalu, W.T.2    De Bruin, T.W.3
  • 110
    • 84918559672 scopus 로고    scopus 로고
    • A review of the efficacy and safety of canagliflozin in elderly patients with type 2 diabetes
    • Elmore LK, Baggett S, Kyle JA, et al. A review of the efficacy and safety of canagliflozin in elderly patients with type 2 diabetes. Consult Pharm. 2014;29:335-346
    • (2014) Consult Pharm , vol.29 , pp. 335-346
    • Elmore, L.K.1    Baggett, S.2    Kyle, J.A.3
  • 111
    • 84923241159 scopus 로고    scopus 로고
    • Use of sodium-glucose cotransporter type 2 inhibitors in older adults with type 2 diabetes mellitus
    • Mikhail N. Use of sodium-glucose cotransporter type 2 inhibitors in older adults with type 2 diabetes mellitus. South Med J. 2015;108:91-96
    • (2015) South Med J , vol.108 , pp. 91-96
    • Mikhail, N.1
  • 112
    • 84898434447 scopus 로고    scopus 로고
    • Evaluating SGLT2 inhibitors for type 2 diabetes: Pharmacokinetic and toxicological considerations
    • Scheen AJ. Evaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations. Expert Opin Drug Metab Toxicol. 2014;10:647-663
    • (2014) Expert Opin Drug Metab Toxicol , vol.10 , pp. 647-663
    • Scheen, A.J.1
  • 113
    • 84882591638 scopus 로고    scopus 로고
    • The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus
    • Kasichayanula S, Liu X, Pe Benito M, et al. The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus. Br J Clin Pharmacol. 2013;76:432-444
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 432-444
    • Kasichayanula, S.1    Liu, X.2    Pe Benito, M.3
  • 114
    • 84893727925 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment
    • Macha S, Mattheus M, Halabi A, et al. Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment. Diabetes Obes Metab. 2014;16:215-222
    • (2014) Diabetes Obes Metab , vol.16 , pp. 215-222
    • Macha, S.1    Mattheus, M.2    Halabi, A.3
  • 117
    • 84876803427 scopus 로고    scopus 로고
    • Renal glucose handling: Impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes
    • Ferrannini E, Veltkamp SA, Smulders RA, et al. Renal glucose handling: impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes. Diabetes Care. 2013;36:1260-1265
    • (2013) Diabetes Care , vol.36 , pp. 1260-1265
    • Ferrannini, E.1    Veltkamp, S.A.2    Smulders, R.A.3
  • 118
    • 84904525477 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in patients with type 2 diabetes and stage 3 nephropathy
    • Yamout H, Perkovic V, Davies M, et al. Efficacy and safety of canagliflozin in patients with type 2 diabetes and stage 3 nephropathy. Am J Nephrol. 2014;40:64-74
    • (2014) Am J Nephrol , vol.40 , pp. 64-74
    • Yamout, H.1    Perkovic, V.2    Davies, M.3
  • 119
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • Yale JF, Bakris G, Cariou B, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15:463-473
    • (2013) Diabetes Obes Metab , vol.15 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 120
    • 84912527805 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes mellitus and chronic kidney disease
    • Yale JF, Bakris G, Cariou B, et al. Efficacy and safety of canagliflozin over 52 weeks in patients with type 2 diabetes mellitus and chronic kidney disease. Diabetes Obes Metab. 2014;16:1016-1027
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1016-1027
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 121
    • 84899961819 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: A randomised, doubleblind, placebo-controlled trial
    • Barnett AH, Mithal A, Manassie J, et al. Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: A randomised, doubleblind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014;2:369-384
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 369-384
    • Barnett, A.H.1    Mithal, A.2    Manassie, J.3
  • 122
    • 84874125170 scopus 로고    scopus 로고
    • Pharmacokinetic considerations for the treatment of diabetes in patients with chronic kidney disease
    • Scheen AJ. Pharmacokinetic considerations for the treatment of diabetes in patients with chronic kidney disease. Expert Opin Drug Metab Toxicol. 2013;9:529-550
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , pp. 529-550
    • Scheen, A.J.1
  • 123
    • 84876938443 scopus 로고    scopus 로고
    • The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM
    • Basile JN. The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM). J Diabetes Complications. 2013;27:280-286
    • (2013) J Diabetes Complications , vol.27 , pp. 280-286
    • Basile, J.N.1
  • 124
    • 84945175811 scopus 로고    scopus 로고
    • Dapagliflozins effects on glycemia and cardiovascular risk factors in highrisk patients with type 2 diabetes: A 24-week, multicenter, randomized, doubleblind, placebo-controlled study with a 28-week extension
    • Cefalu WT, Leiter LA, De Bruin TW, et al. Dapagliflozins effects on glycemia and cardiovascular risk factors in highrisk patients with type 2 diabetes: A 24-week, multicenter, randomized, doubleblind, placebo-controlled study with a 28-week extension. Diabetes Care. 2015;38:1218-1227
    • (2015) Diabetes Care , vol.38 , pp. 1218-1227
    • Cefalu, W.T.1    Leiter, L.A.2    De Bruin, T.W.3
  • 125
    • 84861079280 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibitors on cardiovascular outcomes
    • Foote C, Perkovic V, Neal B. Effects of SGLT2 inhibitors on cardiovascular outcomes. Diab Vasc Dis Res. 2012;9:117-123
    • (2012) Diab Vasc Dis Res , vol.9 , pp. 117-123
    • Foote, C.1    Perkovic, V.2    Neal, B.3
  • 126
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS) : A randomized placebo-controlled trial
    • Neal B, Perkovic V, De Zeeuw D, et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS) : A randomized placebo-controlled trial. Am Heart J. 2013;166:217-23 e11
    • (2013) Am Heart J , vol.166 , pp. 217-2311
    • Neal, B.1    Perkovic, V.2    De Zeeuw, D.3
  • 127
    • 84902756416 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME
    • Zinman B, Inzucchi SE, Lachin JM, et al. Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME). Cardiovasc Diabetol. 2014;13:102
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 102
    • Zinman, B.1    Inzucchi, S.E.2    Lachin, J.M.3
  • 128
    • 84934442921 scopus 로고    scopus 로고
    • Exploring the potential of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: A randomized, double-blind, placebo-controlled pilot study
    • Henry RR, Rosenstock J, Edelman S, et al. Exploring the potential of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: A randomized, double-blind, placebo-controlled pilot study. Diabetes Care. 2015;38:412-419
    • (2015) Diabetes Care , vol.38 , pp. 412-419
    • Henry, R.R.1    Rosenstock, J.2    Edelman, S.3
  • 129
    • 84942258219 scopus 로고    scopus 로고
    • Empagliflozin as adjunct to insulin in patients with type 1 diabetes: A 4-week, randomized, placebo-controlled trial (EASE-1
    • Pieber TR, Famulla S, Eilbracht J, et al. Empagliflozin as adjunct to insulin in patients with type 1 diabetes: A 4-week, randomized, placebo-controlled trial (EASE-1). Diabetes Obes Metab. 2015;17:928-935
    • (2015) Diabetes Obes Metab , vol.17 , pp. 928-935
    • Pieber, T.R.1    Famulla, S.2    Eilbracht, J.3
  • 130
    • 84885960694 scopus 로고    scopus 로고
    • SGLT2 versus DPP4 inhibitors for type 2 diabetes
    • Scheen AJ. SGLT2 versus DPP4 inhibitors for type 2 diabetes. Lancet Diabetes Endocrinol. 2013;1:168-170
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 168-170
    • Scheen, A.J.1
  • 131
    • 84898402096 scopus 로고    scopus 로고
    • The potent synergistic effects of the combination of liraglutide and canagliflozin on glycemic control and weight loss
    • Bell DS. The potent synergistic effects of the combination of liraglutide and canagliflozin on glycemic control and weight loss. Am J Case Rep. 2014;15:152-154.
    • (2014) Am J Case Rep , vol.15 , pp. 152-154
    • Bell, D.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.