Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation

Cancer Letters

Volumn 371, Issue 1, 2016, Pages 38-47

  Xue, Feng ^a   Hu, Lei ^a   Ge, Ruiliang ^a   Yang, Lixue ^a   Liu, Kai ^a   Li, Yunyun ^a   Sun, Yanfu ^a   Wang, Kui ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; DNA damage repair; Hepatic progenitor cells; Neoplastic transformation; Stemness

Indexed keywords

AUTOPHAGY PROTEIN 5; REACTIVE OXYGEN METABOLITE; ATG5 PROTEIN, RAT; ATG7 PROTEIN, RAT; CARBON TETRACHLORIDE; DIETHYLNITROSAMINE; PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CELL DAMAGE; CELL DIFFERENTIATION; CELL EXPANSION; CELL FUNCTION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; HEPATIC PROGENITOR CELL; HOMOLOGOUS RECOMBINATION; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER REGENERATION; MALE; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; ANIMAL; CELL CULTURE; CELL PROLIFERATION; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; FISCHER 344 RAT; GENETIC TRANSFECTION; GENETICS; LIVER; LIVER MITOCHONDRION; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELL; TIME FACTOR;

ANIMALS; AUTOPHAGY; CARBON TETRACHLORIDE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA REPAIR; LIVER; LIVER NEOPLASMS; LIVER REGENERATION; MALE; MITOCHONDRIA, LIVER; PROTEINS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELLS; TIME FACTORS; TRANSFECTION; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84951851433     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2015.11.022     Document Type: Article

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