Taurocholate induces cyclooxygenase-2 expression via the sphingosine 1-phosphate receptor 2 in a human cholangiocarcinoma cell line

Journal of Biological Chemistry

Volumn 290, Issue 52, 2015, Pages 30988-31002

  Liu, Runping ^a,b   Li, Xiaojiaoyang ^a   Qiang, Xiaoyan ^a,b   Luo, Lan ^a   Hylemon, Phillip B ^b   Jiang, Zhenzhou ^a,b   Zhang, Luyong ^a,b   Zhou, Huiping ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CELL CULTURE; CELLS; CHEMICAL ACTIVATION; CYTOLOGY; DIAGNOSIS; FISH; GENE EXPRESSION; LIPIDS; SPHINGOSINES;

CELLULAR MECHANISMS; CHOLANGIOCARCINOMA; EXPRESSION LEVELS; HUMAN MALIGNANCIES; PROSTAGLANDIN E2; SIGNALING CASCADES; SPHINGOSINE 1 PHOSPHATES; THERAPEUTIC TARGETS;

GENE EXPRESSION REGULATION;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BILE ACID CONJUGATE; CELECOXIB; CYCLOOXYGENASE 2; DIMETHYL SULFOXIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PROSTAGLANDIN E2; SHORT HAIRPIN RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PTGS2 PROTEIN, HUMAN; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; S1PR2 PROTEIN, HUMAN;

ARTICLE; BILE DUCT CARCINOMA; CANCER GROWTH; CHOLANGIOCARCINOMA CELL LINE; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; CELL LINE, TUMOR; CHOLANGIOCARCINOMA; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; PYRIDINES; RECEPTORS, LYSOSPHINGOLIPID; TAUROCHOLIC ACID;

EID: 84951817527     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.668277     Document Type: Article

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