Elevated expression of cyclooxygenase-2 and microsomal prostaglandin e synthase-1 in primary sclerosing cholangitis: Implications for cholangiocarcinogenesis

International Journal of Oncology

Volumn 43, Issue 4, 2013, Pages 1073-1079

  Ishii, Yasutaka ^a   Sasaki, Tamito ^a   Serikawa, Masahiro ^a   Minami, Tomoyuki ^a   Okazaki, Akihito ^a   Yukutake, Masanobu ^a   Ishigaki, Takashi ^a   Kosaka, Keiichi ^a   Mouri, Teruo ^a   Yoshimi, Satoshi ^a   Shimizu, Akinori ^a   Tsuboi, Tomofumi ^a   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cholangiocarcinoma; Cyclooxygenase 2; Microsomal prostaglandin E synthase 1; Primary sclerosing cholangitis

Indexed keywords

CYCLOOXYGENASE 2; KI 67 ANTIGEN; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2;

ARTICLE; BILE DUCT; BILE DUCT CARCINOMA; CARCINOGENESIS; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

BILE DUCT NEOPLASMS; CARCINOGENESIS; CELL PROLIFERATION; CHOLANGIOCARCINOMA; CHOLANGITIS, SCLEROSING; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; KI-67 ANTIGEN; RNA, MESSENGER;

EID: 84882297465     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2038     Document Type: Article

References (37)

1. Rosen CB, Nagorney DM, Wiesner RH, Coffey RJ Jr and LaRusso NF: Cholangiocarcinoma complicating primary sclerosing cholangitis. Ann Surg 213: 21-25, 1991.
2. Bergquist A, Ekbom A, Olsson R, et al: Hepatic and extrahepatic malignancies in primary sclerosing cholangitis. J Hepatol 36: 321-327, 2002.
3. Burak K, Angulo P, Pasha TM, Egan K, Petz J and Lindor KD: Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis. Am J Gastroenterol 99: 523-526, 2004.
4. Morris-Stiff G, Bhati C, Olliff S, et al: Cholangiocarcinoma complicating primary sclerosing cholangitis: a 24-year experience. Dig Surg 25: 126-132, 2008.
5. Sheu BS, Yang HB, Sheu SM, Huang AH and Wu JJ: Higher gastric cyclooxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patients. Clin Cancer Res 9: 5245-5251, 2003.
6. Takasu S, Tsukamoto T, Cao XY, et al: Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice. Cancer Sci 99: 2356-2364, 2008.
7. Giannitrapani L, Inqrao S, Soresi M, et al: Cycloxygenase-2 expression in chronic liver disease and hepatocellular carcinoma: an immunohistochemical study. Ann NY Acad Sci 1155: 293-299, 2009.
8. Takii Y, Abiru S, Fujioka H, et al: Expression of microsomal prostaglandin E synthase-1 in human hepatocellular carcinoma. Liver Int 17: 989-996, 2007.
9. Talero E, Sánchez-Fidalgo S, Villegas I, de la Lastra CA, Illanes M and Motilva V: Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis associated carcinogenesis. Inflamm Bowel Dis 17: 696-710, 2011.
10. Wilson KT, Fu S, Ramanujam KS and Meltzer SJ: Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinoma. Cancer Res 58: 2929-2934, 1998.
11. Jang TJ, Min SK, Bae JD, et al: Expression of cycloxygenase-2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux. Gut 53: 27-33, 2004.
12. Wang D and Dubois RN: Eicosanoids and cancer. Nat Rev Cancer 10: 181-193, 2010.
13. Koga H, Sakisaka S, Ohishi M, et al: Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology 29: 688-696, 1999.
14. Wendum D, Masliah J, Trugnan G and Fléjou JF: Cyclooxygenase-2 and its role in colorectal cancer development. Virchows Arch 445: 327-333, 2004.
15. Jang TJ: Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric and during gastric carcinogenesis. Virchows Arch 445: 564-571, 2004.
16. Davies G, Martin LA, Sacks N and Dowsett M: Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. Ann Oncol 13: 669-678, 2002.
17. Ermert L, Dierkes C and Ermert M: Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. Clin Cancer Res 9: 1604-1610, 2003.
18. Hayashi N, Yamamoto H, Hiraoka N, et al: Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. Hepatology 34: 638-650, 2001.
19. Endo K, Yoon BI, Pairojkul C, Demetris AJ and Sirica AE: ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. Hepatology 36: 439-450, 2002.
20. Chariyalersak S, Sirikulchayanonta V, Mayer D, et al: Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma. Gut 48: 80-86, 2001.
21. Wu GS, Wang JH, Liu ZR and Zou SQ: Expression of cyclooxygenase-1 and-2 in extra-hepatic cholangiocarcinoma. Hepatobiliary Pancreat Dis Int 1: 429-433, 2002.
22. Kim HJ, Lee KT, Kim EK, et al: Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis. J Gastroenterol Hepatol 19: 582-588, 2004.
23. Nzeako UC, Guicciardi ME, Yoon JH, Bronk SF and Gores GJ: COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells. Hepatology 35: 552-559, 2002.
24. Wu T, Han C, Lunz JG 3rd, Michalopoulos G, Shelhamer JH and Demetris AJ: Involement of 85-kd cytosolic phospholipase A2 and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. Hepatology 36: 363-373, 2002.
25. Han C and Wu T: Cyclooxygenase-2 derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. J Biol Chem 280: 24053-24063, 2005.
26. Tsuneoka N, Tajima Y, Kitazato A, et al: Chemopreventative effect of a cyclooxygenase-2-specific inhibitor (etodolac) on chemically induced biliary carcinogenesis in hamsters. Carcinogenesis 29: 830-833, 2008.
27. Jaiswal M, LaRusso NF, Shapiro RA, Billar TR and Gores GJ: Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology 120: 190-199, 2001.
28. Komori J, Marusawa H, Machimoto T, et al: Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma. Hepatology 47: 888-896, 2008.
29. Jakobsson PJ, Thorén S, Morgenstern R and Samuelsson B: Identification of human E synthase: a microsomal, glutathione dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96: 7220-7225, 1999.
30. Yoshimitsu K, Altorki NK, Golojanin D, et al: Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. Clin Cancer Res 7: 2669-2674, 2001.
31. Van Rees BP, Sivula A, Thorén S, et al: Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines. Int J Cancer 107: 551-556, 2003.
32. Yoshimatsu K, Golijanin D, Paty PB, et al: Inducible prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clin Cancer Res 7: 3971-3976, 2001.
33. Mehrotra S, Morimiya A, Agarwal B, Konger R and Badve S: Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy. J Pathol 208: 356-363, 2006.
34. Kawata R, Hyo S, Araki M and Takenaka H: Expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in head and neck squamous cell carcinoma. Auris Nasus Larynx 37: 482-487, 2010.
35. Lu D, Han C and Wu T: Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression. Gastroenterology 140: 2084-2094, 2011.
36. Tanabe T and Tohnai N: Cyclooxygenase isozymes and their gene structures and expression. Rostaglandins Other Lipid Mediat 68-69: 95-114, 2002.
37. Subbaramaiah K, Yoshimatsu K, Scheri E, et al: Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of transcription factor Egr-1. J Biol Chem 279: 12647-12658, 2004.