Roadmap to clinical use of gold nanoparticles for radiation sensitization

International Journal of Radiation Oncology Biology Physics

Volumn 94, Issue 1, 2016, Pages 189-205

  Schuemann, Jan ^a   Berbeco, Ross ^a   Chithrani, Devika B ^b   Cho, Sang Hyun ^c   Kumar, Rajiv ^a,d   McMahon, Stephen J ^a,e   Sridhar, Srinivas ^a,d   Krishnan, Sunil ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RYERSON UNIVERSITY   (Canada)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d NORTHEASTERN UNIVERSITY   (United States)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; CHARGED PARTICLES; FIBER OPTIC SENSORS; METAL NANOPARTICLES; RADIATION SHIELDING; RADIOTHERAPY; TUMORS; X RAYS;

CLINICAL SETTINGS; EXPERIMENTAL SYSTEM; EXPERIMENTAL VALIDATIONS; GOLD NANOPARTICLES (GNPS); LOW CONCENTRATIONS; RADIATION SENSITIZERS; RADIOSENSITIZERS; STRONG ABSORPTIONS;

GOLD NANOPARTICLES;

GOLD NANOPARTICLE; PROTON; RADIOSENSITIZING AGENT; GOLD; METAL NANOPARTICLE;

CIRCULATION TIME; COMPUTER ASSISTED TOMOGRAPHY; DOUBLE STRANDED DNA BREAK; DRUG UPTAKE; HUMAN; MACROPHAGE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PHOTON; PRIORITY JOURNAL; RADIATION DOSE; RADIOGRAPHY; RADIOSENSITIZATION; RADIOTHERAPY; REVIEW; SURFACE PROPERTY; TUMOR VASCULARIZATION; ANIMAL; CHEMISTRY; MEDICINAL CHEMISTRY; MONTE CARLO METHOD; NEOPLASMS; PROCEDURES; RADIATION TOLERANCE; THERAPEUTIC USE; VASCULARIZATION;

ANIMALS; BLOOD CIRCULATION TIME; CHEMISTRY, PHARMACEUTICAL; GOLD; HUMANS; METAL NANOPARTICLES; MONTE CARLO METHOD; NEOPLASMS; PARTICLE SIZE; PHOTONS; PROTONS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SURFACE PROPERTIES;

EID: 84951750820     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2015.09.032     Document Type: Review

References (91)

1. R. Santos Mello, H. Callisen, J. Winter, and et al. Radiation dose enhancement in tumors with iodine Med Phys 10 1983 75 78
2. K.T. Butterworth, S.J. McMahon, F.J. Currell, and et al. Physical basis and biological mechanisms of gold nanoparticle radiosensitization Nanoscale 4 2012 4830
3. J.F. Hainfeld, D.N. Slatkin, and H.M. Smilowitz The use of gold nanoparticles to enhance radiotherapy in mice Phys Med Biol 49 2004 N309 N315
4. J.K. Kim, S.J. Seo, H.T. Kim, and et al. Enhanced proton treatment in mouse tumors through proton irradiated nanoradiator effects on metallic nanoparticles Phys Med Biol 57 2012 8309 8323
5. C.J. Liu, C.H. Wang, C.C. Chien, and et al. Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification Nanotechnology 19 2008 295104
6. T. Wolfe, D. Chatterjee, J. Lee, and et al. Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo Nanomedicine 11 2015 1277 1283
7. X. Zhang, J.Z. Xing, J. Chen, and et al. Enhanced radiation sensitivity in prostate cancer by gold-nanoparticles Clin Invest Med 31 2008 E160 E167
8. S.H. Cho Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study Phys Med Biol 50 2005 N163 N173
9. S.H. Cho, B.L. Jones, and S. Krishnan The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sources Phys Med Biol 54 2009 4889 4905
10. S.J. McMahon, W.B. Hyland, M.F. Muir, and et al. Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles Sci Rep 1 2011 18
11. J. Perl, J. Shin, J. Schuemann, and et al. TOPAS: An innovative proton Monte Carlo platform for research and clinical applications Med Phys 39 2012 6818
12. Y. Lin, S.J. McMahon, M. Scarpelli, and et al. Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: A Monte Carlo simulation Phys Med Biol 59 2014 7675 7689
13. B.L. Jones, S. Krishnan, and S.H. Cho Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations Med Phys 37 2010 3809
14. M. Montenegro, S.N. Nahar, A.K. Pradhan, and et al. Monte Carlo simulations and atomic calculations for Auger processes in biomedical nanotheranostics J Phys Chem A 113 2009 12364 12369
15. J.L. Robar, S.A. Riccio, and M.A. Martin Tumour dose enhancement using modified megavoltage photon beams and contrast media Phys Med Biol 47 2002 2433 2449
16. P. Tsiamas, B. Liu, F. Cifter, and et al. Impact of beam quality on megavoltage radiotherapy treatment techniques utilizing gold nanoparticles for dose enhancement Phys Med Biol 58 2013 451 464
17. S.J. McMahon, K.T. Butterworth, C.K. McGarry, and et al. A computational model of cellular response to modulated radiation fields Int J Radiat Oncol Biol Phys 84 2012 250 256
18. Y. Lin, S.J. McMahon, H. Paganetti, and et al. Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy Phys Med Biol 60 2015 4149 4168
19. Arnida, M.M. Janát-Amsbury, A. Ray, and et al. Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages Eur J Pharm Biopharm 77 2011 417 423
20. B.D. Chithrani, A.A. Ghazani, and W.C. Chan Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells Nano Lett 6 2006 662 668
21. J.D. Carter, N.N. Cheng, Y. Qu, and et al. Nanoscale energy deposition by x-ray absorbing nanostructures J Phys Chem B 111 2007 11622 11625
22. K.T. Butterworth, J.A. Coulter, S. Jain, and et al. Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy Nanotechnology 21 2010 295101
23. D.B. Chithrani, S. Jelveh, F. Jalali, and et al. Gold nanoparticles as radiation sensitizers in cancer therapy Radiat Res 173 2010 719 728
24. H. Gao, W. Shi, and L.B. Freund Mechanics of receptor-mediated endocytosis Proc Natl Acad Sci U S A 102 2005 9469 9474
25. J.A. Champion, Y.K. Katare, and S. Mitragotri Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers J Control Release 121 2007 3 9
26. J.C. Kah, K.Y. Wong, K.G. Neoh, and et al. Critical parameters in the pegylation of gold nanoshells for biomedical applications: an in vitro macrophage study J Drug Target 17 2009 181 193
27. C. Yang, J. Uertz, D. Yohan, and et al. Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention Nanoscale 6 2014 12026 12033
28. Y. Zheng, D.J. Hunting, P. Ayotte, and et al. Radiosensitization of DNA by gold nanoparticles irradiated with high-energy electrons Radiat Res 169 2008 19 27
29. F. Xiao, Y. Zheng, P. Cloutier, and et al. On the role of low-energy electrons in the radiosensitization of DNA by gold nanoparticles Nanotechnology 22 2011 465101
30. M.K. Leung, J.C.L. Chow, B.D. Chithrani, and et al. Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production Med Phys 38 2011 624 631
31. H.S. Choi, W. Liu, P. Misra, and et al. Renal clearance of quantum dots Nat Biotechnol 25 2007 1165 1170
32. R. Kumar, I. Roy, T.Y. Ohulchanskky, and et al. In vivo biodistribution and clearance studies using multimodal organically modified silica nanoparticles ACS Nano 4 2010 699 708
33. K. Huang, H. Ma, J. Liu, and et al. Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo ACS Nano 6 2012 4483 4493
34. L.Y. Chou, and W.C. Chan Fluorescence-tagged gold nanoparticles for rapidly characterizing the size-dependent biodistribution in tumor models Adv Healthc Mater 1 2012 714 721
35. W.S. Cho, M. Cho, J. Jeong, and et al. Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles Toxicol Appl Pharmacol 236 2009 16 24
36. Y. Geng, P. Dalhaimer, S. Cai, and et al. Shape effects of filaments versus spherical particles in flow and drug delivery Nat Nanotechnol 2 2007 249 255
37. A. Pluen, P.A. Netti, R.K. Jain, and et al. Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations Biophys J 77 1999 542 552
38. S.Y. Lee, M. Ferrari, and P. Decuzzi Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows Nanotechnology 20 2009 495101
39. P. Tiwari, K. Vig, V. Dennis, and et al. Functionalized gold nanoparticles and their biomedical applications Nanomaterials 1 2011 31 63
40. A. Verma, O. Uzun, Y. Hu, and et al. Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles Nat Mater 7 2008 588 595
41. X.D. Zhang, D. Wu, X. Shen, and et al. Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy Biomaterials 33 2012 6408 6419
42. J. Lipka, M. Semmler-Behnke, R.A. Sperling, and et al. Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection Biomaterials 31 2010 6574 6581
43. S. Hirn, M. Semmler-Behnke, C. Schleh, and et al. Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration Eur J Pharm Biopharm 77 2011 407 416
44. H. Maeda, J. Fang, T. Inutsuka, and et al. Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications Int Immunopharmacol 3 2003 319 328
45. S. Unezaki, K. Maruyama, J.I. Hosoda, and et al. Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy Int J Pharm 144 1996 11 17
46. J.F. Hainfeld, H.M. Smilowitz, M.J. O'Connor, and et al. Gold nanoparticle imaging and radiotherapy of brain tumors in mice Nanomedicine (Lond) 8 2013 1601 1609
47. J.F. Hainfeld, F.A. Dilmanian, Z. Zhong, and et al. Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma Phys Med Biol 55 2010 3045 3059
48. P. Diagaradjane, A. Shetty, J.C. Wang, and et al. Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy Nano Lett 8 2008 1492 1500
49. D.B. Chithrani, M. Dunne, J. Stewart, and et al. Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier Nanomedicine 6 2010 161 169
50. B. Kneidl, M. Peller, G. Winter, and et al. Thermosensitive liposomal drug delivery systems: state of the art review Int J Nanomedicine 9 2014 4387 4398
51. X. Huang, X. Peng, Y. Wang, and et al. A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands ACS Nano 4 2010 5887 5896
52. N. Chattopadhyay, Z. Cai, Y.L. Kwon, and et al. Molecularly targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor xenografts to X-radiation Breast Cancer Res Treat 137 2013 81 91
53. H.J. Park, R.J. Griffin, S. Hui, and et al. Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS) Radiat Res 177 2012 311 327
54. D.W. Siemann The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents Cancer Treat Rev 37 2011 63 74
55. D.W. Siemann, and M.R. Horsman Vascular targeted therapies in oncology Cell Tissue Res 335 2009 241 248
56. D.W. Siemann, E. Mercer, S. Lepler, and et al. Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy Int J Cancer 99 2002 1 6
57. E.A. Murphy, B.K. Majeti, L.A. Barnes, and et al. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis Proc Natl Acad Sci U S A 105 2008 9343 9348
58. O.C. Boerman, R.M. Sharkey, R.D. Blumenthal, and et al. The presence of a concomitant bulky tumor can decrease the uptake and therapeutic efficacy of radiolabeled antibodies in small tumors Int J Cancer 51 1992 470 475
59. R. Murata, D.W. Siemann, J. Overgaard, and et al. Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid Radiat Res 156 2001 503 509
60. D.W. Siemann, and A.M. Rojiani The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors Radiat Oncol Biol 62 2005 846 853
61. W.R. Wilson, A.E. Li, D.S. Cowan, and et al. Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid Radiat Oncol Biol 42 1998 905 908
62. S.D. Perrault, C. Walkey, T. Jennings, and et al. Mediating tumor targeting efficiency of nanoparticles through design Nano Lett 9 2009 1909 1915
63. S. Kunjachan, A. Detappe, R. Kumar, and et al. Nanoparticle mediated tumor vascular disruption: A novel strategy in radiation therapy Nano Lett 15 2015 7488 7496
64. D.Y. Joh, L. Sun, M. Stangl, and et al. Selective targeting of brain tumors with gold nanoparticle-induced radiosensitization Castro MG, ed PLoS One 8 2013 e62425
65. R.I. Berbeco, W. Ngwa, and G.M. Makrigiorgos Localized dose enhancement to tumor blood vessel endothelial cells via megavoltage x-rays and targeted gold nanoparticles: new potential for external beam radiotherapy Int J Radiat Oncol Biol Phys 81 2011 270 276
66. A. Detappe, P. Tsiamas, W. Ngwa, and et al. The effect of flattening filter free delivery on endothelial dose enhancement with gold nanoparticles Med Phys 40 2013 031706
67. W.S. Cho, M. Cho, J. Jeong, and et al. Size-dependent tissue kinetics of PEG-coated gold nanoparticles Toxicol Appl Pharmacol 245 2010 116 123
68. S.J. Soenen, B. Manshian, J.M. Montenegro, and et al. Cytotoxic effects of gold nanoparticles: a multiparametric study ACS Nano 6 2012 5767 5783
69. R. Kumar, H. Korideck, W. Ngwa, and et al. Third generation gold nanoplatform optimized for radiation therapy Transl Cancer Res 2 2013
70. C.M. Goodman, C.D. McCusker, T. Yilmaz, and et al. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains Bioconjug Chem 15 2004 897 900
71. D. Kim, S. Park, J.H. Lee, and et al. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging J Am Chem Soc 129 2007 7661 7665
72. S.K. Cheong, B.L. Jones, A.K. Siddiqi, and et al. x-ray fluorescence computed tomography (XFCT) imaging of gold nanoparticle-loaded objects using 110 kVp x-rays Phys Med Biol 55 2010 647 662
73. A. Agarwal, S.W. Huang, M. O'Donnell, and et al. Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging J Appl Phys 102 2007 064701
74. X.M. Qian, and S.M. Nie Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications Chem Soc Rev 37 2008 912 920
75. X. Huang, and M.A. El-Sayed Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy J Adv Res 1 2010 13 28
76. K. Sokolov, M. Follen, J. Aaron, and et al. Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles Cancer Res 63 2003 1999 2004
77. A. la Zerda de, S. Prabhulkar, V.L. Perez, and et al. Optical coherence contrast imaging using gold nanorods in living mice eyes Clin Experiment Ophthalmol 43 2015 358 366
78. J.V. Jokerst, A.J. Cole, D. Van de Sompel, and et al. Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice ACS Nano 6 2012 10366 10377
79. N. Manohar, F.J. Reynoso, and S.H. Cho Experimental demonstration of direct L-shell x-ray fluorescence imaging of gold nanoparticles using a benchtop x-ray source Med Phys 40 2013 080702
80. J.F. Hainfeld, M.J. O'Connor, F.A. Dilmanian, and et al. Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions Br J Radiol 84 2011 526 533
81. D.P. Clark, K. Ghaghada, E.J. Moding, and et al. In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT Phys Med Biol 58 2013 1683 1704
82. J.A. Park, P.A. Reddy, H.K. Kim, and et al. Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent Bioorg Med Chem Lett 18 2008 6135 6137
83. I. Miladi, C. Alric, S. Dufort, and et al. The in vivo radiosensitizing effect of gold nanoparticles based MRI contrast agents Small 10 2014 1116 1124
84. G. Zhang, Z. Yang, W. Lu, and et al. Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice Biomaterials 30 2009 1928 1936
85. D. Nagesha, G.S. Laevsky, P. Lampton, and et al. In vitro imaging of embryonic stem cells using multiphoton luminescence of gold nanoparticles Int J Nanomedicine 2 2007 813 819
86. D.B. Chithrani Intracellular uptake, transport, and processing of gold nanostructures Mol Membr Biol 27 2010 299 311
87. I.C. Sun, D.K. Eun, H. Koo, and et al. Tumor-targeting gold particles for dual computed tomography/optical cancer imaging Angew Chem Int Ed Engl 50 2011 9348 9351
88. B.L. Jones, N. Manohar, F. Reynoso, and et al. Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams Phys Med Biol 57 2012 N457 N467
89. Y. Kuang, G. Pratx, M. Bazalova, and et al. First demonstration of multiplexed x-ray fluorescence computed tomography (XFCT) imaging IEEE Trans Med Imaging 32 2013 262 267
90. Y.R. Lawrence, B. Vikram, J.J. Dignam, and et al. NCI-RTOG translational program strategic guidelines for the early-stage development of radiosensitizers J Natl Cancer Inst 105 2013 11 24
91. Y. Zheng, and L. Sanche Gold nanoparticles enhance DNA damage induced by anti-cancer drugs and radiation Radiat Res 172 2009 114 119