Biological effects, total phenolic content and flavonoid concentrations of fragrant yellow onion (Allium flavum L.)

Medicinal Chemistry

Volumn 8, Issue 1, 2012, Pages 46-51

  Curcic, Milena G ^a   Stankovic, Milan S ^a   Radojevic, Ivana D ^a   Stefanovic, Olgica D ^a   Comic, Ljiljana R ^a   Topuzovic, Marina D ^a   Djacic, Dragana S ^a   Markovic, Snezana D ^a  

^a UNIVERSITY OF KRAGUJEVAC   (Serbia)

Author keywords

Allium flavum; Antibacterial; Antioxidant; Antiproliferative activity; Extracts; Flavonoids; Phenols

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETIC ACID ETHYL ESTER; ACETONE; ALLIUM FLAVUM EXTRACT; ALUMINUM CHLORIDE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; FLAVONOID; FRAGRANCE; METHANOL; PHENOL DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ALLIUM FLAVUM; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CELL STRAIN HCT116; DRUG DETERMINATION; DRUG EFFECT; DRUG MONITORING; ESCHERICHIA COLI; IC 50; NONHUMAN; ONION; PRIORITY JOURNAL; SOLVENT EXTRACTION; SPECTROPHOTOMETRY; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BACILLUS SUBTILIS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ESCHERICHIA COLI; FLAVONOIDS; HUMANS; MICROBIAL SENSITIVITY TESTS; ONIONS; PHENOLS; PLANT EXTRACTS; STAPHYLOCOCCUS AUREUS; TUMOR CELLS, CULTURED;

EID: 84858224966     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/157340612799278441     Document Type: Article

References (45)

1. Tatic, B. Allium. In: Flore de la Republique Socialiste de Serbie VI, Josifovic M, Ed, Acad. Serb. Sci. & Arts: Belgrade (in Serbian), 1975; 568-592.
2. Gareth, G.; Laurence, T.; Timothy, C.; Brian, T.; Brian, S. Onions - A global benefit to health. Phytother. Res., 2002, 16(7), 603-615.
3. Dion, M.E.; Milner, J.A. Formation and bioactivation of nitrosomorpholine is inhibited by S-allyl cystein. Exp. Biol., 1996, 96, 41-62.
4. Block, E. The chemistry of garlic and onions. Sci. Am., 1985, 252, 114-119.
5. Steiner, M.; Lin, R.I. Cardiovascular and lipid changes in response to aged garlic extract ingestion. J. Amer. Coll. Nutr., 1994, 13, 542-548.
6. Simon, C.B.H.; Shanqin, X. Effects of allyl mercaptan and various allium-derived compounds on cholesterol synthesis and secretion in Hep-G2 cells. Comp. Biochem. Physiol. C, 2000, 126, 195-201.
7. Štajner D.; Milic, N.; Lazic, B.; Mimica-Dukic, N. Study on antioxidant enzymes in Allium cepa L. and Allium fustulosum L. Phytother. Res., 1998a, 12, 15-17.
8. Štajner, D.; Milic, N.; Mimica-Dukic, N.; Lazic, B.; Igic, R. Antioxidant abilities of cultivated and wild species of garlic. Phytother. Res., 1998b, 12, 13-14.
9. Štajner, D.; Milic-DeMarino, N.; Canadanovic-Brunet, J. Screening for antioxidant properties of leeks, Allium sphaerocephalum L. J. Herbs Spices Med. Plants, 2003, 10, 73-82.
10. Štajnertajner, D.; Milic, N.; Canadanovic-Brunet, J.; Kapor, A.; Štajnertajner, M.; Popovic, B.M. Exploring Allium species as a source of potential medicinal agents. Phytother. Res., 2006, 20, 581-584. (Pubitemid 44065141)
11. Yin, M.; Tsao, S. Inhibitory effect of seven Allium plants upon three Aspergillus species. Int. J. Food Microbiol., 1999, 49, 49-56. (Pubitemid 29329424)
12. Sivam, G.P. Protection against Helicobacter pylori and other bacterial infections by garlic. J. Nutr., 2001, 131, 1106-1108.
13. Benkeblia, N. Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garlic (Allium sativum). LWTFood Sci. Technol., 2004, 37(2), 263-268. (Pubitemid 38504008)
14. Pyun, M.S.; Shin, S. Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole. Phytomedicine, 2006, 13, 394-400. (Pubitemid 43728725)
15. Chen, C.H.; Chou, T.W.; Cheng, L.H., Ho, C.W. In vitro antiadenoviral activity of five Allium plants. J. Taiwan Inst. Chem. E., 2011, 42, 228-232.
16. Kaschula, C.H; Hunter, R.; Parker, M.I. Garlic-derived anticancer agents: structure and biological activity of ajoene. Biofactors, 2010, 36(1), 78-85.
17. Lanzotti, V. The Analysis of Onion and Garlic. J. Chromatogr., 2006, 1112(1-2), 3-22.
18. Carson, J.F. Chemistry and biological properties of onions and garlic. Food Rev. Internat., 1987, 3, 1-103.
19. Craig, W.J. Health-promoting properties of common herbs. Am. J. Clin. Nutr., 1999, 70(3), 491-499.
20. Haim, T.; Townsend, D.M.; Kenneth, D. Tew Organosulfur compounds from Alliaceae in the prevention of human pathologies. Biomed. Pharmacother., 2004, 58, 183-193.
21. Rose, P.; Whiteman, M.; Moore, P.K.; Zhu, Y.Z. Bioactives salk (en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Nat. Prod. Rep., 2005, 22, 351-368.
22. Bonaccorsi, P.; Carisiti, C.; Gargiulli, C.; Leuzzi, U. Flavonol glucosides in Allium species: A comparative study by means of HPLC-DAD-ESI-MS-MS. Food Chem., 2008, 107(4), 1668-1673. (Pubitemid 350176634)
23. Parvu, M.; Toiu, A.; Vlase, L.; Alina Parvu, E. Determination of some polyphenolic compounds from Allium species by HPLC-UVMS. Nat. Prod. Res., 2010, 24(14), 1318-24.
24. Singleton, V.L.; Orthofer, R.; Lamuela, R.R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol., 1999, 299, 152-178.
25. Quettier, D.C.; Gressier, B.; Vasseur, J.; Dine, T.; Brunet, C.; Luyckx, M.C.; Cayi, J.C.; Bailleul, F.; Trotin, F. Phenolic compounds and antioxidant activities of buckwheat (Fagopyrum esculentum Moench) hulls and flour. J. Ethnopharmacol., 2000, 72, 35-42.
26. Tekao, T.; Watanabe, N.; Yagi, I.; Sakata, K. A simple screening method for antioxidant and isolation of several antioxidants produced by marine bacteria from fish and shellfish. Biosci. Biotechnol. Biochem., 1994, 58, 1780-1783.
27. Kumarasamy, Y.; Byres, M.; Cox, P.J.; Jasapars, M.; Nahar, L.; Sarker, S.D. Screening seeds of some Scottish plants for freeradical scavenging activity. Phytother. Res., 2007, 21, 615-621. (Pubitemid 47066773)
28. Sarker, S.D.; Nahar, L.; Kumarasamy, Y. Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals. Methods, 2007, 42, 321-324. (Pubitemid 46856865)
29. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 1983, 65, 55-63. (Pubitemid 14203433)
30. Stankovic, M.S.; Topuzovic, M.; Solujic, S.; Mihailovic, V. Antioxidant activity and concentration of phenols and flavonoids in the whole plant and plant parts of Teucrium chamaedrys L. var. glanduliferum Haussk. J. Med. Plant Res., 2010, 4, 2092-2098.
31. Zhou, K.; Yu, L. Effects of extraction solvent on wheat bran antioxidant activity estimation. LWT-Food Sci. Technol., 2004, 37, 717-721. (Pubitemid 39040400)
32. Min, G.; Chun-Zhao, L. Comparison of techniques for the extraction of flavonoids from cultured cells of Saussurea medusa Maxim. World J. Microb. Biot., 2005, 21, 1461-1463.
33. Katalinic, V.; Miloš, M.; Kulišic, T.; Jukic, M. Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols. Food Chem., 2004, 94, 550-557.
34. Corzo-Martinez, M.; Corzo, N.; Villamiel, M. Biological properties of onions and garlic trends. Food Sci. Technol., 2007, 18, 609-625. (Pubitemid 350008034)
35. Delaha, E.C.; Garagusi, V.F. Inhibition of mycobacterial by garlic extract (Allium sativum). Antimicrob. Agents Chemother., 1985, 27, 485-486. (Pubitemid 15097643)
36. Najjaa, H.; Neffati, M.; Zouari, S.; Ammar E. Essential oil composition and antibacterial activity of different extracts of Allium roseum L., a North African endemic species. C. R. Chimie, 2007, 10, 820-826.
37. Cragg, G.M.; Boyd, M.R.; Khanna, R.; Kneller, R.; Mays, T.D.; Mazan, K.D.; Newman, D.J.; Sausville, E.A. International collaboration in drug discovery and development: the NCI experience. Pure. Appl. Chem., 1999, 71, 1619-1633.
38. Rajesh, R.P.; Ramasamy, M.S.; Murugan, A. Anticancer activity of the Ascidian Polyclinum Indicum againist cervical cancer cells (HeLa) mediated throught apoptosis induction. Med. Chem., 2010, 6(6), 396-405.
39. Verpoorte, R. Pharmacognosy in the new millennium: leadfinding and biotechnology. J. Pharm. Pharmacol., 2000, 52, 253-262. (Pubitemid 30189379)
40. Wang, H.K. Plant-derived anticancer agents currently in clinical use or in clinical trials. I. Drugs, 1998, 1, 92-102.
41. Lee, K.H. Novel antitumor agents from higher plants. Med. Res. Rev., 1999, 19, 569-96.
42. Kim, J.; Park, E.J. Cytotoxic anticancer candidates from natural sources. Curr. Med. Chem. Anticancer Agents, 2002, 2, 485-537. (Pubitemid 34649887)
43. Crag, G.M.; Newman, D.J. Plants as a source of anticancer agents. J. Ethopharmacol., 2005, 100, 72-79.
44. Tan, G.; Gyllenhaal, C.; Sorjarto, D.D. Biodiversity as a source of anticancer drugs. Curr. Drug. Targets, 2006, 7, 265-277.
45. Suffness, M.; Pezzuto, J.M. Assays related to cancer drug discovery. In: Methods in Plant Biochemistry: Assays for Bioactivity, Hostettmann, K, Ed.; Academic Press: London, 1990; Vol. 6, pp. 71-133.