Autophagy in macrophages regulates the inflammasome and protects against liver injury

Journal of Hepatology

Volumn 64, Issue 1, 2016, Pages 16-18

  Ding, Wen Xing ^a   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Inflammation; Liver injury; Macrophage

Indexed keywords

ALANINE AMINOTRANSFERASE; FAT DROPLET; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 14; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA; PROTECTIVE AGENT;

ALCOHOL LIVER DISEASE; AUTOPHAGY; CELL DEATH; CHRONIC LIVER DISEASE; EDITORIAL; ENDOTOXIN-INDUCED LIVER INJURY; EXTRAVASATION; HUMAN; INFLAMMATION; LIPID DEGRADATION; LIVER CELL; LIVER DISEASE; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TOXIC HEPATITIS; LIVER;

AUTOPHAGY; HUMANS; INFLAMMASOMES; LIVER; MACROPHAGES; PROTECTIVE AGENTS;

EID: 84951335857     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.10.003     Document Type: Editorial

References (20)

1. C. Brenner, L. Galluzzi, O. Kepp, and G. Kroemer Decoding cell death signals in liver inflammation J Hepatol 59 2013 583 594
2. H.M. Ni, B.L. Woolbright, J. Williams, B. Copple, W. Cui, J.P. Luyendyk, and et al. Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy J Hepatol 61 2014 617 625
3. M.J. Czaja, W.X. Ding, T.M. Donohue Jr., S.L. Friedman, J.S. Kim, M. Komatsu, and et al. Functions of autophagy in normal and diseased liver Autophagy 9 2013 1131 1158
4. W.X. Ding, M. Li, X. Chen, H.M. Ni, C.W. Lin, W. Gao, and et al. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice Gastroenterology 139 2010 1740 1752
5. M. Amir, E. Zhao, L. Fontana, H. Rosenberg, K. Tanaka, G. Gao, and et al. Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation Cell Death Differ 20 2013 878 887
6. H.M. Ni, A. Bockus, N. Boggess, H. Jaeschke, and W.X. Ding Activation of autophagy protects against acetaminophen-induced hepatotoxicity Hepatology 55 2012 222 232
7. K. Liu, E. Zhao, G. Ilyas, G. Lalazar, Y. Lin, M. Haseeb, and et al. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization Autophagy 11 2015 271 284
8. J. Lodder, T. Denaes, M.N. Chobert, J. Wan, J. El-Benna, J.M. Pawlotsky, and et al. Macrophage autophagy protects against liver fibrosis in mice Autophagy 11 2015 1280 1292
9. G. Ilyas, E. Zhao, K. Liu, Y. Lin, L. Tesfa, K.E. Tanaka, and et al. Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1 beta J Hepatol 64 2016 118 127
10. X.M. Yin, and W.X. Ding Death receptor activation-induced hepatocyte apoptosis and liver injury Curr Mol Med 3 2003 491 508
11. H. Jaeschke, M.A. Fisher, J.A. Lawson, C.A. Simmons, A. Farhood, and D.A. Jones Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model J Immunol 160 1998 3480 3486
12. T. Saitoh, N. Fujita, M.H. Jang, S. Uematsu, B.G. Yang, T. Satoh, and et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production Nature 456 2008 264 268
13. W.X. Ding, and X.M. Yin Mitophagy: mechanisms, pathophysiological roles, and analysis Biol Chem 393 2012 547 564
14. M.L. Bajt, A. Farhood, and H. Jaeschke Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature Am J Physiol Gastrointest Liver Physiol 281 2001 G1188 G1195
15. N.A. Essani, M.A. Fisher, A. Farhood, A.M. Manning, C.W. Smith, and H. Jaeschke Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure Hepatology 21 1995 1632 1639
16. J.S. Gujral, J.A. Hinson, A. Farhood, and H. Jaeschke NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia Am J Physiol Gastrointest Liver Physiol 287 2004 G243 G252
17. R.B. Dorman, J.S. Gujral, M.L. Bajt, A. Farhood, and H. Jaeschke Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia Am J Physiol Gastrointest Liver Physiol 288 2005 G880 G886
18. C.W. Lin, H. Zhang, M. Li, X. Xiong, X. Chen, X.C. Dong, and et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice J Hepatol 58 2013 993 999
19. V. Hernandez-Gea, Z. Ghiassi-Nejad, R. Rozenfeld, R. Gordon, M.I. Fiel, Z. Yue, and et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues Gastroenterology 142 2012 938 946
20. A. Mallat, J. Lodder, F. Teixeira-Clerc, R. Moreau, P. Codogno, and S. Lotersztajn Autophagy: a multifaceted partner in liver fibrosis Biomed Res Int 2014 2014 869390