Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Pharmaceutical Biology

Volumn 54, Issue 9, 2016, Pages 1716-1726

  Krishnasamy, Gopinath ^a   Muthusamy, Karthikeyan ^a   Chellappan, David Raj ^b   Subbiah, Nagarajan ^b  

^a ALAGAPPA UNIVERSITY   (India)

^b SASTRA UNIVERSITY   (India)

Author keywords

blood glucose level; diabetes induction; diabetes mellitus; medicinal plant; Cell restoration

Indexed keywords

ACETIC ACID ETHYL ESTER; ALCOHOL; ASCORBIC ACID; CARBOHYDRATE; CATALASE; CHOLESTEROL; CREATININE; FLAVONOID; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; HEMOGLOBIN A1C; HEXANE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINAMIDE; PHENOL DERIVATIVE; PLANT EXTRACT; QUINONE DERIVATIVE; STEROL; STREPTOZOCIN; SUPEROXIDE DISMUTASE; SYZYGIUM DENSIFLORUM EXTRACT; TERPENOID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; URIC ACID; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; ANTIOXIDANT; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLYCOGEN; LIPID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIHYPERLIPIDAEMIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG SAFETY; ENZYME ACTIVITY; FEMALE; FRUIT; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; KIDNEY LEVEL; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PHYTOCHEMISTRY; RAT; SYZYGIUM; SYZYGIUM DENSIFLORUM; TISSUE LEVEL; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL; ANIMAL; BLOOD; CELL PROLIFERATION; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; ISOLATION AND PURIFICATION; LIPID PEROXIDATION; LIVER; MEDICINAL PLANT; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHYTOTHERAPY; REGENERATION; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; BIOMARKERS; BLOOD GLUCOSE; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FRUIT; GLUCOSE TOLERANCE TEST; GLYBURIDE; GLYCOGEN; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN-SECRETING CELLS; LIPID PEROXIDATION; LIPIDS; LIVER; MALE; NIACINAMIDE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS, WISTAR; REGENERATION; STREPTOZOCIN; SYZYGIUM;

EID: 84951276396     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2015.1125932     Document Type: Article

References (61)

1. D.H.Abdelaziz, S.A.Ali, M.M.Mostafa 2015. Phoenix dactylifera seeds ameliorate early diabetic complications in streptozotocin-induced diabetic rats. Pharm Biol. 53:792–799.
2. T.Arif, B.Sharma, A.Gahlaut, V.Kumar, R.Dabur. 2014. Anti-diabetic agents from medicinal plants:a review. Chem Biol Lett. 1:1–13.
3. S.L.Badole, S.L.Bodhankar 2010. Antidiabetic activity of cycloart-23-ene-3beta, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice. Eur J Pharmacol. 632:103–109.
4. A.Bag, S.K.Bhattacharyya, N.K.Pal, R.R.Chattopadhyay. 2012. In vitro antibacterial potential of Eugenia jambolana seed extracts against multidrug-resistant human bacterial pathogens. Microbiol Res. 167:352–357.
5. P.Bagri, M.Ali, V.Aeri, M.Bhowmik, S.Sultana. 2009. Antidiabetic effect of Punica granatum flowers:effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol. 47:50–54.
6. M.S.Baliga, H.P.Bhat, B.R.V.Baliga, R.Wilson, P.L.Palatty. 2011. Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam. (black plum):a review. Food Res Int. 44:1776–1789.
7. M.D.Bhat, B.N.Joshi 2011. Seeds of Syzygium cumini (L.) Skeels:potential for islet regeneration in experimental diabetes. Zhong Xi Yi Jie He Xue Bao. 9:1380–1387.
8. P.S.Ciechanowski, W.J.Katon, J.E.Russo, E.A.Walker. 2001. The patient-provider relationship:attachment theory and adherence to treatment in diabetes. Am J Psychiatry. 158:29–35.
9. M.S.Deutschländer, N.Lall, M.Van de Venter, S.Dewanjee 2012. The hypoglycemic activity of Euclea undulata Thunb. var. myrtina (Ebenaceae) root bark evaluated in a streptozotocin-nicotinamide induced type 2 diabetes rat model. South African J Bot. 80:9–12.
10. S.Dewanjee, A.K.Das, R.Sahu, M.Gangopadhyay 2009. Antidiabetic activity of Diospyros peregrina fruit:effect on hyperglycemia, hyperlipidemia and augmented oxidative stress in experimental type 2 diabetes. Food Chem Toxicol. 47:2679–2685.
11. G.L.Ellman 1959. Tissue sulfhydryl groups. Arch Biochem Biophys. 82:70–77.
12. K.Gopinath, M.Karthikeyan 2015. In vitro evaluation of antioxidant and antidiabetic activities of Syzygium densiflorum fruits. Asian Pacific J Trop Dis. 5:912–917.
13. A.Helmstädter 2008. Syzygium cumini (L.) Skeels (Myrtaceae) against diabetes – 125 years of research. Pharmazie 63:91–101.
14. K.Hermansen, L.S.Mortensen 2007. Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus. Drug Saf. 30:1127–1142.
15. D.Huang, Y.Jiang, W.Chen, F.Yao, G.Huang, L.Sun. 2015. Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense. J Ethnopharmacol. 163:256–263.
16. IDF. 2014. IDF Diabetes Atlas. 6th edn. 2014 update. Belgium:International Diabetes Federation.
17. K.Karthikesan, L.Pari, V.Menon 2010. Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on streptozotocin-nicotinamide-induced diabetic rats. Gen Physiol Biophys. 29:23–30.
18. C.Kharbanda, M.Sarwar Alam, H.Hamid, S.Bano, S.Haider, S.Nazreen, Y.Ali, K.Javed. 2014. Trapa natans L. root extract suppresses hyperglycemic and hepatotoxic effects in STZ-induced diabetic rat model. J Ethnopharmacol. 151:931–936.
19. R.Kumar, D.K.Pate, S.K.Prasad, K.Sairam, S.Hemalatha. 2011. Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats. Asian Pac J Trop Med. 4:904–909.
20. A.T.Larkin, C.Hoffman, A.Stevens, A.Douglas, Z.Bloomgarden. 2015. Determinants of adherence to diabetes treatment. J Diabetes. 6:864–871.
21. G.Mahendran, M.Manoj, E.Murugesh, R.Sathish Kumar, P.Shanmughavel, K.J.Rajendra Prasad, V.Narmatha Bai. 2014a. In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β-d-xylopyranosyl isolated from Swertia corymbosa. Phytomedicine 21:1237–1248.
22. G.Mahendran, G.Thamotharan, S.Sengottuvelu, V.N.Bai 2014b. Anti-diabetic activity of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke aerial parts extract in streptozotocin induced diabetic rats. J Ethnopharmacol. 151:1175–1183.
23. S.Marklund, G.Marklund 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 47:469–474.
24. R.R.Mendonça-Filho 2006. Bioactive phytocompounds:new approaches in the phytosciences. In:I.Ahmad, F.Aqil, M.Owais, editors. Modern phytomedicine:turning medicinal plants into drugs. Weinheim:WILEY-VCH Verlag GmbH & Co. p. 1–24.
25. R.M.Mohan Maruga, D.Agilandeswari, S.Dhanabal 2013. Pharmacognostical, antidiabetic and antioxidant studies on Syzygium densiflorum leaves. Contemp Investig Obs Pharm. 2:43–51.
26. D.E.Moller 2001. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414:821–827.
27. A.Mootoosamy, M.Fawzi Mahomoodally 2014. Ethnomedicinal application of native remedies used against diabetes and related complications in Mauritius. J Ethnopharmacol. 151:413–444.
28. F.Moradi-Afrapoli, B.Asghari, S.Saeidnia, Y.Ajani, M.Mirjani, M.Malmir, R.Dalatabadi, A.Hadjiakhoondi, P.Salehi, M.Hamburger,. 2012. In vitro α-glucosidase inhibitory activity of phenolic constituents from aerial parts of Polygonum hyrcanicum. DARU 20:1–6.
29. S.Naskar, U.K.Mazumder, G.Pramanik, M.Gupta, R.B.Suresh Kumar, A.Bala, A.Islam. 2011. Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats. J Ethnopharmacol. 138:769–773.
30. W.G.J.NiehausWG Jr, B.Samuelsson 1968. Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem. 6:126–130.
31. OECD. (2001). Guidelines for testing of chemicals, guidance. Section 4. Test Guideline 425:Acute Oral Toxicity-Up-and-Down Procedure. 1–26
32. O.O.Olubomehin, K.A.Abo, E.O.Ajaiyeoba 2013. Alpha-amylase inhibitory activity of two Anthocleista species and in vivo rat model anti-diabetic activities of Anthocleista djalonensis extracts and fractions. J Ethnopharmacol. 146:811–814.
33. S.T.Omaye, J.D.Turnbull, H.E.Sauberlich 1979. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. 62:3–11.
34. P.Palsamy, S.Subramanian 2009. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Chem Biol Interact. 179:356–362.
35. L.Pari, S.Srinivasan 2010. Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Biomed Pharmacother. 64:477–481.
36. D.K.Patel, S.K.Prasad, R.Kumar, S.Hemalatha 2012. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2:320–330.
37. J.J.Patel, S.R.Acharya, N.S.Acharya 2014. Clerodendrum serratum (L.) Moon. – a review on traditional uses, phytochemistry and pharmacological activities. J Ethnopharmacol. 154:268–285.
38. R.R.Petchi, C.Vijaya, S.Parasuraman 2014. Antidiabetic activity of polyherbal formulation in streptozotocin – nicotinamide induced diabetic Wistar rats. J Tradit Complement Med. 4:108–117.
39. W.Pierre, A.J.H.Gildas, M.C.Ulrich, W.-N.Modeste, N.T.Benoît, K.Albert. 2012. Hypoglycemic and hypolipidemic effects of Bersama engleriana leaves in nicotinamide/streptozotocin-induced type 2 diabetic rats. BMC Complement Altern Med. 12:6.
40. S.Ramachandran, A.Rajasekaran, N.Adhirajan 2013. In vivo and in vitro antidiabetic activity of Terminalia paniculata bark:an evaluation of possible phytoconstituents and mechanisms for blood glucose control in diabetes. ISRN Pharmacol. 2013:1–10.
41. M.Ramar, B.Manikandan, T.Raman, A.Priyadarsini, S.Palanisamy, M.Velayudam, A.Munusamy, N.Marimuthu Prabhu, B.Vaseeharan. 2012. Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice. Eur J Pharmacol. 690:226–235.
42. S.Ramya, K.Neethirajan, R.Jayakumararaj 2012. Profile of bioactive compounds in Syzygium cumini – a review. J Pharm Res. 5:4548–4553.
43. B.K.Rao, M.M.Kesavulu, C.Apparao 2001. Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats. J Ethnopharmacol. 78:67–71.
44. P.V.Rao, K.Madhavi, M.Dhananjaya Naidu, S.H.Gan 2013. Rhinacanthus nasutus improves the levels of liver carbohydrate, protein, glycogen, and liver markers in streptozotocin-induced diabetic rats. Evid Based Complement Altern Med. 2013:1–7.
45. K.A.Reynertson, M.J.Basile, E.J.Kennelly 2005. Antioxidant potential of seven Myrtaceous fruits. Ethnobot Res Appl. 3:25–35.
46. M.Salahuddin, S.S.Jalalpure 2010. Antidiabetic activity of aqueous fruit extract of Cucumis trigonus Roxb. in streptozotocin-induced-diabetic rats. J Ethnopharmacol. 127:565–567.
47. J.Saranya, P.Eganathan, P.Sujanapal, A.Parida 2012. Chemical composition of leaf essential oil of Syzygium densiflorum Wall. ex Wt & Arn.-A vulnerable tree species. J Essent Oil Bear Plants. 15:283–287.
48. R.Sasi, A.Rajendran 2012. Diversity of wild fruits in Nilgiri Hills of the Southern Western Ghats – ethnobotanical aspects. Int J Appl Biol Pharm Technol. 3:82–87.
49. R.Sathyavathi, K.Janardhanan 2014. Wild edible fruits used by Badagas of Nilgiri District, Western Ghats, Tamilnadu, India. J Med Plants Res. 8:128–132.
50. P.S.Shajeela, V.Kalpanadevi, V.R.Mohan 2012. Potential antidiabetic, hypolipidaemic and antioxidant effects of Nymphaea pubescens extract in alloxan induced diabetic rats. J Appl Pharm Sci. 2:83–88.
51. N.Sheela, M.A.Jose, D.Sathyamurthy, B.N.Kumar 2013. Effect of silymarin on streptozotocin-nicotinamide-induced type 2 diabetic nephropathy in rats. Iran J Kidney Dis. 7:117–123.
52. K.Shukla, P.Dikshit, R.Shukla, J.K.Gambhir 2012. The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats. J Med Food. 15:718–725.
53. J.Singh, P.Kakkar 2009. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. J Ethnopharmacol. 123:22–26.
54. S.Skovsø 2014. Modeling type 2 diabetes in rats using high fat diet and streptozotocin. J Diabetes Investig. 5:349–358.
55. S.Srinivasan, L.Pari 2012. Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Chem Biol Interact. 195:43–51.
56. A.Stevens 1994. Connective tissues and stains. In:J.S.A.Bancroft, editor. Theory and practice of histological techniques. 6th ed. Philadelphia (PA):Churchill Livingstone/Elsevier. p. 129–134.
57. R.Sundaram, R.Naresh, P.Shanthi, P.Sachdanandam 2012. Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats. Phytomedicine 19:725–729.
58. J.Van Der Vies 1954. Two methods for the determination of glycogen in liver. Biochem J. 57:410–416.
59. J.Vijayan, V.Ramachandran, B.Thomas 2014. Role of botanic gardens in conserving edible plants. Eur J Environ Ecol. 1:26–28.
60. W.Wang, Y.He, P.Lin, Y.Li, R.Sun, W.Gu, J.Yu, R.Zhao. 2014. In vitro effects of active components of Polygonum multiflorum Radix on enzymes involved in the lipid metabolism. J Ethnopharmacol. 153:763–770.
61. WHO. 2013. WHO Traditional Medicine Strategy. Geneva:WHO Library Cataloguing-in-Publication Data. p. 1–87