An overview on antidiabetic medicinal plants having insulin mimetic property

Asian Pacific Journal of Tropical Biomedicine

Volumn 2, Issue 4, 2012, Pages 320-330

  Patel, D K ^a   Prasad, S K ^a   Kumar, R ^a   Hemalatha, S ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Antidiabetic activity; Beta cell; Blood glucose; Diabetes; Diabetes mellitus; Herbal medicine; Hypoglycaemic activity; Insulin; Insulin mimetics; Insulin secretagogues; Medicinal plant; Metabolic disorder; Pancrease; Phytoconstituents

Indexed keywords

AEGLE MARMELOS EXTRACT; AGRIMONY EUPATORIA EXTRACT; ALANGIUM SALVIFOLIUM EXTRACT; ALOE VERA EXTRACT; ANNONA MURICATA EXTRACT; ANNONA SQUAMOSA EXTRACT; ANTIDIABETIC AGENT; ASPARAGUS RACEMOSUS EXTRACT; BAUHINIA VARIEGATA EXTRACT; BERBERINE; BIOPHYTUM SENSITIVUM EXTRACT; BOERHAAVIA DIFFUSA EXTRACT; BOUGAINVILLEA SPECTABILIS EXTRACT; BRASSICA NIGRA EXTRACT; CAESALPINIA BONDUCELLA EXTRACT; CAFFEINE; CATHARANTHUS ROSEUS EXTRACT; CINNAMOMUM ZEYLANIUM EXTRACT; COCCINIA INDICA EXTRACT; COLOCYNTH EXTRACT; CORNUS OFFICINALIS EXTRACT; ELEPHANTOPUS SCABER EXTRACT; ENICOSTEMMA LITTORALE EXTRACT; ERIOBOTRYA JAPONICA EXTRACT; EUCCALYPTUS GLOBULUS EXTRACT; GARLIC EXTRACT; HERBACEOUS AGENT; INSULIN; PLANT EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; FLAVONOID; POLYPHENOL;

ACACIA; AGRIMONY EUPATORIA; ALANGIUM SALVIFOLIUM; ALFALFA; ANNONA SQUAMOSA; ANTIDIABETIC ACTIVITY; ARTICLE; BARLEY; BAUHINIA VARIEGATA; BIOPHYTUM SENSITIVUM; BLACK CUMIN; BOUGAINVILLEA SPECTABILIS; BRASSICA NIGRA; CAESALPINIA BONDUC; CAPSICUM FRUTESCENS; CHRONIC DISEASE; CINNAMOMUM ZEYLANIUM; COCCINIA INDICA; DIABETES MELLITUS; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ELEPHANTOPUS SCABER; ENICOSTEMMA LITTORALE; EPHEDRA DISTACHYA; EUCCALYPTUS GLOBULUS; FENUGREEK; FICUS BENGALENSIS; GINKGO BILOBA; GINSENG; GLYCYRRHIZAE; GUAVA; GYMNEMA SYLVESTRE; HELICTERES ISORA; HERBAL MEDICINE; HIBISCUS ROSA-SINENSIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INTERMETHOD COMPARISON; KINO; LEPECHINIA CAULESCENS; LOQUAT; MEDICINAL PLANT; MOMORDICA CHARANTIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OUTCOME ASSESSMENT; PANDANUS ODORUS; PARINARI EXCELSA; PRIORITY JOURNAL; PRUNELLA VULGARIS; REHMANIA GLUTINOSA; REHMANNIAE; RICINUS COMMUNIS; SALVIA LAVANDIFOLIA; SARCOPOTERIUM SPINOSUM; SELAGINELLA TAMARISCINA; SEMEN COICIS; SIMALLANTHUS SONCHIFOLIUS; SOYBEAN; STEVIA; SWERTIA CHIRAYITA; SWERTIA PUNICEA; SYZYGIUM CUMINI; TABERNANTHE IBOGA; TEA; TEUCRIUM POLIUM; TINOSPORA CRISPA; VELVET BEAN; ZIZYPHUS SPINA CHRISTI; ANIMAL; CELL CULTURE; MOUSE; PANCREAS ISLET; PHYTOTHERAPY; RAT;

ALLIUM SATIVUM; ARALIACEAE; ASTERACEAE; CITRULLUS COLOCYNTHIS; CUCURBITACEAE; FICUS BENGHALENSIS; GYMNEMA SYLVESTRE; LAMIACEAE; LILIACEAE; MOMORDICA; MORACEAE; ROSACEAE; TRIGONELLA FOENUM;

ANIMALS; CELLS, CULTURED; FLAVONOIDS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; POLYPHENOLS; RATS;

EID: 84863393217     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(12)60032-X     Document Type: Article

References (53)

1. Patel DK, Kumar R, Prasad SK, Sairam K, Hemalatha S. Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2011; 1(4): 316-322.
2. Patel DK, Kumar R, Prasad SK, Hemalatha S. Pedalium murex Linn (Pedaliaceae) fruits: a comparative antioxidant activity of its different fractions. Asian Pac J Trop Biomed 2011; 1(5): 395-400.
3. Ponnusamy S, Ravindran R, Zinjarde S, Bhargava S, Kumar AR. Evaluation of traditional Indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect in vitro. Evid Based Complement Alternat Med 2011; 2011: 515647.
4. Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004; 92(1): 1-21.
5. Sy GY, Cissé A, Nongonierma RB, Sarr M, Mbodj NA, Faye B. Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxaninduced diabetic rats. J Ethnopharmacol 2005; 98(1-2): 171-175.
6. Saxena A, Vikram NK. Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med 2004; 10(2): 369-378.
7. Lee HS. Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids. J Agric Food Chem 2002; 50(24): 7013-7026.
8. Jung M, Park M, Lee HC, Kang YH, Kang ES, Kim SK. Antidiabetic agents from medicinal plants. Curr Med Chem 2006; 13(10): 1203-1218.
9. Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 2010; 67(2): 113-118.
10. Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetic potential. J Ethnopharmacol 2002; 81(1): 81-100.
11. Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A. Medicinal plants with potential antidiabetic activity-a review of ten years of herbal medicine research (1990-2000). Int J Diabetes Metab 2006; 14: 1-25.
12. Singh LW. Traditional medicinal plants of Manipur as antidiabetics. J Med Plant Res 2011; 5(5): 677-687.
13. Ayodhya S, Kusum S, Anjali S. Hypoglycaemic activity of different extracts of various herbal plants Singh. Int J Ayurveda Res Pharm 2010; 1(1): 212-224.
14. Kshirsagar RP, Darade SS, Takale V. Effect of Alangium salvifolium (Alangiaceae) on dexamethasone induced insulin resistance in rats. J Pharm Res 2010; 3(11): 2714-2716.
15. Chauhan A, Sharma PK, Srivastava P, Kumar N, Duehe R. Plants having potential antidiabetic activity: a review. Der Pharm Lett 2010; 2(3): 369-387.
16. Modak M, Dixit P, Londhe J, Ghaskadbi S, Paul A, Devasagayam T. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 2007; 40(3): 163-173.
17. Mustafa SSS, Eid NI, Jafri SA, El-Latif HAA, Ahmed HMS. Insulinotropic effect of aqueous ginger extract and aqueous garlic extract on the isolated perfused pancreas of streptozotocin induced diabetic rats. Pak J Zool 2007; 39(5): 279-284.
18. Islam MS, Choi H. Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats. Phytother Res 2008; 22(8): 1025-1029.
19. Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YH. Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells. J Endocrinol 2007; 192(1): 159-168.
20. Frankish N, de Sousa Menezes F, Mills C, Sheridan H. Enhancement of insulin release from the beta-cell line INS-1 by an ethanolic extract of Bauhinia variegata and its major constituent roseoside. Planta Med 2010; 76(10): 995-997.
21. Wang ZQ, Lu FE, Leng SH, Fang XS, Chen G, Wang ZS, et al. Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity. World J Gastroenterol 2008; 14(39): 6004-6011.
22. Ko BS, Choi SB, Park SK, Jang JS, Kim YE, Park S. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull 2005; 28(8): 1431-1437.
23. Puri D. The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: preliminary experimental study. J Ethnopharmacol 2001; 78(1): 89-93.
24. Anand P, Murali YK, Tandon V, Murthy PS, Chandra R. Insulinotropic effect of aqueous extract of Brassica nigra improves glucose homeostasis in streptozotocin induced diabetic rats. Exp Clin Endocrinol Diabetes 2009; 117(6): 251-256.
25. Anand P, Murali KY, Tandon V, Murthy PS, Chandra R. Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats. Chem Biol Interact 2010; 186(1): 72-81.
26. Park S, Jang JS, Hong SM. Long-term consumption of caffeine improves glucose homeostasis by enhancing insulinotropic action through islet insulin/insulin-like growth factor 1 signaling in diabetic rats. Metabolism 2007; 56(5): 599-607.
27. Islam MS, Choi H. Green tea, anti-diabetic or diabetogenic: a dose response study. Biofactors 2007; 29(1): 45-53.
28. Dallak M, Al-Khateeb M, Abbas M, Elessa R, Al-Hashem F, Bashir N, et al. In vivo, acute, normo-hypoglycemic, antihyperglycemic, insulinotropic actions of orally administered ethanol extract of Citrullus colocynthis (L.) Schrab pulp. Am J Biochem Biotechnol 2009; 5(3): 119-126.
29. Dallak M, Bashir N, Abbas M, Elessa R, Haidara M, Khalil M, et al. Concomitant down regulation of glycolytic enzymes, upregulation of gluconeogenic enzymes and potential hepatonephro-protective effects following the chronic administration of the hypoglycemic, insulinotropic Citrullus colocynthis pulp extract. Am J Biochem Biotechnol 2009; 5(4): 153-161.
30. Chen CC, Hsu CY, Chen CY, Liu HK. Fructus corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death. J Ethnopharmacol 2008; 117(3): 483-490.
31. Rao MU, Sreenivasulu M, Chengaiah B, Reddy KJ, Chetty CM. Herbal medicines for diabetes mellitus: a review. Int J PharmTech Res 2010; 2(3): 1883-1892.
32. Maroo J, Vasu VT, Aalinkeel R, Gupta S. Glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action. J Ethnopharmacol 2002; 81(3): 317-320.
33. Qa'dan F, Verspohl EJ, Nahrstedt A, Petereit F, Matalka KZ. Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo. J Ethnopharmacol 2009; 124(2): 224-227.
34. Kwon DY, Jang JS, Hong SM, Lee JE, Sung SR, Park HR, et al. Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. Eur J Nutr 2007; 46(1): 44-52.
35. Liu D, Zhen W, Yang Z, Carter JD, Si H, Reynolds KA. Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway. Diabetes 2006; 55(4): 1043-1050.
36. Ko BS, Jang JS, Hong SM, Sung SR, Lee JE, Lee MY, et al. Changes in components, glycyrrhizin and glycyrrhetinic acid, in raw Glycyrrhiza uralensis Fisch, modify insulin sensitizing and insulinotropic actions. Biosci Biotechnol Biochem 2007; 71(6): 1452-1461.
37. Kaczmar T. Herbal support for diabetes management. Clin Nutr Insights 1998; 6(8): 1-4.
38. Fararh KM, Atoji Y, Shimizu Y, Takewaki T. Isulinotropic properties of Nigella sativa oil in streptozotocin plus nicotinamide diabetic hamster. Res Vet Sci 2002; 73(3): 279-282.
39. Kim K, Kim HY. Korean red ginseng stimulates insulin release from isolated rat pancreatic islets. J Ethnopharmacol 2008; 120(2): 190-195.
40. Mentreddy SR, Mohamed AI, Rimando AM. Medicinal plants with hypoglycemic/anti-hyperglycemic properties: a review. Proc Assoc Adv Ind Crop Conf 2005; 20: 341-353.
41. Jeppesen PB, Gregersen S, Alstrup KK, Hermansen K. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. Phytomedicine 2002; 9(1): 9-14.
42. +-channel activity. Metabolism 2000; 49(2): 208-214.
43. Souza A, Mbatchi B, Herchuelz A. Induction of insulin secretion by an aqueous extract of Tabernanhte iboga Baill. (Apocynaceae) in rat pancreatic islets of Langerhans. J Ethnopharmacol 2011; 133(3): 1015-1020.
44. Esmaeili MA, Yazdanparast R. Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets. J Ethnopharmacol 2004; 95(1): 27-30.
45. + channels. Iran Biomed J 2010; 14(4): 178-185.
46. Yazdanparast R, Esmaeili MA, Helan JA. Teucrium polium extract effects pancreatic function of streptozotocin diabetic rats: a histopathological examination. Iran Biomed J 2005; 9(2): 81-85.
47. Noor H, Ashcroft SJH. Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract. J Ethnopharmacol 1998; 62(1): 7-13.
48. Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, et al. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol 1999; 277(4 Pt 1): E617-E623.
49. Haeri MR, Izaddoost M, Ardekani MR, Nobar MR, White KN. The effect of fenugreek 4-hydroxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats. Phytother Res 2009; 23(1): 61-64.
50. Abdel-Zaher AO, Salim SY, Assaf MH, Abdel-Hady RH. Teucrium polium antidiabetic activity and toxicity of Zizyphus spina-christi leaves. J Ethnopharmacol 2005; 101(1-3): 129-138.
51. Patel DK, Kumar R, Laloo D, Hemalatha S. Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) F. Muell. (Violaceae). Asian Pac J Trop Med 2011; 4(5): 391-396.
52. Jarald E, Joshi SB, Jain DC. Diabetes and herbal medicines. Iran J Pharmacol Ther 2008; 7(1): 97-106.
53. Bhushan MS, Rao CHV, Ojha SK, Vijayakumar M, Verma A. An analytical review of plants for anti diabetic activity with their phytoconstituent & mechanism of action. Int J Pharm Sci Res 2010; 1(1): 29-46.