Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

Cell Metabolism

Volumn 22, Issue 6, 2015, Pages 1068-1077

  Bott, Alex J ^a,h   Peng, I Chen ^a,g   Fan, Yongjun ^a   Faubert, Brandon ^c   Zhao, Lu ^b   Li, Jinyu ^a   Neidler, Sarah ^d   Sun, Yu ^a,h   Jaber, Nadia ^a   Krokowski, Dawid ^e   Lu, Wenyun ^f   Pan, Ji An ^a,h   Powers, Scott ^a   Rabinowitz, Joshua ^f   Hatzoglou, Maria ^e   Murphy, Daniel J ^d   Jones, Russell ^c   Wu, Song ^b   Girnun, Geoffrey ^a   Zong, Wei Xing ^a,h  

^a STONY BROOK UNIVERSITY   (United States)

^b Stony Brook University   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f PRINCETON UNIVERSITY   (United States)

^g NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^h RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; DNA; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; DNA (CYTOSINE 5) METHYLTRANSFERASE; MYC PROTEIN; NUCLEOTIDE; SMALL INTERFERING RNA;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DEMETHYLATION; HUMAN; HUMAN CELL; NEOPLASM; NONHUMAN; NUCLEOTIDE METABOLISM; ONCOGENE MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SYNTHESIS; TUMOR GROWTH; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DNA METHYLATION; FEMALE; GENETICS; METABOLISM; MOUSE; NUDE MOUSE; RNA INTERFERENCE;

ANIMALS; CELL LINE; DNA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; GLUTAMATE-AMMONIA LIGASE; GLUTAMIC ACID; HUMANS; MICE; MICE, NUDE; NUCLEOTIDES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84951070852     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.09.025     Document Type: Article

References (33)

1. G. Biolo, F. Zorat, R. Antonione, and B. Ciocchi Muscle glutamine depletion in the intensive care unit Int. J. Biochem. Cell Biol. 37 2005 2169 2179
2. C.V. Dang Links between metabolism and cancer Genes Dev. 26 2012 877 890
3. R.J. DeBerardinis, and T. Cheng Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer Oncogene 29 2010 313 324
4. R.J. DeBerardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, and C.B. Thompson Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis Proc. Natl. Acad. Sci. USA 104 2007 19345 19350
5. R.J. DeBerardinis, J.J. Lum, G. Hatzivassiliou, and C.B. Thompson The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab. 7 2008 11 20
6. Y. Fan, K.G. Dickman, and W.X. Zong Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition J. Biol. Chem. 285 2010 7324 7333
7. J. Fan, J.J. Kamphorst, R. Mathew, M.K. Chung, E. White, T. Shlomi, and J.D. Rabinowitz Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia Mol. Syst. Biol. 9 2013 712
8. P. Gao, I. Tchernyshyov, T.C. Chang, Y.S. Lee, K. Kita, T. Ochi, K.I. Zeller, A.M. De Marzo, J.E. Van Eyk, J.T. Mendell, and C.V. Dang c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism Nature 458 2009 762 765
9. C.R. Goding, D. Pei, and X. Lu Cancer: pathological nuclear reprogramming? Nat. Rev. Cancer 14 2014 568 573
10. Y. He, T.B. Hakvoort, S.E. Köhler, J.L. Vermeulen, D.R. de Waart, C. de Theije, G.A. ten Have, H.M. van Eijk, C. Kunne, W.T. Labruyere, and et al. Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification J. Biol. Chem. 285 2010 9516 9524
11. Y.F. He, B.Z. Li, Z. Li, P. Liu, Y. Wang, Q. Tang, J. Ding, Y. Jia, Z. Chen, L. Li, and et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA Science 333 2011 1303 1307
12. C.T. Hensley, A.T. Wasti, and R.J. DeBerardinis Glutamine and cancer: cell biology, physiology, and clinical opportunities J. Clin. Invest. 123 2013 3678 3684
13. S.R. Hingorani, E.F. Petricoin, A. Maitra, V. Rajapakse, C. King, M.A. Jacobetz, S. Ross, T.P. Conrads, T.D. Veenstra, B.A. Hitt, and et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Cancer Cell 4 2003 437 450
14. S. Ito, L. Shen, Q. Dai, S.C. Wu, L.B. Collins, J.A. Swenberg, C. He, and Y. Zhang Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine Science 333 2011 1300 1303
15. E.L. Jackson, N. Willis, K. Mercer, R.T. Bronson, D. Crowley, R. Montoya, T. Jacks, and D.A. Tuveson Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras Genes Dev. 15 2001 3243 3248
16. G. Kroemer, and J. Pouyssegur Tumor cell metabolism: cancer's Achilles' heel Cancer Cell 13 2008 472 482
17. D. Krokowski, J. Han, M. Saikia, M. Majumder, C.L. Yuan, B.J. Guan, E. Bevilacqua, O. Bussolati, S. Bröer, P. Arvan, and et al. A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux J. Biol. Chem. 288 2013 17202 17213
18. K.S. Kuhn, K. Schuhmann, P. Stehle, D. Darmaun, and P. Fürst Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis-derived endogenous glutamine production Am. J. Clin. Nutr. 70 1999 484 489
19. M. Kulis, and M. Esteller DNA methylation and cancer Adv. Genet. 70 2010 27 56
20. H.N. Kung, J.R. Marks, and J.T. Chi Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia PLoS Genet. 7 2011 e1002229
21. E.A. Maher, I. Marin-Valencia, R.M. Bachoo, T. Mashimo, J. Raisanen, K.J. Hatanpaa, A. Jindal, F.M. Jeffrey, C. Choi, C. Madden, and et al. Metabolism of [U-13 C]glucose in human brain tumors in vivo NMR Biomed. 25 2012 1234 1244
22. I. Marin-Valencia, C. Yang, T. Mashimo, S. Cho, H. Baek, X.L. Yang, K.N. Rajagopalan, M. Maddie, V. Vemireddy, Z. Zhao, and et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo Cell Metab. 15 2012 827 837
23. D.J. Murphy, M.R. Junttila, L. Pouyet, A. Karnezis, K. Shchors, D.A. Bui, L. Brown-Swigart, L. Johnson, and G.I. Evan Distinct thresholds govern Myc's biological output in vivo Cancer Cell 14 2008 447 457
24. P. Newsholme, M.M. Lima, J. Procopio, T.C. Pithon-Curi, S.Q. Doi, R.B. Bazotte, and R. Curi Glutamine and glutamate as vital metabolites Braz. J. Med. Biol. Res. 36 2003 153 163
25. P. Nicklin, P. Bergman, B. Zhang, E. Triantafellow, H. Wang, B. Nyfeler, H. Yang, M. Hild, C. Kung, C. Wilson, and et al. Bidirectional transport of amino acids regulates mTOR and autophagy Cell 136 2009 521 534
26. D. Perna, G. Fagà, A. Verrecchia, M.M. Gorski, I. Barozzi, V. Narang, J. Khng, K.C. Lim, W.K. Sung, R. Sanges, and et al. Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts Oncogene 31 2012 1695 1709
27. G. Svenneby, and I.A. Torgner Localization and function of glutamine synthetase and glutaminase Biochem. Soc. Trans. 15 1987 213 215
28. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
29. S. Walz, F. Lorenzin, J. Morton, K.E. Wiese, B. von Eyss, S. Herold, L. Rycak, H. Dumay-Odelot, S. Karim, M. Bartkuhn, and et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles Nature 511 2014 483 487
30. D.R. Wise, and C.B. Thompson Glutamine addiction: a new therapeutic target in cancer Trends Biochem. Sci. 35 2010 427 433
31. D.R. Wise, R.J. DeBerardinis, A. Mancuso, N. Sayed, X.Y. Zhang, H.K. Pfeiffer, I. Nissim, E. Daikhin, M. Yudkoff, S.B. McMahon, and C.B. Thompson Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction Proc. Natl. Acad. Sci. USA 105 2008 18782 18787
32. H. Wu, and Y. Zhang Reversing DNA methylation: mechanisms, genomics, and biological functions Cell 156 2014 45 68
33. M.O. Yuneva, T.W. Fan, T.D. Allen, R.M. Higashi, D.V. Ferraris, T. Tsukamoto, J.M. Matés, F.J. Alonso, C. Wang, Y. Seo, and et al. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type Cell Metab. 15 2012 157 170