Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced hsp90 isoforms and their conformationally restricted mutants

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Prince, Thomas L ^a   Kijima, Toshiki ^a   Tatokoro, Manabu ^a   Lee, Sunmin ^a   Tsutsumi, Shinji ^a   Yim, Kendrick ^a   Rivas, Candy ^a   Alarcon, Sylvia ^a   Schwartz, Harvey ^a   Khamit Kush, Kofi ^a   Scroggins, Bradley T ^a   Beebe, Kristin ^a   Trepel, Jane B ^a   Neckers, Len ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BINDING PROTEIN; CHAPERONE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GANETESPIB; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 ALPHA; HEAT SHOCK PROTEIN 90BETA; HEAT SHOCK TRANSCRIPTION FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; RHOBTB2 PROTEIN; SCATTER FACTOR RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; BENZOQUINONE DERIVATIVE; DNA BINDING PROTEIN; ERBB2 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; ISOPROTEIN; KEAP1 PROTEIN, HUMAN; MACROCYCLIC LACTAM; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; RHOBTB2 PROTEIN, HUMAN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; TRIAZOLE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN INTERACTION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BENZOQUINONES; BINDING SITES; DNA-BINDING PROTEINS; GTP-BINDING PROTEINS; HEK293 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LACTAMS, MACROCYCLIC; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; RECEPTOR, ERBB-2; TRANSCRIPTION FACTORS; TRIAZOLES; TUMOR SUPPRESSOR PROTEINS;

EID: 84950335560     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0141786     Document Type: Article

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