SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport

Cell Metabolism

Volumn 20, Issue 4, 2014, Pages 603-613

  Stein, Sokrates ^a   Oosterveer, Maaike H ^b   Mataki, Chikage ^a   Xu, Pan ^a   Lemos, Vera ^a   Havinga, Rick ^b   Dittner, Claudia ^c,d   Ryu, Dongryeol ^a   Menzies, Keir J ^a   Wang, Xu ^a   Perino, Alessia ^a   Houten, Sander M ^e   Melchior, Frauke ^c   Schoonjans, Kristina ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c GERMAN CANCER RESEARCH CENTER   (Germany)

^d UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL; COREPRESSOR PROTEIN; LIVER RECEPTOR HOMOLOG 1; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PROSPERO HOMEOBOX PROTEIN 1; SMALL INTERFERING RNA; SUMO 1 PROTEIN; UNCLASSIFIED DRUG; CELL RECEPTOR; HOMEODOMAIN PROTEIN; NR5A2 PROTEIN, MOUSE; PROSPERO-RELATED HOMEOBOX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BILE COMPOSITION; BILE FLOW; BILE SECRETION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DNA BINDING; EMBRYO; GENE MUTATION; GENE SILENCING; GENETIC TRANSFECTION; HINGE REGION; HUMAN; HUMAN CELL; LIVER CELL; LIVER METABOLISM; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVERSE CHOLESTEROL TRANSPORT; SUMOYLATION; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; LIVER; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; SEQUENCE ALIGNMENT; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ATHEROSCLEROSIS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CHOLESTEROL; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, LDL; SEQUENCE ALIGNMENT; SUMOYLATION; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS;

EID: 84907992528     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.07.023     Document Type: Article

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