-
1
-
-
30144433093
-
Generation of a functional mammary gland from a single stem cell
-
Shackleton, M. et al. Generation of a functional mammary gland from a single stem cell. Nature 439, 84-88 (2006).
-
(2006)
Nature
, vol.439
, pp. 84-88
-
-
Shackleton, M.1
-
2
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
-
3
-
-
42649112047
-
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
-
Ben-Porath, I. et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40, 499-507 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 499-507
-
-
Ben-Porath, I.1
-
4
-
-
33747591465
-
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
-
Overholtzer, M. et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc. Natl Acad. Sci. USA 103, 12405-12410 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 12405-12410
-
-
Overholtzer, M.1
-
5
-
-
42449101282
-
A crucial role of WW45 in developing epithelial tissues in the mouse
-
Lee, J.-H. et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 27, 1231-1242 (2008).
-
(2008)
EMBO J.
, vol.27
, pp. 1231-1242
-
-
Lee, J.-H.1
-
6
-
-
77952336576
-
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
-
Lee, K.-P. et al. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc. Natl Acad. Sci. USA 107, 8248-8253 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 8248-8253
-
-
Lee, K.-P.1
-
7
-
-
78049451932
-
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
-
Cai, J. et al. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 24, 2383-2388 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 2383-2388
-
-
Cai, J.1
-
8
-
-
36549074631
-
YAP1 increases organ size and expands undifferentiated progenitor cells
-
Camargo, F. D. et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 17, 2054-2060 (2007).
-
(2007)
Curr. Biol.
, vol.17
, pp. 2054-2060
-
-
Camargo, F.D.1
-
9
-
-
81055140859
-
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
-
Cordenonsi, M. et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147, 759-772 (2011).
-
(2011)
Cell
, vol.147
, pp. 759-772
-
-
Cordenonsi, M.1
-
10
-
-
84874257648
-
The Hippo pathway: Regulators and regulations
-
Yu, F.-X. & Guan, K.-L. The Hippo pathway: regulators and regulations. Genes Dev. 27, 355-371 (2013).
-
(2013)
Genes Dev.
, vol.27
, pp. 355-371
-
-
Yu, F.-X.1
Guan, K.-L.2
-
11
-
-
84865260845
-
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
-
Yu, F.-X. et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780-791 (2012).
-
(2012)
Cell
, vol.150
, pp. 780-791
-
-
Yu, F.-X.1
-
12
-
-
79958284636
-
Role of YAP/TAZ in mechanotransduction
-
Dupont, S. et al. Role of YAP/TAZ in mechanotransduction. Nature 474, 179-183 (2011).
-
(2011)
Nature
, vol.474
, pp. 179-183
-
-
Dupont, S.1
-
13
-
-
84878547831
-
CAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
-
Kim, M. et al. cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J. 32, 1543-1555 (2013).
-
(2013)
EMBO J.
, vol.32
, pp. 1543-1555
-
-
Kim, M.1
-
14
-
-
0038737042
-
Actin dynamics control SRF activity by regulation of its coactivator MAL
-
Miralles, F., Posern, G., Zaromytidou, A.-I. & Treisman, R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113, 329-342 (2003).
-
(2003)
Cell
, vol.113
, pp. 329-342
-
-
Miralles, F.1
Posern, G.2
Zaromytidou, A.-I.3
Treisman, R.4
-
15
-
-
38449102928
-
Expression of the serum response factor in hepatocellular carcinoma: Implications for epithelial-mesenchymal transition
-
Park, M. Y. et al. Expression of the serum response factor in hepatocellular carcinoma: implications for epithelial-mesenchymal transition. Int. J. Oncol. 31, 1309-1315 (2007).
-
(2007)
Int. J. Oncol.
, vol.31
, pp. 1309-1315
-
-
Park, M.Y.1
-
16
-
-
0037119356
-
High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling
-
Psichari, E., Balmain, A., Plows, D., Zoumpourlis, V. & Pintzas, A. High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling. J. Biol. Chem. 277, 29490-29495 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29490-29495
-
-
Psichari, E.1
Balmain, A.2
Plows, D.3
Zoumpourlis, V.4
Pintzas, A.5
-
17
-
-
61849140657
-
Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
-
Medjkane, S., Perez-Sanchez, C., Gaggioli, C., Sahai, E. & Treisman, R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat. Cell Biol. 11, 257-268 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 257-268
-
-
Medjkane, S.1
Perez-Sanchez, C.2
Gaggioli, C.3
Sahai, E.4
Treisman, R.5
-
18
-
-
84867027347
-
TGFb induces the formation of tumour-initiating cells in claudinlow breast cancer
-
Bruna, A. et al. TGFb induces the formation of tumour-initiating cells in claudinlow breast cancer. Nat. Commun. 3, 1055 (2012).
-
(2012)
Nat. Commun.
, vol.3
, pp. 1055
-
-
Bruna, A.1
-
19
-
-
84899734505
-
Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
-
Esnault, C. et al. Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. Genes Dev. 28, 943-958 (2014).
-
(2014)
Genes Dev.
, vol.28
, pp. 943-958
-
-
Esnault, C.1
-
20
-
-
78650202455
-
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
-
Karpowicz, P., Perez, J. & Perrimon, N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 137, 4135-4145 (2010).
-
(2010)
Development
, vol.137
, pp. 4135-4145
-
-
Karpowicz, P.1
Perez, J.2
Perrimon, N.3
-
21
-
-
34548636132
-
Elucidation of a universal size-control mechanism in drosophila and mammals
-
Dong, J. et al. Elucidation of a universal size-control mechanism in drosophila and mammals. Cell 130, 1120-1133 (2007).
-
(2007)
Cell
, vol.130
, pp. 1120-1133
-
-
Dong, J.1
-
22
-
-
47549095853
-
TEAD mediates YAP-dependent gene induction and growth control
-
Zhao, B. et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 22, 1962-1971 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 1962-1971
-
-
Zhao, B.1
-
23
-
-
0025251798
-
Several regions of human estrogen receptor are involved in the formation of receptorheat shock protein 90 complexes
-
Chambraud, B., Berry, M., Redeuilh, G., Chambon, P. & Baulieu, E. E. Several regions of human estrogen receptor are involved in the formation of receptorheat shock protein 90 complexes. J. Biol. Chem. 265, 20686-20691 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 20686-20691
-
-
Chambraud, B.1
Berry, M.2
Redeuilh, G.3
Chambon, P.4
Baulieu, E.E.5
-
24
-
-
30344445706
-
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
-
Hamaratoglu, F. et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat. Cell Biol. 8, 27-36 (2006).
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 27-36
-
-
Hamaratoglu, F.1
-
25
-
-
84867853849
-
Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila
-
Ohsawa, S. et al. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature 490, 547-551 (2012).
-
(2012)
Nature
, vol.490
, pp. 547-551
-
-
Ohsawa, S.1
-
26
-
-
73349128777
-
YAP-dependent induction of amphiregulin identifies a non-cellautonomous component of the Hippo pathway
-
Zhang, J. et al. YAP-dependent induction of amphiregulin identifies a non-cellautonomous component of the Hippo pathway. Nat. Cell Biol. 11, 1444-1450 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1444-1450
-
-
Zhang, J.1
-
27
-
-
72749103664
-
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
-
Visvader, J. E. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev. 23, 2563-2577 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 2563-2577
-
-
Visvader, J.E.1
-
28
-
-
77955895963
-
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
-
Lim, E. et al. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 12, R21 (2010).
-
(2010)
Breast Cancer Res.
, vol.12
, pp. R21
-
-
Lim, E.1
-
29
-
-
84897104535
-
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment
-
Skibinski, A. et al. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep. 6, 1059-1072 (2014).
-
(2014)
Cell Rep.
, vol.6
, pp. 1059-1072
-
-
Skibinski, A.1
-
30
-
-
79952121979
-
Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
-
Iliopoulos, D., Hirsch, H. A., Wang, G. & Struhl, K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc. Natl Acad. Sci. USA 108, 1397-1402 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 1397-1402
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Wang, G.3
Struhl, K.4
-
31
-
-
44649101304
-
Oncogene-induced senescence relayed by an interleukindependent inflammatory network
-
Kuilman, T. et al. Oncogene-induced senescence relayed by an interleukindependent inflammatory network. Cell 133, 1019-1031 (2008).
-
(2008)
Cell
, vol.133
, pp. 1019-1031
-
-
Kuilman, T.1
-
32
-
-
59149088576
-
Both TEAD-binding andWW domains are required for the growth stimulation and oncogenic transformation activity of Yes-associated protein
-
Zhao, B., Kim, J., Ye, X., Lai, Z.-C. & Guan, K.-L. Both TEAD-binding andWW domains are required for the growth stimulation and oncogenic transformation activity of Yes-associated protein. Cancer Res. 69, 1089-1098 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 1089-1098
-
-
Zhao, B.1
Kim, J.2
Ye, X.3
Lai, Z.-C.4
Guan, K.-L.5
-
33
-
-
67649770134
-
TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
-
Chan, S. W. et al. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J. Biol. Chem. 284, 14347-14358 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 14347-14358
-
-
Chan, S.W.1
-
34
-
-
33751253145
-
Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain
-
Anbanandam, A. et al. Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain. Proc. Natl Acad. Sci. USA 103, 17225-17230 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 17225-17230
-
-
Anbanandam, A.1
-
35
-
-
76149138881
-
Structural insights into the YAP and TEAD complex
-
Li, Z. et al. Structural insights into the YAP and TEAD complex. Genes Dev. 24, 235-240 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 235-240
-
-
Li, Z.1
-
36
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
-
37
-
-
68349130357
-
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
-
Lim, E. et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 15, 907-913 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 907-913
-
-
Lim, E.1
-
38
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
Ginestier, C. et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-567 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 555-567
-
-
Ginestier, C.1
-
39
-
-
84897104535
-
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment
-
Skibinski, A. et al. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep. 6, 1059-1072 (2014).
-
(2014)
Cell Rep.
, vol.6
, pp. 1059-1072
-
-
Skibinski, A.1
-
40
-
-
84896824055
-
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis
-
Chen, Q. et al. A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes Dev. 28, 432-437 (2014).
-
(2014)
Genes Dev.
, vol.28
, pp. 432-437
-
-
Chen, Q.1
-
41
-
-
84862605178
-
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
-
Liu-Chittenden, Y. et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26, 1300-1305 (2012).
-
(2012)
Genes Dev.
, vol.26
, pp. 1300-1305
-
-
Liu-Chittenden, Y.1
-
42
-
-
34447327216
-
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
-
Naugler, W. E. et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007).
-
(2007)
Science
, vol.317
, pp. 121-124
-
-
Naugler, W.E.1
-
43
-
-
34447506658
-
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
-
Ancrile, B., Lim, K.-H. & Counter, C. M. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21, 1714-1719 (2007).
-
(2007)
Genes Dev.
, vol.21
, pp. 1714-1719
-
-
Ancrile, B.1
Lim, K.-H.2
Counter, C.M.3
-
44
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103-113 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
-
45
-
-
84867853849
-
Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila
-
Ohsawa, S. et al. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature 490, 547-551 (2012).
-
(2012)
Nature
, vol.490
, pp. 547-551
-
-
Ohsawa, S.1
-
46
-
-
84872406787
-
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
-
Liang, J. et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 23, 107-120 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 107-120
-
-
Liang, J.1
-
47
-
-
0037603113
-
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
-
Debnath, J., Muthuswamy, S. K. & Brugge, J. S. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30, 256-268 (2003).
-
(2003)
Methods
, vol.30
, pp. 256-268
-
-
Debnath, J.1
Muthuswamy, S.K.2
Brugge, J.S.3
-
48
-
-
34447632167
-
Gene expression profiling spares early breast cancer patients from adjuvant therapy: Derived and validated in two population-based cohorts
-
Pawitan, Y. et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res. 7, R953-R964 (2005).
-
(2005)
Breast Cancer Res.
, vol.7
, pp. R953-R964
-
-
Pawitan, Y.1
-
49
-
-
26444546442
-
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
-
Miller, L. D. et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc. Natl Acad. Sci. USA 102, 13550-13555 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 13550-13555
-
-
Miller, L.D.1
-
50
-
-
79958728723
-
A gene expression signature identifies two prognostic subgroups of basal breast cancer
-
Sabatier, R. et al. A gene expression signature identifies two prognostic subgroups of basal breast cancer. Breast Cancer Res. Treat. 126, 407-420 (2011).
-
(2011)
Breast Cancer Res. Treat.
, vol.126
, pp. 407-420
-
-
Sabatier, R.1
-
51
-
-
81155131661
-
Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer
-
Sabatier, R. et al. Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. PLoS ONE 6, e27656 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e27656
-
-
Sabatier, R.1
-
52
-
-
67650444760
-
ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
-
Hu, Y. & Smyth, G. K. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods 347, 70-78 (2009).
-
(2009)
J. Immunol. Methods
, vol.347
, pp. 70-78
-
-
Hu, Y.1
Smyth, G.K.2
-
53
-
-
84873287518
-
Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity
-
Gerber, A. et al. Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell 152, 492-503 (2013).
-
(2013)
Cell
, vol.152
, pp. 492-503
-
-
Gerber, A.1
|