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Volumn 6, Issue , 2015, Pages

A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; ONCOPROTEIN; SERUM RESPONSE FACTOR; UNCLASSIFIED DRUG; YAP PROTEIN; IL6 PROTEIN, HUMAN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SRF PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

EID: 84950273424     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10186     Document Type: Article
Times cited : (146)

References (53)
  • 1
    • 30144433093 scopus 로고    scopus 로고
    • Generation of a functional mammary gland from a single stem cell
    • Shackleton, M. et al. Generation of a functional mammary gland from a single stem cell. Nature 439, 84-88 (2006).
    • (2006) Nature , vol.439 , pp. 84-88
    • Shackleton, M.1
  • 2
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 3
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath, I. et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40, 499-507 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 499-507
    • Ben-Porath, I.1
  • 4
    • 33747591465 scopus 로고    scopus 로고
    • Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
    • Overholtzer, M. et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc. Natl Acad. Sci. USA 103, 12405-12410 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12405-12410
    • Overholtzer, M.1
  • 5
    • 42449101282 scopus 로고    scopus 로고
    • A crucial role of WW45 in developing epithelial tissues in the mouse
    • Lee, J.-H. et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 27, 1231-1242 (2008).
    • (2008) EMBO J. , vol.27 , pp. 1231-1242
    • Lee, J.-H.1
  • 6
    • 77952336576 scopus 로고    scopus 로고
    • The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
    • Lee, K.-P. et al. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc. Natl Acad. Sci. USA 107, 8248-8253 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 8248-8253
    • Lee, K.-P.1
  • 7
    • 78049451932 scopus 로고    scopus 로고
    • The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    • Cai, J. et al. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 24, 2383-2388 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2383-2388
    • Cai, J.1
  • 8
    • 36549074631 scopus 로고    scopus 로고
    • YAP1 increases organ size and expands undifferentiated progenitor cells
    • Camargo, F. D. et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr. Biol. 17, 2054-2060 (2007).
    • (2007) Curr. Biol. , vol.17 , pp. 2054-2060
    • Camargo, F.D.1
  • 9
    • 81055140859 scopus 로고    scopus 로고
    • The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
    • Cordenonsi, M. et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147, 759-772 (2011).
    • (2011) Cell , vol.147 , pp. 759-772
    • Cordenonsi, M.1
  • 10
    • 84874257648 scopus 로고    scopus 로고
    • The Hippo pathway: Regulators and regulations
    • Yu, F.-X. & Guan, K.-L. The Hippo pathway: regulators and regulations. Genes Dev. 27, 355-371 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 355-371
    • Yu, F.-X.1    Guan, K.-L.2
  • 11
    • 84865260845 scopus 로고    scopus 로고
    • Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
    • Yu, F.-X. et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780-791 (2012).
    • (2012) Cell , vol.150 , pp. 780-791
    • Yu, F.-X.1
  • 12
    • 79958284636 scopus 로고    scopus 로고
    • Role of YAP/TAZ in mechanotransduction
    • Dupont, S. et al. Role of YAP/TAZ in mechanotransduction. Nature 474, 179-183 (2011).
    • (2011) Nature , vol.474 , pp. 179-183
    • Dupont, S.1
  • 13
    • 84878547831 scopus 로고    scopus 로고
    • CAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
    • Kim, M. et al. cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J. 32, 1543-1555 (2013).
    • (2013) EMBO J. , vol.32 , pp. 1543-1555
    • Kim, M.1
  • 14
    • 0038737042 scopus 로고    scopus 로고
    • Actin dynamics control SRF activity by regulation of its coactivator MAL
    • Miralles, F., Posern, G., Zaromytidou, A.-I. & Treisman, R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113, 329-342 (2003).
    • (2003) Cell , vol.113 , pp. 329-342
    • Miralles, F.1    Posern, G.2    Zaromytidou, A.-I.3    Treisman, R.4
  • 15
    • 38449102928 scopus 로고    scopus 로고
    • Expression of the serum response factor in hepatocellular carcinoma: Implications for epithelial-mesenchymal transition
    • Park, M. Y. et al. Expression of the serum response factor in hepatocellular carcinoma: implications for epithelial-mesenchymal transition. Int. J. Oncol. 31, 1309-1315 (2007).
    • (2007) Int. J. Oncol. , vol.31 , pp. 1309-1315
    • Park, M.Y.1
  • 16
    • 0037119356 scopus 로고    scopus 로고
    • High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling
    • Psichari, E., Balmain, A., Plows, D., Zoumpourlis, V. & Pintzas, A. High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling. J. Biol. Chem. 277, 29490-29495 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 29490-29495
    • Psichari, E.1    Balmain, A.2    Plows, D.3    Zoumpourlis, V.4    Pintzas, A.5
  • 17
    • 61849140657 scopus 로고    scopus 로고
    • Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
    • Medjkane, S., Perez-Sanchez, C., Gaggioli, C., Sahai, E. & Treisman, R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat. Cell Biol. 11, 257-268 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 257-268
    • Medjkane, S.1    Perez-Sanchez, C.2    Gaggioli, C.3    Sahai, E.4    Treisman, R.5
  • 18
    • 84867027347 scopus 로고    scopus 로고
    • TGFb induces the formation of tumour-initiating cells in claudinlow breast cancer
    • Bruna, A. et al. TGFb induces the formation of tumour-initiating cells in claudinlow breast cancer. Nat. Commun. 3, 1055 (2012).
    • (2012) Nat. Commun. , vol.3 , pp. 1055
    • Bruna, A.1
  • 19
    • 84899734505 scopus 로고    scopus 로고
    • Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
    • Esnault, C. et al. Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts. Genes Dev. 28, 943-958 (2014).
    • (2014) Genes Dev. , vol.28 , pp. 943-958
    • Esnault, C.1
  • 20
    • 78650202455 scopus 로고    scopus 로고
    • The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    • Karpowicz, P., Perez, J. & Perrimon, N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development 137, 4135-4145 (2010).
    • (2010) Development , vol.137 , pp. 4135-4145
    • Karpowicz, P.1    Perez, J.2    Perrimon, N.3
  • 21
    • 34548636132 scopus 로고    scopus 로고
    • Elucidation of a universal size-control mechanism in drosophila and mammals
    • Dong, J. et al. Elucidation of a universal size-control mechanism in drosophila and mammals. Cell 130, 1120-1133 (2007).
    • (2007) Cell , vol.130 , pp. 1120-1133
    • Dong, J.1
  • 22
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao, B. et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 22, 1962-1971 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 1962-1971
    • Zhao, B.1
  • 23
    • 0025251798 scopus 로고
    • Several regions of human estrogen receptor are involved in the formation of receptorheat shock protein 90 complexes
    • Chambraud, B., Berry, M., Redeuilh, G., Chambon, P. & Baulieu, E. E. Several regions of human estrogen receptor are involved in the formation of receptorheat shock protein 90 complexes. J. Biol. Chem. 265, 20686-20691 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 20686-20691
    • Chambraud, B.1    Berry, M.2    Redeuilh, G.3    Chambon, P.4    Baulieu, E.E.5
  • 24
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu, F. et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat. Cell Biol. 8, 27-36 (2006).
    • (2006) Nat. Cell Biol. , vol.8 , pp. 27-36
    • Hamaratoglu, F.1
  • 25
    • 84867853849 scopus 로고    scopus 로고
    • Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila
    • Ohsawa, S. et al. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature 490, 547-551 (2012).
    • (2012) Nature , vol.490 , pp. 547-551
    • Ohsawa, S.1
  • 26
    • 73349128777 scopus 로고    scopus 로고
    • YAP-dependent induction of amphiregulin identifies a non-cellautonomous component of the Hippo pathway
    • Zhang, J. et al. YAP-dependent induction of amphiregulin identifies a non-cellautonomous component of the Hippo pathway. Nat. Cell Biol. 11, 1444-1450 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1444-1450
    • Zhang, J.1
  • 27
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • Visvader, J. E. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev. 23, 2563-2577 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 2563-2577
    • Visvader, J.E.1
  • 28
    • 77955895963 scopus 로고    scopus 로고
    • Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
    • Lim, E. et al. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res. 12, R21 (2010).
    • (2010) Breast Cancer Res. , vol.12 , pp. R21
    • Lim, E.1
  • 29
    • 84897104535 scopus 로고    scopus 로고
    • The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment
    • Skibinski, A. et al. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep. 6, 1059-1072 (2014).
    • (2014) Cell Rep. , vol.6 , pp. 1059-1072
    • Skibinski, A.1
  • 30
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • Iliopoulos, D., Hirsch, H. A., Wang, G. & Struhl, K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc. Natl Acad. Sci. USA 108, 1397-1402 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 31
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukindependent inflammatory network
    • Kuilman, T. et al. Oncogene-induced senescence relayed by an interleukindependent inflammatory network. Cell 133, 1019-1031 (2008).
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1
  • 32
    • 59149088576 scopus 로고    scopus 로고
    • Both TEAD-binding andWW domains are required for the growth stimulation and oncogenic transformation activity of Yes-associated protein
    • Zhao, B., Kim, J., Ye, X., Lai, Z.-C. & Guan, K.-L. Both TEAD-binding andWW domains are required for the growth stimulation and oncogenic transformation activity of Yes-associated protein. Cancer Res. 69, 1089-1098 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 1089-1098
    • Zhao, B.1    Kim, J.2    Ye, X.3    Lai, Z.-C.4    Guan, K.-L.5
  • 33
    • 67649770134 scopus 로고    scopus 로고
    • TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
    • Chan, S. W. et al. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J. Biol. Chem. 284, 14347-14358 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 14347-14358
    • Chan, S.W.1
  • 34
    • 33751253145 scopus 로고    scopus 로고
    • Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain
    • Anbanandam, A. et al. Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain. Proc. Natl Acad. Sci. USA 103, 17225-17230 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 17225-17230
    • Anbanandam, A.1
  • 35
    • 76149138881 scopus 로고    scopus 로고
    • Structural insights into the YAP and TEAD complex
    • Li, Z. et al. Structural insights into the YAP and TEAD complex. Genes Dev. 24, 235-240 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 235-240
    • Li, Z.1
  • 36
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 37
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim, E. et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 15, 907-913 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 907-913
    • Lim, E.1
  • 38
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier, C. et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-567 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1
  • 39
    • 84897104535 scopus 로고    scopus 로고
    • The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment
    • Skibinski, A. et al. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep. 6, 1059-1072 (2014).
    • (2014) Cell Rep. , vol.6 , pp. 1059-1072
    • Skibinski, A.1
  • 40
    • 84896824055 scopus 로고    scopus 로고
    • A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis
    • Chen, Q. et al. A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes Dev. 28, 432-437 (2014).
    • (2014) Genes Dev. , vol.28 , pp. 432-437
    • Chen, Q.1
  • 41
    • 84862605178 scopus 로고    scopus 로고
    • Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
    • Liu-Chittenden, Y. et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26, 1300-1305 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 1300-1305
    • Liu-Chittenden, Y.1
  • 42
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler, W. E. et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007).
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1
  • 43
    • 34447506658 scopus 로고    scopus 로고
    • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
    • Ancrile, B., Lim, K.-H. & Counter, C. M. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21, 1714-1719 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1714-1719
    • Ancrile, B.1    Lim, K.-H.2    Counter, C.M.3
  • 44
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103-113 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1
  • 45
    • 84867853849 scopus 로고    scopus 로고
    • Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila
    • Ohsawa, S. et al. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature 490, 547-551 (2012).
    • (2012) Nature , vol.490 , pp. 547-551
    • Ohsawa, S.1
  • 46
    • 84872406787 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
    • Liang, J. et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 23, 107-120 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 107-120
    • Liang, J.1
  • 47
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath, J., Muthuswamy, S. K. & Brugge, J. S. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30, 256-268 (2003).
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 48
    • 34447632167 scopus 로고    scopus 로고
    • Gene expression profiling spares early breast cancer patients from adjuvant therapy: Derived and validated in two population-based cohorts
    • Pawitan, Y. et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res. 7, R953-R964 (2005).
    • (2005) Breast Cancer Res. , vol.7 , pp. R953-R964
    • Pawitan, Y.1
  • 49
    • 26444546442 scopus 로고    scopus 로고
    • An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
    • Miller, L. D. et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc. Natl Acad. Sci. USA 102, 13550-13555 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13550-13555
    • Miller, L.D.1
  • 50
    • 79958728723 scopus 로고    scopus 로고
    • A gene expression signature identifies two prognostic subgroups of basal breast cancer
    • Sabatier, R. et al. A gene expression signature identifies two prognostic subgroups of basal breast cancer. Breast Cancer Res. Treat. 126, 407-420 (2011).
    • (2011) Breast Cancer Res. Treat. , vol.126 , pp. 407-420
    • Sabatier, R.1
  • 51
    • 81155131661 scopus 로고    scopus 로고
    • Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer
    • Sabatier, R. et al. Down-regulation of ECRG4, a candidate tumor suppressor gene, in human breast cancer. PLoS ONE 6, e27656 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e27656
    • Sabatier, R.1
  • 52
    • 67650444760 scopus 로고    scopus 로고
    • ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
    • Hu, Y. & Smyth, G. K. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J. Immunol. Methods 347, 70-78 (2009).
    • (2009) J. Immunol. Methods , vol.347 , pp. 70-78
    • Hu, Y.1    Smyth, G.K.2
  • 53
    • 84873287518 scopus 로고    scopus 로고
    • Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity
    • Gerber, A. et al. Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity. Cell 152, 492-503 (2013).
    • (2013) Cell , vol.152 , pp. 492-503
    • Gerber, A.1


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