2-(trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate suppresses osteoclast maturation and bone resorption by targeting macrophage-colony stimulating factor signaling

Molecules and Cells

Volumn 37, Issue 8, 2014, Pages 628-635

  Park, So Jeong ^a   Park, Doo Ri ^a   Bhattarai, Deepak ^b   Lee, Kyeong ^b   Kim, Jaesang ^a   Bae, Yun Soo ^a   Lee, Soo Young ^a  

^a Ewha Womans University   (South Korea)

^b Dongguk University   (South Korea)

Author keywords

(R) TEMOSPho; Antiresorptive drugs; Bone destruction; Osteoclast; Osteoclast maturation

Indexed keywords

2 (TRIMETHYLAMMONIUM)ETHYL 3 METHOXY 3 OXO 2 STEARAMIDOPROPYL PHOSPHATE; CBL PROTEIN; COLONY STIMULATING FACTOR 1; LIPOPOLYSACCHARIDE; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN C FMS; PROTEIN VAV3; RAC1 PROTEIN; RECEPTOR; UNCLASSIFIED DRUG; 2-(TRIMETHYLAMMONIUM)ETHYL 3-METHOXY-3-OXO-2-STEARAMIDOPROPYL PHOSPHATE; BONE DENSITY CONSERVATION AGENT; CBL PROTEIN, MOUSE; COLONY STIMULATING FACTOR RECEPTOR; NEUROPEPTIDE; ORGANOPHOSPHATE; OSTEOCLAST DIFFERENTIATION FACTOR; RAC1 PROTEIN, MOUSE; TNFSF11 PROTEIN, MOUSE; VAV PROTEIN; VAV3 PROTEIN, MOUSE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DESTRUCTION; CELL ACTIVITY; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN PHOSPHORYLATION; STEM CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; C57BL MOUSE; CELL DIFFERENTIATION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; FEMUR; GENE EXPRESSION REGULATION; GENETICS; MACROPHAGE; METABOLISM; OSTEOBLAST; PREVENTION AND CONTROL; SIGNAL TRANSDUCTION; SKULL; TIBIA; ULTRASTRUCTURE;

ACTIN CYTOSKELETON; ANIMALS; APOPTOSIS; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CELL DIFFERENTIATION; CELL SURVIVAL; FEMUR; GENE EXPRESSION REGULATION; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; ORGANOPHOSPHATES; OSTEOBLASTS; OSTEOCLASTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-VAV; RAC1 GTP-BINDING PROTEIN; RANK LIGAND; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; SIGNAL TRANSDUCTION; SKULL; TIBIA;

EID: 84950159270     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2014.0190     Document Type: Article

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