Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet

Journal of Molecular Endocrinology

Volumn 56, Issue 1, 2015, Pages 1-10

  Martinez Micaelo N ^a   Gonzalez Abuin N ^a   Ardevol A ^a   Pinent, M ^a   Petretto, E ^a,c,d   Behmoaras, J ^a,b   Blay, M ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Cafeteria diet; Inbred rats; Leptin signaling; LEW; SOCS3; WKY

Indexed keywords

3 HYDROXYBUTYRIC ACID; CYCLOPHILIN A; FATTY ACID; GLUCOSE; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR B; MESSENGER RNA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DIET INDUCED OBESITY; DOWN REGULATION; ENERGY EXPENDITURE; ENERGY METABOLISM; ENERGY RESOURCE; ENERGY YIELD; FAT INTAKE; FATTY ACID BLOOD LEVEL; FATTY ACID SYNTHESIS; FOOD INTAKE; GENE EXPRESSION; GENOTYPE ENVIRONMENT INTERACTION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERPHAGIA; HYPERTRIGLYCERIDEMIA; HYPOTHALAMUS; INFLAMMATION; KETOGENESIS; LEWIS RAT; MALE; NONHUMAN; OBESITY; PHENOTYPE; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT; RESPIRATORY QUOTIENT; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WEIGHT GAIN; WISTAR KYOTO RAT; ADVERSE EFFECTS; ANIMAL; DIET; EATING; FAST FOOD; GENOTYPE; METABOLISM; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY;

ADIPOSITY; ANIMALS; DIET; EATING; ENERGY METABOLISM; FAST FOODS; GENE-ENVIRONMENT INTERACTION; GENOTYPE; LEPTIN; MALE; OBESITY; ORGAN SIZE; RATS, INBRED LEW; RATS, INBRED WKY; SIGNAL TRANSDUCTION; WEIGHT GAIN;

EID: 84950145307     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-15-0089     Document Type: Article

References (37)

1. Arch JRS, Hislop D, Wang SJY & Speakman JR 2006 Some mathematical and technical issues in the measurement and interpretation of open-circuit indirect calorimetry in small animals. International Journal of Obesity 30 1322–1331. (doi:10.1038/sj.ijo.0803280)
2. Behmoaras J, Bhangal G, Smith J, McDonald K, Mutch B, Lai PC, Domin J, Game L, Salama A, Foxwell BM et al. 2008 Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nature Genetics 40 553–559. (doi:10.1038/ng.137)
3. Behmoaras J, Smith J, D’Souza Z, Bhangal G, Chawanasuntoropoj R, Tam FWK, Pusey CD, Aitman TJ & Cook HT 2010 Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis. Journal of the American Society of Nephrology 21 1136–1144. (doi:10.1681/ASN.2009090968)
4. Bjørbæk C, El-Haschimi K, Frantz JD & Flier JS 1999 The role of SOCS-3 in leptin signaling and leptin resistance. Journal of Biological Chemistry 274 30059–30065. (doi:10.1074/jbc.274.42.30059)
5. Bouchard C 2008 Gene-environment interactions in the etiology of obesity: defining the fundamentals. Obesity 16 S5–S10. (doi:10.1038/oby.2008.528)
6. D’Souza Z, McAdoo SP, Smith J, Pusey CD, Cook HT, Behmoaras J & Aitman TJ 2013 Experimental crescentic glomerulonephritis: a new bicongenic rat model. Disease Models & Mechanisms 6 1477–1486. (doi:10.1242/dmm.012328)
7. El-Haschimi K, Pierroz DD, Hileman SM, Bjørbaek C & Flier JS 2000 Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. Journal of Clinical Investigation 105 1827–1832. (doi:10.1172/JCI9842)
8. Ferrannini E 1988 The theoretical bases of indirect calorimetry: a review. Metabolism: Clinical and Experimental 37 287–301. (doi:10.1016/0026-0495(88)90110-2)
9. Frederich RC, Löllmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB & Flier JS 1995a Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. Journal of Clinical Investigation 96 1658. (doi:10.1172/JCI118206)
10. Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB & Flier JS 1995b Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Medicine 1 1311–1314. (doi:10.1038/nm1295-1311)
11. Fröhlich M, Imhof A, Berg G, Hutchinson WL, Pepys MB, Boeing H, Muche R, Brenner H & Koenig W 2000 Association between C-reactive protein and features of the metabolic syndrome: a population-based study. Diabetes Care 23 1835–1839. (doi:10.2337/diacare.23.12.1835)
12. Galic S, Oakhill JS & Steinberg GR 2010 Adipose tissue as an endocrine organ. Molecular and Cellular Biochemistry 316 129–139. (doi:10.1016/j.mce.2009.08.018)
13. Hu CC, Qing K & Chen Y 2004 Diet-induced changes in Stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice. Obesity Research 12 1264–1270. (doi:10.1038/oby.2004.160)
14. Ikeda H, Shino A, Matsuo T, Iwatsuka H & Suzuoki Z 1981 A new genetically obese-hyperglycemic rat (Wistar fatty). Diabetes 30 1045–1050. (doi:10.2337/diab.30.12.1045)
15. Kanneganti T-D & Dixit VD 2012 Immunological complications of obesity. Nature Immunology 13 707–712. (doi:10.1038/ni.2343)
16. Kava R, Peterson RG, West DB & Greenwood MRC 1990 Wistar diabetic fatty rat. ILAR Journal 32 9–13. (doi:10.1093/ilar.32.3.9)
17. Knobelspies H, Zeidler J, Hekerman P, Bamberg-Lemper S & Becker W 2010 Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochemistry 11 2. (doi:10.1186/1471-2091-11-2)
18. Koza RA, Nikonova L, Hogan J, Rim J-S, Mendoza T, Faulk C, Skaf J & Kozak LP 2006 Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genetics 2 e81. (doi:10.1371/journal. pgen.0020081)
19. La Cava A & Matarese G 2004 The weight of leptin in immunity. Nature Reviews Immunology 4 371–379. (doi:10.1038/nri1350)
20. Laffel L 1999 Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metabolism Research and Reviews 15 412–426. (doi:10.1002/(SICI)1520-7560(199911/12)15:6<412::AID-DMRR72>3.0.CO;2-8)
21. Maratou K, Behmoaras J, Fewings C, Srivastava P, D’Souza Z, Smith J, Game L, Cook T & Aitman T 2011 Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains. Genes and Immunity 12 78–89. (doi:10.1038/gene.2010.61)
22. McGarry JD & Foster DW 1980 Regulation of hepatic fatty acid oxidation and ketone body production. Annual Review of Biochemistry 49 395–420. (doi:10.1146/annurev.bi.49.070180.002143)
23. Michaelis OE, Ellwood KC, Tulp OL & Greenwood MRC 1986 Effect of feeding sucrose or starch diets on parameters of glucose tolerance in the LA/N-corpulent rat. Nutrition Research 6 95–99. (doi:10.1016/S0271-5317(86)80203-2)
24. Minokoshi Y, Kim Y-B, Peroni OD, Fryer LGD, Müller C, Carling D & Kahn BB 2002 Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 339–343. (doi:10.1038/415339a)
25. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H & Yoshimura A 2004 Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nature Medicine 10 739–743. (doi:10.1038/nm1071)
26. Morton GJ & Schwartz MW 2011 Leptin and the central nervous system control of glucose metabolism. Physiological Reviews 91 389–411. (doi:10.1152/physrev.00007.2010)
27. Myers MG, Cowley MA & Münzberg H 2008 Mechanisms of leptin action and leptin resistance. Annual Review of Physiology 70 537–556. (doi:10.1146/annurev.physiol.70.113006.100707)
28. Olofsson LE, Unger EK, Cheung CC & Xu AW 2013 Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. PNAS 110 E697–E706. (doi:10.1073/pnas.1218284110)
29. Ordovas JM 2008 Genotype-phenotype associations: modulation by diet and obesity. Obesity 16 S40–S46. (doi:10.1038/oby.2008.515)
30. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ et al. 2013 Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metabolism 17 141–152. (doi:10.1016/j.cmet.2012.12.007)
31. Pérusse L & Bouchard C 2000 Gene-diet interactions in obesity. American Journal of Clinical Nutrition 72 (5 Supplement) 1285s–1290s.
32. Sachithanandan N, Fam BC, Fynch S, Dzamko N, Watt MJ, Wormald S, Honeyman J, Galic S, Proietto J, Andrikopoulos S et al. 2010 Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity. Hepatology 52 1632–1642. (doi:10.1002/hep. 23861)
33. Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB & Makowski L 2011 Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high?fat diet, Obesity 19 1109–1117. (doi:10.1038/oby.2011.18)
34. Speakman JR 2004 Obesity: the integrated roles of environment and genetics. Journal of Nutrition 134 (8 Supplement) 2090S–2105S.
35. Spiegelman BM & Flier JS 2001 Obesity and the regulation of energy balance. Cell 104 531–543. (doi:10.1016/S0092-8674(01)00240-9)
36. Unger RH 2003 The physiology of cellular liporegulation. Annual Review of Physiology 65 333–347. (doi:10.1146/annurev.physiol.65.092101. 142622)
37. Zhang Y & Scarpace PJ 2006 The role of leptin in leptin resistance and obesity. Physiology & Behavior 88 249–256. (doi:10.1016/j.physbeh. 2006.05.038)