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Volumn 5, Issue , 2015, Pages

Rat and human STINGs profile similarly towards anticancer/antiviral compounds

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STING PROTEIN, RAT; VADIMEZAN; XANTHONE DERIVATIVE;

EID: 84950133396     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18035     Document Type: Article
Times cited : (26)

References (37)
  • 1
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
    • Sun, L., Wu, J., Du, F., Chen, X., Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791, doi: 10.1126/science.1232458 (2013).
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 2
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • Wu, J., Chen, Z. J. Innate immune sensing and signaling of cytosolic nucleic acids. Annu Rev Immunol 32, 461-488, doi: 10.1146/annurev-immunol-032713-120156 (2014).
    • (2014) Annu Rev Immunol , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 3
    • 84879385334 scopus 로고    scopus 로고
    • CGAS produces a 2-5-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser, A. et al. cGAS produces a 2-5-linked cyclic dinucleotide second messenger that activates STING. Nature 498, 380-384, doi: 10.1038/nature12306 (2013).
    • (2013) Nature , vol.498 , pp. 380-384
    • Ablasser, A.1
  • 4
    • 84878572947 scopus 로고    scopus 로고
    • The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
    • Diner, E. J. et al. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 3, 1355-1361, doi: 10.1016/j.celrep.2013.05.009 (2013).
    • (2013) Cell Rep , vol.3 , pp. 1355-1361
    • Diner, E.J.1
  • 5
    • 84878309796 scopus 로고    scopus 로고
    • Cyclic [G(2 ,5 )pA(3 ,5 )p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
    • Gao, P. et al. Cyclic [G(2 ,5 )pA(3 ,5 )p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094-1107, doi: 10.1016/j.cell.2013.04.046 (2013).
    • (2013) Cell , vol.153 , pp. 1094-1107
    • Gao, P.1
  • 6
    • 84880508067 scopus 로고    scopus 로고
    • Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
    • Zhang, X. et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51, 226-235, doi: 10.1016/j.molcel.2013.05.022 (2013).
    • (2013) Mol. Cell , vol.51 , pp. 226-235
    • Zhang, X.1
  • 7
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • Ishikawa, H., Barber, G. N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455, 674-678, doi: 10.1038/nature07317 (2008).
    • (2008) Nature , vol.455 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 8
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type i interferon-dependent innate immunity
    • Ishikawa, H., Ma, Z., Barber, G. N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788-792, doi: 10.1038/nature08476 (2009).
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 9
    • 80052662208 scopus 로고    scopus 로고
    • MPYS is required for IFN response factor 3 activation and type i IFN production in the response of cultured phagocytes to bacterial second messengers Cyclic-Di-AMP and cyclic-di-GMP
    • Jin, L. et al. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J. Immunol. 187, 2595-2601, doi: 10.4049/jimmunol.1100088 (2011).
    • (2011) J. Immunol , vol.187 , pp. 2595-2601
    • Jin, L.1
  • 10
    • 66649109939 scopus 로고    scopus 로고
    • ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
    • Sun, W. et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. USA 106, 8653-8658, doi: 10.1073/pnas.0900850106 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 8653-8658
    • Sun, W.1
  • 11
    • 53349168904 scopus 로고    scopus 로고
    • The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    • Zhong, B. et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29, 538-550, doi: 10.1016/j.immuni.2008.09.003 (2008).
    • (2008) Immunity , vol.29 , pp. 538-550
    • Zhong, B.1
  • 12
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu, J. et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339, 826-830, doi: 10.1126/science.1229963 (2013).
    • (2013) Science , vol.339 , pp. 826-830
    • Wu, J.1
  • 13
    • 84857937262 scopus 로고    scopus 로고
    • STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
    • Tanaka, Y., Chen, Z. J. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci. Signal. 5, ra20, doi: 10.1126/scisignal.2002521 (2012).
    • (2012) Sci. Signal , vol.5 , pp. 20
    • Tanaka, Y.1    Chen, Z.J.2
  • 14
    • 84878616469 scopus 로고    scopus 로고
    • STING-Dependent recognition of cyclic di-AMP mediates type i interferon responses during Chlamydia trachomatis infection
    • Barker, J. R. et al. STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. Mbio 4, e00018-00013, doi: 10.1128/mBio.00018-13 (2013).
    • (2013) Mbio , vol.4 , pp. e00018-e00023
    • Barker, J.R.1
  • 15
    • 80054966913 scopus 로고    scopus 로고
    • STING is a direct innate immune sensor of cyclic di-GMP
    • Burdette, D. L. et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478, 515-518, doi: 10.1038/nature10429 (2011).
    • (2011) Nature , vol.478 , pp. 515-518
    • Burdette, D.L.1
  • 16
    • 84886918149 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of human sting can affect innate immune response to cyclic dinucleotides
    • Yi, G. H. et al. Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides. Plos One 8, doi: 10.1371/journal.pone.0077846 (2013).
    • (2013) Plos One , pp. 8
    • Yi, G.H.1
  • 17
    • 84863722786 scopus 로고    scopus 로고
    • The structural basis for the sensing and binding of cyclic di-GMP by STING
    • Huang, Y. H., Liu, X. Y., Du, X. X., Jiang, Z. F., Su, X. D. The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat. Struct. Mol. Biol. 19, 728-730, doi: 10.1038/nsmb.2333 (2012).
    • (2012) Nat. Struct. Mol. Biol , vol.19 , pp. 728-730
    • Huang, Y.H.1    Liu, X.Y.2    Du, X.X.3    Jiang, Z.F.4    Su, X.D.5
  • 18
    • 84882815198 scopus 로고    scopus 로고
    • Structure-function analysis of STING activation by c[G(2 ,5 )pA(3 ,5 )p] and targeting by antiviral DMXAA
    • Gao, P. et al. Structure-function analysis of STING activation by c[G(2 ,5 )pA(3 ,5 )p] and targeting by antiviral DMXAA. Cell 154, 748-762, doi: 10.1016/j.cell.2013.07.023 (2013).
    • (2013) Cell , vol.154 , pp. 748-762
    • Gao, P.1
  • 19
    • 84927544825 scopus 로고    scopus 로고
    • Structural biology of innate immunity
    • Yin, Q., Fu, T. M., Li, J., Wu, H. Structural biology of innate immunity. Annu Rev Immunol 33, 393-416, doi: 10.1146/annurevimmunol-032414-112258 (2015).
    • (2015) Annu Rev Immunol , vol.33 , pp. 393-416
    • Yin, Q.1    Fu, T.M.2    Li, J.3    Wu, H.4
  • 20
    • 0026686247 scopus 로고
    • Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice
    • Ching, L. M., Joseph, W. R., Baguley, B. C. Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice. Br J Cancer 66, 128-130 (1992).
    • (1992) Br J Cancer , vol.66 , pp. 128-130
    • Ching, L.M.1    Joseph, W.R.2    Baguley, B.C.3
  • 21
    • 0037125028 scopus 로고    scopus 로고
    • Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid
    • Ching, L. M. et al. Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid. Br J Cancer 86, 1937-1942, doi: 10.1038/sj.bjc.6600368 (2002).
    • (2002) Br J Cancer , vol.86 , pp. 1937-1942
    • Ching, L.M.1
  • 23
    • 0018933441 scopus 로고
    • High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters
    • Taylor, J. L., Schoenherr, C. K., Grossberg, S. E. High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters. Antimicrob Agents Chemother 18, 20-26 (1980).
    • (1980) Antimicrob Agents Chemother , vol.18 , pp. 20-26
    • Taylor, J.L.1    Schoenherr, C.K.2    Grossberg, S.E.3
  • 24
    • 84878638162 scopus 로고    scopus 로고
    • Species-specific detection of the antiviral small-molecule compound CMA by STING
    • Cavlar, T., Deimling, T., Ablasser, A., Hopfner, K. P., Hornung, V. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J 32, 1440-1450, doi: 10.1038/emboj.2013.86 (2013).
    • (2013) EMBO J , vol.32 , pp. 1440-1450
    • Cavlar, T.1    Deimling, T.2    Ablasser, A.3    Hopfner, K.P.4    Hornung, V.5
  • 25
    • 84869208004 scopus 로고    scopus 로고
    • 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential
    • Prantner, D. et al. 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential. J. Biol. Chem. 287, doi: DOI 10.1074/jbc. M112.382986 (2012).
    • (2012) J. Biol. Chem , pp. 287
    • Prantner, D.1
  • 26
    • 34447330454 scopus 로고    scopus 로고
    • The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis
    • Roberts, Z. J. et al. The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. J. Exp. Med. 204, 1559-1569, doi: DOI 10.1084/jem.20061845 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1559-1569
    • Roberts, Z.J.1
  • 27
    • 84877795529 scopus 로고    scopus 로고
    • Mouse, but not Human STING, binds and signals in response to the vascular disrupting agent 5,6-Dimethylxanthenone-4-Acetic Acid
    • Conlon, J. et al. Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid. J. Immunol. 190, 5216-5225, doi: DOI 10.4049/jimmunol.1300097 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 5216-5225
    • Conlon, J.1
  • 28
    • 0036143156 scopus 로고    scopus 로고
    • Systematic identification of novel protein domain families associated with nuclear functions
    • Doerks, T., Copley, R. R., Schultz, J., Ponting, C. P., Bork, P. Systematic identification of novel protein domain families associated with nuclear functions. Genome Res 12, 47-56, doi: DOI 10.1101/gr.203201 (2002).
    • (2002) Genome Res , vol.12 , pp. 47-56
    • Doerks, T.1    Copley, R.R.2    Schultz, J.3    Ponting, C.P.4    Bork, P.5
  • 29
    • 34547566008 scopus 로고    scopus 로고
    • Toward rational protein crystallization: A Web server for the design of crystallizable protein variants
    • Goldschmidt, L., Cooper, D. R., Derewenda, Z. S., Eisenberg, D. Toward rational protein crystallization: A Web server for the design of crystallizable protein variants. Protein Sci 16, 1569-1576, doi: 10.1110/ps.072914007 (2007).
    • (2007) Protein Sci , vol.16 , pp. 1569-1576
    • Goldschmidt, L.1    Cooper, D.R.2    Derewenda, Z.S.3    Eisenberg, D.4
  • 30
    • 84863009492 scopus 로고    scopus 로고
    • Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
    • Ouyang, S. et al. Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity 36, 1073-1086, doi: 10.1016/j.immuni.2012.03.019 (2012).
    • (2012) Immunity , vol.36 , pp. 1073-1086
    • Ouyang, S.1
  • 31
    • 84863726252 scopus 로고    scopus 로고
    • Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
    • Shu, C., Yi, G., Watts, T., Kao, C. C., Li, P. Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. 19, 722-724, doi: 10.1038/nsmb.2331 (2012).
    • (2012) Nat. Struct. Mol. Biol , vol.19 , pp. 722-724
    • Shu, C.1    Yi, G.2    Watts, T.3    Kao, C.C.4    Li, P.5
  • 32
    • 84862996389 scopus 로고    scopus 로고
    • Cyclic di-GMP sensing via the innate immune signaling protein STING
    • Yin, Q. et al. Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol. Cell 46, 735-745, doi: 10.1016/j. molcel.2012.05.029 (2012).
    • (2012) Mol. Cell , vol.46 , pp. 735-745
    • Yin, Q.1
  • 33
    • 84941804631 scopus 로고    scopus 로고
    • Ancient origin of cGAS-STING reveals mechanism of universal 2 ,3 cGAMP Signaling
    • Kranzusch, P. J. et al. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2 ,3 cGAMP Signaling. Mol. Cell, doi: 10.1016/j.molcel.2015.07.022 (2015).
    • (2015) Mol. Cell
    • Kranzusch, P.J.1
  • 34
    • 84875421431 scopus 로고    scopus 로고
    • Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
    • Chin, K. H. et al. Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING. Acta Crystallogr D Biol Crystallogr 69, 352-366 (2013).
    • (2013) Acta Crystallogr D Biol Crystallogr , vol.69 , pp. 352-366
    • Chin, K.H.1
  • 35
    • 84907409467 scopus 로고    scopus 로고
    • Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA
    • Gao, P. et al. Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. Cell Rep. 8, 1668-1676, doi: 10.1016/j.celrep.2014.08.010 (2014).
    • (2014) Cell Rep , vol.8 , pp. 1668-1676
    • Gao, P.1
  • 36
    • 84928929061 scopus 로고    scopus 로고
    • Identification and characterization of phosphodiesterases that specifically degrade 3 3-cyclic GMP-AMP
    • Gao, J. et al. Identification and characterization of phosphodiesterases that specifically degrade 3 3-cyclic GMP-AMP. Cell Res 25, 539-550, doi: 10.1038/cr.2015.40 (2015).
    • (2015) Cell Res , vol.25 , pp. 539-550
    • Gao, J.1
  • 37
    • 80054694130 scopus 로고    scopus 로고
    • Activation of STAT6 by STING is critical for antiviral innate immunity
    • Chen, H. et al. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell 147, 436-446, doi: 10.1016/j.cell.2011.09.022 (2011).
    • (2011) Cell , vol.147 , pp. 436-446
    • Chen, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.