Hydrogel-based drug delivery systems for poorly water-soluble drugs

Molecules

Volumn 20, Issue 11, 2015, Pages 20397-20408

  McKenzie, Matthew ^a   Betts, David ^a   Suh, Amy ^a   Bui, Kathryn ^a   Kim, London Doyoung ^a   Cho, Hyunah ^a  

^a ST LOUIS COLLEGE OF PHARMACY   (United States)

Author keywords

Block copolymers; Hydrogels; Hydrophobic drugs; Thermosensitive

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG; DRUG CARRIER; HYDROGEL; POLYMER; WATER;

ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DELIVERY SYSTEM; HUMAN; HYDROGEL; NEOPLASMS; SOLUBILITY; TEMPERATURE;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGELS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NEOPLASMS; PHARMACEUTICAL PREPARATIONS; POLYMERS; SOLUBILITY; TEMPERATURE; WATER;

EID: 84949939521     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules201119705     Document Type: Review

References (49)

1. Gupta, P.; Vermani, K.; Garg, S. Hydrogels: From controlled release to pH-responsive drug delivery. Drug Discov. Today 2002, 7, 569-579. [Cross Ref]
2. Kopecek, J. Hydrogels from soft contact lenses and implants to self-assembled nanomaterials. J. Polym. Sci. A Polym. Chem. 2009, 47, 5929-5946. [Cross Ref] [Pub Med]
3. Singh, N.K.; Lee, D.S. In situ gelling pH- and temperature-sensitive biodegradable block copolymer hydrogels for drug delivery. J. Control Release 2014, 193, 214-227. [Cross Ref] [Pub Med]
4. Simoes, S.; Figueiras, A.; Francisco, V. Modular hydrogels for drug delivery. J. Biomater. Nanobiotechnol. 2012, 3, 185-199. [Cross Ref]
5. Sakai, S.; Ueda, K.; Taya, M. Peritoneal adhesion prevention by a biodegradable hyaluronic acid-based hydrogel formed in situ through a cascade enzyme reaction initiated by contact with body fluid on tissue surfaces. Acta Biomater. 2015, 24, 152-158. [Cross Ref] [Pub Med]
6. Xinming, L.; Yingde, C.; Lloyd, A.W.; Mikhalovsky, S.V.; Sandeman, S.R.; Howel, C.A.; Liewen, L. Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review. Contact. Lens Anterior Eye 2008, 31, 57-64. [Cross Ref] [Pub Med]
7. Hoare, T.R.; Kohane, D.S. Hydrogels in drug delivery: Progress and challenges. Polymer 2008, 49, 1993-2007. [Cross Ref]
8. Maya, S.; Sarmento, B.; Nair, A.; Rejinold, N.S.; Nair, S.V.; Jayakumar, R. Smart stimuli sensitive nanogels in cancer drug delivery and imaging: A review. Curr. Pharm. Des. 2013, 19, 7203-7218. [Cross Ref] [Pub Med]
9. Cho, H.; Kwon, G.S. Thermosensitive poly-(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-blockpoly-(D,L-lactide-co-glycolide) hydrogels for multi-drug delivery. J. Drug Target 2014, 22, 669-677. [Cross Ref] [Pub Med]
10. Lipinski, C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44, 235-249. [Cross Ref]
11. Nguyen, M.K.; Lee, D.S. Injectable biodegradable hydrogels. Macromol. Biosci. 2010, 10, 563-579. [Cross Ref] [Pub Med]
12. Bonacucina, G.; Cespi, M.; Mencarelli, G.; Giorgioni, G.; Palmieri, G.F. Thermosensitive self-assembling block copolymers as drug delivery systems. Polymers 2011, 3, 779-811. [Cross Ref]
13. Raymond, E.G. On the theory of lower critical solution points in hydrogen-bonded mixtures. J. Chem. Phys. 1984, 80, 5340-5341.
14. Al-Saden, A.A.; Florence, A.T.; Morrison, H.; Whateley, T.L. Association of poloxamer block copolymers in aqueous solution [proceedings]. J. Pharm. Pharmacol. 1979, 31, 81. [Cross Ref]
15. Wang, P.; Johnson, T.P. Kinetics of sol-to-gel transition for poloxamer polyols. J. App. Polym. Sci. 1991, 43, 283-292. [Cross Ref]
16. Brown, W.; Schillen, K.; Almgren, M.; Hvidt, S.; Bahadur, P. Micelle and gel formation in a poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) triblock copolymer in water solution: Dynamic and static light scattering and oscillatory shear measurements. J. Phys. Chem. 1991, 95, 1850-1858. [Cross Ref]
17. Wanka, G.; Hoffmann, H.; Ulbricht, W. The aggregation behavior of poly-(oxyethylene)-poly- (oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution. Colloid Polym. Sci. 1990, 268, 101-117. [Cross Ref]
18. Rassing, J.; Attwood, D. Ultrasonic velocity and light-scattering studies on the polyoxyethylene-polyoxypropylene copolymer pluronic F127 in aqueous solution. Int. J. Pharm. 1982, 13, 47-55. [Cross Ref]
19. Vadnere, M.; Amidon, G.; Lindenbaum, S.; Haslam, J.L. Thermodynamic studies on the gel-sol transition of some pluronic polyols. Int. J. Pharm. 1984, 22, 207-218. [Cross Ref]
20. Pandit, N.K.;Wang, D. Salt effects on the diffusion and release rate of propranolol from poloxamer 407 gels. Int. J. Pharm. 1998, 167, 183-189. [Cross Ref]
21. Devi, D.R.; Sandhya, P.; Hari, B.N.V. Poloxamer: A novel functional molecule for drug delivery and gene therapy. J. Pharm. Sci. Res. 2013, 5, 159-165.
22. Lee, W.C.; Li, Y.C.; Chu, I.M. Amphiphilic poly(D,L-lactic acid)/poly(ethylene glycol)/poly(D,L-lactic acid) nanogels for controlled release of hydrophobic drugs. Macromol. Biosci. 2006, 6, 846-854. [Cross Ref] [Pub Med]
23. Asadi, H.; Rostamizadeh, K.; Salari, D.; Hamidi, M. Preparation and characterization of tri-block poly(lactide)-poly(ethylene glycol)-poly(lactide) nanogels for controlled release of naltrexone. Int. J. Pharm. 2011, 416, 356-364. [Pub Med]
24. Loh, X.J.; Li, J. Biodegradable thermosensitive copolymer hydrogels for drug delivery. Expert Opin. Ther. Pat. 2007, 17, 965-977. [Cross Ref]
25. Cho, H.; Lai, T.C.; Tomoda, K.; Kwon, G.S. Polymeric micelles for multi-drug delivery in cancer. AAPS Pharm. Sci. Technol. 2015, 16, 10-20. [Cross Ref] [Pub Med]
26. Qiao, M.; Chen, D.; Ma, X.; Liu, Y. Injectable biodegradable temperature-responsive PLGA-PEG-PLGA copolymers: Synthesis and effect of copolymer composition on the drug release from the copolymer-based hydrogels. Int. J. Pharm. 2005, 294, 103-112. [Cross Ref] [Pub Med]
27. Jeong, B.; Bae, Y.H.; Kim, S.W. Drug release from biodegradable injectable thermosensitive hydrogel of peg-plga-peg triblock copolymers. J. Control Release 2000, 63, 155-163. [Cross Ref]
28. Gong, C.; Shi, S.; Dong, P.; Kan, B.; Gou, M.; Wang, X.; Li, X.; Luo, F.; Zhao, X.; Wei, Y.; et al. Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. Int. J. Pharm. 2009, 365, 89-99. [Cross Ref] [Pub Med]
29. Lee, B.H.; Lee, Y.M.; Sohn, Y.S.; Song, S.C. A thermosensitive poly(organophosphazene) gel. Macromolecules 2002, 35, 3876-3879. [Cross Ref]
30. Seong, J.Y.; Juna, Y.J.; Jeong, B.; Sohn, Y.S. New thermogelling poly(organophosphazenes) with methoxypoly(ethylene glycol) and oligopeptide as side groups. Polymer 2005, 46, 5075-5081. [Cross Ref]
31. Shim, W.S.; Yoo, J.S.; Bae, Y.H.; Lee, D.S. Novel injectable ph and temperature sensitive block copolymer hydrogel. Biomacromolecules 2005, 6, 2930-2934. [Cross Ref] [Pub Med]
32. Choi, B.G.; Sohn, Y.S.; Jeong, B. Closed-loop sol-gel transition of peg-pec aqueous solution. J. Phys. Chem. B 2007, 111, 7715-7718. [Cross Ref] [Pub Med]
33. Yoo, J.S.; Kim, M.S.; Lee, D.S.; Kim, B.S.; Kim, J.H. Novel pH and temperature-sensitive block copolymers: Poly(ethylene glycol)-b-poly(#-caprolactone)-b-poly(β-amino ester). Macromol. Res. 2006, 14, 117-120. [Cross Ref]
34. Huynh, D.P.; Nguyen, M.K.; Pi, B.S.; Kim, M.S.; Chae, S.Y.; Lee, K.C.; Kim, B.S.; Kim, S.W.; Lee, D.S. Functionalized injectable hydrogels for controlled insulin delivery. Biomaterials 2008, 29, 2527-2534. [Cross Ref] [Pub Med]
35. Huynh, D.P.; Nguyen, M.K.; Kim, B.S.; Lee, D.S. Molecular design of novel pH/temperature-sensitive hydrogels. Polymer 2009, 50, 2565-2571. [Cross Ref]
36. Almomen, A.; Cho, S.; Yang, C.H.; Li, Z.; Jarboe, E.A.; Peterson, C.M.; Huh, K.M.; Janat-Amsbury, M.M. Thermosensitive progesterone hydrogel: A safe and effective new formulation for vaginal application. Pharm. Res. 2015, 32, 2266-2279. [Cross Ref] [Pub Med]
37. Li, Z.; Cho, S.; Kwon, I.C.; Janát-Amsbury, M.M.; Huh, K.M. Preparation and characterization of glycol chitin as a new thermogelling polymer for biomedical applications. Carbohydr. Polym. 2013, 92, 2267-2275. [Cross Ref] [Pub Med]
38. De Alvarenga, E.S. Characterization and properties of chitosan. In Biotechnology of Biopolymers; Elnashar, M., Ed.; In Tech: Rijeka, Croatia, 2011; pp. 91-108.
39. Xuan, J.J.; Yan, Y.D.; Oh, D.H.; Choi, Y.K.; Yong, C.S.; Choi, H.G. Development of thermo-sensitive injectable hydrogel with sustained release of doxorubicin: Rheological characterization and in vivo evaluation in rats. Drug Deliv. 2011, 18, 305-311. [Cross Ref] [Pub Med]
40. Kulkarni, C.V.; Moinuddin, Z.; Patil-Sen, Y.; Littlefield, R.; Hood, M. Lipid-hydrogel films for sustained drug release. Int. J. Pharm. 2015, 479, 416-421. [Cross Ref] [Pub Med]
41. Kushwaha, S.K.S.; Rai, A.K.; Singh, S. Formulation of thermosensitive hydrogel containing cyclodextrin for controlled drug delivery of camptothecin. Trop. J. Pharm. Res. 2014, 13, 1007-1012. [Cross Ref]
42. Ju, C.; Sun, J.; Zi, P.; Jin, X.; Zhang, C. Thermosensitive micelles-hydrogel hybrid system based on poloxamer 407 for localized delivery of paclitaxel. J. Pharm. Sci. 2013, 102, 2707-2717. [Cross Ref] [Pub Med]
43. Gao, Y.; Ren, F.; Ding, B.; Sun, N.; Liu, X.; Ding, X.; Gao, S. A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel. J. Drug Target 2011, 19, 516-527. [Cross Ref] [Pub Med]
44. Pillai, J.J.; Thulasidasan, A.K.; Anto, R.J.; Chithralekha, D.N.; Narayanan, A.; Kumar, G.S. Folic acid conjugated cross-linked acrylic polymer (fa-clap) hydrogel for site specific delivery of hydrophobic drugs to cancer cells. J. Nanobiotechnol. 2014, 12, 25-33. [Cross Ref] [Pub Med]
45. Elstad, N.L.; Fowers, K.D. Oncogel (regel/paclitaxel)-clinical applications for a novel paclitaxel delivery system. Adv. Drug Deliv. Rev. 2009, 61, 785-794. [Cross Ref] [Pub Med]
46. Pados, G.; Makedos, A.; Tarlatzis, B. Adhesion prevention strategies in laparoscopic surgery. In Endoscopy; Amornyotin, S., Ed.; In Tech: Rijeka, Croatia, 2013; pp. 49-72.
47. Yang, B.; Gong, C.; Qian, Z.; Zhao, X.; Li, Z.; Qi, X.; Zhou, S.; Zhong, Q.; Luo, F.; Wei, Y. Prevention of post-surgical abdominal adhesions by a novel biodegradable thermosensitive pece hydrogel. BMC Biotechnol. 2010, 10, 65-73. [Cross Ref] [Pub Med]
48. Di Zerega, G.S. Biochemical events in peritoneal tissue repair. Eur. J. Surg. Suppl. 1997, 577, 10-16.
49. Gao, X.; Deng, X.; Wei, X.; Shi, H.; Wang, F.; Ye, T.; Shao, B.; Nie, W.; Li, Y.; Luo, M.; et al. Novel thermosensitive hydrogel for preventing formation of abdominal adhesions. Int. J. Nanomed. 2013, 8, 2453-2463. [Cross Ref] [Pub Med]