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Volumn 3, Issue , 2016, Pages 63-77

Hepatoprotective effect of grape seed proanthocyanidins on Cadmium-induced hepatic injury in rats: Possible involvement of mitochondrial dysfunction, inflammation and apoptosis

Author keywords

Cd; GSP; Liver; Mitochondria; Oxidative stress; Rats

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CADMIUM; CALCIUM; CYTOCHROME C OXIDASE; HYDROXYPROLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE; OXOGLUTARATE DEHYDROGENASE; PROANTHOCYANIDIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UBIQUINONE;

EID: 84949844535     PISSN: 22147500     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxrep.2015.11.010     Document Type: Article
Times cited : (41)

References (60)
  • 2
    • 0033631609 scopus 로고    scopus 로고
    • Mechanisms of cadmium-mediated acute hepatotoxicity
    • Rikans L.E., Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. Biochem. Mol. Toxicol. 2000, 14:110-117.
    • (2000) Biochem. Mol. Toxicol. , vol.14 , pp. 110-117
    • Rikans, L.E.1    Yamano, T.2
  • 3
    • 0021127528 scopus 로고
    • Time course of cadmium-induced ultrastructural changes in rat liver
    • Dudley R.E., Svoboda D.J., Klaassen C.D. Time course of cadmium-induced ultrastructural changes in rat liver. Toxicol. Appl. Pharmacol. 1984, 76:150-160.
    • (1984) Toxicol. Appl. Pharmacol. , vol.76 , pp. 150-160
    • Dudley, R.E.1    Svoboda, D.J.2    Klaassen, C.D.3
  • 5
    • 0015882341 scopus 로고
    • The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen
    • Boveris A., Chance B. The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen. Biochem. J. 1973, 134:707-716.
    • (1973) Biochem. J. , vol.134 , pp. 707-716
    • Boveris, A.1    Chance, B.2
  • 6
    • 0035827448 scopus 로고    scopus 로고
    • Renal cortical mitochondrial dysfunction upon cadmium metallothionein administration to Sprague-Dawley rats
    • Tang W., Shaikh Z.A. Renal cortical mitochondrial dysfunction upon cadmium metallothionein administration to Sprague-Dawley rats. J. Toxicol. Environ. Health. A 2001, 63:221-235.
    • (2001) J. Toxicol. Environ. Health. A , vol.63 , pp. 221-235
    • Tang, W.1    Shaikh, Z.A.2
  • 8
    • 38049130488 scopus 로고    scopus 로고
    • Chemical characterization and antioxidant activities of oligomeric and polymeric procyanidin fractions from grape seeds
    • Spranger I., Sun B., Mateus A.M., Freitas V., Ricardo-da-Silva J.M. Chemical characterization and antioxidant activities of oligomeric and polymeric procyanidin fractions from grape seeds. Food Chem. 2008, 108:519-532.
    • (2008) Food Chem. , vol.108 , pp. 519-532
    • Spranger, I.1    Sun, B.2    Mateus, A.M.3    Freitas, V.4    Ricardo-da-Silva, J.M.5
  • 9
    • 0345215163 scopus 로고    scopus 로고
    • Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice
    • Bagchi D., Garg A., Krohn R., et al. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Gen. Pharmacol. 1998, 30:771-776.
    • (1998) Gen. Pharmacol. , vol.30 , pp. 771-776
    • Bagchi, D.1    Garg, A.2    Krohn, R.3
  • 10
    • 84894181399 scopus 로고    scopus 로고
    • Protective role of grape seed proanthocyanidins against cadmium induced hepatic dysfunction in rats
    • Nazimabashir, Manoharan V., Milton Prabu S. Protective role of grape seed proanthocyanidins against cadmium induced hepatic dysfunction in rats. Toxicol. Res. 2014, 3:131-141.
    • (2014) Toxicol. Res. , vol.3 , pp. 131-141
    • Nazimabashir1    Manoharan, V.2    Milton Prabu, S.3
  • 13
    • 75949131110 scopus 로고    scopus 로고
    • Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin
    • Renugadevi J., Prabu S.M. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp. Toxicol. Pathol. 2010, 62:171-181.
    • (2010) Exp. Toxicol. Pathol. , vol.62 , pp. 171-181
    • Renugadevi, J.1    Prabu, S.M.2
  • 14
    • 0542399330 scopus 로고
    • Interferences in inductively coupled plasma mass spectrometry
    • Evans H., Giglio J. Interferences in inductively coupled plasma mass spectrometry. J. Anal. At. Absorpt. Spectrom. 1993, 8:1-18.
    • (1993) J. Anal. At. Absorpt. Spectrom. , vol.8 , pp. 1-18
    • Evans, H.1    Giglio, J.2
  • 17
    • 71849104860 scopus 로고
    • Protein measurement with the folin phenol reagent
    • Lowry O.H., Rosebrough N.J., Farr A.L., et al. Protein measurement with the folin phenol reagent. Biol. Chem. 1951, 193:265-275.
    • (1951) Biol. Chem. , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3
  • 18
    • 0032504151 scopus 로고    scopus 로고
    • HIV-1 rat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-d-aspartate receptors by a NF-kB-independent mechanism
    • New D.R., Maggirwar S.B., Epstein L.G., Dewhurst S., Gelbard H.A. HIV-1 rat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-d-aspartate receptors by a NF-kB-independent mechanism. J. Biol. Chem. 1998, 273:17852-17858.
    • (1998) J. Biol. Chem. , vol.273 , pp. 17852-17858
    • New, D.R.1    Maggirwar, S.B.2    Epstein, L.G.3    Dewhurst, S.4    Gelbard, H.A.5
  • 19
    • 1942502823 scopus 로고    scopus 로고
    • Mammalian transforming growth factor betas: smad signaling and physio-pathological roles
    • Javelaud D., Mauviel A. Mammalian transforming growth factor betas: smad signaling and physio-pathological roles. Int. J. Biochem. Cell Biol. 2004, 36:1161-1165.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1161-1165
    • Javelaud, D.1    Mauviel, A.2
  • 20
    • 15744373610 scopus 로고    scopus 로고
    • Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus
    • Nolan Y., Maher F.O., Martin D.S., Clarke R.M., Brady M.T., Bolton A.E., et al. Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus. J. Biol. Chem. 2005, 280:9354-9362.
    • (2005) J. Biol. Chem. , vol.280 , pp. 9354-9362
    • Nolan, Y.1    Maher, F.O.2    Martin, D.S.3    Clarke, R.M.4    Brady, M.T.5    Bolton, A.E.6
  • 21
    • 0346099102 scopus 로고    scopus 로고
    • Overexpression of tumor necrosis factor-α diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-β
    • Fujita M., Shannon J.M., Morikawa O., Gauldie J., Hara N., Mason R.J. Overexpression of tumor necrosis factor-α diminishes pulmonary fibrosis induced by bleomycin or transforming growth factor-β. Am. J. Respir. Cell Mol. Biol. 2003, 29:669-676.
    • (2003) Am. J. Respir. Cell Mol. Biol. , vol.29 , pp. 669-676
    • Fujita, M.1    Shannon, J.M.2    Morikawa, O.3    Gauldie, J.4    Hara, N.5    Mason, R.J.6
  • 22
    • 0034693836 scopus 로고    scopus 로고
    • Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis
    • Singh N.P. Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis. Mutat. Res. 2000, 455:111-127.
    • (2000) Mutat. Res. , vol.455 , pp. 111-127
    • Singh, N.P.1
  • 23
    • 0002924492 scopus 로고
    • Preparation and use of mitochondria in toxicological research
    • IRL, Press, England, Oxford, K. Snell, B. Mullock (Eds.)
    • Cain K., Skilleter D.N. Preparation and use of mitochondria in toxicological research. Biochemical Toxicology-A Practical Approach 1987, 221-223. IRL, Press, England, Oxford. K. Snell, B. Mullock (Eds.).
    • (1987) Biochemical Toxicology-A Practical Approach , pp. 221-223
    • Cain, K.1    Skilleter, D.N.2
  • 24
    • 0014089693 scopus 로고
    • Kritchevsky lipid composition of mitochondria from bovine heart liver and kidney
    • Fleischer S., Rouser G., Fleisher B., Casu A. Kritchevsky lipid composition of mitochondria from bovine heart liver and kidney. J. Lipid Res. 1967, 8:170-179.
    • (1967) J. Lipid Res. , vol.8 , pp. 170-179
    • Fleischer, S.1    Rouser, G.2    Fleisher, B.3    Casu, A.4
  • 25
    • 0002212391 scopus 로고
    • Isocitrate dehydrogenase
    • Van Nostrand Co Ltd, London, J.C. King, D. Van (Eds.)
    • King J. Isocitrate dehydrogenase. Practical Clinical Enzymology 1965, 257-363. Van Nostrand Co Ltd, London. J.C. King, D. Van (Eds.).
    • (1965) Practical Clinical Enzymology , pp. 257-363
    • King, J.1
  • 26
    • 77956995420 scopus 로고
    • α-Ketoglutarate dehydrogenase complex from E. coli
    • Academic Press, London, J.M. Lowenstein (Ed.)
    • Reed L.J., Mukherjee R.B. α-Ketoglutarate dehydrogenase complex from E. coli. Methods in Enzymology 1969, 53-61. Academic Press, London. J.M. Lowenstein (Ed.).
    • (1969) Methods in Enzymology , pp. 53-61
    • Reed, L.J.1    Mukherjee, R.B.2
  • 27
    • 73649196367 scopus 로고
    • Studies on the respiratory chain linked dehydro diphosphopyridine nucleotide dehydrogenase I. Assay of the enzyme in particulate and in soluble preparation
    • Minakami S., Ringer R.L., Singer T.P. Studies on the respiratory chain linked dehydro diphosphopyridine nucleotide dehydrogenase I. Assay of the enzyme in particulate and in soluble preparation. J. Biol. Chem. 1962, 237:569-576.
    • (1962) J. Biol. Chem. , vol.237 , pp. 569-576
    • Minakami, S.1    Ringer, R.L.2    Singer, T.P.3
  • 30
    • 0000807711 scopus 로고
    • The determination of inorganic phosphate in the presence of labile phosphate esters
    • Lowry O.H., Lopez J.A. The determination of inorganic phosphate in the presence of labile phosphate esters. J. Biol. Chem. 1946, 162:421-428.
    • (1946) J. Biol. Chem. , vol.162 , pp. 421-428
    • Lowry, O.H.1    Lopez, J.A.2
  • 31
    • 0021986181 scopus 로고
    • The respiration and calcium content of heart mitochondria from rats with vitamin d-induced cardio necrosis
    • Zydowo M.M., Swiercynski J., Nagel G., Wrzolkowo T. The respiration and calcium content of heart mitochondria from rats with vitamin d-induced cardio necrosis. J.Biochem. 1985, 226:155-161.
    • (1985) J.Biochem. , vol.226 , pp. 155-161
    • Zydowo, M.M.1    Swiercynski, J.2    Nagel, G.3    Wrzolkowo, T.4
  • 32
    • 0032502866 scopus 로고    scopus 로고
    • Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition
    • Petit P.X., Goubern M., Diolez P., Susin S.A., Zamzami N., Kroemer G. Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition. FEBS Lett. 1998, 426:111-116.
    • (1998) FEBS Lett. , vol.426 , pp. 111-116
    • Petit, P.X.1    Goubern, M.2    Diolez, P.3    Susin, S.A.4    Zamzami, N.5    Kroemer, G.6
  • 33
    • 0022492812 scopus 로고
    • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties
    • Emaus R.K., Grunwald R., Lemasters J.J. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim. Biophys. Acta. 1986, 85:436-448.
    • (1986) Biochim. Biophys. Acta. , vol.85 , pp. 436-448
    • Emaus, R.K.1    Grunwald, R.2    Lemasters, J.J.3
  • 34
    • 0003676382 scopus 로고    scopus 로고
    • Subcellular fraction, 1st (ed.)
    • Oxford University Press, USA
    • Graham J.M., Rickwood D. Subcellular fraction, 1st (ed.). A Practical Approach 1997, 120-128. Oxford University Press, USA.
    • (1997) A Practical Approach , pp. 120-128
    • Graham, J.M.1    Rickwood, D.2
  • 35
    • 34547657455 scopus 로고    scopus 로고
    • Existence of a distinct concentration window governing daunorubicin induced mammalian liver mitotoxicity-implication for determining therapeutic window
    • Paul M.K., Patkari M., Mukhopadhayay A.K. Existence of a distinct concentration window governing daunorubicin induced mammalian liver mitotoxicity-implication for determining therapeutic window. Biochem. Pharmacol. 2007, 74:821-830.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 821-830
    • Paul, M.K.1    Patkari, M.2    Mukhopadhayay, A.K.3
  • 36
    • 0035750172 scopus 로고    scopus 로고
    • Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage
    • Ercal N., Gurer-Orhan H., Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr. Top. Med. Chem. 2001, 1:529-539.
    • (2001) Curr. Top. Med. Chem. , vol.1 , pp. 529-539
    • Ercal, N.1    Gurer-Orhan, H.2    Aykin-Burns, N.3
  • 37
    • 84876015394 scopus 로고    scopus 로고
    • Ameliorative effect of aqueous curry leaf (murraya koenigii) extract against cadmium-induced oxidative stress in rat liver: involvement of antioxidant mechanisms
    • Elina M., Arnab K.G., Debosree G., Syed B.F., Debasri M., Aindrila C., Sanjib K.P., Santanu D., Debasish B. Ameliorative effect of aqueous curry leaf (murraya koenigii) extract against cadmium-induced oxidative stress in rat liver: involvement of antioxidant mechanisms. Int. J. Pharm. Sci. 2013, 2:570-583.
    • (2013) Int. J. Pharm. Sci. , vol.2 , pp. 570-583
    • Elina, M.1    Arnab, K.G.2    Debosree, G.3    Syed, B.F.4    Debasri, M.5    Aindrila, C.6    Sanjib, K.P.7    Santanu, D.8    Debasish, B.9
  • 38
    • 33744982431 scopus 로고    scopus 로고
    • Protective effect of curcumin, capsaicin and garlic on erythrocyte integrity in high fat fed rats
    • Kempaiah R.K., Srinivasan K. Protective effect of curcumin, capsaicin and garlic on erythrocyte integrity in high fat fed rats. J. Nutritional. Biochem. 2006, 17:471-478.
    • (2006) J. Nutritional. Biochem. , vol.17 , pp. 471-478
    • Kempaiah, R.K.1    Srinivasan, K.2
  • 39
    • 0035865819 scopus 로고    scopus 로고
    • Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
    • Ishige K., Schubert D., Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free. Radic. Biol. Med. 2001, 30:433-446.
    • (2001) Free. Radic. Biol. Med. , vol.30 , pp. 433-446
    • Ishige, K.1    Schubert, D.2    Sagara, Y.3
  • 40
    • 84930209054 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins ameliorates cadmium-induced renal injury and oxidative stress in experimental rats through the up-regulation of nuclear related factor 2 and antioxidant responsive elements
    • Nazimabashir V., Manoharan S.M., iltonprabu Grape seed proanthocyanidins ameliorates cadmium-induced renal injury and oxidative stress in experimental rats through the up-regulation of nuclear related factor 2 and antioxidant responsive elements. Biochem. Cell Biol. 2015, 93:1-17.
    • (2015) Biochem. Cell Biol. , vol.93 , pp. 1-17
    • Nazimabashir1    Manoharan, V.2    Miltonprabu, S.3
  • 41
    • 79251598329 scopus 로고    scopus 로고
    • Quercetin regulate oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR NF-k{cyrillic}B signaling pathway
    • Bhaskar S., Shalini V., Helen A. Quercetin regulate oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR NF-k{cyrillic}B signaling pathway. Immunobiology 2011, 216:367-373.
    • (2011) Immunobiology , vol.216 , pp. 367-373
    • Bhaskar, S.1    Shalini, V.2    Helen, A.3
  • 42
    • 0027947675 scopus 로고
    • New insights into the regulation of inducible nitric oxidesynthesis
    • Morris S.M., Billiar T.R. New insights into the regulation of inducible nitric oxidesynthesis. Am. J. Physiol. 1994, 266:829-839.
    • (1994) Am. J. Physiol. , vol.266 , pp. 829-839
    • Morris, S.M.1    Billiar, T.R.2
  • 43
    • 0030271387 scopus 로고    scopus 로고
    • NF-kB: ten years after
    • Baeuerle P.A., Baltimore D. NF-kB: ten years after. Cell 1996, 87:13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 44
    • 80052244695 scopus 로고    scopus 로고
    • Proanthocyanidins from grape seeds modulate the NF-kB signal transduction pathways in rats with TNBS-induced ulcerative colitis
    • Li X., Yang X., Cai Y., Qin H., Wang L., Wang Y., et al. Proanthocyanidins from grape seeds modulate the NF-kB signal transduction pathways in rats with TNBS-induced ulcerative colitis. Molecules 2011, 16:6721-6731.
    • (2011) Molecules , vol.16 , pp. 6721-6731
    • Li, X.1    Yang, X.2    Cai, Y.3    Qin, H.4    Wang, L.5    Wang, Y.6
  • 45
    • 2342646206 scopus 로고    scopus 로고
    • Cadmium inhibits the electron transfer chain and induces reactive oxygen species
    • Wang Y., Fang J., Leonard S.S., Rao K.M. Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free. Radic. Biol. Med. 2004, 36:1434-1443.
    • (2004) Free. Radic. Biol. Med. , vol.36 , pp. 1434-1443
    • Wang, Y.1    Fang, J.2    Leonard, S.S.3    Rao, K.M.4
  • 46
    • 0035229427 scopus 로고    scopus 로고
    • The mitochondrion in apoptosis: how pandora's box opens
    • Zamzami N., Kroemer G. The mitochondrion in apoptosis: how pandora's box opens. Nat. Rev. 2001, 2:67-71.
    • (2001) Nat. Rev. , vol.2 , pp. 67-71
    • Zamzami, N.1    Kroemer, G.2
  • 47
    • 0036146436 scopus 로고    scopus 로고
    • Glucocorticoids suppress the inflammation-mediated tolerance to acute toxicity of cadmium in mice
    • Min K.S., Kim H., Fujii M., Tetsuchikawahara N., Onosaka S. Glucocorticoids suppress the inflammation-mediated tolerance to acute toxicity of cadmium in mice. Toxicol. Appl. Pharmacol 2002, 178:1-7.
    • (2002) Toxicol. Appl. Pharmacol , vol.178 , pp. 1-7
    • Min, K.S.1    Kim, H.2    Fujii, M.3    Tetsuchikawahara, N.4    Onosaka, S.5
  • 48
    • 0032693019 scopus 로고    scopus 로고
    • Ubiquinone redox cycle as a cellular antioxidant defense system
    • Kishi T., Takahashi T., Usui A., Okamoto T. Ubiquinone redox cycle as a cellular antioxidant defense system. Biofactors 1999, 10:131-138.
    • (1999) Biofactors , vol.10 , pp. 131-138
    • Kishi, T.1    Takahashi, T.2    Usui, A.3    Okamoto, T.4
  • 49
    • 28644449676 scopus 로고    scopus 로고
    • Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage
    • Echtay K.S., Pakay J.L., Esteves T.C., Rand M.D. Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage. Biofactors 2005, 24:119-130.
    • (2005) Biofactors , vol.24 , pp. 119-130
    • Echtay, K.S.1    Pakay, J.L.2    Esteves, T.C.3    Rand, M.D.4
  • 50
    • 34848922114 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in rat with nonalcoholic fatty liver involvement of complex I, reactive oxygen species and cardiolipin
    • Petrosillo G., Portincasa P., Grattagliano I., Casanova G., Matera M., Francesca M.R., Domenico F., Giuseppe P. Mitochondrial dysfunction in rat with nonalcoholic fatty liver involvement of complex I, reactive oxygen species and cardiolipin. BBA 2007, 1260-1267.
    • (2007) BBA , pp. 1260-1267
    • Petrosillo, G.1    Portincasa, P.2    Grattagliano, I.3    Casanova, G.4    Matera, M.5    Francesca, M.R.6    Domenico, F.7    Giuseppe, P.8
  • 51
    • 0024247516 scopus 로고
    • Impairment of the respiratory chain in b-c1 region as early functional event during fe2+/ascorbate induced peroxidation in rat liver mitochondria
    • Trumper L., Hoffman B., Wiswedel T., et al. Impairment of the respiratory chain in b-c1 region as early functional event during fe2+/ascorbate induced peroxidation in rat liver mitochondria. Biomed. Biochim. Acta. 1988, 47:933-939.
    • (1988) Biomed. Biochim. Acta. , vol.47 , pp. 933-939
    • Trumper, L.1    Hoffman, B.2    Wiswedel, T.3
  • 52
    • 0018833016 scopus 로고
    • Time dependent changes in canine cardiac mitochondrial function and ultra structure resulting from coronary occlusion and reperfusion
    • Bush L.R., Shlafer H., Haack D.W., et al. Time dependent changes in canine cardiac mitochondrial function and ultra structure resulting from coronary occlusion and reperfusion. Basic. Res. Cardiol. 1980, 75:553-571.
    • (1980) Basic. Res. Cardiol. , vol.75 , pp. 553-571
    • Bush, L.R.1    Shlafer, H.2    Haack, D.W.3
  • 53
    • 77955553628 scopus 로고    scopus 로고
    • GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart
    • Aguirre E., Cadenas S. GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart. Biochim. Biophys. Acta. 2010, 1797:1716-1726.
    • (2010) Biochim. Biophys. Acta. , vol.1797 , pp. 1716-1726
    • Aguirre, E.1    Cadenas, S.2
  • 54
    • 33645117749 scopus 로고    scopus 로고
    • Single and combination toxic metal exposures induce apoptosis in cultured murine podocytes exclusively via the extrinsic caspase 8 pathway
    • Eichler T., Ma Q., Kelly C., Mishra J., Parikh S., Ransom R.F., Devarajan P., Smoyer W.E. Single and combination toxic metal exposures induce apoptosis in cultured murine podocytes exclusively via the extrinsic caspase 8 pathway. Toxicol. Sci. 2006, 90:392-399.
    • (2006) Toxicol. Sci. , vol.90 , pp. 392-399
    • Eichler, T.1    Ma, Q.2    Kelly, C.3    Mishra, J.4    Parikh, S.5    Ransom, R.F.6    Devarajan, P.7    Smoyer, W.E.8
  • 56
    • 0033198675 scopus 로고    scopus 로고
    • Novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver
    • Ray S.D., Kumar M.A., Bagchi D.A. Novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch. Biochem. Biophys. 1999, 369:42-58.
    • (1999) Arch. Biochem. Biophys. , vol.369 , pp. 42-58
    • Ray, S.D.1    Kumar, M.A.2    Bagchi, D.A.3
  • 57
    • 0034065020 scopus 로고    scopus 로고
    • Combined effects of okadaic acid and cadmium on lipid peroxidation and DNA bases modifications (m5dC and 8-(OH)-dG) in Caco-2 cells
    • Traore A., Ruiz S., Baudrimont I., et al. Combined effects of okadaic acid and cadmium on lipid peroxidation and DNA bases modifications (m5dC and 8-(OH)-dG) in Caco-2 cells. Arch. Toxicol. 2000, 74:79-84.
    • (2000) Arch. Toxicol. , vol.74 , pp. 79-84
    • Traore, A.1    Ruiz, S.2    Baudrimont, I.3
  • 58
    • 0036385733 scopus 로고    scopus 로고
    • Oss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo
    • Whiteman M., Hong H.S., Jenner A., et al. oss of oxidized and chlorinated bases in DNA treated with reactive oxygen species: implications for assessment of oxidative damage in vivo. Biochem. Biophys. Res. Commun. 2002, 296:883-889.
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , pp. 883-889
    • Whiteman, M.1    Hong, H.S.2    Jenner, A.3
  • 59
    • 0034460429 scopus 로고    scopus 로고
    • In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin induced cardio toxicity by a novel IH636 grape seed proanthocyanidin extract
    • Ray S.D., Patel D., Wong V., Bagchi D. In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin induced cardio toxicity by a novel IH636 grape seed proanthocyanidin extract. Res. Commun. Mol. Pathol. Pharmacol. 2000, 107:137-166.
    • (2000) Res. Commun. Mol. Pathol. Pharmacol. , vol.107 , pp. 137-166
    • Ray, S.D.1    Patel, D.2    Wong, V.3    Bagchi, D.4
  • 60
    • 84880604062 scopus 로고    scopus 로고
    • The potential protective effect of natural honey against cadmium induced hepatotoxicity and nephrotoxicity
    • Abdel-Moneim W.M., Ghafeer H.H., Mansoura J. The potential protective effect of natural honey against cadmium induced hepatotoxicity and nephrotoxicity. Forensic Med. Clin. Toxicol. 2007, 15:75-98.
    • (2007) Forensic Med. Clin. Toxicol. , vol.15 , pp. 75-98
    • Abdel-Moneim, W.M.1    Ghafeer, H.H.2    Mansoura, J.3


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