Minocycline ameliorates hypoxia-induced blood-brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway

Neuroscience

Volumn 304, Issue , 2015, Pages 250-259

  Yang, F ^a,b   Zhou, L ^a   Wang, D ^a,b   Wang, Z ^a   Huang, Q Y ^a,b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Air Defense Forces Command CollegePLA   (China)

Author keywords

Blood brain barrier; HIF 1 ; Hypoxia; Minocycline; Neuro inflammation; SIRT 3

Indexed keywords

CLAUDIN 5; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MINOCYCLINE; OCCLUDIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE HYDROXYLASE 2; PROTEIN ZO1; SIRTUIN 3; TIGHT JUNCTION PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; EGLN1 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HIF1A PROTEIN, RAT; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; NEUROPROTECTIVE AGENT; PHD2 PROTEIN, RAT; SIRT-3 PROTEIN, RAT; SIRT3 PROTEIN, HUMAN; SIRTUIN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HYPOXIA; BRAIN PROTECTION; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; GENE; GENE EXPRESSION; HIF 1APHA GENE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MMP2 GENE; MMP9 GENE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TJ GENE; TRANSCRIPTION REGULATION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL HYPOXIA; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM CELL; GENE SILENCING; GENETICS; HYPOXIA, BRAIN; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD-BRAIN BARRIER; CELL HYPOXIA; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HYPOXIA, BRAIN; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; MALE; MINOCYCLINE; NEUROPROTECTIVE AGENTS; PROCOLLAGEN-PROLINE DIOXYGENASE; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIRTUIN 3; SIRTUINS;

EID: 84949791075     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.07.051     Document Type: Article

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