P21Waf1/Cip1 plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation

Food and Chemical Toxicology

Volumn 88, Issue , 2016, Pages 1-12

  Deng, Sijun ^a   Tang, Shusheng ^a   Dai, Chongshan ^a   Zhou, Yan ^a   Yang, Xiayun ^a   Li, Daowen ^a   Xiao, Xilong ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase activation; Furazolidone; p21; ROS

Indexed keywords

CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1; FURAZOLIDONE; HEME OXYGENASE 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HEPG2 CELL LINE; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; HUMAN; METABOLISM; PHYSIOLOGY;

APOPTOSIS; CASPASE 3; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; FURAZOLIDONE; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 84949751766     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.12.004     Document Type: Article

References (49)

1. Ali B. Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research. Veterinary Res. Commun. 1999, 23:343-360.
2. Ali B., Hassan T., Wasfi I., Mustafa A. Toxicity of furazolidone to Nubian goats. Veterinary Hum. Toxicol. 1984, 26:197-200.
3. Asada M., Yamada T., Ichijo H., Delia D., Miyazono K., Fukumuro K., Mizutani S. Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation. EMBO J. 1999, 18:1223-1234.
4. Blundell R.A. The biology of p21-review paper. Am. J. Biochem. Biotechnol. 2006, 2:33.
5. Chen Q., Liu J., Merrett J. Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem. J. 2000, 347:543-551.
6. Chen W., Sun Z., Wang X.-J., Jiang T., Huang Z., Fang D., Zhang D.D. Direct interaction between Nrf2 and p21 Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response. Mol. Cell 2009, 34:663-673.
7. Circu M.L., Aw T.Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic. Biol. Med. 2010, 48:749-762.
8. Czarnecki C.M. Quantitative morphological alterations during the development of furazolidone-induced cardiomyopathy in turkeys. J. Comp. Pathol. 1986, 96:63-75.
9. Datla S.R., Dusting G.J., Mori T.A., Taylor C.J., Croft K.D., Jiang F. Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress. Hypertension 2007, 50:636-642.
10. De Angelis I., Hoogenboom L., Huveneers-Oorsprong M., Zucco F., Stammati A. Established cell lines for safety assessment of food contaminants: differing furazolidone toxicity to V 79, HEp-2 and Caco-2 cells. Food Chem. Toxicol. 1994, 32:481-488.
11. De Angelis I., Rossi L., Pedersen J., Vignoli A., Vincentini O., Hoogenboom L., Polman T.H., Stammati A., Zucco F. Metabolism of furazolidone: alternative pathways and modes of toxicity in different cell lines. Xenobiotica 1999, 29:1157-1169.
12. De Luca A., Maiello M.R., D'Alessio A., Pergameno M., Normanno N. The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin. Ther. targets 2012, 16:S17-S27.
13. Deng S., Tang S., Zhang S., Zhang C., Wang C., Zhou Y., Dai C., Xiao X. Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells. Food & Chem. Toxicol. 2015, 75:173-186.
14. Deng S., Yuan H., Yi J., Lu Y., Wei Q., Guo C., Wu J., Yuan L., He Z. Gossypol acetic acid induces apoptosis in RAW264. 7 cells via a caspase-dependent mitochondrial signaling pathway. J. veterinary Sci. 2013, 14:281-289.
15. Dotto G.P. p21WAF1/Cip1: more than a break to the cell cycle?. Biochim. Biophys. Acta Vol. 2000, 1471(14):43-56.
16. Egan B.J., Marzio L., O'Connor H., O'Morain C. Treatment of Helicobacter pylori infection. Helicobacter 2008, 13:35-40.
17. Gartel A.L. The conflicting roles of the cdk inhibitor p21 (CIP1/WAF1) in apoptosis. Leukemia Res. 2005, 29:1237-1238.
18. Gartel A.L., Serfas M.S., Tyner A.L. p21-negative regulator of the cell cycle. Exp. Biol. Med. 1996, 213:138-149.
19. Gartel A.L., Tyner A.L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis 1 supported in part by NIH grant R01 DK56283 (to ALT) for the p21 research and campus research board and Illinois department of public health penny severns breast and cervical Cancer grants (to ALG). 1. Mol. cancer Ther. 2002, 1:639-649.
20. Gogada R., Amadori M., Zhang H., Jones A., Verone A., Pitarresi J., Jandhyam S., Prabhu V., Black J.D., Chandra D. Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis. Cell cycle 2011, 10:4128-4137.
21. Hausen M.A., Freitas J.C.M., Monteiro-Leal L.H. The effects of metronidazole and furazolidone during Giardia differentiation into cysts. Exp. Parasitol. 2006, 113:135-141.
22. Ido Y. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One 2012, 7:172-174.
23. Jackson J.G., Pant V., Li Q., Chang L.L., Quintás-Cardama A., Garza D., Tavana O., Yang P., Manshouri T., Li Y. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell 2012, 21:793-806.
24. Jacobson M.D., Weil M., Raff M.C. Programmed cell death in animal development. Cell 1997, 88:347-354.
25. Jiang X., Sun L., Qiu J.J., Sun X., Li S., Wang X., So C.W.E., Dong S. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One 2013, 8:e72335.
26. Jin X., Tang S., Chen Q., Zou J., Zhang T., Liu F., Zhang S., Sun C., Xiao X. Furazolidone induced oxidative DNA damage via up-regulating ROS that caused cell cycle arrest in human hepatoma G2 cells. Toxicol. Lett. 2011, 201:205-212.
27. Jin Y.H., Yoo K.J., Lee Y.H., Lee S.K. Caspase 3-mediated cleavage of p21 WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J. Biol. Chem. 2000, 275:30256-30263.
28. Jung Y.-S., Qian Y., Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell. Signal. 2010, 22:1003-1012.
29. Kaneto H., Kajimoto Y., Fujitani Y., Matsuoka T., Sakamoto K., Matsuhisa M., Yamasaki Y., Hori M. Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction. Diabetologia 1999, 42:1093-1097.
30. Kobayashi M., Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid. Redox Signal. 2005, 7:385-394.
31. Lee J.Y., Yu S.J., Park Y.G., Kim J., Sohn J. Glycogen synthase kinase 3β phosphorylates p21 WAF1/CIP1 for proteasomal degradation after UV irradiation †. Mol. Cell Biol. 2007, 27:3187-3198.
32. Li Y., Dowbenko D., Lasky L.A. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J. Biol. Chem. 2002, 277:11352-11361.
33. Macip S., Igarashi M., Fang L., Chen A., Pan Z.Q., Lee S.W., Aaronson S.A. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J. 2002, 21:2180-2188.
34. Mandal S., Mandal M.D., Pal N.K. Cholera: a great global concern. Asian Pac. J. Trop. Med. 2011, 4:573-580.
35. Marrot L., Jones C., Perez P., Meunier J.R. The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis. Pigment Cell & Melanoma Res. 2008, 21:79-88.
36. O'Reilly M.A., Staversky R.J., Watkins R.H., Reed C.K., de Mesy Jensen K.L., Finkelstein J.N., Keng P.C. The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am. J. Respir. Cell Mol. Biol. 2001, 24:703-710.
37. Okafor C.C., Perreault-Micale C., Hajjar R.J., Lebeche D., Skiroman K., Jabbour G., Doye A.A., Lee M.X., Laste N., Gwathmey J.K. Chronictreatment with carvedilol improves ventricular function and reducesmyocyte apoptosis in an animal model of heart failure. Bmc Physiol. 2003, 3:1-9.
38. Orrenius S., Gogvadze V., Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu. Rev. Pharmacol. Toxicol. 2007, 47:143-183.
39. Scott M.T., Ingram A., Ball K.L. PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein. EMBO J. 2002, 21:6771-6780.
40. Speidel D. The role of DNA damage responses in p53 biology. Arch. Toxicol. 2015, 89.
41. Stroo W.E., Schaffer S.W. Furazolidone-enhanced production of free radicals by avian cardiac and hepatic microsomal membranes. Toxicol. Appl. Pharmacol. 1989, 98:81-86.
42. Suzuki A., Ito T., Kawano H., Hayashida M., Hayasaki Y., Tsutomi Y., Akahane K., Nakano T., Miura M., Shiraki K. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene 2000, 19:1346-1353.
43. Tsao Y.P. Adenovirus-mediated p21((WAF1/SDII/CIP1)) gene transfer induces apoptosis of human cervical cancer cell lines. J. Virol. 1999, 73:4983-4990.
44. Villeneuve N.F., Sun Z., Chen W., Zhang D.D. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle 2009, 8:3255-3256.
45. Vitiello P.F., Wu Y.-C.M., Staversky R.J., O'Reilly M.A. p21 Cip1 protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways. Free Radic. Biol. Med. 2009, 46:33-41.
46. Wu Q., Kirschmeier P., Hockenberry T., Yang T.-Y., Brassard D.L., Wang L., McClanahan T., Black S., Rizzi G., Musco M.L. Transcriptional regulation during p21 WAF1/CIP1-induced apoptosis in human ovarian cancer cells. J. Biol. Chem. 2002, 277:36329-36337.
47. Zhan J. Negative regulation of ASK1 by p21(Cip1) involves a small domain that includes serine 98 that is phosphorylated by ASK1 in vivo. Mol. Cell. Biol. 2007, 27:3530-3541.
48. Zhao H., Spitz M.R., Tomlinson G.E., Zhang H., Minna J.D., Wu X. γ-Radiation-induced G2 delay, apoptosis, and p53 response as potential susceptibility markers for lung Cancer. Cancer Res. 2001, 61:7819-7824.
49. Zolla L., Timperio A.M. Involvement of active oxygen species in protein and oligonucleotide degradation induced by nitrofurans. Biochem. Cell Biol. 2005, 83:166-175.