Chronic treatment with Carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure

BMC Physiology

Volumn 3, Issue , 2003, Pages 1-9

  Okafor, Chukwuka C ^a,b   Perreault Micale, Cynthia ^c,e   Hajjar, Roger J ^d   Lebeche, Djamel ^c   Skiroman, Klara ^c   Jabbour, George ^d   Doye, Angelia A ^c   Lee, Michael X ^c,e   Laste, Nancy ^f   Gwathmey, Judith K ^a,c,e  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Gwathmey Inc   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f Angell Memorial Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE COURSE; ECHOCARDIOGRAPHY; HEART CONTRACTION; HEART FAILURE; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART VENTRICLE FUNCTION; LONG TERM CARE; NONHUMAN; TREATMENT OUTCOME; TURKEY (BIRD);

EID: 2942650804     PISSN: 14726793     EISSN: None     Source Type: Journal    
DOI: 10.1186/1472-6793-3-1     Document Type: Article

References (40)

1. Eichhorn EJ and Bristow MR: Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure Circulation 1996, 94(9):2285-2296.
2. Yeh ETH: Life and death in the cardiovascular system Circulation 1997, 95(4):782-786.
3. Haunstetter A and Izumo S: Apoptosis: basic mechanisms and implications for cardiovascular disease Circ Res 1998, 82(11):1111-1129.
4. Chien KR, Zhu H, Knowlton KU, Miller-Hance W, van-Bilsen M, O'Brien TX and Evans SM: Transcriptional regulation during cardiac growth and development Annu Rev Physiol 1993, 55:77-95.
5. Katz AM: Cell death in the failing heart: role of an unnatural growth response to overload Clinical Cardiology 1995, 18:IV36-44.
6. Singh K, Xiao L, Remondino A, Sawyer DB and Colucci WS: Adrenergic regulation of cardiac myocyte apoptosis J Cell Physiol 2002, 201:189:257-265.
7. Mann DL, Kent RL, Parsons B and Cooper G: Adrenergic effects on the biology of the adult mammalian cardiocyte Circulation 1992, 85:790-804.
8. Leri A, Claudio PP, Li Q, Wang X, Reiss K, Wang S, Malhotra A, Kajstura J and Anversa P: Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell J Clin Invest 1998, 101:1326-1342.
9. Diez J, Fortuno MA and Ravassa S: Apoptosis in hypertensive heart disease Curr Opin Cardiol 1998, 13:317-325.
10. Teiger E, Than VD, Richard L, Wisnewsky C, Tea BS, Gaboury L, Tremblay J, Schwartz K and Hamet P: Apoptosis in pressure overload-induced heart hypertrophy in the rat J Clin Invest 1996, 97:2891-2897.
11. Krown KA, Page MT, Nguyen C, Zechner D, Gutierrez V, Comstock KL, Glembotski CC, Quintana PJ and Sabbadini RA: Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death J Clin Invest 1996, 98(12):2854-2865.
12. Feuerstein GZ, Poste G and Ruffolo RR: Carvedilol update III: rationale for use in congestive heart failure Drugs of Today 1995, 31(5):307-326.
13. Olsen SL, Gilbert EM, Renlund DG, Taylor DO, Yanowitz FD and Bristow MR: Carvedilol improves left ventricular function and symptoms in chronic heart failure: a double-blind randomized study J Am Coll Cardiol 1995, 25:1225-1231.
14. Di Lenarda A, Sabbadini G, Salvatore L, Sinagra G, Mestroni L, Pinamonti B, Gregori D, Ciani F, Muzzi A, Klugmann S and Camerini F: Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprolol. The Heart-Muscle Disease Study Group J Am Coll Cardiol 1999, 33(7):1926-1934.
15. Quaife RA, Gilbert EM, Christian PE, Datz FL, Mealey PC, Volkman K, Olsen SL and Bristow MR: Effects of carvedilol on systolic and diastolic left ventricular performance in idiopathic dilated cardiomyopathy or ischemic cardiomyopathy Am J Cardiol 1996, 78(7):779-784.
16. Frishman WH: Drug therapy: Carvedilol N Engl J Med 1998, 339(24):1759-1765.
17. Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM and Shusterman NH: The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure N Engl J Med 1996, 334(21):1349-1355.
18. Gwathmey JK, Kim CS, Hajjar RJ, Khan F, DiSalvo TG, Matsumori A and Bristow MR: Cellular and molecular remodeling in a heart failure model treated with the beta-blocker carteolol Am J Physiol 1999, 276(5 Pt 2):H1678-1690.
19. Jankus EF, Noren GR and Staley NA: Furazolidone-induced cardiac dilatation in turkeys Avian Dis 1972, 16(4):958-961.
20. Czarnecki CM, Jankus EF and Hultgren BD: Effects of furazolidone on the development of cardiomyopathies in turkey poults Avian Dis 1974, 18(1):125-133.
21. 2+channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force Circ Re 1993, 73(6):1077-1089.
22. Hajjar RJ, Liao R, Young JB, Fuleihan F, Glass MG and Gwathmey JK: Pathophysiological and biochemical characterisation of an avian model of dilated cardiomyopathy: comparison to findings in human dilated cardiomyopathy Cardiovasc Res 1993, 27(12):2212-2221.
23. Mann DL, Kent RL, Parsons B and Cooper G 4th: Adrenergic effects on the biology of the adult mammalian cardiocyte Circulation 1992, 85:790-804.
24. Doughty RN, MacMahon S and Sharpe N: Beta-blockers in heart failure: promising or proved? J Am Coll Cardiol 1994, 23(3):814-821.
25. Tominaga M, Matsumori A, Okada I, Yamada T and Kawai C: Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice Circulation 1991, 83(6):2021-2028.
26. Sabbah HN, Shimoyama H, Kono T, Gupta RC, Sharov VG, Scicli G, Levine TB and Goldstein S: Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction Circulation 1994, 89(6):2852-2859.
27. Hall SA, Cigarroa CG, Marcoux L, Risser RC, Grayburn PA and Eichhorn EJ: Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade J Am Coll Cardiol 1995, 25(5):1154-1161.
28. Bristow MR, Gilbert EM, Abraham WT, Adams KF, Fowler MB, Hershberger RE, Kubo SH, Narahara KA, Ingersoll H, Krueger S, Young S and Shusterman N: Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators Circulation 1996, 94(11):2807-2816.
29. MacLellan WR and Schneider MD: Death by design: Programmed cell death in cardiovascular biology and disease Circ Res 1997, 81:137-144.
30. Sharov VG, Sabbah HN, Shimoyama H, Goussev AV, Lesch M and Goldstein S: Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure Am J Pathol 1996, 148:141-149.
31. Liu Y, Cigola E and Cheng W et al.: Myocyte nuclear mitotic division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs Laboratory Investigation 1995, 73:771-787.
32. Olivetti G, Abbi R and Quaini F et al.: Apoptosis in the failing human heart N Engl J Med 1997, 336:1131-1141.
33. Narula J, Haider N and Virmani R et al.: Apoptosis in myocytes in end-stage heart failure N Engl J Med 1996, 335:1182-1189.
34. McCarthy NJ and Evan GI: Methods for detecting and quantifying apoptosis Curr Top Dev Bio 1998, 36:259-278.
35. Rossig L, Haendeler J, Mallat Z, Hugel B, Freyssinet J, Tedgui A, Dimmeler S and Zeiher AM: Congestive Heart Failure Induces Endothelial Cell Apoptosis: Protective Role of Carvedilol J Am Coll Cardiol 2000, 36(7):2081-2089.
36. Sabbah HN, Sharov VG, Gupta RC, Todor A, Singh V and Goldstein S: Chronic Therapy With Metoprolol Attenuates Cardiomyocyte Apoptosis in Dogs With Heart Failure J Am Coll Cardiol 2000, 36(5):1698-1705.
37. Li Z, Bing OH, Long X, Robinson KG and Lakatta EG: Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat Am J Physiol 1997, 272:H2313-H2319.
38. Kajstura J, Cigola E, Malhotra A, Li P, Cheng W, Meggs LG and Anversa P: Angiotensin II induces apoptosis of adult ventricular myocytes in vitro J Mol Cell Cardiol 1997, 29(3):859-870.
39. Buttle TM and Sandstrom PA: Oxidative stress as a mediator of apoptosis Immunol Today 1994, 15:7-10.
40. Flesch M, Maack C, Cremers B, Baumer AT, Sudkamp M and Bohm M: Effect of beta-blockers on free radical-induced cardiac contractile dysfunction Circulation 1999, 100(4):346-353.